Clinical trials: ADHF, open to volunteers
Cardiogenic Shock, Acute Decompensated Heart Failure
Study of Patients Admitted to a Cardiac Intensive Care Unit With Acute CardioVascular Disease
This is a registry of the patients that are admitted to CICU and treated by the Scientific Staff of the 2nd Department of Cardiology, due to an acute cardiovascular disease (acute coronary syndrome, acute heart failure…
- Conditions
- Cardiogenic Shock, Acute Decompensated Heart Failure, Acute Pulmonary Embolism, Acute Myocardial Infarction
- Trial name
- NCT06081205
- Testing
- Admission in the Cardiac Intensive Care Unit (CICU)
- Where
- Greece
- Volunteers
- 1,000 people
- Sponsor
- University Hospital, Ioannina
Heart Failure, Diabetes Mellitus
CGM Use in Heart Failure
Heart failure (HF) is a major cause of hospital admissions in the US, with over 6 million hospital days annually. More than 40% of hospitalized patients with HF have diabetes mellitus (DM), which increases the risk of recurrent…
- Trial name
- NCT07045298
- Testing
- Libre 2 rt-CGM, POC BG + Blinded CGM
- Where
- United States
- Volunteers
- 140 people
- Sponsor
- Emory University
Chronic Heart Failure, Acute Decompensated Heart Failure
Therapy Adjustment and IndividuaLized Response With Biomarker Observation in ReaL-world Heart Failure
The goal of TAILOR-HF is to integrate clinical data, laboratory parameters, treatment patterns, and circulating biomarkers to identify factors that predict individual response to pharmacological treatment in patients with heart…
- Trial name
- TAILOR-HF (NCT07647848)
- Volunteers
- 600 people
- Sponsor
- Maastricht University Medical Center
Acute Decompensated Heart Failure
Add-on Diuretics in Acute Decompensated Heart Failure
The aim of this study is to compare the efficacy and safety of empagliflozin, acetazolamide, and metolazone as add-on therapies to loop diuretics in patients with acute decompensated heart failure.
- Trial name
- NCT07372040
- Testing
- empagliflozin, Acetazolamide, metolazone
- Where
- Egypt
- Volunteers
- 66 people
- Sponsor
- Tanta University
Empagliflozin in Cardiorenal Syndrome Type 1
The Treatment Effects of Empagliflozin on Renal Outcomes in Cardiorenal Syndrome Type 1
Effects of Empagliflozin compared with placebo in cardiorenal syndrome type 1, evaluated by MAKE30.
- Trial name
- TREAT-CRS (NCT06030843)
- Testing
- Empagliflozin 10 MG
- Where
- Thailand
- Volunteers
- 200 people
- Sponsor
- Chulalongkorn University
Acute Heart Failure (AHF), Decompensated Chronic Heart Failure
Assessment of Residual Congestion in Acute Decompensated Heart Failure
DESIGN: A prospective, multicenter, observational cohort study including 580 patients admitted for acute decompensated heart failure (ADHF).
- Trial name
- VExUS-AHF (NCT07682298)
- Where
- 3 sites in Denmark
- Volunteers
- 580 people
- Sponsor
- Aarhus University Hospital
Acute Decompensated Heart Failure (ADHF)
Efficacy and Safety of Compression Boots in Patients With Acute Decompensated Heart Failure.
The aim of this clinical trial is to investigate whether pulsatile compression therapy can support heart and kidney function in patients admitted with acute heart failure and fluid accumulation in the legs.
- Trial name
- COMPLEX (NCT07377019)
- Testing
- Pulsatile Compression Boots (PCB)
- Where
- Denmark
- Volunteers
- 100 people
- Sponsor
- Odense University Hospital
Acute Decompensated Heart Failure
Fluid Management of Acute Decompensated Heart Failure Subjects Treated With Reprieve System (FASTR-II) (IDE-G210258)
The objective of this study is to prospectively compare decongestive therapy administered by the Reprieve System to Optimal Diuretic Therapy (ODT) in the treatment of patients diagnosed with acute decompensated heart failure…
- Trial name
- FASTR-II (NCT06898515)
- Testing
- Reprieve System, furosemide infusion
- Where
- 50 sites in United States, Germany and 3 more
- Volunteers
- 400 people
- Sponsor
- Reprieve Cardiovascular, Inc
Heart Failure, Decompensated Heart Failure
A Prospective, Observational, Single Centre Study to Assess the Feasibility of the Data Harvested by the Acorai Intracardiac Pressure Monitoring (ICPM) System in Predicting Prognosis in Patients Discharged From Hospital After Treatment for Acute Decompensated Heart Failure
Acorai is developing the Acorai Heart Monitor, a handheld electronic device for monitoring pressures inside the heart in a non-invasive manner, by placing the device on the chest of a patient.
- Trial name
- NCT06397833
- Testing
- Acorai ICPM system
- Where
- United Kingdom
- Volunteers
- 150 people
- Sponsor
- Royal Brompton & Harefield NHS Foundation Trust
Acute Decompensated Heart Failure
A Study Of Acute Decompensated Heart Failure
The purpose of this study is to examine shorter hospitalization length as well as a reduced rates of recurrent heart failure hospitalization compared to current standard of care in Acute Decompensated Heart Failure.
- Trial name
- NCT07572955
- Testing
- Lung Ultrasound
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Mayo Clinic
Cardiorenal Syndrome, Heart Failure
Venous Ultrasound Guided Organ Decongestion in Patients Hospitalized with Acute Decompensated Heart Failure
The purpose of this study is to assess the feasibility, safety and effectiveness of VExUS guided organ decongestion compared to standard of care in patients hospitalized with acute decompensated heart failue (ADHF).
- Conditions
- Cardiorenal Syndrome, Heart Failure, Acute Kidney Injury, Acute Decompensated Heart Failure
- Trial name
- VExOUS-ADHF (NCT06714409)
- Testing
- VExUS guided decongestion
- Where
- Norway
- Volunteers
- 180 people
- Sponsor
- Oslo University Hospital
Congestive Heart Failure(CHF), Pleural Effusion Due to Congestive Heart Failure
DRAIN: DRainage in Acute Decompensated Heart faIlure With Pleural effusioNs
The goal of this study is to assess if removal of fluid around the lungs (pleural effusion) by a routine procedure called as thoracentesis is helpful to decrease shortness of breath in hospitalized patients with congestive heart…
- Trial name
- DRAIN-IT (NCT07419360)
- Testing
- Thoracentesis
- Where
- United States
- Volunteers
- 216 people
- Sponsor
- Albany Medical College
Heart Failure Acute, Ventilator Lung
SGLT2 Inhibitors in Patients With ADHF During Ventilator Weaning
This study will explore the potential benefits of sodium-glucose cotransporter 2 (SGLT2) inhibitors in preventing cardiac ischemia and cardiopulmonary edema in patients with acute decompensated heart failure during weaning from…
- Trial name
- NCT06142474
- Testing
- SGLT2 inhibitor
- Where
- Taiwan
- Volunteers
- 450 people
- Sponsor
- National Taiwan University Hospital
Acute Decompensated Heart Failure, Heart Failure
Circulating Markers That Underlie the Transition From Compensated Hypertrophy to Heart Failure
The purpose of this research is to determine if two proteins in the blood are increased during acute heart failure. These two proteins are produced when the heart becomes dysfunctional and unable to contract normally.
- Trial name
- NCT00762008
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- UConn Health
Acute Hypoxic Respiratory Failure, Acute Respiratory Distress Syndrome (ARDS)
WIN Ratio Analysis to Determine a Strategy of Non- Invasive SUpport for Respiratory Failure in the EmeRgency Department
The purpose of this clinical trial is to determine the best initial non-invasive respiratory support (NIRS) strategy for adults who present to the emergency department with acute hypoxemic respiratory failure, a condition in…
- Trial name
- WINDSURFER (NCT07558265)
- Testing
- Non-Invasive Positive Pressure Ventilation, High Flow Nasal Oxygen
- Where
- 9 sites in United States
- Volunteers
- 500 people
- Sponsor
- Ohio State University
Acute Decompensated Heart Failure
Safety and Performance Evaluation of the Nephronyx System for the Treatment of Patients With ADHF
The objective of this interventional study is to evaluate the safety and functional performance of the Nephronyx System in patients with ADHF, presenting clinical signs of volume overload and compromised response to diuretics.
- Trial name
- NCT05759806
- Testing
- Nephronyx system (Perfuser)
- Where
- 4 sites in Israel
- Volunteers
- 10 people
- Sponsor
- Nephronyx LTD
Heart Failure, Cardiorenal Syndrome
Diuretics Alone vs. Aortix Endovascular Device for Acute Heart Failure
Aortix is a circulatory support device for chronic heart failure patients on medical management who have been hospitalized for acute decompensated heart failure (ADHF) and have persistent congestion despite usual medical therapy.
- Conditions
- Heart Failure, Cardiorenal Syndrome, Cardio-Renal Syndrome, ADHF
- Trial name
- DRAIN-HF (NCT05677100)
- Testing
- Aortix System
- Where
- 50 sites in United States, Hungary
- Volunteers
- 320 people
- Sponsor
- Procyrion
Heart; Decompensation, Congestive
The Safety and Feasibility of the eLym™ System
The goal of this feasibility study is to evaluated the safety and performance of the WhiteSwell eLym System in the treatment of fluid overload or congestion in adult patients with Acute Decompensated Heart Failure (ADHF).
- Trial name
- DELTA-HF (NCT05747196)
- Testing
- WhiteSwell eLym System
- Where
- 11 sites in Georgia, Poland and 1 more
- Volunteers
- 70 people
- Sponsor
- WhiteSwell, Limited
Heart Failure, ADHF
Care Coordination to Assess Improvement in Outcomes in Hospital Readmissions
Heart failure is a syndrome that is defined by distinctive clinical, hemodynamic, and neurohormonal findings. HF represents a final common pathway for many different cardiovascular diseases, including coronary disease…
- Conditions
- Heart Failure, ADHF, Acute MI
- Trial name
- COMPASSION (NCT04905160)
- Testing
- COMPASSION Digital Biomarker
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Aventyn, Inc.
Acute Decompensated Heart Failure
Reprieve System Pilot Study
The objective of the study is to evaluate the use of the Reprieve System to decongest subjects with acute decompensated heart failure.
- Trial name
- NCT06272734
- Testing
- Reprieve System
- Where
- Georgia
- Volunteers
- 50 people
- Sponsor
- Reprieve Cardiovascular, Inc