Clinical trials: ACS
Angina, Unstable, Non-ST-Segment Elevation Myocardial Infarction
OCT Based Edge and In-stent Vascular Response After Cordimax Stent in patIents With NSTE-ACS
This study evaluates the completeness of strut coverage and vessel wall response, at different time points (3-6-12 Months), following CordimaxTM stent implantation in patients with non-ST elevation acute coronary syndrome
- Trial name
- NCT02868203
- Testing
- OCT, eLuting stent
- Volunteers
- 80 people
- Sponsor
- Xijing Hospital
Sickle Cell Disease
Effect of Ticagrelor vs. Placebo in the Reduction of Vaso-occlusive Crises in Pediatric Patients With Sickle Cell Disease
The purpose of the study is to Evaluate the Effect of Ticagrelor versus Placebo in Reducing the Rate of Vaso-Occlusive Crises in Paediatric Patients with Sickle Cell Disease
- Trial name
- HESTIA3 (NCT03615924)
- Testing
- Ticagrelor
- Where
- 55 sites in United States, Belgium and 14 more
- Volunteers
- 193 people
- Sponsor
- AstraZeneca
Cancer
Improving Adherence to ACS Guidelines on Nutrition and Physical Activity in Latinas With Cancer and Their Informal Caregivers
This research study is testing the feasibility and acceptability of a 12-week intervention that integrates telephone coaching and printed materials about the ACS guidelines and healthy lifestyle behaviors in order to manage…
- Trial name
- NCT04314479
- Testing
- Symptom Assessment and Health Coaching
- Where
- United States
- Volunteers
- 144 people
- Sponsor
- University of Arizona
Acute Compartment Syndrome
Predicting Acute Compartment Syndrome (PACS)
The long-term objective is to develop a tool to aid in making a timely and accurate diagnosis of acute compartment syndrome (ACS).
- Trial name
- PACS (NCT01561261)
- Testing
- Continuous tissue perfusion monitoring by near-infrared spectroscopy (NIRS) and intramuscular pressure (IMP)
- Where
- 7 sites in United States
- Volunteers
- 194 people
- Sponsor
- Major Extremity Trauma Research Consortium
Acute Myocardial Infarction (AMI), Acute Coronary Syndrome (ACS)
Determination of the Role of Oxygen in Suspected Acute Myocardial Infarction by Biomarkers
Oxygen treatment is widely used in acutely ill patients, both pre-hospital and in hospital. The indication for oxygen is sometimes unquestionable, such as in many hypoxic patients, but in other situations its use is more of a…
- Conditions
- Acute Myocardial Infarction (AMI), Acute Coronary Syndrome (ACS), ST Elevation (STEMI) Myocardial Infarction, Ischemic Reperfusion Injury
- Trial name
- DETO2X-bio (NCT02290080)
- Testing
- Oxygen
- Where
- 2 sites in Sweden
- Volunteers
- 175 people
- Sponsor
- Karolinska Institutet
Acute Coronary Syndrome
DAPT Strategy in HBR Patients Undergoing Complex PCI Following ACS: Second-Phase Beta Testing of a Patients Decision Aid
Among patients with acute coronary syndrome (ACS) treated with percutaneous coronary intervention (PCI) and stent implantation, 17.5% are both at high bleeding risk (HBR) and have undergone complex PCI, which also places them at…
- Trial name
- BETA-DAPT (NCT07391358)
- Testing
- Patient decision aid to support shared decision-making between patients and clinicians
- Where
- Canada
- Volunteers
- 26 people
- Sponsor
- Montreal Heart Institute
Acute Coronary Syndrome
Statin Contrast Induced Nephropathy Prevention
This open-label study, prospective, randomized trial evaluating the acute (in-hospital) pleiotropic and clinical effects of a hydrophilic statin (rosuvastatin) in patients with acute coronary syndrome
- Trial name
- PRATO-ACS (NCT01185938)
- Testing
- Rosuvastatin
- Where
- Italy
- Volunteers
- 500 people
- Sponsor
- Centro Cardiopatici Toscani
Depression, Coronary Artery Disease (CAD)
A Trial of Inflammatory Markers, Depressive Symptoms, and Heart Disease
The purpose of this study is to examine the relationship between depressive symptoms and markers of inflammation, two predictors of heart disease.
- Conditions
- Depression, Coronary Artery Disease (CAD), Acute Coronary Syndrome (ACS)
- Trial name
- CHIME (NCT00208117)
- Testing
- Sertraline (Zoloft), Simvastatin (Zocor)
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- New York State Psychiatric Institute
Acute Coronary Syndrome, Non-ST-Elevation Myocardial Infarction
Risk Stratification of Non ST Elevation ACS With Computed Tomographic Angiography (REACT)
The purpose of this project is to examine the effectiveness of computed tomographic angiography (CTA) in patients with non-ST elevation acute coronary syndrome (NSTE-ACS).
- Conditions
- Acute Coronary Syndrome, Non-ST-Elevation Myocardial Infarction, Unstable Angina
- Trial name
- NCT00449826
- Testing
- Computed Tomographic Angiography
- Where
- Canada
- Volunteers
- 107 people
- Sponsor
- Ottawa Heart Institute Research Corporation
Sleep Disturbance, Insomnia
The SleepWell Study - Chronotherapeutic Intervention to Improve Sleep Following ACS
This two-phase pilot study will test the feasibility of a "combined chronotherapy" (CC) intervention consisting of morning bright light therapy (BLT) and evening blue light blocking (BLB), administered daily for 4 weeks in…
- Conditions
- Sleep Disturbance, Insomnia, Acute Coronary Syndrome
- Trial name
- NCT05299723
- Testing
- BLT Intervention, BLB Intervention, Sleep Hygiene Education
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Columbia University
Degenerative Disc Disease
Pivotal Study of rhBMP-2/ACS/LT-CAGE® Device for Anterior Lumbar Interbody Fusion in Patients With Symptomatic Degenerative Disc Disease
This study is designed to assess the safety and effectiveness of the rhBMP-2/ACS/LT-CAGE® device as compared to the LT-CAGE® device with autogenous bone in patients with symptomatic degenerative disc disease using an open…
- Trial name
- NCT01491386
- Testing
- rhBMP-2/ACS/LT-CAGE® Device, Autogenous Bone/LT-CAGE® Device
- Volunteers
- 279 people
- Sponsor
- Medtronic Spinal and Biologics
Acute Coronary Syndrome
The Role of Netrin -1 in Acute Coronary Syndrome
In our study, Netrin -1; We found that patients with ACS increased at the time of admission, decreased TIMI 3 flow after angiography, and higher risk groups in high risk groups such as TIMI and GRACE were found to have higher…
- Trial name
- ACS-NETRİN-1 (NCT04027127)
- Testing
- netrin-1 value on admission to hospital
- Volunteers
- 238 people, healthy volunteers welcome
- Sponsor
- Aksaray University Training and Research Hospital
Pain, Sickle Cell Disease
Choosing Opioid Management for Pain and Analyzing Acute Chest Syndrome (ACS) Rates Equally
The pathophysiology of sickle cell disease (SCD) manifestations, are complex with interactions of intracellular hemoglobin, membrane and endothelial activation but the hallmark remains recurrent and painful vaso-occlusive…
- Trial name
- COMPARE (NCT01380197)
- Testing
- Morphine, Nubain
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Children's Healthcare of Atlanta
Acute Compartment Syndrome, Fracture, Bone
Evaluation of the Diagnostic and Therapeutic Value of Tissue Ultrafiltration in Patients at Risk of Acute Compartment Syndrome (ACS)
The goal of this clinical trial is to learn if tissue ultrafiltration (TUF) catheters can reduce intramuscular pressure and prevent acute compartment syndrome (ACS) in adults ages 18-60 with severe proximal tibia or tibial shaft…
- Conditions
- Acute Compartment Syndrome, Fracture, Bone, Tibial Fractures
- Trial name
- NCT05889559
- Testing
- Tissue Ultrafiltration Catheters
- Where
- 4 sites in United States
- Volunteers
- 60 people
- Sponsor
- Major Extremity Trauma Research Consortium
Non-ST-elevation Acute Coronary Syndromes
Exploring Efficacy of Intensive Rosuvastatin Treatment Peri-PCI in Chinese Patients With Non ST-segment Elevated Acute Coronary Syndrome(NSTE-ACS)
This is a 30-day, randomized, open-label, 3-arm, parallel-group, multicenter study exploring efficacy of intensive rosuvastatin treatment peri-PCI in Chinese patients with NSTE-ACS.
- Trial name
- NCT02284503
- Testing
- Rosuvastatin
- Where
- China
- Volunteers
- 1,350 people
- Sponsor
- Shanghai Zhongshan Hospital
Acute Coronary Syndromes, Flow Mediated Dilation
A Prospective, Single-center, Observational Study Aiming to Assess the Predictive Role of Flow Mediated Dilatation in Acute Coronary Syndromes, Combined With Echocardiographic and Biochemical Indices
A prospective, single-center, observational study aiming to assess the predictive role of flow mediated dilatation in acute coronary syndromes, combined with echocardiographic and biochemical indices.
- Conditions
- Acute Coronary Syndromes, Flow Mediated Dilation, Endothelial Function (FMD)
- Trial name
- FLARE-ACS (NCT06890013)
- Testing
- Observation group
- Where
- Greece
- Volunteers
- 100 people
- Sponsor
- Aristotle University Of Thessaloniki
Emergency Laparotomy
Evaluation of Surgical Risk Prediction Tools.
Introduction: In modern surgery, the prediction of perioperative death gains significant importance due to the availability of treatment options, means of improving the surgical outcome and for proper patient information.
- Trial name
- NCT04615520
- Where
- Greece
- Volunteers
- 660 people
- Sponsor
- University Hospital of Crete
Coronary Arterial Disease (CAD), Vulnerable Coronary Plaques
Effectiveness of Interventional Therapy for Non-Flow-Limiting Vulnerable Plaques
The aim of this clinical trial is to explore the optimal preventative treatment strategy for non-flow-limiting vulnerable plaques.
- Conditions
- Coronary Arterial Disease (CAD), Vulnerable Coronary Plaques, Thin-cap fIbroatheroma, Acute Coronary Syndromes (ACS)
- Trial name
- NCT06855537
- Testing
- PCI strategy, OMT strategy
- Where
- China
- Volunteers
- 2,190 people
- Sponsor
- Beijing Anzhen Hospital
High Grade Obstructive NSTE-ACS
Infrasensor for Early Detection of a High-grade Obstructive NSTE-ACS
The objective of this prospective, cross-sectional, multicenter pivotal trial study is to validate Infrasensor's clinical performance for the detection of high grade obstructive NSTE-ACS.
- Trial name
- NCT07464704
- Where
- 6 sites in United States
- Volunteers
- 350 people
- Sponsor
- Remote Cardiac Enablement
Acute Coronary Syndrome
Ranolazine Cardioprotection in PCI
The investigators will test if upfront dosing of Ranolazine can reduce myocardial biomarker release (CK-MB, Troponin) post percutaneous coronary intervention (PCI).
- Trial name
- NCT01767987
- Testing
- Ranolazine
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Harvey Hahn