Clinical trials: sponsored by Semmelweis University
Alveolar Bone Loss, Edentulism Nos
The Application of a Biphasic Calcium Sulfate Graft Material in Sinus Floor Elevation
Pneumatization of the maxillary sinus may lead to insufficient bone volume for dental implant placement in the edentulous posterior maxilla.
- Trial name
- NCT06533397
- Testing
- Sinus floor elevation (SFE), preoperative cone beam computed tomography (CBCT), postoperative CBCT
- Where
- Hungary
- Volunteers
- 40 people
- Sponsor
- Semmelweis University
Colorectal Cancer, Colorectal Neoplasms
Resistance vs Aerobic Prehabilitation Before Colorectal Cancer Surgery
The goal of this clinical trial is to learn which type of exercise before surgery best reduces complications after colorectal surgery in adults with colorectal cancer or precancerous lesions.
- Conditions
- Colorectal Cancer, Colorectal Neoplasms, Postoperative Complications
- Trial name
- NCT07896174
- Testing
- Resistance Training Prehabilitation, Aerobic Training Prehabilitation, Standard Trimodal Care
- Where
- Hungary
- Volunteers
- 480 people
- Sponsor
- Semmelweis University
Cerebral Palsy
The Effects of Protocolized Breathing Exercises on Pulmonary Function in Adolescents With Cerebral Palsy.
This multicenter randomized controlled pilot trial evaluates whether an 8-week protocolized breathing exercise program improves pulmonary function and quality of life in adolescents and young adults with cerebral palsy.
- Trial name
- NCT07873593
- Testing
- Protocolized breathing exercises
- Where
- Hungary
- Volunteers
- 360 people
- Sponsor
- Semmelweis University
Anxiety, Hospitalization
Virtual Nature Versus Guided Imagery for Anxiety and Well-Being in Hospitalized Older Adults
Long hospital stays can be difficult for older adults. Being confined to a ward, with limited mobility and little access to the outdoors, may contribute to anxiety, low mood, and reduced well-being.
- Conditions
- Anxiety, Hospitalization, Quality of Life, Psychological Distress
- Trial name
- NCT07765355
- Testing
- Immersive virtual reality nature exposure, Guided imagery
- Where
- 2 sites in Hungary
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Semmelweis University
TMD/Orofacial Pain, Malocclusions
Evaluation of the Effects of Orthognathic Surgeries on the Temporomandibular Joint Using a Mandibular Movement Analyzer Device
Condylar position and mandibular motion assessment with digital facebows Arcus Digma III before and after orthognathic surgery.
- Trial name
- NCT07828041
- Where
- Hungary
- Volunteers
- 50 people
- Sponsor
- Semmelweis University
Critically Ill, Oral Health Care
Professional Oral Care and Staff Education in Critically Ill Patients
This study evaluated oral health in critically ill patients admitted to two intensive care units in Budapest, Hungary, and examined whether professional oral care and education of intensive care staff could improve oral hygiene.
- Conditions
- Critically Ill, Oral Health Care, Critical Illness, Oral Care Performance
- Trial name
- NCT07831564
- Testing
- Professional Oral Care, Standard Oral Care, ICU Staff Oral Care Education
- Where
- 2 sites in Hungary
- Volunteers
- 161 people
- Sponsor
- Semmelweis University
Endometriosis, Adenomyosis of Uterus
Artificial Intelligence Into Ultrasound Diagnostics in Reproductive Medicine
The goal of this observational study is to develop and validate artificial intelligence (AI)-based algorithms that support ultrasound diagnosis of endometriosis, adenomyosis, myometrial masses, uterine malformations, and impaired…
- Conditions
- Endometriosis, Adenomyosis of Uterus, Leiomyoma (Uterine Fibroids), Uterine Neoplasms
- Trial name
- AUDRIE (NCT07810920)
- Where
- Hungary
- Volunteers
- 1,600 people
- Sponsor
- Semmelweis University
Aorta Aneurysm, Carotid Arteriosclerosis
The Role Oral Microbiome in the Development and Progression of Aorta Aneurysm and Carotid Atherosclerosis
The goal of this observational study is to compare the microbiome (bacterial al community) of the diseased vascular site and the oral cavity with specific attention to chronic inflammatory periodontitis in patients who have aorta…
- Trial name
- OMB (NCT07824921)
- Where
- Hungary
- Volunteers
- 100 people
- Sponsor
- Semmelweis University
Stroke, Gait Disorders, Neurologic
Advanced Technology-Based Rehabilitation for Gait Relearning After Stroke
High-tech therapy, an innovative field of neurorehabilitation, has expanded rapidly in recent years. Advances in technology have enabled the use of devices that can assist with movement development from simple movements to more…
- Trial name
- NCT06497309
- Testing
- Treadmill training, Overground training, DIERS
- Where
- Hungary
- Volunteers
- 80 people
- Sponsor
- National Institute for Medical Rehabilitation, Hungary
Age Over 50 Years
The Impact of Exercise Intervention on Biological and Functional Aging Through the Lens of Epigenetic Clocks
This study investigated the effects of a structured 6-month high-intensity interval training (HIIT) program on blood DNA methylation-based measures of biological ageing, physical fitness, cardiovascular function, body…
- Trial name
- NCT07799103
- Testing
- Exercise - Relative High-Intensity Interval Training (HIIT)
- Where
- Hungary
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Hungarian University of Sports Science
Acute Biliary Pancreatitis
Prophylactic Sphincterotomy in Acute Biliary Pancreatitis Patients Unfit for Surgery
This is a prospective, multicenter, open-label, randomized controlled trial designed to evaluate the efficacy and safety of prophylactic endoscopic sphincterotomy (ES) in frail patients unfit for cholecystectomy following an…
- Trial name
- PROSECCO (NCT07238296)
- Testing
- Prophylactic endoscopic sphincterotomy
- Volunteers
- 92 people
- Sponsor
- Semmelweis University
Cerebral Palsy
Effects of Lokomat-Robot Assisted Gait Training on Gross Motor Function in Children and Young Adults With Cerebral Palsy
This single-center, controlled, delayed-intervention, quasi-experimental study evaluates the effectiveness of Lokomat®-assisted robotic gait training on gross motor function and health-related quality of life in children and…
- Trial name
- NCT07732205
- Testing
- Sessions with Lokomat robot-assisted system, Control arm
- Where
- Hungary
- Volunteers
- 96 people
- Sponsor
- Semmelweis University
Palatal Expansion Technique
Investigation of Skeletally Anchored Expansion of the Maxilla
This study aims to compare two different methods for maxillary expansion in adult patients with transverse maxillary deficiency. Participants will receive either miniscrew-assisted rapid palatal expansion (MARPE-MICRO-4).
- Trial name
- NCT07383376
- Testing
- MARPE, SARME
- Where
- Hungary
- Volunteers
- 90 people
- Sponsor
- Semmelweis University
Maxillary Expansion, Forensic Dentistry
Evaluation of Palatal Rugae-Based Identification After Maxillary Expansion Using Local Morphological Patch Analysis
This study investigates the reliability of palatal rugae-based identification following maxillary expansion procedures, including Miniscrew-Assisted Rapid Palatal Expansion (MARPE) and Surgically Assisted Rapid Maxillary…
- Conditions
- Maxillary Expansion, Forensic Dentistry, Intraoral Scanner, Orthodontic Appliance
- Trial name
- NCT07667933
- Testing
- SARME, MARPE, Untreated Control
- Where
- Hungary
- Volunteers
- 45 people
- Sponsor
- Semmelweis University
Osteoarthritis, Osteoarthritis (OA) of the Knee
Effect of Autologous Ear Cartilage Micrografting in Knee Osteoarthritis
The goal of this clinical trial is to learn if a single injection of autologous cartilage micrografts suspension, obtained through processing with a specialized technology patient's own small piece of ear cartilage, can improve…
- Conditions
- Osteoarthritis, Osteoarthritis (OA) of the Knee, Moderate Osteoarthritis
- Trial name
- EAR2KNEE (NCT07755579)
- Testing
- Mytocel MSK - Autologous Ear Cartilage Micrografting
- Where
- Hungary
- Volunteers
- 33 people
- Sponsor
- Regenera Activa Worldwide S.L.
Atrial Fibrillation (AF), Pulsed-field Ablation
Durability of Pulmonary Vein Isolation With Farapulse System Using Minimal Fluoroscopy
Objective: To evaluate the feasibility, acute, and three-month efficacy and safety of near-zero fluoroscopy PVI performed with the Farapulse system (Faravawe catheter, Faradrive sheath, Faraview module).
- Trial name
- Faraview Remap (NCT07752771)
- Testing
- catheter ablation
- Where
- Hungary
- Volunteers
- 20 people
- Sponsor
- Semmelweis University
Epilepsy
Temporally Interfering Electric Field Stimulation in the Treatment of Epilepsy
This study investigates the potential for temporally-interfering electric field stimulation (TIEFS) to treat epilepsy. In this case series within and between subjects design, the impact of TIEFS on epilepsy biomarkers was studied…
- Trial name
- EE-DES-TIEF (NCT06716866)
- Testing
- temporally-interfering electric field stimulation
- Where
- 3 sites in United States, Czechia
- Volunteers
- 100 people
- Sponsor
- University of California, Davis
Ocular Surface Allergy, Conjunctivitis, Allergic
Treatment of Ocular Surface Inflammations
The goal of this clinical trial is to learn if topical Cyclosporine 1% works to treat severe allergic ocular surface inflammation in pediatric population.
- Conditions
- Ocular Surface Allergy, Conjunctivitis, Allergic, Blepharoconjunctivitis
- Trial name
- NCT07732855
- Testing
- Topical Cyclosporine 1%
- Where
- Hungary
- Volunteers
- 50 people
- Sponsor
- Semmelweis University
Septic Shock
Effects of Hemoadsorption on Vascular Integrity in Septic Shock
This study aims to investigate the effects of adjunctive CytoSorb hemoadsorption therapy versus standard medical treatment on endothelial dysfunction in patients with refractory septic shock.
- Trial name
- ADSORP-VIP (NCT07711197)
- Testing
- CytoSorb hemoadsorption, Standard Medical Therapy (SMT)
- Where
- Hungary
- Volunteers
- 110 people
- Sponsor
- Semmelweis University
Myopia Progression, Myopia
Inhibition of Myopia Progression With Optical Devices
This observational study aims to determine whether optical devices designed to slow myopia progression and/or environmental factors can prevent myopia progression in the pediatric and adolescent myopic population.
- Conditions
- Myopia Progression, Myopia, Myopia, Child Myopia Progression
- Trial name
- NCT07698977
- Testing
- Wearing myopia-control D.I.M.S. glasses while awake, DIMS (Defocus Incorporated Multiple Segments) lenses
- Where
- Hungary
- Volunteers
- 50 people
- Sponsor
- Semmelweis University