Clinical trials: AECOPD
Lung Disease,Obstructive
Airway Responsiveness in Patients With AECOPD Mechanical Ventilation by Inspiratory and Bronchial Dilation Testchronic Obstructive Pulmonary Disease
In the patients with COPD mechanical ventilation, the bronchial dilatation is very common. However, the evaluation of the efficacy of the medical examination and other subjective indicators, such as doctors, depends on the…
- Trial name
- NCT02592122
- Testing
- Salbutamol Aerosol, No drugs
- Where
- China
- Volunteers
- 120 people
- Sponsor
- snow
Acute Exacerbation Chronic Obstructive Pulmonary Disease
Is it Necessary to Set External PEEP in AECOPD Patients
Acute exacerbation of chronic obstructive pulmonary disease patients with intrinsic positive end-expiratory pressure (PEEPi), Neurally adjusted ventilatory assist (NAVA) reduce work of breathing and trigger delay at any external…
- Trial name
- NCT02114567
- Testing
- PEEP titration
- Where
- China
- Volunteers
- 12 people
- Sponsor
- Southeast University, China
Acute Heart Failure, COPD Exacerbation
Use of PARniv for Early Diagnosis of LVF in AECOPD
Left ventricular failure (LVF) is a common cause of acute exacerbation of chronic obstructive pulmonary disease (AECOPD). This association is frequently underestimated with regard to the difficulty of clinical diagnosis .
- Trial name
- NCT05189119
- Testing
- non invasive ventilation
- Where
- Tunisia
- Volunteers
- 80 people
- Sponsor
- University of Monastir
Procalcitonin, Chronic Obstructive Pulmonary Disease
A Trial of Procalcitonin in Patients With Acute Exacerbation of Chronic Obstructive Pulmonary Disease
Current antibiotic prescription for patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) is generally based on the Anthonisen criteria in The Global Initiative for Chronic Obstructive Pulmonary…
- Trial name
- NCT04682899
- Testing
- procalcitonin-guided antibiotic therapy, guideline-guided antibiotic therapy
- Volunteers
- 500 people
- Sponsor
- Capital Medical University
Chronic Obstructive Pulmonary Disease
Personalized Variable Versus Fixed Dose Glucocorticoid Therapy in AECOPD
The hypothesis is that in acute exacerbated Chronic Obstructive Pulmonary Disease (AECOPD), personalized variable dose glucocorticoid treatment will result in superior clinical outcome when compared to fixed dose therapy.
- Trial name
- NCT02147015
- Testing
- Glucocorticoids, Antibiotics, Inhaled corticosteroid (ICS)
- Where
- China
- Volunteers
- 248 people
- Sponsor
- Daping Hospital and the Research Institute of Surgery of the Third Military Medical University
Pulmonary Disease, Chronic Obstructive, Acute Exacerbation
Effects of Traditional Chinese Medicine on AECOPD Patients
This is a multi-center, randomized, double-blind, controlled trial to compare the efficacy of two therapies for patients with AECOPD.
- Conditions
- Pulmonary Disease, Chronic Obstructive, Acute Exacerbation, Medicine, Chinese Traditional
- Trial name
- NCT03428412
- Testing
- TCM and conventional drug
- Volunteers
- 378 people
- Sponsor
- Henan University of Traditional Chinese Medicine
Acute Exacerbation Copd, Venous Thromboembolism
Study of Prophylactic Effect of Rivaroxaban on Venous Thromboembolism in AECOPD
AECOPD increases the risk of VTE.VTE prevention is a long way to go for high-risk VTE patients in China.The incidence of AECOPD complicated with VTE in Asian population is high and the mortality rate is high.Rivaroxaban, a new…
- Trial name
- SUPREME (NCT03277001)
- Testing
- Rivaroxaban, Enoxaparin
- Where
- China
- Volunteers
- 438 people
- Sponsor
- Huashan Hospital
Acute Exacerbation of Chronic Obstructive Pulmonary Disease, Microbiome
Prospective Cohort Study of Molecular Mechanism of Lower Respiratory Tract Microbes in Patients With AECOPD
How to reduce the rapid decline of lung function in patients with AECOPD is a clinically urgent problem to be solved. Studies have suggested that there is a bacterial flora imbalance in the lower respiratory tract of COPD…
- Trial name
- REASON (NCT04259736)
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Huashan Hospital
Acute Decompensated Heart Failure, COPD Exacerbation
Use of ΔIVC for Early Diagnosis of AHF in AECOPD
Acute Heart failure (AHF) is a common cause of acute exacerbation of chronic obstructive pulmonary disease (AECOPD). This association is frequently underestimated with regard to the difficulty of clinical diagnosis.
- Trial name
- NCT05327374
- Testing
- calculation of the inferior vena cava collapsibility index
- Where
- 3 sites in Tunisia
- Volunteers
- 401 people
- Sponsor
- University of Monastir
Chronic Obstructive Pulmonary Disease, COPD
Interleukin 6-guided Antibiotic Prescriptions in AECOPD Inpatients
In this multicenter, prospective, randomized controlled study, we aimed to figure out, compared with the global chronic obstructive pulmonary disease initiative (GOLD) guideline -guided antibiotic therapy, whether Interleukin 6…
- Trial name
- NCT06612476
- Testing
- Interleukin 6-guided antibiotic therapy, GOLD-guided antibiotic therapy
- Volunteers
- 440 people
- Sponsor
- Ningbo No. 1 Hospital
Acute Exacerbation of Chronic Obstructive Pulmonary Disease
High-Intensity vs Low-Intensity NPPV in Patients With an AECOPD: The HAPPEN Trial
To determine whether high-intensity NPPV, compared with low-intensity NPPV, could reduce the need for endotracheal intubation during hospitalization in patients with an AECOPD and hypercapnia.
- Trial name
- NCT02985918
- Testing
- High-intensity NPPV, Low-intensity NPPV
- Where
- 31 sites in China
- Volunteers
- 300 people
- Sponsor
- Beijing Chao Yang Hospital
Pulmonary Disease, Chronic Obstructive, Infections, Bacterial
Observational Study Of An Electronic Questionnaire In Patients With Chronic Obstructive Pulmonary Disease (COPD)
The aim of the study is to develop a new patient-reported outcome (PRO) questionnaire measuring the impact of an acute exacerbation on daily lives of patients with chronic obstructive pulmonary disease (COPD).
- Trial name
- NCT00259909
- Testing
- GSK questionnaire, St. George's Respiratory Questionnaire, Acute Short Form 12 version 2
- Where
- 123 sites in United States, Germany and 1 more
- Volunteers
- 259 people
- Sponsor
- GlaxoSmithKline
Chronic Obstructive Pulmonary Disease
Supine Daoyin in the Treatment of AECOPD
The purpose of this study was to evaluate the clinical efficacy and safety of supine daoyin in the treatment of AECOPD.
- Trial name
- NCT04913961
- Testing
- Supine Daoyin, western medicine conventional therapy
- Where
- China
- Volunteers
- 228 people
- Sponsor
- Henan University of Traditional Chinese Medicine