Clinical trials: AECOPD
Machine Learning, Chronic Obstructive Pulmonary Disease
Machine Learning-based Models in Prediction of DVT and PTE in AECOPD Patients
Chronic Obstructive Pulmonary Disease (COPD) is a common respiratory system disease characterized by persistent respiratory symptoms and irreversible airflow restriction, which seriously endangers people's health.
- Conditions
- Machine Learning, Chronic Obstructive Pulmonary Disease, Chronic Obstructive Pulmonary Disease With Acute Exacerbation, Unspecified, Pulmonary Thromboembolisms
- Trial name
- NCT05905874
- Testing
- Machine learning-based prediction model
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- West China Hospital
Acute Exacerbation of Chronic Obstructive Pulmonary Disease
The Effect of EDP on Diaphragmatic Function and Neural Respiratory Drive in Patient With AECOPD
Chronic Obstructive Pulmonary Disease (COPD) is a common respiratory disease characterized by airflow limitation that is progressive and not fully reversible.
- Trial name
- NCT03083418
- Testing
- control group, EDP
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Zhujiang Hospital
COPD, COPD Exacerbation (AECOPD)
COPD Flare-Up Clinic After Severe Exacerbations
This prospective randomized controlled trial evaluates whether a specialized "COPD flare-up clinic service" improves outcomes in patients following an acute exacerbation of chronic obstructive pulmonary disease (AECOPD).
- Trial name
- FLARE-COPD (NCT07629869)
- Testing
- Follow-up in a flare-up clinic
- Where
- Israel
- Volunteers
- 240 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Chronic Obstructive Pulmonary Disease
Effects of NAVA and PSV to AECOPD Patients' Air Distribution and Dead Space
Chronic obstructive pulmonary disease(COPD) is a common disease among people. Acute exacerbation of chronic obstructive pulmonary disease(AECOPD) is the acute and aggravating phase of COPD which may lead to respiratory failure.
- Trial name
- NCT02289573
- Testing
- NAVA and PSV
- Volunteers
- 15 people
- Sponsor
- Southeast University, China
To Reduce Duration of Antibiotics Exposure in Patients With COPD Hospitalized in Intensive Care Unit With Pneumonia
An Antibiotic Protocol Guided by a Multimodal Approach in AECOPD With Pneumonia in Intensive Care
Investigators propose to conduct a multicenter, prospective, randomized, controlled, assessing the interests of an antibiotic protocol guided by the combined use of serum procalcitonin (PCT) and a broad-panel respiratory…
- Trial name
- BPCTréa2 (NCT06301841)
- Testing
- experimental
- Where
- France
- Volunteers
- 64 people
- Sponsor
- University Hospital, Caen
Acute Exacerbation of Chronic Obstructive Pulmonary Disease
The Severity Assessment Model for AECOPD With Combination of Disease and Syndrome
The establishment of the AECOPD severity assessment model can quickly and accurately evaluate the condition, which is of great significance for standardizing diagnosis and treatment, improving efficacy, and improving prognosis.
- Trial name
- NCT06918353
- Testing
- Diagnosis and Severity Grading of AECOPD Disease
- Where
- China
- Volunteers
- 1,500 people
- Sponsor
- Henan University of Traditional Chinese Medicine
Acute Exacerbation COPD
Pattern of Microbial Infection in AECOPD Patients and Its Sensitivity to Antibiotics
Measurement of bacterial species causing AECOPD and their Sensitivity pattern to antibiotics.
- Trial name
- NCT06123780
- Volunteers
- 140 people
- Sponsor
- Assiut University
Chronic Respiratory Failure
Treatment of CRF With Syndrome Differentiation of TCM
Taking the patients with chronic respiratory failure caused by COPD as the research object and the acute exacerbation of COPD as the main outcome index, the investigators hope to establish the syndrome differentiation and…
- Trial name
- NCT04694755
- Testing
- Traditional Chinese medicine prescription
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Henan University of Traditional Chinese Medicine
Chronic Obstructive Pulmonary Disease
BACE Trial Substudy 2 - FarmEc Substudy
A second sub-analysis of the BACE trial will include a detailed cost-effectiveness study.
- Trial name
- FarmEc (NCT02205255)
- Testing
- Azithromycin
- Where
- 20 sites in Belgium
- Volunteers
- 350 people
- Sponsor
- Wim Janssens
Respiratory Disorders
Infectious Pathogens in Acute Respiratory Illness in Adults and Elderly
The aim of this study is to generate epidemiological data to further explore determinants of Chronic Obstructive Pulmonary Disease (COPD) and the contribution of bacterial and viral pathogens to Acute Exacerbation of COPD…
- Trial name
- NCT01360398
- Testing
- Blood sample, Sputum sample, Nasopharyngeal swab
- Where
- United Kingdom
- Volunteers
- 127 people
- Sponsor
- GlaxoSmithKline
COPD, COPD Exacerbation
Inhaled Amikacin in Preventing AECOPD
The underlying bacterial colonization in lower respiratory tract (LRT) of COPD patients may be related to acute exacerbation of COPD (AECOPD) and disease progression.
- Trial name
- NCT05213507
- Testing
- aerosol inhaled Amikacin Sulfate Injection, conventional therapy
- Where
- 5 sites in China
- Volunteers
- 136 people
- Sponsor
- Shanghai Zhongshan Hospital
COPD Exacerbation
Physical Activity Barriers in AECOPD
Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality worldwide. Patients require good communication with the physician to improve control illness.
- Trial name
- NCT04162392
- Testing
- shared decision making, control group
- Volunteers
- 40 people
- Sponsor
- Universidad de Granada
COPD Exacerbation
Shared Decision Making in Hospitalized AECOPD
Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality worldwide. Patients require good communication with the physician to improve control illness.
- Trial name
- NCT03772639
- Testing
- Shared decision making
- Volunteers
- 42 people
- Sponsor
- Universidad de Granada
Obstructive Pulmonary Disease, Exacerbation Copd
AECOPD and Nutritional Supplementation in COPD
Better understanding of the duration needed to overcome metabolic disturbances in patients experiencing exacerbation. Also, the explore role of nutritional intervention in the treatment program of stable COPD patients and in…
- Trial name
- NCT06801964
- Testing
- Stable isotope infusion, Protein and Fish Oil, Protein and Olive Oil
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Texas A&M University
Acute Exacerbation of Chronic Obstructive Pulmonary Disease
Clinical Practice of AECOPD Management in China
The purpose of this study is observe clinical practice including glucocorticoids treatment in AECOPD in China.
- Trial name
- NCT02051166
- Where
- 13 sites in China
- Volunteers
- 5,095 people
- Sponsor
- AstraZeneca
Angina, Acute Bronchiolitis
Impact of a Multimodal Intervention on Antibiotic Prescribing for Respiratory Infections in Primary Care
Antimicrobial resistance (AMR), considered one of the greatest global threats by the WHO, justifies the development of initiatives to promote appropriate antibiotic use-especially in primary care, where most antibiotics in France…
- Conditions
- Angina, Acute Bronchiolitis, Acute Bronchitis, COPD Exacerbation (AECOPD)
- Trial name
- GRASP (NCT07359287)
- Testing
- Antibiotic prescribing according to guidelines
- Where
- France
- Volunteers
- 4,500 people
- Sponsor
- University Hospital, Caen
Chronic Obstructive Pulmonary Disease
A Study of the Inflammatory Pathways Associated With Chronic Obstructive Pulmonary Disease Exacerbations
The purpose of this study is to observe how the inflammatory pathways differ in subjects with chronic obstructive pulmonary disease (COPD) during an acute exacerbation of COPD (AECOPD).
- Trial name
- NCT01337661
- Where
- Ireland
- Volunteers
- 26 people
- Sponsor
- MedImmune LLC
COPD Exacerbation
Physiotherapy in Hypoxic AECOPD Patients
Hypoxia is considered a key player in many of the comorbidities that characterize COPD, such as pulmonary hypertension, skeletal muscle dysfunction, and systemic inflammation.
- Trial name
- NCT04295655
- Testing
- Global Exercise intervention, Functional Electrostimulation Group, Standard treatment
- Where
- Spain
- Volunteers
- 36 people
- Sponsor
- Universidad de Granada
Chronic Obstructive Pulmonary Disease
The Role of HNHF to Improve Clinical Outcomes Following Severe AECOPD
Chronic Obstructive Pulmonary Disease (COPD) is a common lung disease, affecting 1.2 million people in the United Kingdom (UK). COPD patients suffer with episodes of worsening breathing symptoms called acute exacerbations…
- Trial name
- NCT03899558
- Testing
- Humidified nasal high-flow device
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
COPD Exacerbation, Oxygen Toxicity
Influence of FreeO2 on Percentage of Time Within Oxygen Saturation Target Using Noninvasive Ventilation (NIV) and Continuous Positive Airway Pressure (CPAP) for Patients Admitted for AECOPD or Bariatric Surgery
The main objective is to evaluate the FreeO2 device combined with noninvasive respiratory support technique for COPD patients and postoperative bariatric surgery patients.
- Conditions
- COPD Exacerbation, Oxygen Toxicity, Abdominal Obesity, Surgery
- Trial name
- NCT04136717
- Testing
- Washout period, NIV - FreeO2, Nasal High flow Oxygen therapy - FreeO2
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- François Lellouche