Clinical trials: A Single-blind Randomized Controlled Trial
Wet Age Related Macular Degeneration
Clinical Study for the Evaluation of Safety and Tolerability of SCAI-005 Eye Drops
To assess the single-dose and multiple-dose pharmacokinetics (PK), safety and tolerability of SCAI-005 eyedrops(axitinib) in healthy volunteers
- Trial name
- NCT06969001
- Where
- South Korea
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- SCAI Therapeutics
Body Weight
Body Weight, Aspirin Dose and Pro-resolving Mediators
This study employs a placebo-controlled randomized cross-over design to investigate the impact of body weight and aspirin dose on levels of specialized pro-resolving lipid mediators in blood and neutrophils.
- Trial name
- NCT04697719
- Testing
- Aspirin 81mg, Aspirin 325mg
- Where
- United States
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Atopic Dermatitis
A Phase 1 Trial of OPA-15406 Ointment in Healthy Adult Male Subjects
To assess the safety (especially skin findings) and pharmacokinetics by applying 0.3%, 1%, or 3% formulation of 5g OPA-15406 ointment to a 1000 cm2 area as a single-dose and as a multiple-dose twice daily for 2 weeks in Japanese…
- Trial name
- NCT02334787
- Testing
- 0.3% OPA-15406 Ointment, 1% OPA-15406 Ointment, 3% OPA-15406 Ointment
- Where
- Japan
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Otsuka Pharmaceutical Co., Ltd.
Bacterial Vaginosis
A First-in-human Safety Trial of BNT331 Administered as Single Ascending Doses in Healthy Women and as Multiple Ascending Doses in Women Diagnosed With Bacterial Vaginosis
This was a two-part, randomized, double-blind, placebo-controlled study to assess the safety, tolerability, pharmacokinetics, pharmacodynamics, and efficacy (for Part B) of BNT331 in healthy women (Part A) and in women diagnosed…
- Trial name
- NCT06469164
- Testing
- BNT331
- Where
- 6 sites in United States
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- BioNTech SE
Labor Pain
Left Lateral Position vs Supine Position to Reduce Active Labor Duration
This randomized clinical trial aims to compare the effect of the left lateral decubitus position versus the supine position on the duration of the active phase of labor in nulliparous women.
- Trial name
- DLI-SP (NCT07411352)
- Testing
- Left Lateral Decubitus Group, Supine Position Group
- Where
- Honduras
- Volunteers
- 188 people, healthy volunteers welcome
- Sponsor
- Universidad Nacional Autonoma de Honduras
Headache
Efficacy of a Single Dose of Aspirin vs. Acetaminophen in Tension Type Headache
The purpose of this trial is to determine if a single, oral dose of a fast release aspirin 1000 mg provides relief compared to acetaminophen 1000 mg and placebo in subjects with tension-type headache pain.
- Trial name
- Tarot Headache (NCT01552798)
- Testing
- Acetylsalicylic acid (Aspirin, BAY1019036), Acetaminophen
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Bayer
Healthy
A Clinical Trial of CS12192 in Healthy Subjects
The study is to evaluate the safety, tolerability, pharmacokinetic and pharmacodynamic profiles of CS12192 after single or multiple oral administration, as well as the food effect on the pharmacokinetics in healthy subjects.
- Trial name
- NCT05922709
- Testing
- CS12192 capsule
- Where
- China
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Chipscreen Biosciences, Ltd.
Gaucher Disease
A Study of the Tolerability, Safety, and Pharmacokinetics of ISU302 in Healthy Volunteers
The purpose of this study is to assess the safety, tolerability, and pharmacokinetics of single dosing study with three ascending dose cohorts of ISU302 in healthy subjects.
- Trial name
- NCT01881633
- Testing
- ISU302
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- ISU Abxis Co., Ltd.
Exercise, Pain
Effect of Brain Training Through Visual Mirror Feedback, Action Observation Training and Motor Imagery on Orofacial Sensorimotor Variables in Asymptomatic Subjects: A Single-blind Randomized Controlled Trial.
The main objective of the present study was to evaluate the effects of action observation (AO), visual mirror feedback (VMF), motor imagery (MI) combined with an orofacial exercise program in asymptomatic subjects.
- Trial name
- NCT04021147
- Testing
- Exercise plus action observation, Exercise plus motor imagery, Exercise plus visual mirror feedback
- Where
- Spain
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Universidad Autonoma de Madrid
Aging, Dehydration
The Effect of Fluids Consumption on Balance and Gait Function in Old Adults
Experimental design overview The proposed project is a prospective experimental RCT study design. Independent old adults(age 65 years old and older) who do not suffer from balance problems willing to participate in the study will…
- Trial name
- NCT01181180
- Testing
- water consumption
- Where
- Israel
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Soroka University Medical Center
Meningococcal Vaccine
A Trial To Assess The Safety, Tolerability, And Immunogenicity Of Rlp2086 Vaccine When Administered In Either 2- Or 3-Dose Regimens In Healthy Subjects Aged ≥11 To <19 Years
This study is to look at a new vaccine that might prevent meningococcal disease, and to look at the safety of the new vaccine as well as how well it is tolerated.
- Trial name
- NCT01299480
- Testing
- Vaccine
- Where
- 63 sites in Czechia, Denmark and 5 more
- Volunteers
- 1,714 people, healthy volunteers welcome
- Sponsor
- Pfizer
Nonalcoholic Steatohepatitis
A Trial to Evaluate the Safety Tolerability and Pharmacokinetics of B1344 by Subcutaneous Injection in Healthy Subjects
To evaluate the safety, tolerability, and immunogenicity of B1344 by single subcutaneous (s.c.) injection in healthy subjects
- Trial name
- NCT05655221
- Testing
- B1344
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Tasly Biopharmaceuticals Co., Ltd.
Alzheimer's Disease
A Study to Evaluate the Safety, Tolerability and Pharmacokinetics of SHR 3201 Injection in Healthy Participants
This study is a randomized, double-blind, dose-escalation, placebo-controlled Phase I clinical trial in healthy participants to evaluate the safety, tolerability, and pharmacokinetics of single intravenous and subcutaneous…
- Trial name
- NCT07889349
- Testing
- SHR 3201 Injection
- Where
- China
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Beijing Suncadia Pharmaceuticals Co., Ltd
Human Papilloma Virus
A Cohort Study of Hyperthermia and Imiquimod for the Treatment of Flat Warts
flat warts are a superficial viral skin disease, extremely common in childhood.Treatment of warts is often difficult and involves different destructive procedures.Although several pharmacological and physical topical treatments…
- Trial name
- NCT05146895
- Testing
- Imiquimod treatment, Local Hyperthermia at 44℃
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- First Hospital of China Medical University
Asthma
A Trial of HBM9378 in Healthy Chinese Subjects
The objective is to evaluate the safety, tolerability and pharmacokinetic profile of a single subcutaneous injection of HBM9378 (SKB378) at different doses in healthy Chinese subjects.
- Trial name
- NCT05790694
- Testing
- HBM9378 (SKB378) Injection
- Where
- China
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Harbour BioMed (Guangzhou) Co. Ltd.
Parkinson's Disease
Trial to Evaluate the Pharmacokinetics, Safety, and Tolerability of Rotigotine in Healthy Korean Subjects
The objective of this trial is to investigate the PK (Pharmacokinetic) of repeated-dose applications of the Rotigotine transdermal patch in healthy young male and female Korean subjects to be submitted to MFDS for new drug…
- Trial name
- NCT01964573
- Testing
- Rotigotine
- Where
- South Korea
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- UCB Pharma
Healthy
BI 409306 Cardiac Safety Trial in Healthy Volunteers
This trial will be conducted to further evaluate, in a controlled setting, potential cardiac effects of an anticipated therapeutic and supra-therapeutic dose of BI 409306 under resting and exercise conditions.
- Trial name
- NCT02438683
- Testing
- BI 409306
- Where
- Germany
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Stress
Effectiveness of Mindfulness-based Stress Reduction Program
Having a physically disabled child presents serious challenges for parents, not only in the practice of daily living, but also on a psychological and emotional level.
- Trial name
- NCT06449118
- Testing
- Mindfulness Stress Reduction Program
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Muş Alparslan University
Mood
Impact of Botox Treatment Into the Upper One Third of the Face an Area on Mood and Self -Appearance Satisfaction
Botox treatment into the upper one third of the face (glabella, forehead lines and/or lateral canthal lines) to analyze mood and self -appearance satisfaction in a Post Covid period on non-naïve Botox patients
- Trial name
- NCT04439825
- Testing
- Botulinum Neurotoxin
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- DeNova Research
Viremia
Yellow Fever Virus Vaccine and Immune Globulin Study
The purpose of this study is to determine whether immune globulin can limit the amount of yellow fever vaccine virus present in the blood after vaccination without compromising the immunity associated with the yellow fever…
- Trial name
- NCT00254826
- Testing
- YF-VAX® plus saline, 17D YF Vaccine plus Ig,
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Emory University