Clinical trials: A, open to volunteers
Hospitalized Patients
Cultural Adaptation, and Validation of Fundamentals of Care PRO-tool
A research team from the University of Seville and Flinders University has created a new 41-item questionnaire to assess fundamental nursing care.
- Trial name
- NCT07042880
- Testing
- No intervention
- Where
- 2 sites in Denmark
- Volunteers
- 205 people
- Sponsor
- Nordsjaellands Hospital
Atrial Fibrillation, Postoperative Complications
Atrial Dyssynchrony to Predict Arrhythmias in the Postoperative Setting of Cardiovascular Surgery.
This study aims to improve the prediction for developing arrhythmias in the postoperative period of cardiovascular surgery by using non-invasive echocardiographic techniques that are sensitive to detect inter and intra-atrial…
- Trial name
- SAD-POAF (NCT07388108)
- Testing
- Atrial dyssynchrony
- Where
- Argentina
- Volunteers
- 138 people
- Sponsor
- School of Medicine. National University of Cuyo
Diabetes Mellitus, Type 2
Lifestyle Management App for Adults With Diabetes Type
This study will evaluate whether the 12-week health coaching mobile application (LIVEN) will succeed in enhancing lifestyle behaviors in adults with Type 2 Diabetes compared to typical treatment.
- Trial name
- LIVEN (NCT05630508)
- Testing
- interactive Mhealth Lifestyle behavior intervention
- Where
- Saudi Arabia
- Volunteers
- 90 people
- Sponsor
- Princess Nourah Bint Abdulrahman University
Pulpectomy Agents
Clinical and Radiographic Evaluation of Ultrasonic Activated Irrigation Versus Non Activated Irrigation in Pulpectomy of Necrotic Primary Molars : A Randomized Clinical Trial
This is a Clinical and Radiographic Evaluation of Canal Irrigation Using Ultrasonically Activated vs. Non-Activated Irrigants in Pulpectomy of Necrotic Primary Molars: A Randomized Clinical Trial" This study aims to compare the…
- Trial name
- NCT07025525
- Testing
- Ultrasonic activated sodium hypochlorite, Ultrasonic acivated saline, Sodium Hypochlorite Solution
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Cairo University
Radiation Necrosis, High Grade Glioma (III or IV)
Bevacizumab Versus Corticosteroids as First-line Treatment in Patients With Symptomatic Cerebral Radiation Necrosis After Radiation for High-grade Glioma or Brain Metastases
Cerebral radiation necrosis (CRN) is a severe complication of high-dose radiation for brain metastases (BM) or glioma, which can potentially cause significant neurologic symptoms leading to serious morbidity and impaired quality…
- Conditions
- Radiation Necrosis, High Grade Glioma (III or IV), Brain Metastasases, Radiation Toxicity
- Trial name
- BRAINS (NCT06888817)
- Testing
- Bevacizumab, Dexamethasone
- Where
- 6 sites in Netherlands
- Volunteers
- 408 people
- Sponsor
- The Netherlands Cancer Institute
For Prevention of Bone Events in Patients With Bone Metastases From Solid Tumors
A Trial of SHR-2017 Injection in Patients With Bone Metastases From Solid Tumors
The study is being conducted to evaluate the efficacy, and safety of SHR-2017 Injection in Patients with Bone Metastases from Solid Tumors.
- Trial name
- NCT07028268
- Where
- China
- Volunteers
- 210 people
- Sponsor
- Suzhou Suncadia Biopharmaceuticals Co., Ltd.
Solid Tumor Malignancy
A Clinical Trial of SIBP-A18 Injection in the Treatment of Advanced Malignant Solid Tumor Patients
The main purpose To evaluate the safety, tolerability, and pharmacokinetic characteristics of SIBP-A18 and determine the maximum tolerable dose (MTD) and phase II recommended dose (RP2D).
- Trial name
- NCT06985368
- Testing
- SIBP-A18
- Where
- China
- Volunteers
- 156 people
- Sponsor
- Shanghai Institute Of Biological Products
Metabolism and Nutrition Disorder
Amino Acid Metabolism in Fed Surgical Critically Ill Patients
Introduction Sarcopenia is defined as progressive generalized loss of skeletal muscle mass, strength and function. Sarcopenia due to lack of physical activity is a known phenomenon and is usually observed as a normal part of…
- Trial name
- NCT03451968
- Testing
- amino acid tracer injection for metabolism analysis
- Where
- Israel
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Rabin Medical Center
Motoric Cognitive Risk Syndrome, Dual-Task Performance
Dual-Task Effects on Gait and Balance in MCRS
This study aims to investigate the effects of cognitive load on gait and balance performance in individuals with Motoric Cognitive Risk Syndrome (MCRS).
- Conditions
- Motoric Cognitive Risk Syndrome, Dual-Task Performance, Gait, Balance
- Trial name
- NCT07572968
- Testing
- Assessment Protocol
- Where
- Turkey (Türkiye)
- Volunteers
- 35 people
- Sponsor
- Balikesir University
Breast Cancer, Brain Metastases
A Two-cohort Study of SHR-A1811 in the Treatment of HER2-positive Breast Cancer With Brain Metastases
This is a multi-center, open-label, two-cohort study. The purpose of this study is to evaluate the safety, tolerability and efficacy of SHR-A1811 in the treatment of HER2-positive breast cancer with brain and leptomeningeal…
- Conditions
- Breast Cancer, Brain Metastases, Leptomeningeal Metastasis
- Trial name
- NCT07177950
- Testing
- SHR-A1811, radiotherapy
- Volunteers
- 51 people
- Sponsor
- Peking University Cancer Hospital & Institute
Healthy Participants, Hepatic Impairment
Comparative PK Assessment Study of Casdatifan in Moderate Hepatically Impaired Participants Versus Matched Participants With Normal Hepatic Function
The purpose of the study is to compare the single dose PK of casdatifan between participants with moderate hepatic impairment (HI) and healthy matched control participants with normal hepatic function.
- Trial name
- NCT07751250
- Testing
- Casdatifan
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Arcus Biosciences, Inc.
Paramedian Forehead Flap
Topical CBD Scar Healing Study
The purpose of this study is to find out what effects (good and bad) that cannabidiol (CBD) has on scar healing and appearance in patients who have undergone paramedian forehead flap reconstruction.
- Trial name
- NCT06129591
- Testing
- Vantage Hemp CBD Isolate + Silicone patch, Silicone patch
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- University of Oklahoma
Postmenopausal Symptoms, Telerehabilitation
Relaxation Training Via Tele-Rehabilitation in Postmenopausal Women
Menopause is associated with various physiological and psychological changes that may adversely affect women's quality of life. Menopausal symptoms, sleep disturbances, and fatigue are among the most common complaints during the…
- Conditions
- Postmenopausal Symptoms, Telerehabilitation, Relaxation Training, Menopause
- Trial name
- NCT07737691
- Testing
- Relaxation Training Delivered via Tele-Rehabilitation
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Marmara University
Radioiodine-refractory Differentiated Thyroid Cancer
A Real-World Study of Second-line Therapies Among Radioiodine-refractory Differentiated Thyroid Cancer (RAI-R DTC) Patients
This study aims to assess patient characteristics and treatment patterns of second-line systematic therapies, including BRAF V600E mutation-guided dabrafenib plus trametinib (D+T) and MKIs, among Chinese adult patients with RAI-R…
- Trial name
- NCT07770074
- Volunteers
- 200 people
- Sponsor
- Novartis Pharmaceuticals
Whole-Brain Radiotherapy
Anlotinib Plus Whole-Brain Radiotherapy for Brain Metastases in SCLC Patients.
This study is a multicenter, randomized, prospective Phase III study to evaluate the efficacy and safety of anlotinib plus whole-brain radiotherapy (WBRT) compared with WBRT alone in small cell lung cancer (SCLC) patients with…
- Trial name
- NCT07443397
- Testing
- Anlotinib, Whole-brain Radiotherapy
- Where
- China
- Volunteers
- 134 people
- Sponsor
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Cornelia de Lange Syndrome
Use of N-Acetylcysteine in the Treatment of Repetitive and Self-Injurious Behaviors in Cornelia de Lange Syndrome
This research project is a randomized cross-over pilot trial which aims to test the efficacy of N-acetylcysteine (NAC) for the treatment of Repetitive Behaviors (RB) and self-injurious behavior (SIB) in patients with Cornelia de…
- Trial name
- NCT04381897
- Testing
- N-acetyl cysteine
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Johns Hopkins University
Apathy, Apathy in Dementia
Robotic Technologies for APATHy in Dementia: a Randomised Controlled Trial (RAPHAel)
The goal of this trial is to learn whether home-based robotic interventions can reduce apathy in people with cognitive decline. Apathy means reduced motivation, interest, or initiative in daily life.
- Trial name
- RAPHAel (NCT07404410)
- Testing
- telepresence robotic system, Pepper robot connected to a CAIR server, Occupational Therapy
- Where
- 2 sites in Italy
- Volunteers
- 75 people
- Sponsor
- Giovanna Zamboni
Autism Sibling
Sibwatch: Optimizing Intervention Options for Infants and Toddler Siblings of Autistic Children
This rigorous randomized controlled trial will evaluate the efficacy and acceptability of a preemptive, telehealth intervention (tele-ImPACT) in a large, representative sample of infant siblings of autistic children, who are…
- Trial name
- Sibwatch (NCT07069413)
- Testing
- tele-ImPACT
- Where
- 2 sites in United States
- Volunteers
- 140 people
- Sponsor
- University of Texas at Austin
Healthy Volunteers
Study of HX15001 in Adult Healthy Volunteers.
This is a phase I, randomized, double-blinded, placebo-controlled, single and multiple dose escalation study to evaluate the safety, tolerability, pharmacokinetic characteristics and pharmacodynamics of HX15001 in adult healthy…
- Trial name
- NCT06999720
- Testing
- HX15001 (SAD), HX15001 (MAD)
- Where
- Australia
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Helixon Biotechnology (Suzhou) Co., Ltd
Placenta Accreta Spectrum
Effectiveness of REBOA in Reducing Blood Loss During Cesarean Section in Patients with PAS
Obstetric hemorrhage is one of the leading causes of maternal mortality and morbidity worldwide. The major risk factors for obstetric hemorrhage include placenta previa and placenta accreta spectrum (PAS) disorders.
- Trial name
- NCT06721182
- Testing
- REBOA
- Volunteers
- 100 people
- Sponsor
- Nazarbayev University
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