Clinical trials: sponsored by Thomas Jefferson University
Hypertension, Portal
SHAPE of Portal Hypertension in Children
Early diagnosis of portal hypertension is difficult as symptoms rarely manifest until the later stages of liver disease. Both cirrhotic and non-cirrhotic portal hypertension can result in life-threatening complications, the most…
- Trial name
- NCT04720456
- Testing
- SHAPE measurement using the ultrasound contrast agent Sonazoid (perfluorobutane microbubbles), SHAPE measurement using the ultrasound contrast agent Lumason (sulfur hexafluoride lipid-type A microspheres)
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Thomas Jefferson University
Hypoxic-Ischemic Encephalopathy, Birth Asphyxia
Comparative Outcomes Related to Delivery-room Cord Milking In Low-resourced Kountries
The investigators will conduct a study on non-vigorous infants at birth to determine if umbilical cord milking (UCM) results in lower rate of moderate to severe hypoxic ischemic encephalopathy (HIE) or death than early clamping…
- Trial name
- CORDMILK (NCT03657394)
- Testing
- Umbilical cord milking
- Where
- 9 sites in India
- Volunteers
- 3,442 people
- Sponsor
- Nemours Children's Clinic
Cesarean Delivery, Postpartum Comfort
Post-cesarean Analgesia: Comparing Effectiveness of Staggered v. Simultaneous Therapies
Cesarean delivery is a commonly performed surgical procedure associated with worse postpartum pain when compared to vaginal birth. Uncontrolled postpartum pain is associated with increased neonatal and maternal risks.
- Conditions
- Cesarean Delivery, Postpartum Comfort, Postpartum Pain, Post-operative Pain
- Trial name
- PACESS (NCT07102641)
- Testing
- Acetaminophen, NSAID (Ketorolac/Ibuprofen)
- Where
- United States
- Volunteers
- 825 people
- Sponsor
- Thomas Jefferson University
Prostate Carcinoma
Enhanced Genetic Awareness and Genetic Evaluation for Men Through Technology, ENGAGEMENT Study
This study assesses perceived usefulness of a web-based virtual prostate cancer genetics board for providers across academic, community, and veteran affairs settings to discuss prostate cancer genetics cases, precision treatment…
- Trial name
- NCT04789018
- Testing
- Educational Intervention, Survey Administration, Interview
- Where
- United States
- Volunteers
- 118 people
- Sponsor
- Thomas Jefferson University
HIV
Streamlining Telehealth for Expanded PrEP Utilization Through Community Partnerships
The goal of this study is to learn if STEP-UP (Streamlining Telehealth for Expanded PrEP Utilization through community Partnerships) works to expand access to PrEP for people who could benefit from HIV prevention tools.
- Trial name
- STEP-UP (NCT07246057)
- Testing
- STEP-UP, Philadelphia TelePrEP Program Direct-to-Consumer Model
- Where
- United States
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Obesity &Amp; Overweight, Adolescence
Sanctuary Farm Prescription in Adolescents
The goal of this research study is to learn if an 8-week produce prescription program (in partnership with a local urban farm) can increase fruit and vegetable consumption in overweight teens and improve their blood pressure and…
- Trial name
- NCT07218588
- Testing
- dietary / produce
- Where
- 3 sites in United States
- Volunteers
- 40 people
- Sponsor
- Nemours Children's Clinic
Amyotrophic Lateral Sclerosis (ALS)
Personalized Antisense Oligonucleotide Therapy for a Participant With TARDBP ALS
This research project entails delivery of a personalized antisense oligonucleotide (ASO) drug designed for a single participant with amyotrophic lateral sclerosis (ALS) due to a pathogenic variant in TARDBP.
- Trial name
- NCT07703462
- Testing
- nL-TARDB-002
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- n-Lorem Foundation
Nonimmune Fetal Hydrops, Nonimmune Hydrops in Neonate
Whole Exome Sequencing and Whole Genome Sequencing for Nonimmune Fetal/Neonatal Hydrops
Brief Summary: Nonimmune hydrops fetalis (NIHF) is a potentially fatal condition characterized by abnormal fluid accumulation in two or more fetal compartments.
- Conditions
- Nonimmune Fetal Hydrops, Nonimmune Hydrops in Neonate, Genetic Disorders
- Trial name
- NCT03911531
- Testing
- Whole Exome Sequencing, Whole Genome Sequencing
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- Thomas Jefferson University
Preterm, Infant Death
Comparative Outcomes Related to Delivery-room Cord Milking In Low-resourced Kountries- PreTerm
The goal of this multicenter, cluster-randomized, crossover trial is to determine if umbilical cord milking compared to early cord clamping will reduce in-hospital mortality in non-vigorous preterm infants born between 30 weeks…
- Trial name
- CORDMILK-PT (NCT06240715)
- Testing
- Umbilical cord milking
- Where
- 9 sites in India
- Volunteers
- 800 people
- Sponsor
- Nemours Children's Clinic
Hypoxic-Ischemic Encephalopathy, Birth Asphyxia
Comparative Outcomes Related to Delivery-room Cord Milking In Low-resourced Kountries Developmental Follow Up
An extension of the CORDMILK trial, the CORDMILK follow-up trial will evaluate the neurodevelopmental outcomes at 22-26 months age of term/late preterm infants who were non-vigorous at birth and received umbilical cord milking…
- Trial name
- CORDMILK-FU (NCT03682042)
- Testing
- Umbilical Cord Milking
- Where
- 9 sites in India
- Volunteers
- 3,442 people
- Sponsor
- Nemours Children's Clinic
Postpartum Anemia
Prevention of Iron Deficiency Anemia Post-delivery
PRIORITY is designed as a 2-arm, randomized-controlled trial focused on postpartum women. The trial will recruit women who are diagnosed with moderate anemia based on a blood sample taken 6-48 hours after childbirth.
- Trial name
- PRIORITY (NCT05590260)
- Testing
- Ferric carboxymaltose (FCM) and folic acid tablets, Oral iron tablets and folic acid tablets
- Where
- 8 sites in Bangladesh, Democratic Republic of the Congo and 5 more
- Volunteers
- 4,857 people
- Sponsor
- NICHD Global Network for Women's and Children's Health
Hypoxic Ischemic Encephalopathy (HIE)
Caffeine for Hypoxic Ischemic Encephalopathy
CHIME is a randomized, parallel-arm, double-blind, placebo-controlled trial focused on infants with hypoxic ischemic encephalopathy (HIE).
- Trial name
- CHIME (NCT06855108)
- Testing
- Caffeine citrate oral solution
- Where
- 7 sites in Bangladesh, Democratic Republic of the Congo and 4 more
- Volunteers
- 830 people
- Sponsor
- NICHD Global Network for Women's and Children's Health
Respiratory Infections in Children
Trial of an AI-enabled Digital Stethoscope to Improve Antibiotic Stewardship
Antibiotics are a mainstay of the treatment of lower respiratory infections in young children even though most episodes are caused by self-limiting viruses.
- Trial name
- BLAAAST (NCT07362433)
- Testing
- Automated digital stethoscope
- Where
- Bangladesh
- Volunteers
- 2,500 people
- Sponsor
- Johns Hopkins University
IUD Insertion Complication
Postplacental LNG-IUD Ultrasound Use Study
This study will enroll women planning to have an intrauterine device (IUD) placed for contraception immediately following a vaginal delivery.
- Trial name
- PLUS (NCT04474548)
- Testing
- Ultrasound use
- Where
- United States
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- Thomas Jefferson University
Spinal Dural Arteriovenous Fistula
Spinal Dural Arteriovenous Fistula International Data and Outcomes Registry
Given the lack of large multicenter datasets in the context of Spinal arteriovenous fistula, the strength of the evidence surrounding this rare disease is limited.
- Trial name
- SPIDER (NCT07574645)
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- Thomas Jefferson University
Tetralogy of Fallot, Pulmonary Insufficiency
Contrast Enhanced 3D Echocardiographic Quantification of Right Ventricular Volumes in Repaired CHD
We propose the novel integration of two echocardiographic technologies - three-dimensional echocardiography using semi-automated right ventricular analysis coupled with the administration of ultrasound enhancing agents - to…
- Trial name
- NCT05186415
- Testing
- Sulfur Hexafluoride Lipid Type A Microspheres 25 MG Injection Powder for Suspension [LUMASON]
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Nemours Children's Clinic
Suicide, Engagement, Patient
The BH-Works Suicide Prevention Program for Sexual and Gender Minority Youth
Youth suicide is a serious public health concern. Compared to their heterosexual and cisgender peers, sexual and gender minority (SGM) adolescents report higher rates of suicidal ideation and suicide attempts.
- Trial name
- NCT05922670
- Testing
- The Behavioral Health-Works Suicide Prevention Program for Sexual and Gender Minority Youth
- Where
- 4 sites in United States
- Volunteers
- 18 people
- Sponsor
- Virginia Polytechnic Institute and State University
Sickle Cell Disease
Zinc Supplementation in Sickle Cell Disease: A Precursor to the Think Zinc for Bones Trial
The goal of this short term prospective Phase II study is to compare the effects of two alternate daily doses of zinc (25 and 40 mg/day) in 34 randomly assigned homozygous Sickle Cell Disease (SCD-SS) patients aged 15-40 years…
- Trial name
- ZnSCD (NCT06260891)
- Testing
- 25 mg/day zinc, 40 mg/day zinc
- Where
- 6 sites in United States
- Volunteers
- 34 people
- Sponsor
- University of California, San Francisco
Endometriosis
Cabergoline for the Treatment of Chronic Pain Due to Endometriosis
Endometriosis is dependent on angiogenesis (the sprouting of new blood vessels) for its growth and maintenance, but the side effects of currently approved angiogenesis inhibitors make these agents inappropriate for use in…
- Trial name
- NCT03928288
- Testing
- Cabergoline 0.5 MG
- Where
- 6 sites in United States
- Volunteers
- 129 people
- Sponsor
- Boston Children's Hospital
COVID-19
COVID Booster in Pregnancy and Lactation
This is a prospective longitudinal cohort study to evaluate the impact of COVID-19 vaccination and booster on maternal and infant immunity against COVID-19 variants over time.
- Trial name
- NCT05543993
- Testing
- Bivalent COVID-19 Booster
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Thomas Jefferson University