Clinical trials: sponsored by Thomas Jefferson University
Prostate Cancer, Adenocarcinoma of the Prostate
High-Dose Rate Brachytherapy and Stereotactic Body Radiation Therapy in Treating Patients With Prostate Cancer
The first technology is called high dose rate brachytherapy. Brachytherapy is sometimes called internal radiation therapy. High dose rate brachytherapy is a procedure that involves temporarily placing radioactive material inside…
- Conditions
- Prostate Cancer, Adenocarcinoma of the Prostate, Recurrent Prostate Cancer, Stage IIA Prostate Cancer
- Trial name
- NCT01655836
- Testing
- Brachytherapy, Stereotactic Body Radiation Therapy, Quality-of-life assessment
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University
Stress Urinary Incontinence
Feasibility of Resisted Expiratory Muscle Training for Females Assigned at Birth With Stress Urinary Incontinence: A Pilot Study
The goal of this randomized pilot study is to determine whether adding expiratory muscle strength training (EMST) to standard pelvic floor muscle training (PFMT) is feasible and may help improve stress urinary incontinence (SUI)…
- Trial name
- NCT07905586
- Testing
- Pelvic floor muscle training, Expiratory muscle strength training
- Volunteers
- 24 people
- Sponsor
- Thomas Jefferson University
Metastatic Prostate Carcinoma, Stage IIIB Prostate Cancer AJCC v8
Extending Prostate Genetic Awareness, Navigation, and Delivery: The EXPAND Network
This trial evaluates whether a network of peer genetic coaches is useful for addressing disparities in genetic testing and screening among African American men with prostate cancer that has spread from where it first started…
- Conditions
- Metastatic Prostate Carcinoma, Stage IIIB Prostate Cancer AJCC v8, Stage IIIC Prostate Cancer AJCC v8, Stage IV Prostate Cancer AJCC v8
- Trial name
- NCT05627219
- Testing
- Training and Education, Educational Intervention, Discussion
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Thomas Jefferson University
Cancer
From Screening to Support: A Multi-Method Analysis of HRSN Integration in Cancer Care
This observational study aims to identify the factors that influence whether cancer patients accept or decline supportive care services after screening positive for health-related social needs (HRSNs) at the Sidney Kimmel…
- Trial name
- NCT07352579
- Testing
- Survey, Interview
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- Thomas Jefferson University
Stress, Cognitive Change
Surviving Daily Life
The primary goal of this project is to evaluate the feasibility of a 14-day mobile daily diary study among racially diverse breast cancer survivors.
- Conditions
- Stress, Cognitive Change, Breast Cancer, Breast Carcinoma
- Trial name
- GOCE (NCT07054723)
- Testing
- Mobile Daily Diary
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Thomas Jefferson University
Solid Tumor Cancer, Immune-Related Adverse Events
Cancer Nutrition Study - A Study of Dietary Interventions in Cancer Patients Treated With Immune Checkpoint Inhibitors
The goal of this clinical trial is to learn whether changing the diet can help improve gut health and support recovery from immune-related side effects caused by immune checkpoint inhibitor (ICI) cancer treatment in adults with…
- Trial name
- CaNS (NCT07804225)
- Testing
- High-Fermented Food Diet, HI-MAIZE 260 Resistant Starch
- Volunteers
- 50 people
- Sponsor
- Thomas Jefferson University
Aphasia
Effects of Semantic Context on Criterion-learning Naming Treatment in Aphasia
Aphasia is a disorder of spoken and written language, most commonly following a stroke. It is estimated that between 2.5 and 4 million Americans are living with aphasia today.
- Trial name
- NCT07673198
- Testing
- Criterion-learning practice
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Albert Einstein Healthcare Network
Head and Neck Cancer, Head and Neck Small Cell Carcinoma
Pembrolizumab Plus Ultrasound-Induced Microbubble Cavitation in Head and Neck Cancer
This is a feasibility trial studying anti-PD-1 therapy (Pembrolizumab) among patients with R/M HNSCC, delivered with ultrasound-induced microbubble cavitation, with the goal of optimizing delivery of Pembrolizumab and tumor…
- Conditions
- Head and Neck Cancer, Head and Neck Small Cell Carcinoma, Metastatic Head and Neck Cancer, Recurrent Head and Neck Cancer
- Trial name
- NCT07501650
- Testing
- Pembrolizumab, Definity, Ultrasound-Induced Microbubble Cavitation
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Thomas Jefferson University
Pancreatic Ductal Adenocarcinoma, Colorectal Adenocarcinoma
A Vaccine (Ad5.F35-hGCC-PADRE) for the Treatment of Gastrointestinal Adenocarcinoma
The goal of this clinical trial is to learn whether the Ad5.F35-hGCC-PADRE vaccine is safe and can stimulate an immune response against gastrointestinal (GI) cancers in patients with pancreatic, colorectal, esophageal, gastric…
- Conditions
- Pancreatic Ductal Adenocarcinoma, Colorectal Adenocarcinoma, Gastric Adenocarcinoma, Clinical Stage II Gastric Cancer AJCC v8
- Trial name
- NCT04111172
- Testing
- Adenovirus 5/F35-Human Guanylyl Cyclase C-PADRE
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Thomas Jefferson University
Lung Cancer
Improving Utilization of Lung Cancer Screening in Underserved PA Populations
This study is an interventional study intended to assess the impact of a centralized outreach intervention that includes shared decision-making about lung cancer screening (LCS) in LCS-eligible primary care patients.
- Trial name
- NCT04806399
- Testing
- Educational Materials and Decision Counseling
- Where
- 2 sites in United States
- Volunteers
- 2,572 people, healthy volunteers welcome
- Sponsor
- American College of Radiology
Cigarette Smoking Behavior, E-Cigarette Use
Project E-Shift: A Harm Reduction Intervention for Chronically Unhoused Smokers.
This pilot randomized trial tested whether switching to e-cigarettes, compared with standard nicotine replacement therapy (NRT; patch and gum), helped adults with a history of chronic homelessness stop smoking combustible…
- Trial name
- ESHIFT (NCT07897058)
- Testing
- E-cigarette, Nicotine replacement therapy (patch, gum), both arms, CO-contingent financial incentives, both arms
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- Thomas Jefferson University
Cancer
Cannabis Use and Outcomes in Black and White Patients With Cancer
The goal of the observational study is to learn how black and white patients with solid tumor cancer use cannabis, opioids and tobacco.
- Trial name
- C4C (NCT06037681)
- Where
- 3 sites in United States
- Volunteers
- 600 people
- Sponsor
- State University of New York at Buffalo
ASCVD
Improving Implementation of Guideline-Recommended LDL-C Management in High-Risk Cardiovascular Patients
The goal of this observational study is to learn whether implementing evidence-based strategies in cardiology practices can improve guideline-recommended low-density lipoprotein cholesterol (LDL-C) management in adults at high…
- Trial name
- EMPOWER (NCT07883564)
- Where
- 5 sites in United States
- Volunteers
- 2,500 people
- Sponsor
- Cardiology Consultants of Philadelphia
Lymphoma
Study of Ruxolitinib in Relapsed or Refractory T or NK Cell Lymphoma
The purpose of this study is to test any good and bad effects of the study drug called ruxolitinib. Ruxolitinib works by blocking a protein called JAK.
- Trial name
- NCT02974647
- Testing
- Ruxolitinib
- Where
- 10 sites in United States
- Volunteers
- 83 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Ventral Hernia, Ventral Incisional Hernia
The IMPACT Study: Personalized Physical Therapy for Better Recovery and a Stronger Core After Hernia Surgery
Ventral hernia repair is among the most common operations performed in the United States each year, yet the great majority of patients receive no structured rehabilitation for the persistent pain, weakness, and functional loss…
- Conditions
- Ventral Hernia, Ventral Incisional Hernia, Post Operative Pain
- Trial name
- IMPACT (NCT07145099)
- Testing
- PT Group, Usual Care
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Thomas Jefferson University
Metastatic Prostate Carcinoma, Stage III Prostate Cancer AJCC v8
Peer Navigation for the Support of Metastatic Prostate Cancer Patients Undergoing Genetic Evaluation
This clinical trial evaluates whether having a trained peer navigator helps African American men with prostate cancer that has spread to other parts of the body (metastatic) understand and navigate the genetic testing process…
- Conditions
- Metastatic Prostate Carcinoma, Stage III Prostate Cancer AJCC v8, Stage IV Prostate Cancer AJCC v8
- Trial name
- NCT05487846
- Testing
- Patient Navigation, Genetic Counseling, Survey Administration
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Thomas Jefferson University
Ciliary Body and Choroid Melanoma, Medium/Large Size, Ciliary Body and Choroid Melanoma, Small Size
Sunitinib Malate or Valproic Acid in Preventing Metastasis in Patients With High-Risk Uveal Melanoma
This randomized phase II trial studies how well sunitinib malate or valproic acid works in preventing high-risk uveal (eye) melanoma from spreading to other parts of the body.
- Conditions
- Ciliary Body and Choroid Melanoma, Medium/Large Size, Ciliary Body and Choroid Melanoma, Small Size, Iris Melanoma, Stage I Intraocular Melanoma
- Trial name
- NCT02068586
- Testing
- Sunitinib, Valproic Acid, Sunitinib Malate
- Where
- United States
- Volunteers
- 210 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University
Lung Cancer
Lung Cancer Detection in Never Smokers Using Urine Volatile Organic Compound (VOCs)
The goal of this observational study is to learn whether a urine-based test that measures volatile organic compounds (VOCs) can help detect lung cancer in people who have never smoked.
- Trial name
- NCT07871656
- Testing
- Biosensor Platform
- Where
- United States
- Volunteers
- 87 people
- Sponsor
- Thomas Jefferson University
Colorectal Cancer, Small Bowel Adenocarcinoma
GUCY2C Prime-Boost Vaccination for Advanced Colorectal and Small Bowel Adenocarcinomas
This is an open-label, non-randomized, single-center, dose-escalation Phase 1 trial using a heterologous prime-boost strategy of vaccination with Ad5.F35-hGUCY2C-PADRE and recombinant Listeria monocytogenes (Lm-GUCY2C) vaccines…
- Trial name
- NCT07417488
- Testing
- Ad5.F35-hGUCY2C-PADRE vaccine, Lm-GUCY2C vaccine, CT Scan
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Thomas Jefferson University
Lip, Oral Cavity Squamous Cell Carcinoma
Nivolumab and BMS986205 in Treating Patients With Stage II-IV Squamous Cell Cancer of the Head and Neck
This phase II trial studies how well nivolumab works, with or without BMS986205, in treating patients with stage II-IV squamous cell cancer of the head and neck.
- Conditions
- Lip, Oral Cavity Squamous Cell Carcinoma, Pharynx, Larynx
- Trial name
- NCT03854032
- Testing
- Nivolumab, IDO1 Inhibitor BMS-986205, Therapeutic Conventional Surgery
- Where
- 2 sites in United States
- Volunteers
- 65 people
- Sponsor
- Thomas Jefferson University