Clinical trials: AF - Atrial Fibrillation
Atrial Fibrillation
Biomarkers and Epigenetic Markers Associated With Pain in Patients With Symptomatic Atrial Fibrillation
Atrial fibrillation (AF) is the most common sustained arrhythmia and the number of patients with AF is expected to increase substantially in the coming decades.
- Trial name
- PAIN (NCT05201989)
- Where
- Sweden
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Region Örebro County
Anticoagulants, Platelet Aggregation Inhibitors
WOEST ( What is the Optimal antiplatElet & Anticoagulant Therapy in Patients With Oral Anticoagulation and Coronary StenTing)
The study will assess the hypothesis that the combination warfarin \& clopidogrel 75 mg/day is superior to triple therapy (warfarin + clopidogrel 75mg/day + aspirin 80mg/day) with respect to bleeding complications while equally…
- Conditions
- Anticoagulants, Platelet Aggregation Inhibitors, Stents, Atrial Fibrillation
- Trial name
- WOEST (NCT00769938)
- Testing
- PCI (percutaneous coronary intervention)
- Where
- 15 sites in Belgium, Netherlands
- Volunteers
- 573 people, healthy volunteers welcome
- Sponsor
- R&D Cardiologie
Atrial Fibrillation, Catheter Ablation
Post-Ablation Pericarditis Reduction Study
There has not been a prospective, randomized controlled trial of colchicine to reduce post-AF ablation pericarditis in an era of newer AF ablation techniques.
- Conditions
- Atrial Fibrillation, Catheter Ablation, Pericarditis
- Trial name
- PAPERS (NCT04906720)
- Testing
- Colchicine
- Where
- United States
- Volunteers
- 248 people, healthy volunteers welcome
- Sponsor
- St. Vincent Cardiovascular Research Institute
Acute Ischemic Stroke, Haemorrhagic Stroke
Translational Immunodiagnostics in Stroke (TrImS)
In adult patients presenting to emergency departments within 24 hours of symptom onset with suspected acute stroke, we aim: 1. to identify early brain- and pathology-specific circulating, whole blood, plasma and serum panorOmic…
- Conditions
- Acute Ischemic Stroke, Haemorrhagic Stroke, Transient Ischemic Attacks, Cardioembolic Stroke
- Trial name
- TrImS (NCT05300997)
- Testing
- Biomarker blood draw and saliva collection
- Where
- China
- Volunteers
- 650 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Atrial Fibrillation, Atrial Flutter
Get With the Guidelines Atrial Fibrillation Registry
Get With The Guidelines-Atrial Fibrillation is designed to assist hospital care teams in consistently providing the latest evidence-based treatment for their AFib patients.
- Trial name
- GWTG-AF (NCT06245187)
- Testing
- GWTG Atrial Fibrillation program
- Where
- United States
- Volunteers
- 17,198 people, healthy volunteers welcome
- Sponsor
- American Heart Association
Atrial Fibrillation
The Effectiveness of Patch-Based Screening for Pre-Symptomatic Atrial Fibrillation to Improve Patient Outcome
The goal of the screening trial is to determine whether early screening for atrial fibrillation improves outcomes, including lowering the chance of death, hospitalization for stroke, blood clots, heart failure, heart attack, and…
- Trial name
- VALIANT-AF-S (NCT06953778)
- Testing
- Zio XT® Patch
- Where
- United States
- Volunteers
- 24,060 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Nonvalvular Atrial Fibrillation, Health, Subjective
Pharmacokinetic Study to Evaluate Dabigatran Etexilate in Elderly Subjects
This study intends to collect blood samples of adult healthy subjects, elderly healthy subjects and elderly patients with atrial fibrillation after taking dabigatran etexilate for pharmacokinetics and other studies, aiming to…
- Trial name
- NCT05715658
- Testing
- Dabigatran etexilate capsule
- Where
- China
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Dongyang Liu
Atrial Fibrillation
Study to Assess the Safety, Tolerability, Pharmacokinetic of Thrv-1268
This is a single-center, randomized, double-blind, placebo-controlled study to be conducted in 2 parts: single ascending dose (SAD) incorporating a food effect arm and multiple ascending dose (MAD).
- Trial name
- NCT06507839
- Testing
- THRV-1268
- Where
- Canada
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Thryv Therapeutics, Inc.
Atrial Fibrillation, Pericardial Effusion
Active Clearance of Chest Tubes After Cardiac Surgery: A Prospective Randomized Controlled Study
The purpose of this study is to assess the effectiveness of the PleuraFlow® Active Tube Clearance (ATC) technology in reducing the rate of postoperative atrial fibrillation (POAF) among post cardiac surgery patients and to…
- Conditions
- Atrial Fibrillation, Pericardial Effusion, Pleural Effusion, Hemothorax
- Trial name
- NCT02808897
- Testing
- Standard drainage, Active Tube Clearance drainage
- Where
- 2 sites in Canada
- Volunteers
- 520 people, healthy volunteers welcome
- Sponsor
- Montreal Heart Institute
Non-valvular Atrial Fibrillation
The CONFORMAL Early Feasibility Study
An evaluation of the safety and performance of the Conformal Left Atrial Appendage Seal for Left Atrial Appendage Occlusion
- Trial name
- NCT03616028
- Testing
- left atrial appendage closure
- Where
- 11 sites in United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Conformal Medical, Inc
Atrial Fibrillation, Stroke
Systematic NT-proBNP and ECG Screening for Atrial Fibrillation Among 75 Year Old Subjects in the Region of Stockholm, Sweden - STROKESTOP II
STROKESTOP II will study if the biomarker NT-proBNP together with single-lead ECG can be used as a primary population screening tool for silent atrial fibrillation, and builds on previous results from the STROKESTOP study.
- Trial name
- STROKESTOP II (NCT02743416)
- Testing
- ECG screening (Zenicor-ECG) for atrial fibrillation
- Where
- Sweden
- Volunteers
- 6,868 people, healthy volunteers welcome
- Sponsor
- Karolinska University Hospital
Nonalcoholic Fatty Liver Disease, Atrial Fibrillation
Nonalcoholic Fatty Liver Disease is Associated With Increased Atrial Fibrillation Risk in an Elderly Chinese Population
Atrial fibrillation and nonalcoholic fatty liver disease are two pathological conditions that are highly prevalent worldwide and share multiple CVD risk factors. There is rare research performed among elderly adults.
- Conditions
- Nonalcoholic Fatty Liver Disease, Atrial Fibrillation, Cross-sectional Study
- Trial name
- NCT03366987
- Where
- China
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Ningbo No. 1 Hospital
Postoperative Atrial Fibrillation
Prevention of Postop Atrial Fibrillation Through Intraoperative Inducibility of Atrial Fibrillation and Amiodarone Treatment
Patients undergoing first time cardiac surgery will undergo rapid atrial pacing prior to initiation of cardiopulmonary bypass to screen for AF inducibility.
- Trial name
- NCT03868150
- Testing
- Amiodarone Injection, Intraoperative Rapid Atrial Pacing
- Where
- United States
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Stanford University
Atrial Fibrillation
Atrial Fibrillation (AF) and Electrocardiogram (EKG) Interpretation Project ECHO
The goal of this study is to determine the effectiveness of a direct-to-provider virtual education program ("AF and EKG Interpretation Project ECHO") for primary care providers who manage patients with atrial fibrillation (AF).
- Trial name
- NCT05890274
- Testing
- AF and EKG Interpretation Project ECHO
- Where
- 3 sites in United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Healthy Volunteers
Safety and Pharmacokinetic Study of OMT-28 in Healthy Subjects
The aim of this first-in-human study is to assess the safety, tolerability, PK and exploratory pharmacodynamics (PD) of single and multiple oral ascending doses of OMT-28 in healthy male subjects to support further clinical…
- Trial name
- NCT03078738
- Testing
- OMT-28
- Where
- Germany
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Omeicos Therapeutics GmbH
Atrial Fibrillation, Inflammation
Impact of Inflammatory Indexes and Gene Scores in Prediction of Atrial Fibrillation
Because of the high recurrence rates following electrical cardioversion and high morbidity in AF patients there is a need to explore prediction models for AF recurrence following ECV.
- Conditions
- Atrial Fibrillation, Inflammation, Genetic Predisposition to Disease
- Trial name
- IERV (NCT06399666)
- Testing
- Blood sampling
- Where
- 2 sites in Sweden
- Volunteers
- 182 people, healthy volunteers welcome
- Sponsor
- Vrinnevi Hospital
Patients with Atrial Fibrillation and Healthy Volunters
Magnetic Resonance Imaging Development for High Resolution Atrial Structural and Functional Characterization
The main objective is to optimize the MRI protocol for the assessment of the LA in addition to a basic CMR protocol in order to define the best compromise between acquisition time and image quality (contrast between the different…
- Trial name
- MRI-HiRA (NCT06617624)
- Testing
- MRI, MRI Contrast
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Atrial Fibrillation (AF)
Atrial Fibrillation Risk Estimation With Single-lead Handheld Electrocardiograms
The goal of this prospective, non-randomized pilot study is to learn whether predictions from a previously validated 12-lead ECG-based artificial intelligence (AI) algorithm (ECG-AI) identify people more likely to have…
- Trial name
- AFRESHE (NCT07468123)
- Testing
- 1L ECG screening, Patch monitor
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Fibrillation, Atrial, Atrial Fibrillation
Odiparcil QT Definitive Study
This study is being completed to demonstrate the lack of effect of repeat dosing with Odiparcil on the QTc interval.
- Trial name
- NCT00437242
- Testing
- Odiparcil
- Where
- United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Cardiovascular Diseases, Coronary Disease
Lifetime Risk for Cardiovascular Disease Among Non-White Ethnic Groups
Cardiovascular disease (CVD) is one of the leading causes of death in the United States. Currently, there is little information about the lifetime risk of CVD among non-white ethnic groups.
- Conditions
- Cardiovascular Diseases, Coronary Disease, Heart Failure, Congestive, Atrial Fibrillation
- Trial name
- NCT00377702
- Where
- United States
- Volunteers
- 500,000 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)