Clinical trials: ACS
Hypertension, Acute Coronary Syndrome (ACS) Undergoing Percutaneous Coronary Intervention (PCI)
Neck-to-Waist Ratio Identifies Chronic Hypertensive Phenotype and Occlusive Myocardial Infarction in Patients Presenting With Acute Coronary Syndrome
aim of this study was to evaluate the relationship between multiple conventional and novel anthropometric measurements and hypertension in patients presenting to the ED with ACS and whether anthropometric indices differ according…
- Conditions
- Hypertension, Acute Coronary Syndrome (ACS) Undergoing Percutaneous Coronary Intervention (PCI), Obesity (Disorder)
- Trial name
- NCT07676656
- Where
- Turkey (Türkiye)
- Volunteers
- 238 people
- Sponsor
- Ercis Sehit Rıdvan Cevik State Hospital
Acute Coronary Syndrome, Percutaneous Coronary Intervention
Effectiveness of Artificial Intelligent Based mHealth System to Reduce ACS Patients Bleeding Events After PCI
The present study was designed to observe the effectiveness of artificial intelligent based mHealth system(Chronic disease management system) to reduce bleeding events in ACS patients undergoing PCI.
- Conditions
- Acute Coronary Syndrome, Percutaneous Coronary Intervention, Bleeding
- Trial name
- NCT03738930
- Testing
- AI based mHealth system
- Where
- China
- Volunteers
- 420 people
- Sponsor
- Chinese PLA General Hospital
Myocardial Ischemia
Multimodality Investigation of Intermediate Culprit Lesion With Negative FFR in NSTE-ACS
Ten-fifteen percent of acute coronary syndromes without ST-segment elevation (NSTE-ACS) are caused by intermediate lesions without signs of unstable plaque.
- Trial name
- SHERLOCK (NCT03205514)
- Testing
- NSTE-ACS with intermediate stenosis and negative FFR
- Where
- Italy
- Volunteers
- 35 people
- Sponsor
- University Hospital of Ferrara
Coronary Stenosis
Thin Strut Sirolimus-eluting Stent in All Comers Population vs Everolimus-eluting Stent
The primary objective of this study is to compare the performance of SUPRAFLEX to that of XIENCE in an all-comers patient population with symptomatic ischemic heart disease.
- Trial name
- TALENT (NCT02870140)
- Testing
- SUPRAFLEX, XIENCE
- Where
- 23 sites in Bulgaria, Hungary and 5 more
- Volunteers
- 1,435 people
- Sponsor
- ECRI bv
Coronary Artery Disease, Acute Coronary Syndromes (ACS)
DECisive Intracoronary PHysiology and Imaging in the Evaluation and Reclassification of Non-culprit Lesions in Acute Coronary Syndrome
Despite all advances in diagnostic and therapeutic methods over the past century, ischemic heart disease (IHD) remains a leading cause of mortality and morbidity worldwide.
- Conditions
- Coronary Artery Disease, Acute Coronary Syndromes (ACS), Optic Coherence Tomography, Fractional Flow Reserve
- Trial name
- DECIPHER (NCT07548554)
- Testing
- Intracoronary Physiology, Intracoronary imaging
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Istanbul Mehmet Akif Ersoy Educational and Training Hospital
Acute Coronary Syndromes, Dyslipidemia
Early Triple Lipid-Lowering Therapy With Bempedoic Acid After Acute Coronary Syndrome
This randomized clinical trial will evaluate whether starting bempedoic acid in addition to high-intensity statin therapy and ezetimibe within 72 hours after percutaneous coronary intervention improves low-density lipoprotein…
- Trial name
- EARLY-BIRD ACS (NCT07824323)
- Testing
- bempedoic acid, Ezetimibe, High-Intensity Statin Therapy
- Where
- Taiwan
- Volunteers
- 400 people
- Sponsor
- Taipei Medical University Hospital
Acute Coronary Syndrome
Treatment With Adenosine Diphosphate (ADP) Receptor Inhibitors: Longitudinal Assessment of Treatment Patterns and Events After Acute Coronary Syndrome
The TReatment with ADP receptor iNhibitorS: Longitudinal Assessment of Treatment Patterns and Events after Acute Coronary Syndrome (TRANSLATE-ACS) study is a prospective, observational longitudinal study to evaluate the real…
- Trial name
- TRANSLATE-ACS (NCT01088503)
- Testing
- ADP receptor inhibitors
- Where
- 186 sites in United States, Puerto Rico
- Volunteers
- 12,227 people
- Sponsor
- Eli Lilly and Company
Preterm Labor, Premature Birth
Effectiveness of ACS in Extreme Preemies
This is a randomized prospective clinical study that will evaluate the effects of antenatal corticosteroid administration (ACS) vs.
- Trial name
- NCT02351310
- Testing
- Betamethasone
- Volunteers
- healthy volunteers welcome
- Sponsor
- Pediatrix
ST Elevated Myocardial Infarction, Sleep-Disordered Breathing
PRedictOrs, PHEnotypes and Timing of Obstructive Sleep Apnea in Acute Coronary Syndrome
Obstructive Sleep Apnea (OSA) is a well-known disorder of upper airways collapse during sleep time leading to oxygen desaturation and sleep fragmentation.
- Conditions
- ST Elevated Myocardial Infarction, Sleep-Disordered Breathing, Sleep, NSTEMI - Non-ST Segment Elevation MI
- Trial name
- PROPHET-ACS (NCT04002739)
- Testing
- Polygraphy
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
CLOPIDOGREL, POOR METABOLISM of (Disorder)
Genotyping Guided Individualized Treatment of Clopidogrel and Ticagrelor in ACS
Clopidogrel, in addition to aspirin, is the cornerstone of therapy in patients suffering from Acute coronary syndrome. However, the platelet inhibitory response to clopidogrel varies substantially among individuals.
- Trial name
- GI-CT (NCT02048228)
- Testing
- genotyping guided therapy Ticagrelor, Clopidogrel, standard therapy clopidogrel
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Chinese PLA General Hospital
Compartment Syndromes
Can Near-Infrared Spectroscopy (NIRS) or Intramuscular Glucose Levels Detect Impaired Leg Compartment' Perfusion?
Near infrared spectroscopy (NIRS), a technique that relies on differential absorption of infrared light to provide relative estimation of tissue oxygenation, has been successfully used to monitor perfusion of various tissues…
- Trial name
- NIRS (NCT06512870)
- Testing
- Near infrared spectroscopy (NIRS)
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Florida
Acute Coronary Syndrome, Coronary Artery Disease
IPD Meta-analysis of De-escalation Treatment Strategy After PCI in ACS
We will perform a systemic review of previously published data and an updated patient-level meta-analysis of studies, including the most recent publications.
- Trial name
- NCT04848766
- Testing
- De-escalation Treatment Strategy of dual antiplatelet therapy
- Where
- South Korea
- Volunteers
- 9,000 people
- Sponsor
- Seoul National University Hospital
Telomere Shortening, Telomere Length, Mean Leukocyte
Rosuvastatin Effect on Telomere-telomerase System in ACS
Coronary heart disease (CHD) is one of the diseases characterised by biological aging as one of the important risk factors in several epidemiological studies.
- Conditions
- Telomere Shortening, Telomere Length, Mean Leukocyte, 22q Telomere Deletion Syndrome
- Trial name
- NCT02299245
- Testing
- rosuvastatin
- Volunteers
- 400 people
- Sponsor
- Xiao-dong Zhuang
Acute Coronary Syndrome (ACS)
OPTImal Management of Antithrombotic Agents: OPTIMA-5
This is a prospective, randomized, open-label clinical trial which will enroll 80 acute coronary syndrome (ACS) patients after Percutaneous Transluminal Coronary Intervention (PCI) in China.
- Trial name
- NCT04116931
- Testing
- Switch ticagrelor to clopidogrel
- Where
- China
- Volunteers
- 80 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Cardiotoxicity, DPP3
Cardiovascular Complications in Patients Undergoing Allogeneic Hematopoietic Stem Cell Transplantation.
Allogeneic hematopoietic stem cell transplantation (HSCT) represents a major therapeutic strategy for malignant hematologic diseases, with the number of procedures steadily increasing in France each year.
- Conditions
- Cardiotoxicity, DPP3, HSCT, Allogeneic Hematopoietic Stem Cell Transplantation
- Trial name
- ALLOCARDIOTOX (NCT07157670)
- Where
- France
- Volunteers
- 400 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Acute Coronary Syndrome
BAY81-8781, I.V. Aspirin in the Indication of Acute Coronary Syndrome (ACS)
The objective of this study is to investigate whether intravenous administration (injected into a vein) of acetylsalicylic acid (Aspirin) in doses of 250 and 500 mg is superior to oral treatment of ACS with tablets containing 300…
- Trial name
- ACUTE (NCT00910065)
- Testing
- D,L-lysine acetylsalicylate (Aspirin, BAY81-8781) 500 mg IV, D,L-lysine acetylsalicylate (Aspirin, BAY81-8781) 250 mg IV, Acetylsalicylic acid (Aspirin, BAYe4465) 300 mg Tablet
- Where
- 37 sites in China, Germany and 2 more
- Volunteers
- 270 people
- Sponsor
- Bayer
Acute Myocardial Infarction
Effect of the Biomarker Copeptin in Managing Patients With Suspected Acute Coronary Syndrome (ACS)
Acute chest pain is commonly known to be the classic symptom of acute myocardial infarction. Of the many patients which visit the Emergency Department because of chest pain, less than half do actually suffer from an acute…
- Trial name
- BiC-8 (NCT01498731)
- Testing
- Discharge home
- Where
- 6 sites in Austria, Germany and 1 more
- Volunteers
- 902 people
- Sponsor
- Charite University, Berlin, Germany
Acute Coronary Syndrome, Culprit Plaque
OCT-Features in Culprit and Not Culprit Coronary Plaque in ACS Patients
The OCT-FORMIDABLE register will include with a retrospective fashion all consecutive patients that perform OCT on culprit and not culprit plaque in any subset in patients with ACS.
- Conditions
- Acute Coronary Syndrome, Culprit Plaque, Non Culprit Plaque
- Trial name
- OCT-FORMIDABLE (NCT02486861)
- Testing
- optical coherence tomography
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- A.O.U. Città della Salute e della Scienza
Acute Coronary Syndrome, Troponin
Pragmatic Randomised Trial of the ESC 0/1 Versus 0/3 Hour Troponin Pathway
The primary objective of this study is to assess the feasibility and impact of implementing the ESC 0-1 hour high sensitive troponin pathway in clinical practice and with specific reference to the 0-3 hour pathway currently in…
- Conditions
- Acute Coronary Syndrome, Troponin, Chest Pain, Point-of-care Systems
- Trial name
- MACROS2 (NCT05322395)
- Testing
- ESC 0/1 hour troponin pathway
- Where
- United Kingdom
- Volunteers
- 3,536 people
- Sponsor
- Liverpool University Hospitals NHS Foundation Trust
Acute Coronary Syndromes (ACS), Chronic Coronary Syndrome
Effects of Icosapent Ethyl on Coronary Plaque, Inflammation, and Ventricular Remodeling
Even with standard treatments like statins, patients with coronary artery disease often face a residual risk of further heart events.
- Conditions
- Acute Coronary Syndromes (ACS), Chronic Coronary Syndrome, Coronary Artery Disease, Atherosclerosis Cardiovascular Disease
- Trial name
- NCT07641257
- Volunteers
- 420 people
- Sponsor
- Ruijin Hospital