Clinical trials: ABD
Hemodynamic
Three Different GHDT ( Goal Hemodynamic Directed Therapy) Strategies for Intraoperative Fluid Management Optimization During Major Abdominal Surgery: A Randomized Controlled Trial
Major oncological surgery is among the most complex procedures, involving patients with a combination of high-risk factors that can significantly influence immediate postoperative outcomes and quality of life.
- Trial name
- SMART FLUID (NCT06871150)
- Testing
- Flotrac sensor, HPI, HPI-AFM
- Where
- 3 sites in Italy
- Volunteers
- 150 people
- Sponsor
- ASST Sette Laghi
Abdominal Injuries, Physical Abuse
Effectiveness of Contrast-Enhanced Ultrasound
The purpose of the study is to generate pilot data describing test characteristics of contrast enhanced ultrasound in young children with concern for abdominal trauma.
- Conditions
- Abdominal Injuries, Physical Abuse, Accidental Fall, Motor Vehicle Injury
- Trial name
- NCT03473249
- Testing
- Contrast-Enhanced Ultrasound using Lumason
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Philadelphia
Gastric Cancer Stage IV, Peritoneal Carcinomatosis
Intraperitoneal Paclitaxel Plus Systemic mFOLFOX6
Treatment for stage 4 gastric cancer with peritoneal carcinomatosis has been unchanged for decades. The median survival for stage 4 gastric cancer is 9-14 months with systemic chemotherapy.
- Conditions
- Gastric Cancer Stage IV, Peritoneal Carcinomatosis, Intraperitoneal Paclitaxel, mFOLFOX6
- Trial name
- IPLUS (NCT03618758)
- Testing
- Paclitaxel, mFOLFOX6 regimen
- Where
- South Korea
- Volunteers
- 35 people
- Sponsor
- Seoul National University Bundang Hospital
Inguinal Hernia
Isolation of the Spermatic Cord in Mesh Inguinal Hernia Repair
There are in excess of 1 million operations performed annually to repair inguinal hernias, mostly in the male population. Unfortunately, some patients continue to suffer both groin or testicular pain for varying lengths of time…
- Trial name
- NCT01391455
- Testing
- Isolation of the spermatic cord from mesh
- Where
- Canada
- Volunteers
- 220 people
- Sponsor
- Chatham Kent Health Alliance
Hypovolemia, Diuretic Toxicity
Diagnosis Accuracy of Abdominal Compression and Hemoconcentration to Detect Diuretic Induced Fluid Removal Intolerance.
Fluid overload increases morbidity and mortality of pediatrics patients in intensive care unit (ICU). It could be interesting to predict the decrease in stroke volume when diuretics are prescribed.
- Conditions
- Hypovolemia, Diuretic Toxicity, Fluid Overload
- Trial name
- NCT03145935
- Testing
- Abdominal compression (AC), blood sample
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Hopital Louis Pradel
Peripheral Arterial Disease
DOTAREM®-Enhanced MRA Compared to GADOVIST®-Enhanced MRA in Patients With Abdominal or Lower Limb Arterial Diseases
This study is an intra-individual comparison of DOTAREM®-enhanced MRA and GADOVIST®-enhanced MRA in the diagnosis of clinically significant abdominal or lower limb arterial diseases.
- Trial name
- NCT00955617
- Testing
- Contrast-enhanced MRA - Imaging examination
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Guerbet
Gait, Unsteady
At-home Walking Cadence Functional Assessment and Recovery Trajectory for Older Adults Undergoing Major Surgery
This is a prospective observational study looking at gait-cadence in older adults who are scheduled to have major abdominal surgery at the University of Chicago.
- Trial name
- CADENCE (NCT05886725)
- Testing
- Patients using Step Test Application and Accelerometer
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Chicago
Acute Respiratory Distress Syndrome
Continuous Negative Abdominal Pressure in ARDS (CNAP in ARDS)
The aim is to test a device for applying continuous negative abdominal pressure in patients with ARDS
- Trial name
- CNAP in ARDS (NCT03425318)
- Testing
- CNAP
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- The Hospital for Sick Children
Performance and Tolerance of Colonoscopy
Carolina-ColoWrap® in Colonoscopy Performance and Outcomes Study
Colonoscopy is the gold-standard for colorectal cancer screening in the US. However, complete colonoscopy can be a challenging technical procedure, even for expert gastroenterologists due to variations in patient anatomy…
- Trial name
- C3PO (NCT02025504)
- Testing
- ColoWrap
- Where
- 3 sites in United States
- Volunteers
- 350 people
- Sponsor
- ColoWrap, LLC
Abdomen Hernia, Respiratory Complication
Virtual Reality on Pulmonary Function After Upper Abdominal Surgeries
After upper abdomen surgery, respiratory muscle dysfunction is well recognised. After laparotomy and even laparoscopy, maximum static inspiratory and expiratory pressures are lowered, and recovery can take several days.
- Trial name
- NCT06301126
- Testing
- Virtual reality, conventional physical therapy exercise program
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Cairo University
Irritable Bowel Syndrome
Nursing Management of Irritable Bowel Syndrome (IBS) 2008
The aim of this study is test the efficacy of a comprehensive self-management therapy to decrease abdominal pain/discomfort and improve quality of life in patients with irritable bowel syndrome (IBS) compared to IBS patients…
- Trial name
- NCT00907790
- Testing
- Usual Care (Control Group), Comprehensive Self-Management (CSM)
- Where
- United States
- Volunteers
- 92 people
- Sponsor
- University of Washington
Abdominal Aortic Aneurysm
Endoprosthesis Treatment Effects on Human Abdominal Aorta Aneurysms (AAA) Metabolic Activity
The purpose of this study is to determine whether Positron Emission Tomography imaging can help to predict the evolutivity of AAA treated with endovascular prosthesis.
- Trial name
- AAAendo (NCT01253252)
- Testing
- [18F] Fluorodeoxyglucose PET Scan Imaging, CT scan, Blood sampling for biological investigations
- Where
- 7 sites in France
- Volunteers
- 45 people
- Sponsor
- Central Hospital, Nancy, France
Abdominal Surgery
Development of a Patient-Reported Outcome Measure to Assess Recovery After Abdominal Surgery
As surgery enters the era of value-based care, it is advocated that postoperative recovery be measured using patient-reported outcomes (PROs) as they provide a mean to incorporate the patient's perspectives and experiences into…
- Trial name
- NCT03461497
- Where
- 7 sites in United States, Brazil and 3 more
- Volunteers
- 530 people, healthy volunteers welcome
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Appendicitis, Abdominal Abscess
Laparoscopic Management of Periappendicular Abscess
According to retrospective studies the conservative management of periappendicular abscess is associated with decreased complication and re-operation rate compared with open appendectomy.
- Trial name
- NCT01283815
- Testing
- Laparoscopic appendectomy, Conservative management with percutaneous drainage
- Where
- Finland
- Volunteers
- 60 people
- Sponsor
- Helsinki University Central Hospital
Peritoneal Carcinomatosis, Ovarian Cancer
Study of Radspherin® in Recurrent Ovarian Cancer Subjects With Peritoneal Carcinomatosis
RAD-18-001 is a First-In-Man, Dose Escalation study conducted at 2 sites. The dose escalation will be performed based on a 3 + 3 design. Increasing dose levels starting at 1 MBq will be followed by 2, 4 and 7 MBq.
- Trial name
- NCT03732768
- Testing
- Radspherin
- Where
- 4 sites in Belgium, Norway and 1 more
- Volunteers
- 21 people
- Sponsor
- Oncoinvent Solutions AS
the Necrotizing Enterocolitis, Preterm Infants
Prognostic Contribution of Abdominal Ultrasound in Necrotizing Enterocolitis in Preterm Infants Less Than 33SA.
Enterocolitis necrotizing (ECUN) is a common and serious gastrointestinal disease in premature infants. The diagnosis of ECUN based on clinical and radiological criteria.
- Trial name
- ECUN (NCT02872350)
- Testing
- Abdominal ultrasound
- Where
- France
- Volunteers
- 95 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Parkinson's, Disease
Light Therapy Plus Exercise to Improve Motor, Non-Motor Symptoms and QoL in Parkinson's Disease
Parkinson's disease (PD) is a lifelong and progressive disease and is the second most common progressive neurodegenerative disease worldwide.
- Trial name
- NCT06036433
- Testing
- Infrared laser photobiomodulation device, Infrared & Red LED photobiomodulation device
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Gaitway Neurophysio
Surgery--Complications, Pelvic Cancer
Reconstruction in Extended MArgin Cancer Surgery
Advanced pelvic cancers are uncommon, with treatment being challenging. Around 4000 patients every year need treatment in the UK. Cancers can involve multiple organs and often need radiotherapy and chemotherapy before surgery.
- Conditions
- Surgery--Complications, Pelvic Cancer, Abdominal Cancer, Quality of Life
- Trial name
- REMACS (NCT05219058)
- Testing
- Biological mesh reconstruction, Myocutaneous flap reconstruction, Primary closure reconstruction
- Where
- 18 sites in United Kingdom
- Volunteers
- 236 people
- Sponsor
- University Hospital Southampton NHS Foundation Trust
Obesity
High Density Lipoprotein Turnover
The objective of the study is to evaluate the effect of Rimonabant 20mg in comparison to placebo, on HDL and VLDL lipoprotein kinetics, over a 12 months period.
- Trial name
- NCT00408148
- Testing
- Rimonabant
- Where
- 4 sites in Australia, Finland and 2 more
- Volunteers
- 64 people
- Sponsor
- Sanofi
Peritoneal Neoplasms
A Phase II Study of Surgical Debulking With Peritonectomy and Biweekly Intraperitoneal 5FU With Systemic Oxaliplatin/5FU/Leucovorin in Patients With Pseudomyxoma Peritonei or Peritoneal Carcinomatosis
This study prospectively evaluates a multidisciplinary approach to patients with intraperitoneal carcinomatosis at Washington University.
- Trial name
- NCT00352755
- Testing
- Surgical debulking with peritonectomy, Intraperitoneal 5FU, FOLFOX
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Washington University School of Medicine
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