Clinical trials: sponsored by University of Iowa
Unilateral Hearing Loss
Audiological Rehabilitation of Children With Unilateral Hearing Loss
The goal of this study is to examine the effects of hearing aids and early intervention on hearing, language, and neural development in children with hearing loss in one ear, known as unilateral hearing loss.
- Trial name
- SHINE (NCT07911852)
- Testing
- hearing aids
- Where
- 3 sites in United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Father Flanagan's Boys' Home
Speech Sound Disorder
Treatment Targets in Spanish and English Bilingual Speech Intervention
The goal of this clinical trial is to learn which speech treatment targets result in the greatest amount of speech learning in Spanish-English bilingual children with speech sound disorders.
- Trial name
- NCT06416306
- Testing
- Speech Intervention
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Philip Combiths
Healthy
Pregnancy 24/7 Offspring Study
There is growing evidence that maternal health and behaviors in pregnancy, such as pre-pregnancy obesity, excessive gestational weight gain, poor diet, smoking, and adverse pregnancy outcomes, are linked to fetal programming for…
- Trial name
- NCT07172880
- Where
- 3 sites in United States
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Kara Whitaker
Charcot-Marie-Tooth Disease, Type Ia (Disorder), HMSN
Genetics of Charcot Marie Tooth (CMT) - Modifiers of CMT1A, New Causes of CMT2
This project includes two projects. One is looking for new genes that cause Charcot Marie Tooth disease (CMT). The other is looking for genes that do not cause CMT, but may modify the symptoms a person has.
- Trial name
- INC-6602 (NCT01193088)
- Where
- 24 sites in United States, Australia and 4 more
- Volunteers
- 1,050 people, healthy volunteers welcome
- Sponsor
- University of Iowa
Glioblastoma (GBM), Diffuse Midline Glioma (DMG)
Intrathecal Azacitidine and Nivolumab in Patients With Recurrent High-grade Glioma
This is a single-arm open-label phase 1 dose escalation/expansion trial assessing the safety and efficacy of concurrent intrathecal azacitidine and intrathecal nivolumab in recurrent high-grade glioma.
- Conditions
- Glioblastoma (GBM), Diffuse Midline Glioma (DMG), Astrocytoma, IDH-Mutant, Grade 4, Diffuse Hemispheric Glioma, H3 G34-Mutant
- Trial name
- NCT06896110
- Testing
- Nivolumab, Azacitidine (AZA), lumbar puncture
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Andrew P. Groves
Charcot Marie Tooth Disease
Development of Charcot Marie Tooth Disease (CMT) Pediatric Scale for Children With CMT
The primary goal of this project is to develop and test a Charcot Marie Tooth disease (CMT) Pediatric Scale for use in evaluation in natural history CMT study.
- Trial name
- INC-6603 (NCT01203085)
- Where
- 14 sites in United States, Australia and 3 more
- Volunteers
- 1,201 people
- Sponsor
- University of Iowa
Charcot Marie Tooth Disease
Natural History Evaluation of Charcot Marie Tooth Disease (CMT) Types CMT1B, CMT2A, CMT4A, CMT4C, and Others
This is an observational longitudinal study to determine the natural history and genotype-phenotype correlations of disease causing mutations in Charcot Marie Tooth disease (CMT) type 1B (CMT1B), 2A (CMT2A), 4A (CMT4A), and 4C…
- Trial name
- INC-6601 (NCT01193075)
- Where
- 24 sites in United States, Australia and 4 more
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Michael Shy
Neonatal Prematurity, Hypotension
Effects of Transitional Circulation in ELBW Infants
Prematurity is a very important problem in this country. Prematurity can cause problems with organ (such as the brain, heart, kidneys) growth and development.
- Trial name
- NCT02016599
- Testing
- Monitoring and biospecimen collection
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- University of Iowa
Aplastic Anemia
UI-Romi-02; Romiplostim Added to Standard of Care for Treatment Naive and Relapsed or Refractory Severe Aplastic Anemia
This Phase II open-label interventional clinical trial aims to evaluate the efficacy of romiplostim, in patients with severe aplastic anemia (SAA), both treatment naïve and relapsed/refractory, in inducing trilineage…
- Trial name
- NCT07001254
- Testing
- Romiplostim, Immunosuppressive therapy (IST)
- Where
- United States
- Sponsor
- Anjali Sharathkumar
Hip Dysplasia
Can PLIA Reduce Early Post-operative Pain After PAO Surgery?
The goal of this clinical trial is to compare different peri-incisional local infiltrative anesthesia (PLIA) methods in patients ages 13 to 50 undergoing a periacetabular osteotomy (PAO). The main questions to answer here are: 1.
- Trial name
- PILA PAO (NCT06519955)
- Testing
- Ropivacaine, Epinephrine, Ketorolac, NaCl (Saline)
- Where
- United States
- Volunteers
- 121 people, healthy volunteers welcome
- Sponsor
- Michael C Willey
Cystic Fibrosis-related Diabetes
EnVision CF Multicenter Study of Glucose Tolerance in Cystic Fibrosis
Cystic Fibrosis Related Diabetes has been identified by the CF community as one of the top ten priorities for CF research. In CF clinical decline due to dysglycemia begins early, prior to diagnosis of diabetes and increases…
- Trial name
- NCT03650712
- Testing
- Oral glucose tolerance test, Continuous glucose monitoring, Dexa scan
- Where
- 4 sites in United States
- Volunteers
- 317 people
- Sponsor
- Katie Larson Ode
Acanthamoeba Keratitis
Parasitic Ulcer Treatment Trial
The Parasitic Ulcer Treatment Trial (PUTT) is a multi-center, parallel-group, randomized clinical trial. The purpose of this study is to determine whether including topical corticosteroids in a regimen for acanthamoeba keratitis…
- Trial name
- PUTT (NCT06213649)
- Testing
- Polyhexamethylene biguanide (PHMB), Topical corticosteroid
- Where
- 22 sites in United States, Brazil and 2 more
- Volunteers
- 232 people
- Sponsor
- Jeremy Keenan, MD, MPH
Cystic Fibrosis
BEGIN Novel ImagiNG Biomarkers
To determine the treatment effect of triple-combination therapy in 6-8 year olds after presumed FDA approval, using rapid structural and functional pulmonary and abdominal MRI (UTE and 129Xe).
- Trial name
- BEGINNING (NCT05517655)
- Testing
- 129Xe
- Where
- 3 sites in United States
- Volunteers
- 19 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Cystic Fibrosis in Children, Cystic Fibrosis
Sinus Disease in Young Children With Cystic Fibrosis
This is a prospective, observational study examining the impact of highly effective cystic fibrosis transmembrane conductance regulator (CFTR) modulators on chronic rhinosinusitis (CRS) and olfactory dysfunction (OD) in young…
- Conditions
- Cystic Fibrosis in Children, Cystic Fibrosis, Chronic Rhinosinusitis (Diagnosis), Olfactory Disorder
- Trial name
- NCT06191640
- Testing
- Ivacaftor or elexacaftor/tezacaftor/ivacaftor
- Where
- 6 sites in United States
- Volunteers
- 80 people
- Sponsor
- University of California, Los Angeles
Motor Vehicle Accident, Interaction, Parent-Offspring
Hazard Anticipation Program for Parents of Teen Drivers
This study will test an intervention that was developed to improve parents\' driving instruction of teens\' hazard anticipation skills when teens are in the learner phase of licensure.
- Trial name
- HazAPP (NCT06611241)
- Testing
- Hazard Anticipation Program for Parents of Teen Drivers
- Where
- United States
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- Elizabeth O'Neal
LAMA2-MD \(Merosin Deficient Congenital Muscular Dystrophy, MDC1A\)
Observation Study in Patients Age 0-5 Years With LAMA2-related Congenital Muscular Dystrophy
The goal of this observational study is to understand how young children with LAMA2-related dystrophy move and change over time. We will also learn about how this condition impacts other body systems.
- Trial name
- NCT06503367
- Where
- 14 sites in United States
- Volunteers
- 44 people
- Sponsor
- Nationwide Children's Hospital
Cavities of Teeth
Effectiveness of Silver Diamine Fluoride (SDF) in Arresting Cavitated Caries Lesions
This trial is a Phase III, multisite, randomized, placebo-controlled trial, with two parallel groups. The groups are SDF or placebo and they are applied every 6 months.
- Trial name
- NCT03649659
- Testing
- Silver Diamine Fluoride
- Where
- 3 sites in United States
- Volunteers
- 830 people
- Sponsor
- University of Michigan
Autism Disorders and Maternal Stress, Development Delay
Perinatal Autism Genetics and Epigenetics Study
The University of Iowa's Center for Disabilities and Development is researching how pregnancy, early childhood experiences, and genetic factors influence child development, with a focus on autism spectrum disorder (ASD).
- Conditions
- Autism Disorders and Maternal Stress, Development Delay, Prenatal Stress, Social Behavior
- Trial name
- PAGES (NCT07738003)
- Testing
- Change in child's DNA methylation, Perinatal stress, Early social experience
- Where
- United States
- Volunteers
- 7,200 people, healthy volunteers welcome
- Sponsor
- University of Iowa
Dental Caries
Povidone Iodine for Caries Prevention
The goal of this clinical trial is to learn if Povidone Iodine works to prevent tooth decay and suppress the mouth germs responsible for tooth decay. The main questions it aims to answer are: 1.
- Trial name
- NCT07741409
- Testing
- Povidone Iodine 5% Soln,Top,Kit, Probiotics
- Where
- United States
- Volunteers
- 174 people, healthy volunteers welcome
- Sponsor
- Jeffrey A. Banas
Neonatal Anemia
Optimized Erythropoietin (EPO) Treatment
Neonatal anemia is the most commonly encountered hematologic problem among all neonates cared for in the neonatal intensive care unit (NICU).
- Trial name
- OETNA (NCT02075970)
- Testing
- Epoetin Alpha
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- University of Iowa