Clinical trials: 18F- Fluorocholine
18F-fluorocholine, Positron-Emission Tomography
FCH PET/MRI Parathyroid Localization
A prospective trial comparing the accuracy of [F-18]-FCH PET/MRI to US and 99mTc-MIBI SPECT/CT for pre-operative parathyroid localization in patients with primary hyperparathyroidism
- Conditions
- 18F-fluorocholine, Positron-Emission Tomography, Hyperparathyroidism, Primary
- Trial name
- NCT03324893
- Testing
- [F-18]-FCH PET/MRI
- Where
- Canada
- Volunteers
- 47 people
- Sponsor
- University Health Network, Toronto
Patients Eligible to a Curative Treatment for Primary HCC
Combined Fluorocholine Positron Emission Tomography and Magnetic Resonance Imaging (FCH-PET/MRI) in Curative Treatment of a Hepatocellular Carcinoma
Hepatocellular carcinoma (HCC) is the fifth most common cancer in terms of incidence and the second in terms of mortality. At an early stage, which is based on a low number and size of liver nodules and the absence of…
- Trial name
- TOMIC (NCT02824185)
- Testing
- PET/MRI system (SIEMENS AG, Munich, Germany; distributed in France by SIEMENS S.A.S, Saint-Denis, France)
- Where
- 4 sites in France
- Volunteers
- 61 people
- Sponsor
- Hospices Civils de Lyon
Prostate Cancer
Comparison of PET With 68GA-PSMA-11 and 18F-Fluorocholine for Recurrence in Men With Prostate Cancer
As choline transport and phosphorylation are upregulated in most cancers, including prostate cancer, positron emission tomography (PET) with choline tracers has found widespread use to detect recurrent disease.
- Trial name
- TEPGALCHOL (NCT03623425)
- Testing
- 68Ga-PSMA-11 PET, 18F-FCH PET
- Where
- France
- Volunteers
- 46 people
- Sponsor
- Central Hospital, Nancy, France
Hepatocellular Carcinoma Non-resectable
Evaluation of Treatment Predictors Reflecting Beta-catenin Activation in Hepatocellular Carcinoma
This prospective clinical trial will evaluate PET/CT and genomic liquid biopsy based biomarkers as predictors of clinical therapeutic response to immune-checkpoint inhibitor (ICI) therapy for patients with inoperable…
- Trial name
- ExTRACT-HCC (NCT04965454)
- Testing
- Fluorine-18 fluorocholine
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Queen's Medical Center
Brain Metastases
18F-Fluorocholine (18F-FCho) to Distinguish Necrosis From Recurrence in Brain Metastases
The main purpose of this study is to determine the distribution of 18F Fluorocholine (18F-FCH) in the brain which can help distinguishing radiation-induced scarring from tumor regrowth.
- Trial name
- NCT02037945
- Testing
- 18F-FCH PET Scan
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Hepatocellular Carcinoma, Radioembolization
Multi-modal Characterisation of Hepatocellular Carcinoma (HCC) Treated With Targeted Radionuclide Therapy (TRT): Prospective Interventional Multicentre National Cohort
OPERANDI project aims to address unmet clinical needs in the current management of advanced-stage HCC treated with TARE by exploring new opportunities provided by imaging-based artificial intelligence (AI) and data augmentation…
- Trial name
- OPERANDI-HCC (NCT06334965)
- Testing
- Simultaneous 18F-Choline PET-MRI
- Where
- 5 sites in France
- Volunteers
- 180 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Hyperparathyroidism
18F-fluorocholine PET/CT Imaging in Hyperparathyroidism
To assess the efficiency of 18F-fluorocholine PET/CT in localization of hyperfunctioning parathyroid tissue in hyperparathyroidism, thereby enabling minimally invasive surgical approaches with fewer complications and comparable…
- Trial name
- NCT03203668
- Testing
- 18F-choline PET/CT
- Where
- Slovenia
- Volunteers
- 1,000 people
- Sponsor
- University Medical Centre Ljubljana
Parathyroid Adenoma
99mTc Sestamibi SPECT/CT vs 18F Fluorocholine PET/CT
This study proposes the use of a well-established PET isotope, Fluorine-18 (18F), bound to Choline, for a prospective single-center, single-arm study for participants with suspected parathyroid adenoma and negative or equivocal…
- Trial name
- 18FCH (NCT05891769)
- Testing
- 18Fluorocholine
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Andrei Iagaru
Hepatocellular Carcinoma
Combination PET With 18F-fluorodeoxyglucose (18F-FDG) and 18 F-choline in Patient With HCC
The objective of this protocol is to obtain a better match between the actual staging and the proposed treatment in order to avoid inadequate treatments at risk of complications.
- Trial name
- PET-HCC01 (NCT04391348)
- Testing
- PET-TDM with 18F-FDG + PET-TDM with 18F-fluorocholine
- Where
- France
- Volunteers
- 230 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Prostate Cancer, Fluorocholine
18F-fluorocholine and 18F-fluoride PET in Prostate Cancer
Prostate cancer remains to be a public health problem around the world. For patients with prostate cancer, diphosphonate bone scintigraphy (BS) and pelvic tomographic imaging are major imaging tools to evaluate the disease…
- Trial name
- NCT04340765
- Testing
- 18F-fluorocholine
- Where
- Taiwan
- Volunteers
- 36 people
- Sponsor
- Buddhist Tzu Chi General Hospital
Prostate Cancer
Measurement of Anti-Androgen Response Using Fluorine-18 Fluorocholine PET/CT in Androgen-Insensitive Prostate Cancer
The purpose of this study is to determine whether positron emission tomography / computed tomography (PET/CT) using fluorine-18 fluorocholine as an imaging agent can characterize regional responses to anti-androgen therapies in a…
- Trial name
- NCT00928174
- Testing
- IV administration of fluorine-18 fluorocholine followed by PET/CT imaging
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Queen's Medical Center
Breast Cancer Diagnosis, Positron Emission Tomography
Proton MR Spectroscopy and 18F-Fluorocholine PET for Breast Cancer Diagnosis
The application of FCH PET in breast cancer diagnosis has not been reported. We hypothesize that FCH reveals choline metabolic profiles of breast cancers, and shows the similar pathophysiological mechanism to choline on proton…
- Conditions
- Breast Cancer Diagnosis, Positron Emission Tomography, Magnetic Resonance Imaging
- Trial name
- NCT01956409
- Testing
- 18F-FCH, Magnevist
- Where
- Taiwan
- Volunteers
- 80 people
- Sponsor
- National Taiwan University Hospital
Primary Hyperparathyroidism, Parathyroid Cancer
Accuracy of 18F-Fluorocholine PET/MR and NeuroEXPLORER PET/CT Imaging for Localization of Parathyroid Tumors
Background: People have 4 parathyroid glands near the thyroid gland in the neck. Surgery is needed to remove a parathyroid gland that is too large or has a tumor.
- Conditions
- Primary Hyperparathyroidism, Parathyroid Cancer, Multiple Endocrine Neoplasias, Heritable Hyperparathyroidism
- Trial name
- NCT07444723
- Testing
- 18F-FCH, NeuroEXPLORER
- Where
- United States
- Volunteers
- 193 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Prostate Cancer
18F-FCH PET/MRI to Assess Tumor Response in Castration Resistant Prostate Cancer
Evaluate the ability of 18F-FCH PET/MRI scan to detect pre-treatment tumor burden and assess response to treatment in men with castration resistant prostate cancer (CRPC).
- Trial name
- NCT02121600
- Testing
- [F-18]-FCH, PET scan, MRI scan
- Where
- 3 sites in Canada
- Volunteers
- 5 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Prostate Cancer
Prospective Study Using Hybrid PET/MRI to Evaluate Men With Suspected Recurrence Following Treatment for Prostate Cancer
Evaluate the impact of hybrid 18F-Fluoro-choline (18F-FCH) PET/MRI imaging on the clinical management of men with suspected recurrent prostate cancer post prostatectomy or radiotherapy.
- Trial name
- IGPC-3 (NCT01804231)
- Testing
- 18F-FCH PET/MRI imaging
- Where
- Canada
- Volunteers
- 22 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Prostate Cancer
Correlation Between SUV on 18F-Fluorocholine PET/CT and Gleason Score in Prostate Cancer
1.0 Background \& Introduction Positron emission tomography / computer tomography (PET/CT) is a nuclear medicine procedure based on the measurement of positron emission from radiolabelled tracers.
- Trial name
- NCT02793882
- Testing
- 18F-Fluorocholine PET/CT
- Where
- Canada
- Volunteers
- 218 people
- Sponsor
- Sir Mortimer B. Davis - Jewish General Hospital
Hormone Refractory Prostate Cancer
Chemotherapy Response Monitoring With 18F-choline PET/CT in Hormone Refractory Prostate Cancer
The purpose of this study is to determine whether imaging with 18F-choline PET/CT can provide information that may help guide subsequent investigational or clinical treatments for patients with advanced (hormone-refractory)…
- Trial name
- NCT00928252
- Testing
- IV fluorine-18 labeled methylcholine before PET/CT
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Queen's Medical Center
Myeloma Multiple
Prospective Comparison of 18F-choline PET/CT and 18F-FDG PET/CT in the Initial Work-up of Multiple Myeloma
Multiple myeloma (MM) survival has been improved during the last decade owing to new treatments. Hence, it has become a matter of importance to precisely define the depth of MM response to therapy.
- Trial name
- MYELOCHOL (NCT03891914)
- Testing
- Positron Emission Tomography using 18F-FCH, Positron Emission Tomography using 18F-FDG
- Where
- France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Bordeaux
Fluorocholine PET/CT
Fluorocholine PET/CT Basket Trial
This is a single-arm, open-label, phase III trial in up to 2000 patients with known or suspected benign or malignant tumors which are known or suspected to be 18F-fluorocholine-avid.
- Trial name
- NCT04150458
- Testing
- 18F-fluorocholine PET/CT.
- Where
- Canada
- Volunteers
- 2,000 people
- Sponsor
- Sir Mortimer B. Davis - Jewish General Hospital
Prostate Cancer
The Effectiveness of 18F-fluorocholine Positron Emission Tomography (PET) in Detecting, Staging and Following-up Prostate Cancer
Choline is one of the components of phosphatidylcholine, an essential element of phospholipids in the cell membrane. Some malignant cells show their ability to actively incorporate choline to produce phosphocholine and…
- Trial name
- NCT01089881
- Where
- Taiwan
- Volunteers
- 150 people
- Sponsor
- National Taiwan University Hospital