Clinical trials: A Single-blind Randomized Controlled Trial
Healthy
Safety and Tolerability of PNT001 in Healthy Adults
This first in human study is a multi-center, randomized, double-blind, placebo-controlled single ascending dose study to evaluate the safety, tolerability, pharmacokinetics, and immunogenicity of intravenous PNT001 in healthy…
- Trial name
- NCT04096287
- Testing
- PNT001
- Where
- 4 sites in United States
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Pinteon Therapeutics, Inc
COVID-19
Efficacy and Safety of SA58 Nasal Spray in Close Contact With COVID-19 People
This is a randomized, single-blind, placebo-controlled clinical trial to evaluate the efficacy and safety of SA58 nasal spray in close contact with COVID-19 people.
- Trial name
- NCT05667714
- Testing
- SA58 Nasal Spray
- Where
- China
- Volunteers
- 2,900 people, healthy volunteers welcome
- Sponsor
- Sinovac Life Sciences Co., Ltd.
Overactive Bladder Syndrome
Vaginal Estradiol vs Oral Beta-3 Agonist for Overactive Bladder Syndrome
A single site, double-blinded, randomized controlled trial for postmenopausal women with urinary frequency, urgency, nocturia with or without urgency urinary incontinence symptoms.
- Trial name
- NCT05221021
- Testing
- Vaginal estrogen, Mirabegron 50 MG [Myrbetriq]
- Where
- United States
- Volunteers
- 152 people, healthy volunteers welcome
- Sponsor
- Walter Reed National Military Medical Center
Healthy Infants
Comparative Effects of A2 Platinum Stage 1 Infant Formula on Infant Digestion and Comfort
This trial is a single-blind, randomized, controlled, parallel-designed trial to compare the effects of a2 Platinum® stage 1 infant formula versus conventional, A1 and A2 β-casein-containing stage 1 infant formula versus…
- Trial name
- NCT04733937
- Testing
- a2 Platinum® stage 1 infant formula, Conventional, A1 and A2 β-casein containing stage 1 infant formula
- Where
- 5 sites in China
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- a2 Milk Company Ltd.
Healthy Adult Participants
Safety, Tolerability, and Pharmacokinetic Evaluation of ADB116 for Injection
A Phase I Study of ADB116 for Injection in Healthy Chinese Adults. This study aims as follows: Primary Objective: To evaluate the safety and tolerability of a single intravenous bolus dose of ADB116 for injection in healthy…
- Trial name
- NCT07729839
- Testing
- ADB116 for Injection
- Where
- China
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Jiangsu Aidea Pharmaceutical Group Co., Ltd.
Healthy Volunteer
A Phase 1 Study of S-1117
This is the first-in-human study of S-1117 designed to provide safety, tolerability, pharmacokinetic, and pharmacodynamic data in healthy volunteers.
- Trial name
- NCT06828393
- Testing
- S-1117
- Where
- Australia
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Seismic Therapeutic AU Pty Ltd
Pregnancy, Excessive Weight Gain
Effect of Regular Exercise in Prevention of Excessive Weight Gain in Pregnancy
Background: Use of variable definitions of exercise and disparate results, emphasize the need of proper randomized controlled trials examining the relationship between physical activity and weight development during pregnancy.
- Trial name
- NCT00617149
- Testing
- Supervised exercise for the prevention high weight gain
- Where
- Norway
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Norwegian School of Sport Sciences
Sedentary Healthy Young Individuals
The Effect of Square Stepping Exercises Training on Lower Extremity
Physical activity plays an indispensable role to lead a healthy life. Square-stepping exercises (SSE) are aerobic exercises.Our study was designed to investigate the effects of square-stepping exercise training on lower-extremity…
- Trial name
- NCT04910035
- Testing
- Exercises Training
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Nigde Omer Halisdemir University
Dry Eye
Preliminary Clinical Study of the Effectiveness and Safety of Ocular Surface Microbiota Transplantation in the Treatment of Dry Eye Disease
Evaluate the efficacy and safety of ocular surface microbiota transplantation as an adjunctive therapy for dry eye, and explore its impact on the structure of the ocular surface microbiota.
- Trial name
- NCT07298811
- Testing
- Ocular surface microbiota transplantation
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital of Nanchang University
Dentin Sensitivity
Effect of Glutaraldehyde-based Desensitizer in the Control of Tooth Sensitivity and Tooth Color Post- Whitening
Tooth whitening is one of the most indicated aesthetic procedures in dentistry and there is evidence that it interferes with aspects of patients' quality of life.
- Trial name
- NCT05309967
- Testing
- GLUMA DESINSITIZER
- Where
- Brazil
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Universidade Federal do Para
Healthy Volunteers
Adrecizumab Phase 1 Trial
This is the first clinical trial with ADRECIZUMAB. The purpose of this clinical trial to identify safety and tolerability of different doses of ADRECIZUMAB in healthy volunteers.
- Trial name
- NCT02991508
- Testing
- Adrecizumab
- Where
- Netherlands
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Healthy Volunteers
To Assess Safety, Tolerability and Pharmacokinetics of BI 730357 in Healthy Male Volunteers
The primary objective of the Single Rising Dose (SRD) part (trial part 1) is to investigate the safety and tolerability of BI 730357 in healthy subjects following oral administration of single rising doses after fasting and/or…
- Trial name
- NCT03004404
- Testing
- BI 730357
- Where
- Germany
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Healthy Volunteer
MT1013 Clinical TRIAL In Healthy Subject
This is a randomized, double-blind, placebo-controlled, single ascending dose administration phase one clinical trial to evaluate the safety, tolerability, pharmacokinetics and preliminary pharmacodynamics of MT1013 injection in…
- Trial name
- NCT04783090
- Testing
- MT1013
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Shaanxi Micot Pharmaceutical Technology Co., Ltd.
Phenylketonuria
GenSci144 Tablets Phase I Clinical Trial
This study is a Phase I single ascending dose clinical trial in which healthy adult volunteers were administered single oral doses of GenSci144 tablets at different levels.
- Trial name
- NCT07685210
- Testing
- GenSci144 tablets
- Where
- China
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Changchun GeneScience Pharmaceutical Co., Ltd.
Facial Wrinkles
A Clinical Study to Evaluate the Efficacy and Satisfaction of RHC Serum Combined With RHC(III) Injection
To evaluate the efficacy and safety of recombinant humanized collagen (type III) solution for injection combined with SkinCeuticals recombinant humanized collagen (RHC) serum Participants will be assessed by subjective…
- Trial name
- NCT06322875
- Testing
- Recombinant type III humanized collagen solution for injection, SkinCeuticals recombinant humanized collagen (RHC) serum, Regular face cream smear
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- DeYi Aesthetic Medical Clinic
Influenza
A Randomized, Controlled Trial on the Efficacy and Safety of Live-Attenuated Influenza Vaccine (LAIV) Among Children in Bangladesh
This is a single center, multi-site, double-blind, parallel group, placebo-controlled trial of the clinical efficacy of trivalent Serum Institute of India, Ltd.
- Trial name
- NCT01797029
- Testing
- SIIL Live Attenuated Influenza Vaccine
- Where
- 2 sites in Bangladesh
- Volunteers
- 1,761 people, healthy volunteers welcome
- Sponsor
- PATH
Healthy
A Phase I Trial to Investigate the Safety and Tolerability of PF-06649751
This study will determine the safety and tolerability of PF-06649751 given orally to healthy volunteers. To determine the optimal dose for future studies, the concentration of the drug over time will be determined by periodic…
- Trial name
- NCT01981694
- Testing
- PF-06649751
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Pfizer
Vaccinia
SIGA-246 to Treat Smallpox
This study will test an experimental antiviral drug called SIGA-246 for use against the smallpox virus (variola). Although smallpox has been universally eradicated, it could possibly be brought back as a bioweapon.
- Trial name
- NCT00303225
- Testing
- Vaccine: SIGA-246
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Healthy
A Dose-escalation Study of LPM3480392 in Chinese Healthy Subjects
This is a randomized, double-blind, placebo-controlled, dose-increasing Phase I clinical trial to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of a single intravenous infusion of LPM3480392 injection…
- Trial name
- NCT05862974
- Testing
- LPM3480392
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Luye Pharma Group Ltd.
HIV Infections
Safety and Immunogenicity of TBC-M4, a MVA HIV Vaccine Alone or in a Prime-Boost Regimen With ADVAX DNA HIV Vaccine
This trial will study a prime-boost vaccine approach designed mainly to induce cell-mediated immune (CTL) responses.
- Trial name
- NCT00902824
- Testing
- ADVAX, TBC-M4
- Where
- United Kingdom
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- International AIDS Vaccine Initiative