Clinical trials: A
Ulcerative Colitis
Oligofructose-enriched Inulin for the Treatment of Mild to Moderate Active Ulcerative Colitis
Based on the efficacy of inulin and oligofructose in treating experimental colitis and emerging evidence suggesting probiotics are efficacious in maintaining and inducing remission in human ulcerative colitis (UC), the…
- Trial name
- NCT02093767
- Testing
- Synergy1
- Where
- Canada
- Volunteers
- 24 people
- Sponsor
- University of Alberta
HIV Infections, HPV-Related Cervical Carcinoma
Self-collected Vaginal and Urine Samples in HIV-positive Women
This study assesses topics as Human Immunodeficiency Virus (HIV), Human Papilloma Virus (HPV), and cancer screening methods. The focus will be on evaluating feasibility of implementing novel cancer screening modalities in a…
- Conditions
- HIV Infections, HPV-Related Cervical Carcinoma, Cervical Cancer, Coinfection, HIV
- Trial name
- NCT05783167
- Testing
- Self-sampling for HPV infection
- Where
- Guinea-Bissau
- Volunteers
- 502 people
- Sponsor
- University of Aarhus
Critical Limb Ischemia (CLI)
Initial Feasibility Study of the STENTiT Resorbable Fibrillated Scaffold (RFS). The RFS is Intended to Restore Lumen Patency and Blood Flow to Infrapopliteal Arteries. The RFS is a Fully Electrospun Tubular Device With a Fibrillated Microarchitecture and Designed for Transcatheter Delivery
This is the First-In-Human feasibility study of the RFS for below the knee lesions in subjects who experience critical limb ischemia due to the peripheral artery disease.
- Trial name
- VITAL-IT 1 (NCT07006467)
- Testing
- Implantation of RFS
- Where
- Austria
- Volunteers
- 10 people
- Sponsor
- Stentit
Obesity, Morbid Obesity
DIT After RYGB - A Prospective Study
Bariatric surgery is the only satisfactory treatment for loss and weight maintenance in obese patients. This loss is a result of several factors that go beyond the simple anatomical abnormality of the gastrointestinal tract and…
- Conditions
- Obesity, Morbid Obesity, Bariatric Surgery
- Trial name
- DIT RYGB (NCT01759667)
- Testing
- A standard mixed Meal
- Where
- Brazil
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Silvia Leite Faria
Diabetes
Comparative Glucose Clamp Study of Wockhardt's Human Isophane Insulin With Novolin N,in Healthy Subjects
The aim of this trial is to demonstrate bioequivalence of Wosulin N to Novolin® N with regard to its total and to its maximum serum insulin concentrations.
- Trial name
- NCT00772265
- Testing
- Wosulin N, Novolin N
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Wockhardt
Allogeneic Hematopoietic Stem Cell Transplantation (HSCT)
Early Detection of Infectious and Noninfectious Lung Diseases Following Allogeneic Hematopoietic Stem Cell Transplantation
Background: Stem cell transplants (called hematopoietic stem cell transplantation, or HSCT) are used to treat various diseases. But when the cells for this procedure are donated by someone other than the person who receives the…
- Trial name
- NCT06093867
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
HIV Infections
A Multicenter, Randomized, Placebo-Controlled, Double-Blind Trial to Evaluate the Safety and Immunogenicity of a Recombinant Vaccinia-HIV-1 IIIB Env/Gag/Pol Vaccine (TBC-3B)
To evaluate, in healthy HIV-1 seronegative vaccinia-immune and vaccinia-naive volunteers, the safety and immunogenicity of an HIV-1 candidate vaccine (TBC-3B) consisting of a live recombinant vaccinia virus expressing the env…
- Trial name
- NCT00000767
- Testing
- TBC-3B Vaccine, Smallpox Vaccine
- Where
- 5 sites in United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Breast Cancer
Breast Reconstruction and Neoadjuvant Radiotherapy
The purpose the BRENAR pilot study is to assess acute post-surgical complications following mastectomy and immediate breast reconstruction after neoadjuvant radiotherapy (NART).
- Trial name
- BRENAR (NCT05216900)
- Testing
- Neoadjuvant radiotherapy
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- UMC Utrecht
Glomerulonephritis, Proteinuria
Efficacy and Safety of Shenyankangfu Tablets for Primary Glomerulonephritis
-Evaluate the efficacy and safety of Shenyankangfu Tablets to control the proteinuria of patients with primary glomerulonephritis compare with Losartan potassium.
- Trial name
- NCT02063100
- Testing
- Shenyankangfu tablets, Losartan potassium 50mg, Shenyankangfu tablets and Losartan potassium 50mg
- Where
- 43 sites in China
- Volunteers
- 720 people
- Sponsor
- Chinese PLA General Hospital
Anxiety, Depression
Emotion Focused Family Therapy for Parents of Children With Mental Health Difficulties
Emotion Focused Family Therapy (EFFT) is a promising intervention that aims to teach parents advanced skills to support their child's development of emotion skills and increase their adaptive behaviours, potentially leading to…
- Conditions
- Anxiety, Depression, Behavior Problem
- Trial name
- NCT05603000
- Testing
- Emotion Focused Family Therapy
- Where
- Canada
- Volunteers
- 200 people
- Sponsor
- University of Guelph
Benign Prostatic Hyperplasia, Prostate Carcinoma
Human Prostate Tissue Model to Maintain and Study Prostate Cancer Stem Cells
This pilot research trial studies the use of a human prostate tissue model to maintain and study prostate cancer stem cells. A human prostate tissue model uses leftover tissue that was removed during surgery from patients with…
- Trial name
- NCT02425800
- Testing
- Cytology Specimen Collection Procedure, Laboratory Biomarker Analysis
- Where
- 2 sites in United States
- Volunteers
- 43 people
- Sponsor
- Wake Forest University Health Sciences
Non-Alcoholic Steatohepatitis (NASH), Type2 Diabetes Mellitus
A Pilot Study to Assess the Safety of Oral Insulin in Patients With Nonalcolholic Steatohepatitis (NASH)
This is an open, pilot study using the oral ORMD-0801 insulin formulation in patients with NASH and confirmed type 2 DM or pre-diabetes.
- Trial name
- NCT02653300
- Testing
- Oral Insulin
- Where
- Israel
- Volunteers
- 10 people
- Sponsor
- Oramed, Ltd.
Brain and Central Nervous System Tumors
Temozolomide + Everolimus in Newly Diagnosed, Recurrent, or Progressive Malignant Glioblastoma Multiforme
RATIONALE: Drugs used in chemotherapy, such as temozolomide, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00387400
- Testing
- everolimus, temozolomide, microarray analysis
- Where
- 9 sites in Canada
- Volunteers
- 32 people
- Sponsor
- NCIC Clinical Trials Group
Univentricular Heart, Lymphatic Abnormalities
Lymphatic Function in Patients With a Fontan Circulation From Brazil
It is suggested that the elevated central venous pressure in patients with a Fontan circulation can provoke manifestation of lymphatic dysfunction, met as plastic bronchitis, peripheral oedema and most feared protein-losing…
- Conditions
- Univentricular Heart, Lymphatic Abnormalities, Lymphatic Edema
- Trial name
- NCT04394507
- Testing
- Near-Infrared Fluorescence imaging, Strain Gauge Plethysmography
- Where
- 2 sites in Denmark
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Solid Tumor
Study of AK119 in Subjects With Advanced Solid Tumors
This is Phase 1, Multicenter, Open-Label, Dose-Escalation and Dose-Exploration Study to Evaluate the Safety, Pharmacokinetics, and Anti-tumor Activity of AK119 (Anti-CD73) in Subjects with Advanced or Metastatic Solid Tumors.
- Trial name
- NCT05173792
- Testing
- AK119
- Where
- 2 sites in China
- Volunteers
- 16 people
- Sponsor
- Akeso
Pulmonary Embolism
Effect of a Global Simplified Strategy on Thromboembolic Events in Emergency Department Patients with Suspected Pulmonary Embolism
Pulmonary embolism (PE) is frequently suspected in emergency departments (ED) patients which often leads to the prescription of DDimer testing and irradiative chest imaging (Computed Tomographic Pulmonary Angiogram CTPA in most…
- Trial name
- MODS STRATEGY (NCT06190392)
- Testing
- MODS Modified simplified diagnostic strategy
- Where
- France
- Volunteers
- 1,223 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Spinal Cord Injury
Riluzole in the Treatment of Spasticity in the Traumatic Chronic Spinal Cord Injury Condition
The study will be conducted in two steps: 1. Determination of the Minimal Effective Dose (MED) among the four doses of the panel 2. Estimation of the probability of response associated to the MED.
- Trial name
- RILUSCI (NCT02859792)
- Testing
- Riluzole, Blood Samples
- Where
- France
- Volunteers
- 90 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Microalbuminuria, Sickle Cell Nephropathy
Efficacy of Antioxidant Therapy Compared With Enalapril in Sickle Nephropathy
The purpose of this study is to determine whether enalapril or antioxidant therapy (N-Acetylcysteine) is effective in reducing microalbuminuria in children with sickle cell disease and and its progression to sickle nephropathy
- Trial name
- NCT01891292
- Testing
- Enalapril, N-Acetylcysteine
- Where
- Jamaica
- Volunteers
- 30 people
- Sponsor
- The University of The West Indies
Osteoarthritis of the Knee
A Study of the Safety and Efficacy of REGN475(SAR164877) in Patients With Osteoarthritis of the Knee
This is a double-blind, prospective, randomized study in which patients will be randomized to 1 of 4 treatment arms (3 active and 1 placebo).
- Trial name
- NCT00944892
- Testing
- REGN475
- Where
- 3 sites in United States
- Volunteers
- 200 people
- Sponsor
- Regeneron Pharmaceuticals
F01.318 Child Rearing, F01.470 Emotions
Clinical Trial of Emotion-Focused Skills Training for Parents
Children with externalizing and internalizing symptoms has been linked to poor emotional competence, problematic understanding and regulation of emotions.
- Conditions
- F01.318 Child Rearing, F01.470 Emotions, F01.145.179 Child Behavior
- Trial name
- NCT03807336
- Testing
- Emotion-Focused Skills Training for Parents - Experiential, Emotion-Focused Skills Training for Parents - Psychoeducational
- Where
- Norway
- Volunteers
- 220 people
- Sponsor
- Institutt for Psykologisk Radgivning
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