Clinical trials: A-PRF, open to volunteers
Periodontitis, Periodontal Inflammation
PRF as Adjunct to Subgingival Instrumentation in Step 2 Periodontal Therapy
Periodontitis is characterized by a chronic, multifactorial inflammatory process driven by dysbiotic plaque biofilms. It is recognized as the most common chronic inflammatory non-communicable disease in humans.
- Conditions
- Periodontitis, Periodontal Inflammation, Periodontal Attachment Loss
- Trial name
- PRFSTEP2 (NCT07013682)
- Testing
- PRF as adjunct to non-surgical mechanical debridement, Control, non-surgical mechanical debridement alone
- Where
- Switzerland
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Bern
Papillary Reconstruction
Papillary Reconstruction Using Three Different Modalities
papillary reconstruction will be done by three techniques : injection of hyaluronic acid in the base of the papilla and booster doses can be required , injection of ALB-PRF which resorbs slowly and so longer effect the last…
- Trial name
- NCT07159802
- Testing
- Papillary reconstruction
- Where
- Egypt
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Thin Peri-implant Mucosal Phenotype
Peri-implant Soft Tissue Augmentation Using Microneedling With i-PRF vs. Connective Tissue Graft
This randomized controlled clinical trial aims to evaluate a minimally invasive technique for peri-implant soft tissue augmentation using microneedling combined with injectable platelet-rich fibrin (i-PRF) compared with the…
- Trial name
- NCT07667855
- Testing
- Connective Tissue Graft (CTG), Microneedling with Injectable Platelet-Rich Fibrin (MN+i-PRF)
- Where
- Lebanon
- Volunteers
- 24 people
- Sponsor
- Beirut Arab University
Apical Periodontitis, Periapical Diseases
Evaluation of Revitalization Success Using i-PRF in Non-Surgical Root Canal Retreatment
The goal of this randomized controlled clinical trial is to determine whether regenerative endodontic treatment can improve healing outcomes in teeth with apical periodontitis following failed root canal treatment.
- Trial name
- NCT07448571
- Testing
- Non-Surgical Root Canal Retreatment, Regenerative Endodontic Treatment
- Where
- Turkey (Türkiye)
- Volunteers
- 140 people
- Sponsor
- Marmara University
Pudendal Neuralgia
Conventional Versus High-Voltage Long-Duration Pulsed Radiofrequency of the Pudendal Nerve
This study is a single-center, prospective, randomized controlled trial evaluating two types of pulsed radiofrequency (PRF) treatment for patients with pudendal neuralgia.
- Trial name
- NCT07356102
- Testing
- Intervention Type * Select the type of intervention. Procedure / Surgery Intervention Name * Enter a brief, descriptive name for the intervention. Use a non-proprietary (generic) name, if available, High-Voltage Long-Duration Pulsed Radiofrequency
- Where
- Turkey (Türkiye)
- Volunteers
- 38 people
- Sponsor
- Ankara City Hospital Bilkent
Symptomatic Irreversible Pulpitis (SIP)
Regenerative Potentials of Mature Mandibular Molars With Symptomatic Irreversible Pulpitis Enhanced With Different Scaffolds
The current study aims to assess the influence of different scaffolds on postoperative pain and success rate of pulpotomy in mandibular mature molars with symptomatic irreversible pulpitis
- Trial name
- NCT07196683
- Testing
- Regenerative pulpotomy
- Where
- Egypt
- Volunteers
- 36 people
- Sponsor
- Cairo University
Nasal Septum; Deviation, Nasal Septal Srur
Outcomes of PRF on Septoplasty in Patient With Nasal Septal Deviation
The aim of this study is to assess the effectiveness of Platelet-Rich Fibrin (PRF) in improving postoperative healing, reducing complications, and enhancing functional outcomes in patients undergoing septoplasty
- Trial name
- NCT06996106
- Testing
- Effect of Platelet Rich Fibrin on Septoplasty
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Kafrelsheikh University
Periodontal Diseases, Periodontal Attachment Loss
Clinical Effectiveness of Biologic Agents as an Adjunct to Non-surgical Periodontal Therapy of Intrabony Defects
The aim of the present study is to clinically and radiographically compare the efficacy of recombinant human platelet-derived growth factor (rhPDGF), Leukocyte-Platelet Rich Fibrin (L-PRF) and Enamel Matrix Derivatives (EMD) in…
- Conditions
- Periodontal Diseases, Periodontal Attachment Loss, Pocket, Periodontal, Intrabony Periodontal Defect
- Trial name
- NCT05858411
- Testing
- SRP+rhPDGF, SRP+L-PRF, MINST alone
- Where
- Albania
- Volunteers
- 88 people
- Sponsor
- G. d'Annunzio University
Gingival Recession
Changes of Soft Tissue Grafting: A Randomized Study
To correct gum recession, patient's own tissue from the roof of the mouth is harvested and placed where there is root exposed. This is considered gold standard of treatment.
- Trial name
- NCT05633511
- Testing
- Split Mouth Design
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Tufts University
DENT IMPLANTS
Delayed Short Dental Implants With Immediate Loading
> Evaluation of the wound healing in immediate occlusal loading of endosseous delayed short dental implant with or without CGF or A-PRF.
- Trial name
- NCT07675772
- Testing
- Dental Implant Surgery
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Sana'a University
Soft Tissue Thickness Around Delayed Implants in Patients With Thin Gingival Phenotype
Effectiveness of Connective Tissue Graft With and Without Leukocyte Platelet Rich Fibrin on Peri-implant Soft Tissue Thickness Around Delayed Implants in Patients With Thin Gingival Phenotype: A Randomized Controlled Clinical Trial
A stable soft and hard tissues around Osseo-integrated implants are very crucial. Soft tissue thickness around implants is crucial as it prevents peri-implant bone loss and enhance the esthetic outcomes.
- Trial name
- NCT07368621
- Testing
- Connective tissue graft(CTG), Connective tissue graft (CTG) + leukocyte platelet-rich fibrin (L-PRF)
- Where
- Egypt
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- British University In Egypt
Sinus Lifting, Dental Implant
Comparative Evaluation of Xenograft Alone and Sticky Bone in Sinus Lift With Concurrent Implant Placement
Introduction \& Background: Modern dental implantology offers solutions for patients with edentulism in the maxillary arch, where sinus pneumatization and alveolar ridge atrophy are common conditions.
- Conditions
- Sinus Lifting, Dental Implant, Sticky Bone
- Trial name
- NCT07444970
- Testing
- Sticky bone, traditional xenograft
- Volunteers
- 18 people
- Sponsor
- Fayoum University
Periodontitis, Periodontitis Stage III
Alb-PRF as an Adjunct to Regenerative Periodontal Surgery
Periodontitis is characterized by the progressive destruction of tooth-supporting tissues and may lead to the formation of intrabony periodontal defects.
- Conditions
- Periodontitis, Periodontitis Stage III, Periodontal Intrabony Defects
- Trial name
- NCT07805317
- Testing
- Regenerative Periodontal Surgery With EDTA and Allogeneic Bone Graft, Albumin Platelet-Rich Fibrin
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 24 people
- Sponsor
- Halil Ata BIÇAKÇIOĞLU
Gingival Recession
Clinical Evaluation of Two Different Surgical Techniques With PRF in the Treatment of Multiple Gingival Recessions
This prospective clinical study aims to evaluate and compare the effectiveness of coronally advanced flap (CAF) and tunnel techniques, both combined with platelet-rich fibrin (PRF), in the treatment of multiple Miller Class I-II…
- Trial name
- NCT06986525
- Testing
- CAF with PRF, Tunnel with PRF
- Where
- Turkey (Türkiye)
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Pamukkale University
Extraction, Tooth, Tooth Fracture
Platelet-Rich Fibrin (PRF) vs Bone Graft With Membrane for Ridge Preservation After Tooth Extraction
This study uses a natural material called Platelet-Rich Fibrin (PRF) to help improve healing after tooth removal. PRF is made from your own blood.
- Conditions
- Extraction, Tooth, Tooth Fracture, Tooth Crown Fracture, Root; Fracture
- Trial name
- NCT07595198
- Testing
- Platelet-rich fibrin (PRF), Freeze-dried bone allograft, Collagen barrier membrane
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Chronic Skin Ulcer
PRF With Topical Antibiotics or Antiseptics in Chronical Wounds Version 1.4
Platelet rich fibrin (PRF) is a new therapy option for chronic wounds with yet unproven therapeutic efficacy. This randomised controlled trial aims to provide evidence of the efficacy of PRF as monotherapy as well as a growth…
- Trial name
- PRF-TAT (NCT02652169)
- Testing
- PRF mixed with amikacin and teicoplanin, PRF mixed with PHMB plus Macrogolol, PRF plus normal saline
- Where
- Austria
- Volunteers
- 120 people
- Sponsor
- Medical University of Vienna
Intrabony Periodontal Defect
Comparison of MIST With PRF and GBT With PRF in the Treatment of Intrabony Periodontal Defect. A Prospective RCT
The aim is to evaluate in a prospective, randomized, controlled clinical study the healing of a MIST procedure combined with PRF, or GBT combined with PRF.
- Trial name
- NCT06768424
- Testing
- Guided biofilm therapy, Platelet Rich Fibrin, Minimally Invasive Surgical Technique
- Where
- Hungary
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Semmelweis University
Alveolar Ridge Preservation Post-Extraction Bone Healing Dental Implant Site Development Tooth Loss, Alveolar Bone Regeneration Following Odontectomy
Effect of Ascorbic Acid-Loaded I-PRF With Partially Demineralized Dentin Graft on Alveolar Ridge Preservation
The goal of this clinical trial is to find out which treatment best preserves the jawbone after tooth extraction in adults planning to receive a dental implant later.
- Conditions
- Alveolar Ridge Preservation Post-Extraction Bone Healing Dental Implant Site Development Tooth Loss, Alveolar Bone Regeneration Following Odontectomy, Assisted Alveolar Bone Healing After Dental Extraction, Alveolar Bone Preservation
- Trial name
- AA-IPRF-PDDG (NCT07916545)
- Testing
- Alveolar Ridge Preservation Using Partially Demineralized Dentin Graft alone, Alveolar Ridge Preservation Using PDDG Combined with I-PRF, Alveolar Ridge Preservation Using PDDG Combined with Ascorbic Acid-Loaded I-PRF
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Nahda University
Partial Edentulism, Dental Implant Placement
Effect of Advanced PRF and Hyaluronic Acid on Dental Implant Healing
This randomized parallel-group clinical trial aimed to evaluate the clinical efficacy of advanced platelet-rich fibrin (A-PRF) combined with hyaluronic acid (HA) in enhancing peri-implant bone formation in patients undergoing…
- Trial name
- NCT07792720
- Testing
- Delayed Dental Implant Placement, Advanced Platelet-Rich Fibrin (A-PRF), Hyaluronic Acid 1.5%
- Where
- Yemen
- Volunteers
- 30 people
- Sponsor
- Samar Ali Abdu Salamah
Palate; Wound
Clinical Comparison of Alb-PRF vs PRF on Postoperative Morbidity Following FGG Harvesting
Clinical Comparison of Albumin Platelet Rich- Fibrin (Alb- PRF) versus Platelet-rich fibrin (PRF) on Postoperative Morbidity Following Free Gingival Graft Harvesting: A Randomized Controlled Clinical Trial(RCT) Study settings…
- Trial name
- NCT06567548
- Testing
- control group, Platelet-rich fibrin (PRF), Albumin Platelet Rich- Fibrin
- Where
- 3 sites in Egypt
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Cairo University