Clinical trials: A
Anesthesia
Ketamine and Propofol for Upper Endoscopy
The purpose of this study is to examine the dose-response relationship of ketamine in combination with propofol.
- Trial name
- NCT02295553
- Testing
- Ketamine, Propofol
- Where
- Canada
- Volunteers
- 56 people
- Sponsor
- The Hospital for Sick Children
ESRD
Calcium Mass Balance and Dialytic Efficiency of a New cITRate-containing and Acetate-free Dialysis flUidS: CITRUS Study
This study aimed to evaluate the effect on the calcium balance of a concentrate with 1 mM citrate and locate the equivalent concentration of calcium (Ca_eq) at a concentration of 3 mM acetate and traditional with 1.5 mM calcium…
- Trial name
- CITRUS (NCT02848937)
- Testing
- Bath with citrate, Bath with citrate and Ca_eq
- Where
- Italy
- Volunteers
- 62 people
- Sponsor
- Azienda Ospedaliera, Ospedale Civile di Legnano
Healthy
Safety Study of 7 Botulinum Antitoxin Serotypes Derived From Horses
The primary purpose of the study is to evaluate the safety of the 7 Botulinum Antitoxin Serotypes derived from horses using various laboratory measurements, clinical examinations and adverse events.
- Trial name
- NCT00360737
- Testing
- Botulinum Antitoxin Heptavalent (A B C D E F G) - (EQUINE)
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Emergent BioSolutions
Advanced Cancer
A Phase I Clinical Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy of TQB3122 Capsules in Subjects With Advanced Malignant Tumors
This is the first-in-human clinical study of TQB3122, aiming to evaluate the safety, tolerability, and pharmacokinetic characteristics of TQB3122 in advanced solid tumors, and to preliminarily explore its efficacy in solid tumors.
- Trial name
- NCT07269145
- Testing
- TQB3122 Capsules
- Where
- 5 sites in China
- Volunteers
- 86 people
- Sponsor
- Chia Tai Tianqing Pharmaceutical Group Co., Ltd.
Inflammatory Bowel Disease
Study to Evaluate the Testicular Safety of Filgotinib in Adult Males With Moderately to Severely Active Inflammatory Bowel Disease
The primary objective of this study is to evaluate the testicular safety of filgotinib in adult males with moderately to severely active inflammatory bowel disease (IBD).
- Trial name
- MANTA (NCT03201445)
- Testing
- Filgotinib, Standard of Care
- Where
- 56 sites in United States, Australia and 9 more
- Volunteers
- 139 people
- Sponsor
- Lakefront Biotherapeutics NV
Hepatocellular Carcinoma, Liver Cancer
Radioembolization With Yttrium-90 Microspheres for Intermediate or Advanced Hepatocellular Carcinoma
Rationale: Patients diagnosed with hepatocellular carcinoma (HCC) at an intermediate or advanced stage (according to the BCLC classification system) are not amenable of curative treatment.
- Trial name
- NCT00910572
- Testing
- Yttrium-90 microspheres (Therasphere MDS Nordion)
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
Healthy Volunteers
A Study to Evaluate the Safety, Tolerability and Pharmacokinetics of KL0011034 Injection in Healthy Volunteers
To evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of single intravenous doses of KL0011034 injection in healthy volunteers.
- Trial name
- NCT07474545
- Testing
- KL0011034 injection, Etomidate Injectable Emulsion
- Where
- China
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Hunan Kelun Pharmaceutical Co., Ltd.
Tooth Erosion
Evaluation of a Test Mouthwash and Dentifrice Regimen in an In-situ Model of Dental Erosion
An in situ model will be used to evaluate and compare enamel remineralization of bovine enamel specimens.
- Trial name
- NCT01128972
- Testing
- Sodium fluoride, Sodium monoflurophosphate, Sterile water
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Castration-Resistant Prostatic Cancer, Metastasis
A Clinical Study of Ifinatamab Deruxtecan Based Treatment Combinations or as Monotherapy to Treat Metastatic Castrate Resistant Prostate Cancer (mCRPC) (MK-2400-01A/IDeate-Prostate02)
The purpose of this substudy is to assess the efficacy and safety of ifinatamab deruxtecan (I-DXd), given alone or with other treatments in participants with metastatic castration-resistant prostate cancer (mCRPC).
- Trial name
- NCT06863272
- Testing
- Docetaxel, Ifinatamab Deruxtecan, Opevesostat
- Where
- 82 sites in United States, Argentina and 17 more
- Volunteers
- 360 people
- Sponsor
- Merck Sharp & Dohme LLC
Carpal Tunnel Syndrome, Diagnosis
Statistically Analysis of Carpal Tunnel Syndrome Diagnosis
Trap neuropathies; They are compression neuropathies that occur as a result of peripheral nerves being compressed for various reasons along their anatomical paths.
- Trial name
- NCT05584839
- Testing
- Statistically Analysis
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- İSMAİL CEYLAN
Blood Pressure
Computer Assisted Learning (CAL) Module Use for Re-training of Blood Pressure Measurements by Physical Therapy Students
The purpose of this study is to determine the effectiveness of a Computer Assisted Learning Module for supplemental blood pressure measurement retraining for doctor of physical therapy students.
- Trial name
- NCT05915039
- Testing
- Computer Assisted Learning (CAL) Module
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Youngstown State University
Unexplained Subfertile Couples With a Good Prognosis.
FertiScreen: an Online Application to Improve the Quality of Fertility Care
Objectives The investigators present an online application to empower and inform patients and improve guideline adherence in unexplained subfertility.
- Trial name
- NCT01820039
- Testing
- FertiScreen
- Where
- Netherlands
- Volunteers
- 152 people
- Sponsor
- Radboud University Medical Center
The Translation of a Screening Tool
French Translation of The Female Sexual Distress Scale-Revised
Two independent teams (Brest and Nice) each produce a forward translation from English to French. The translations are compared, and discrepancies are discussed with the translation coordinator, the second translator, and the…
- Trial name
- f-FSDS-R (NCT07090239)
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University Hospital, Brest
Quality Improvement
Developing a Practice-Based Learning and Improvement Quality Improvement (QI) Systems Impact Assessment Questionnaire
The Accreditation Council for Graduate Medical Education (ACGME) acknowledged the changing needs of physicians in training when it endorsed practice-based learning and improvement (PBLI) -- a competency that is typically omitted…
- Trial name
- NCT00754377
- Testing
- PBLI Curriculum
- Where
- United States
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Diffuse Large B-cell Lymphoma
R-DA-EDOCH Versus R-CEOP90, With/Without Upfront Auto-HSCT in Young Patients With High-risk DLBCL
Patients initially are randomized into 2 arms: Arm I: R-DA-EPOCH; Arm II: R-CEOP90; Patients who achieved complete remission (CR) or partial remission (PR) after 6 cycles of R-DA-EPOCH (Arm I) or R-CEOP90 (Arm II), continue to…
- Trial name
- NCT03213977
- Testing
- R-DA-EPOCH, R-CEOP90
- Where
- China
- Volunteers
- 475 people
- Sponsor
- Fujian Medical University
Obesity, Morbid
Clinical Efficacy of a Virtual Reality Tool for the Treatment of Obesity
The objective of the study, which is framed within European Union's H2020 project titled SOCRATES, is to assess the clinical efficacy of a Virtual Reality (VR) embodiment tool for treating obesity and to compare it to usual care…
- Trial name
- SOCRATES (NCT05094557)
- Testing
- Experimental Group 1: Body swapping VR intervention + psychoeducational video + Treatment As usual, Experimental Group 2: VR intervention without body swapping + psychoeducational video + Treatment As usual, Control Group: Psychoeducational video + Treatment As usual
- Where
- Spain
- Volunteers
- 96 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Brain Metastases
Evaluating AGuIX® Nanoparticles in Combination With Stereotactic Radiation for Brain Metastases
This study evaluates the clinical impact of AGuIX® nanoparticles in combination with Fractionated Stereotactic Radiation in oligo brain metastases.
- Trial name
- NANOSTEREO (NCT04094077)
- Testing
- AGuIX
- Where
- 2 sites in France
- Volunteers
- 1 people
- Sponsor
- Centre Leon Berard
Psoriasis
BI 655066 Versus Placebo & Active Comparator (Ustekinumab) in Patients With Moderate to Severe Chronic Plaque Psoriasis
This is a randomized double blind, double dummy, placebo and active comparator controlled, parallel design study that is being performed to assess the safety and efficacy of risankizumab (BI 655066) to support registration for…
- Trial name
- NCT02684357
- Testing
- risankizumab, ustekinumab
- Volunteers
- 577 people
- Sponsor
- AbbVie
Genetic Conditions, Genetic Disorders
RNA to the RESCUE: Evaluation to Assess the Clinical Utility of RNA Sequencing in Establishing a Genetic Diagnosis or Adjudicating a Previously Established Genetic Diagnosis.
The goal of this observational study is to see if ribonucleic acid (RNA) sequencing can improve the diagnostic yield and accuracy of genetic testing compared to gene sequencing alone.
- Trial name
- NCT07787975
- Testing
- RNA sequencing
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of California, San Francisco
Food Allergy
Improving the Safety of Oral Immunotherapy for Cow's Milk Allergy
Allergy to cow's milk is the most common food allergy affecting children. There is currently no accepted routine clinical therapy to cure milk allergy.
- Trial name
- SOCMA (NCT02216175)
- Testing
- SLIT to cow's milk, Low dose OIT, Conventional OIT to cow's milk
- Where
- 2 sites in Spain, United Kingdom
- Volunteers
- 68 people
- Sponsor
- Imperial College London
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