Clinical trials: ACL
Anterior Cruciate Ligament Rupture
Anterior Cruciate Ligament (ACL) Revision Surgery: French National Study
This is a national multicentric study led by the French Arthroscopy Society (SFA) evaluating clinical practice in anterior cruciate ligament (ACL) revision surgery (epidemiological data, morphological data, operative data…
- Trial name
- NCT06379308
- Testing
- questionaries, datas of medical record
- Where
- France
- Volunteers
- 300 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Anterior Cruciate Ligament Injury
A Novel Analgesia Technique for ACL Reconstruction
A comparison of two anesthetic techniques-- the Adductor Canal Block (ACB) and the Adductor Canal Block with Infiltration of the interspace between the popliteal artery and the capsule of the posterior knee (ACB/IPACK)-- in…
- Trial name
- NCT03292926
- Testing
- Bupivacaine, Ultrasound, Dexamethasone
- Where
- United States
- Volunteers
- 78 people
- Sponsor
- Hospital for Special Surgery, New York
Anterior Cruciate Ligament (ACL) Tear, Anterior Cruciate Ligament Reconstruction Rehabilitation
Analysis Of Knee Joint Of Patients With Anterior Cruciate Ligament Injury Undergoing Physiotherapy After Two Different Surgical Techniques: A Randomized Clinical Trial.
The objetive is compare knee joint stability, functional capacity, postural control, activation, and muscle strength of patients undergoing conventional Anterior Cruciate Ligament Reconstruction or the conventional Anterior…
- Trial name
- NCT06809920
- Testing
- Group 1 ACL reconstruction with quadruple flexor tendons and conventional physiotherapy, Group 2 ACL reconstruction with quadruple flexor tendons + ALL reconstruction
- Where
- 2 sites in Brazil
- Volunteers
- 26 people
- Sponsor
- Universidade Estadual de Londrina
Anterior Cruciate Ligament Reconstruction
Effect of Patient Resilience on Return to Sport Post ACL Reconstruction Surgery
Despite the large majority of patients that undergo ACL reconstruction reporting successful outcomes in regard to tests of knee function, only about 2/3 return to their prior level or athletic activity after surgery.
- Trial name
- NCT03013231
- Testing
- Brief Resilience Scale
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- St. Louis University
ACL Reconstruction
Methylprednisolone Addition to Multimodal Pain Regimens After Anterior Cruciate Ligament Reconstruction
Patients who are being seen for ACL tears will be approached in the UAB Orthopedic Clinic. Included patients will be those aged 14-65 undergoing ACL Reconstruction.
- Trial name
- NCT07605923
- Testing
- Methyl Prednisolone (MP), Standard Post-Operative Pain Control, Surgeon's Standard ACL Postoperative Regimen
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- University of Alabama at Birmingham
Dyslipidemia
A Study to Investigate the Pharmacokinetics, Safety, Tolerability, and Efficacy of AZD0780 With Ezetimibe Combinations in Healthy Adults With Elevated LDL-C.
The main aim of this study is to assess the effects of AZD0780 when added on top of ezetimibe or ezetimibe and rosuvastatin or ezetimibe and bempedoic acid.
- Trial name
- NCT06742853
- Testing
- AZD0780, Ezetimibe, Rosuvastatin
- Where
- 3 sites in United States, United Kingdom
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Anterior Cruciate Ligament (ACL)
Comparison of Standard ACL Reconstruction Versus TARS-Augmented Reconstruction
This study is designed to compare standard anterior cruciate ligament (ACL) reconstruction using hamstring autograft with ACL reconstruction augmented using the Tape Active Reconstruction System (TARS).
- Trial name
- NCT07418476
- Testing
- ACL Reconstruction, TARS-Augmented ACL Reconstruction
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Samsun University
Type 1 Diabetes (T1D)
Insulin Delivery With Self-Adjusting Closed-Loop and Behavioral Glycemic Control Enhanced by Prediction
This study is a randomized cross-over trial comparing AIDANET with Anticipation to AIDANET in FCL without Anticipation. Participants will complete 4 weeks of AID data collection which will be used to establish baseline and…
- Trial name
- INSIGHT (NCT07507708)
- Testing
- Automated Insulin Delivery (AID), AIDANET + Fully Closed Loop (FCL), AIDANET + Anticipatory Closed Loop (ACL)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Sue Brown
ACL-injury
The Effectiveness of Neuromuscular Training in Healthy and ACL-Injured Adolescent Females
Recently, there has been a dramatic rise in the number of children participating in competitive sports. Adolescents involved in sports that require cutting, pivoting or body contact are at greatest risk for sustaining an anterior…
- Trial name
- NCT02316639
- Testing
- Neuromuscular Training
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Leg Injuries
Neuromuscular Training to Reduce Sports Injuries Among Children and Adolescents
Sports-related injuries are a serious concern for physically active children and adolescents. Previous research, including ours at Chicago public high schools, shows our neuromuscular training program, the Knee Injury Prevention…
- Trial name
- KIPP (NCT01406054)
- Testing
- neuromuscular exercises
- Where
- United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Ann & Robert H Lurie Children's Hospital of Chicago
Anterior Cruciate Ligament Rupture, Osteoarthritis, Knee
A Cohort Study of Non-surgical Treatment and Exercise Rehabilitation in Patients With Anterior Cruciate Ligament Rupture
This clinical trial compared the prognosis of surgical and non-surgical treatment in patients with complete anterior cruciate ligament rupture
- Trial name
- NCT05403905
- Testing
- non surgical treatment, surgical treatment
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Peking University Third Hospital
Knee Injuries, Anterior Cruciate Ligament Rupture
Stopping OsteoARthritis After an ACL Tear
By 2040, 25% of Canadians will have osteoarthritis, a disabling joint condition. Most people think osteoarthritis only affects older adults, but 50% of the 700,000 Canadian youth who hurt their knee playing sports annually will…
- Conditions
- Knee Injuries, Anterior Cruciate Ligament Rupture, Osteoarthritis, Knee
- Trial name
- SOAR (NCT06195423)
- Testing
- Stop OsteoARthritis (SOAR) program, Living Well after ACLR program
- Where
- 2 sites in Canada
- Volunteers
- 210 people
- Sponsor
- University of British Columbia
ACL Injury
Continuous Vs Single Shot Block After ACL
The investigators will be randomizing patients to either receive an adductor canal block in the operating room postoperatively as single shot of 20-30cc bupivacaine or to have a catheter inserted into the adductor canal which…
- Trial name
- NCT04101682
- Testing
- Bupivacaine
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Northwell Health
ACL Injury, Knee Injuries
Subjective Outcomes After ACL Reconstruction With BQT Autograft
The purpose of the study is to compare short-term patient reported outcome measures (PROM) of Bone-Quadriceps-Tendon (BQT) autograft with Semitendinosus-Gracilis (STG) and Bone-Patellar-Tendon-Bone (BPTB) autografts following…
- Trial name
- NCT04901559
- Testing
- Graft type at ACLR
- Volunteers
- 30,000 people
- Sponsor
- Region Zealand
ACL Injury
Immediate Versus Optional Delayed Surgical Repair for Treatment of Acute ACL Injuries
Currently, most patients with an anterior cruciate ligament injury undergo surgery. There is a general belief that surgical reconstruction is necessary to safely return to sports and to prevent early knee osteoarthritis or…
- Trial name
- IODA (NCT05747079)
- Testing
- Rehabilitation, Optional delayed anterior cruciate ligament reconstruction, Immediate anterior cruciate ligament reconstruction
- Where
- Belgium
- Volunteers
- 280 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Anterior Cruciate Ligament Tear, Pain, Postoperative
Evaluation of Exparel Adductor Canal Field Block for Pain Control After ACL Reconstruction
This is a prospective, randomized study for adult patients presenting to the Carilion Clinic Institute of Orthopedics and Neurosurgery. Patients undergoing isolated ACL reconstruction will be eligible for inclusion.
- Conditions
- Anterior Cruciate Ligament Tear, Pain, Postoperative, Opioid Use
- Trial name
- NCT04764916
- Testing
- Liposomal bupivacaine, Bupivacaine Hydrochloride
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Carilion Clinic
Anterior Cruciate Ligament (ACL) Tear
Sciatic Technique Comparison of Nerve Blockade for Pain Control Following Hamstring Autograft Harvest in Adolescents
The purpose of this research is to compare the effect of single-injection sciatic PNB to continuous sciatic PNB on 1) postoperative pain control as measured by self-reported pain scores, pain medication use, and unplanned…
- Trial name
- NCT02947633
- Testing
- Single-injection sciatic PNB, Continuous sciatic PNB
- Where
- United States
- Volunteers
- 141 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
ACL Reconstruction
Readiness Outcomes Affecting Return to Sport 3.0
The primary aim is to determine if MST will improve coping skills in young athletes returning to sport after ACLR as measured by ACSI-28.
- Trial name
- ROAR 3 (NCT07476430)
- Testing
- Mental Skills Training (MST)
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- Boston Children's Hospital
ACL - Anterior Cruciate Ligament Rupture
Prospective Evaluation of Osseous Integration in ACL Reconstruction Comparing Tightrope vs Interference Screw Fixation
The purpose of our study was to compare osseous integration of the bone block in Achilles tendon allograft ACL reconstruction using a cortical button versus biocomposite interference screw fixation.
- Trial name
- NCT03841500
- Testing
- Biocomposite intereference screw femoral tunnel fixation, Endobutton (Tightrope) femoral tunnel fixation
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Kelsey-Seybold Clinic
Anterior Cruciate Ligament (ACL) Tear
Measuring Knee Laxity and Pivot Shift in ACL-Deficient Patients
The goal of this observational study is to learn whether the Robotic Knee Testing system can measure knee looseness in adults with an anterior cruciate ligament, or ACL, tear.
- Trial name
- NCT07688967
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Arthroresearch LLC