Clinical trials: sponsored by Semmelweis University
Infection, Sepsis
A Study to Compare the Efficacy and Safety of Extended and Intermittent Infusion of Beta-lactams in Critically Ill Paediatric Patients
The goal of this clinical trial is to examine the success and safety of administering certain antibiotics (beta-lactams) given in a longer 3-hour infusion to children (0-17 years) who are critically ill and have severe infection.
- Conditions
- Infection, Sepsis, NICU, PICU
- Trial name
- PEBBLE (NCT07484633)
- Testing
- Extended infusion time of the following beta-lactam: meropenem, Short-term infusion time of the following beta-lactam: meropenem, Extended infusion time of the following beta-lactam: piperacillin/tazobactam
- Where
- 2 sites in Hungary
- Volunteers
- 110 people
- Sponsor
- Semmelweis University
Cerebral Palsy
The Effects of Protocolized Breathing Exercises on Pulmonary Function in Adolescents With Cerebral Palsy.
This multicenter randomized controlled pilot trial evaluates whether an 8-week protocolized breathing exercise program improves pulmonary function and quality of life in adolescents and young adults with cerebral palsy.
- Trial name
- NCT07873593
- Testing
- Protocolized breathing exercises
- Where
- Hungary
- Volunteers
- 360 people
- Sponsor
- Semmelweis University
Cerebral Palsy
Effects of Lokomat-Robot Assisted Gait Training on Gross Motor Function in Children and Young Adults With Cerebral Palsy
This single-center, controlled, delayed-intervention, quasi-experimental study evaluates the effectiveness of Lokomat®-assisted robotic gait training on gross motor function and health-related quality of life in children and…
- Trial name
- NCT07732205
- Testing
- Sessions with Lokomat robot-assisted system, Control arm
- Where
- Hungary
- Volunteers
- 96 people
- Sponsor
- Semmelweis University
Palatal Expansion Technique
Investigation of Skeletally Anchored Expansion of the Maxilla
This study aims to compare two different methods for maxillary expansion in adult patients with transverse maxillary deficiency. Participants will receive either miniscrew-assisted rapid palatal expansion (MARPE-MICRO-4).
- Trial name
- NCT07383376
- Testing
- MARPE, SARME
- Where
- Hungary
- Volunteers
- 90 people
- Sponsor
- Semmelweis University
Maxillary Expansion, Forensic Dentistry
Evaluation of Palatal Rugae-Based Identification After Maxillary Expansion Using Local Morphological Patch Analysis
This study investigates the reliability of palatal rugae-based identification following maxillary expansion procedures, including Miniscrew-Assisted Rapid Palatal Expansion (MARPE) and Surgically Assisted Rapid Maxillary…
- Conditions
- Maxillary Expansion, Forensic Dentistry, Intraoral Scanner, Orthodontic Appliance
- Trial name
- NCT07667933
- Testing
- SARME, MARPE, Untreated Control
- Where
- Hungary
- Volunteers
- 45 people
- Sponsor
- Semmelweis University
Ocular Surface Allergy, Conjunctivitis, Allergic
Treatment of Ocular Surface Inflammations
The goal of this clinical trial is to learn if topical Cyclosporine 1% works to treat severe allergic ocular surface inflammation in pediatric population.
- Conditions
- Ocular Surface Allergy, Conjunctivitis, Allergic, Blepharoconjunctivitis
- Trial name
- NCT07732855
- Testing
- Topical Cyclosporine 1%
- Where
- Hungary
- Volunteers
- 50 people
- Sponsor
- Semmelweis University
Myopia Progression, Myopia
Inhibition of Myopia Progression With Optical Devices
This observational study aims to determine whether optical devices designed to slow myopia progression and/or environmental factors can prevent myopia progression in the pediatric and adolescent myopic population.
- Conditions
- Myopia Progression, Myopia, Myopia, Child Myopia Progression
- Trial name
- NCT07698977
- Testing
- Wearing myopia-control D.I.M.S. glasses while awake, DIMS (Defocus Incorporated Multiple Segments) lenses
- Where
- Hungary
- Volunteers
- 50 people
- Sponsor
- Semmelweis University
Neurodevelopmental Disorder (Diagnosis)
Virtual Reality Headset as an Alternative Tool for Reducing Dental Anxiety
The aim of this study is to investigate whether the use of virtual reality (VR) headsets can have a positive effect on dental fear during dental procedures and stress induced by the dental environment.
- Trial name
- NCT07667023
- Testing
- Virtual reality headset, standard dental care
- Where
- Hungary
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Semmelweis University
Cancer, Reproduction
ProspectiveMaleAYA - Frequency and Prediction of Therapy-induced Testicular Dysfunction in AYA Cancer Survivors
This study describes the ProspectiveMaleAYA cohort, a multicentre, prospective, longitudinal European study designed to investigate the long-term impact of cancer and cancer treatments on reproductive and endocrine health in…
- Conditions
- Cancer, Reproduction, Infertility, Late Effects
- Trial name
- FertiTestAYA (NCT07612943)
- Volunteers
- 1,000 people
- Sponsor
- Karolinska Institutet
Bone Loss, Tooth Movement
The Introduction of a Novel PAOO Technique
The aim of this study is to evaluate in a prospective, randomized, controlled clinical trail the effectiveness of preorthodontic piezotomy combined with a buccal bone augmentation (in other name periodontlly accelerated…
- Trial name
- NCT05264480
- Testing
- Bone augmentation with minimally invasive corticotomy (piezotomy), Bone augmentation without corticotomy
- Where
- Hungary
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Semmelweis University
Children, Only, Anesthesia
VR Based Simulation in the Preparation of Children for MRI - MRVR
The goal of this randomized controlled trial is to evaluate whether a virtual reality based preparation method can efficiently decrease the proportion of children requiring general anesthesia during MRI examinations.
- Trial name
- MRVR (NCT06132854)
- Testing
- VR, Booklet
- Where
- Hungary
- Volunteers
- 288 people
- Sponsor
- Semmelweis University
Hypoxic-Ischemic Encephalopathy, Asphyxia
Hydrocortisone Therapy Optimization During Hypothermia Treatment in Asphyxiated Neonates
This is a prospective, single center, pharmacokinetic study of intravenous hydrocortisone therapy for systemic low blood pressure during hypothermia treatment in asphyxiated newborns.
- Conditions
- Hypoxic-Ischemic Encephalopathy, Asphyxia, Hypotension, Circulatory Failure Neonatal
- Trial name
- UniCort (NCT05836610)
- Testing
- Hydrocortisone
- Where
- Hungary
- Volunteers
- 50 people
- Sponsor
- Semmelweis University
Chronic Pain
Motivational, Movement and Self-Management Training for Adolescents in Pain
With this randomized controlled trial, we have three aims. First of all, to investigate underlying mechanisms that might contribute to the success of a physical activity focused self-management program in paediatric chronic pain.
- Trial name
- M3 Training (NCT05220384)
- Testing
- In-person Motivational Interview combined with Self-Management techniques, Video-based Motivational Interview combined with Self-Management techniques
- Where
- Hungary
- Volunteers
- 96 people
- Sponsor
- Semmelweis University
Odontogenic Cysts
Decompression of Odontogenic Cysts Using an Appliance Fabricated With a Fully Digital Workflow
The aim of this prospective case series is to present clinical results with cystostomy, decompression and final enucleation of odontogenic cysts using a decompression device fabricated with a full digital workflow and delivered…
- Trial name
- NCT05253261
- Testing
- Preoperative Cone Beam Computed Tomography (CBCT) scan, tooth removal and cystostomy, Decompression
- Where
- Hungary
- Volunteers
- 15 people
- Sponsor
- Semmelweis University
Impacted Tooth
Application of Surgical Templates in the Surgical Exposure of Impacted Canines
The first choice therapy in case of palatally impacted canines is their exposure and orthodontic eruption to improve facial esthetics and prevent pathologies associated with impacted teeth and Temporomandibular Joint Disorders.
- Trial name
- NCT05909254
- Testing
- Palatally impacted canine exposure using a surgical guide, Palatally impacted canine exposure using the conventional free.hand method
- Where
- Hungary
- Volunteers
- 40 people
- Sponsor
- Semmelweis University
Diabetes (Insulin-requiring, Type 1 or Type 2)
Investigation of the Effectiveness of Prophylactic NPWT (ciNPWT) in High-risk Diabetic Patients With Acute Laparotomy Wounds
The aim of this study is to evaluate the effectiveness of prophylactic Negative Pressure Wound Therapy (NPWT) in patients with diabetes mellitus undergoing laparotomy who are at high risk for Surgical Site Infections (SSI).
- Trial name
- NCT07392853
- Testing
- Prophylactic/Incisional Negative Pressure Wound Therapy
- Where
- Hungary
- Volunteers
- 110 people
- Sponsor
- Semmelweis University
Hearing Loss, Screening
Adaptation of Pediatric Speech Audiometry Tests Into Other Languages
The objective of this study was to offer a comprehensive framework for the adaptation of speech audiometric tests into other languages.
- Trial name
- NCT07156825
- Where
- Hungary
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Semmelweis University
Injury Prevention, Shoulder Injuries
Shoulder Injury Prevention in Adolescent Handball Players Based on Scandinavian Protocols
This cluster-randomised controlled trial will evaluate the effects of two internationally recognised shoulder injury prevention programmes - the Swedish Shoulder Control programme and the Norwegian Oslo Sports Trauma Research…
- Trial name
- HBSP-HU-25 (NCT07146243)
- Testing
- Swedish Shoulder Control Programme, Norwegian OSTRC Shoulder Injury Prevention Programme
- Where
- Hungary
- Volunteers
- 137 people, healthy volunteers welcome
- Sponsor
- Semmelweis University
Autism Spectrum Disorder (ASD)
Associations of Autistic Traits and Feeding Difficulties
The objective is to assess the prevalence of autistic traits and feeding disorders in the general population.
- Trial name
- BAMBI2025 (NCT07188870)
- Where
- Hungary
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Semmelweis University
Pectus Excavatum, Pectus Deformity
Assessing Virtual Reality for Perioperative Anxiolysis in Adolescents Undergoing MIRPE Surgery
In this randomized control trial, investigators would like to assess as primary objective the effectiveness of VR in anxiolysis via using State Trait Anxiety- Inventory test various time during the perioperative period with…
- Trial name
- NCT06446518
- Testing
- Virtual reality exposure
- Where
- Hungary
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Semmelweis University