Clinical trials: AD - Alzheimer's Disease
Alzheimer Disease
Phase 2 Estimation Study of Fixed Dose Drugs Combination Type of Polypill
This is an estimation-focused Phase 2 study designed to explore and quantify treatment-related changes across multiple clinical outcomes in patients with Alzheimer's disease over a 210-day period.
- Trial name
- NCT06597058
- Testing
- MAR
- Where
- 16 sites in United States
- Volunteers
- 121 people
- Sponsor
- Noah Pharmaceuticals, Inc.
Elderly, Alzheimer Disease
Orexin and Tau Pathology in Cognitively Normal Elderly
Alzheimer's disease (AD) is a common neurodegenerative disease characterized by the accumulation of amyloid plaques and neurofibrillary tangles.
- Trial name
- NCT03053908
- Testing
- Actigraphy, Nocturnal Polysomnograpahy (NPSG)
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- NYU Langone Health
Alzheimer Disease
A Study of JNJ-64042056 in Participants With Preclinical Alzheimer's Disease
The purpose of this study is to assess whether JNJ-64042056 affects the spread and build up of tau (a protein in brain) when compared with placebo, using brain scan (tau PET) to determine results from specific areas of the brain.
- Trial name
- Reτain (NCT06544616)
- Testing
- JNJ-64042056
- Where
- 90 sites in United States, Australia and 7 more
- Volunteers
- 55 people
- Sponsor
- Janssen Pharmaceutica N.V., Belgium
Mild Cognitive Impairment, Prodromal Alzheimer's Disease
Study of AGB101 in Mild Cognitive Impairment Due to Alzheimer's Disease
The primary objective of the study is to evaluate the efficacy of AGB101 on slowing cognitive and functional impairment as measured by changes in the Clinical Dementia Rating-Sum of Boxes (CDR-SB) score as compared with placebo…
- Trial name
- HOPE4MCI (NCT03486938)
- Testing
- AGB101 220 mg tablet
- Where
- 24 sites in United States, Canada
- Volunteers
- 164 people
- Sponsor
- AgeneBio
Alzheimer Disease
The Ketogenic Diet in the Treatment of Alzheimer's Disease
This research is a randomized, double-blind, placebo-parallel controlled, and multi-center clinical study in China, aiming to evaluate the tolerability, efficacy, and safety of JT821 (Ketogenic Diet) in the treatment of mild to…
- Trial name
- JT821 (NCT06681948)
- Testing
- Ketogenic diet
- Where
- China
- Volunteers
- 32 people
- Sponsor
- Capital Medical University
Dementia
Treatment in Occupational Therapy With Significant Activities to Improve Quality of Life
We followed a pretest-posttest non-equivalent control group experimental design study comparing two cohorts of patient with different types of dementia.
- Trial name
- NCT05359978
- Testing
- To with significance activities
- Where
- Spain
- Volunteers
- 240 people
- Sponsor
- Universidad de Burgos
Mild Cognitive Impairment
Rhythmic Light Therapy for Alzheimer's Disease Patients
The investigator will investigate how light delivering 40 hertz (Hz) affects subjective sleep and cognition in a controlled laboratory study.
- Trial name
- NCT05015478
- Testing
- Tailored Rhythmic Lighting Intervention
- Where
- 2 sites in United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Alzheimer's Disease, Mild Cognitive Impairment
Multiple Dose Trial of MK-4334 in Participants With Alzheimer's Clinical Syndrome (MK-4334-005)
This study will evaluate the safety, tolerability, and pharmacokinetics of MK-4334 administered once daily (QD) in participants with Alzheimer's clinical syndrome receiving a stable, daily dose of donepezil 10 mg, taken orally…
- Trial name
- NCT03740178
- Testing
- MK-4334, Donepepzil
- Sponsor
- Merck Sharp & Dohme LLC
Alzheimer Disease
Open-Label Extension Protocol to SNK01-AD01 Study
Open-Label Extension Protocol to SNK01-AD01 Study
- Trial name
- NCT07228078
- Testing
- SNK01
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- NKGen Biotech, Inc.
Alzheimer Disease
University of Washington Alzheimer's Disease Research Center (UW ADRC) Imaging & Biomarker Core
This is a cross-sectional, observational study that characterizes research participants with Alzheimer's disease (AD) for their patterns of brain degeneration with the investigational tau positron emission tomography (PET)…
- Trial name
- NCT04437290
- Testing
- investigational radiotracer [18F]MK6240
- Volunteers
- 300 people
- Sponsor
- University of Washington
Alzheimer Disease
CLarifying ABCB1's Role in Alzheimer's Disease
Alzheimer's disease is biologically defined by the accumulation of amyloid beta and tau protein, identified using cerebrospinal fluid biomarkers.
- Trial name
- CLeAR-AD (NCT07393113)
- Testing
- ABCB1 genotyping
- Where
- France
- Volunteers
- 510 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Alzheimer Disease
Glutathione, Brain Metabolism and Inflammation in Alzheimer's Disease
Alzheimer's disease (AD) is associated with significant, progressive cognitive decline. Key defects in mitochondrial fuel metabolism insulin resistance, inflammation and decreased brain glucose uptake are linked to AD.
- Trial name
- NCT04740580
- Testing
- Glycine, N-acetylcysteine, Alanine
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Baylor College of Medicine
Alzheimer Dementia, Agitation,Psychomotor
Electroconvulsive Therapy (ECT) for Agitation in Dementia (AD)
This study will explore the effect of ECT treatments plus usual care (ECT+UC) in reducing severe agitation in patients with moderate to severe dementia including Alzheimer's Disease, Vascular dementia, Frontotemporal dementia…
- Trial name
- ECT-AD (NCT03926520)
- Testing
- Electroconvulsive Therapy (ECT)
- Where
- 5 sites in United States
- Volunteers
- 41 people
- Sponsor
- Brent Forester
Alzheimer Disease
Head-to-Head Harmonization of Tau Tracers in Alzheimer's Disease
The purpose of this study is to compare/harmonize cross-sectional and longitudinal tau tangle measurements obtained with the tau PET radiopharmaceuticals Flortaucipir and MK-6240 to elucidate the advantages and caveats of their…
- Trial name
- HEAD (NCT05361382)
- Testing
- 18F-Flortaucipir radiopharmaceutical, 18F-MK-6240 radiopharmaceutical, Amyloid-β radiopharmaceutical (11C-PiB or 18F-Florbetaben or 18F-NAV-4694 or 18F-Flutemetamol)
- Where
- 9 sites in United States, Canada and 1 more
- Volunteers
- 822 people, healthy volunteers welcome
- Sponsor
- Tharick Pascoal
Diet, Polyphenols, Flavonoids, Stilbenes, Aged, Dementia, Alzheimer's Disease, Epidemiology
Polyphenols and Risk of Dementia
This project aims to leverage existing data from a large observational prospective study on dementia, the Three-City study, to investigate the relationship between intakes of polyphenols and the risk to develop dementia in the 12…
- Trial name
- NCT03286608
- Testing
- observational study (no intervention)
- Volunteers
- 1,329 people, healthy volunteers welcome
- Sponsor
- Jean-François Dartigues
Alzheimer Disease
The Effect of Repeated Transcranial Magnetic Stimulation on Off-line Resting Electroencephalographic Signal in Alzheimer's Disease
The purpose of this study is to examine whether the rTMS (repetitive Transcranial Magnetic Stimulation) could change cortical excitability measured by off-line EEG in Alzheimer's Disease (AD) patients.
- Trial name
- NCT01970150
- Testing
- rTMS real
- Where
- Canada
- Volunteers
- 5 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Alzheimer's Disease
Early-onset and Late-onset Sporadic Alzheimer's Disease (AD)
Alzheimer's disease (AD) is usually associated with aging, age being the principal identified risk factor. However, younger subjects also develop AD and the prevalence of early onset AD is unknown.
- Trial name
- NCT00987090
- Testing
- Clinic and neuropsychologic evaluation, MRI, PET
- Where
- France
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Assistance Publique Hopitaux De Marseille
Coronary Heart Disease, Anemia
The Role of Concomitant Diseases in Postoperative Complications Risk Stratification.
Study is conducted to assess the prevalence and structure of comorbidity among patients undergoing abdominal surgery and produce the stratification of the risk of postoperative complications by identifying independent predictors…
- Conditions
- Coronary Heart Disease, Anemia, Bronchial Asthma, Stroke
- Trial name
- STOPRISK (NCT03945968)
- Where
- 38 sites in Russia
- Volunteers
- 16,000 people
- Sponsor
- Russian Federation of Anesthesiologists and Reanimatologists
Alzheimer Disease, Late Onset
Does BCG Vaccination Reduce Biomarkers of Alzheimer's Disease?
The goal of this clinical trial is to test whether vaccination with the BCG vaccine may improve the blood level of a biomarker of Alzheimer's disease (AD) in participants who are cognitively- and functionally- intact elderly…
- Trial name
- BCG-AD (NCT06078891)
- Testing
- BCG vaccine
- Where
- Israel
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Tamir Ben-Hur
Dementia, Caregiver Burnout
Equality in Caregiving: Facilitating Caregiver Mastery Among LGBT Caregivers of PLWD
The goal of this study is to adapt existing Savvy Caregiving Program (SCP) for lesbian, gay, bisexual, transgender (LGBT) caregivers of person living with dementia (PLWD).
- Trial name
- EIC (NCT04394260)
- Testing
- Savvy Caregiver Program via Remote Learning, Focus group
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Emory University
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