Clinical trials: AHRF
Acute Hypoxemic Respiratory Failure, Acute Respiratory Distress Syndrome (ARDS)
EIT-Guided Ventilator Settings in AHRF
This exploratory study aims to investigate the effect of Electrical Impedance Tomography (EIT)-guided ventilator settings on mechanical power in patients with acute hypoxemic respiratory failure (AHRF), including both ARDS and…
- Conditions
- Acute Hypoxemic Respiratory Failure, Acute Respiratory Distress Syndrome (ARDS), Mechanical Power, Ventilator Induced Lung Injury
- Trial name
- NCT06936618
- Testing
- Electrical Impedance Tomography (EIT), Enlight 2100
- Where
- Thailand
- Volunteers
- 17 people
- Sponsor
- Mahidol University
ARDS (Moderate or Severe), AHRF
STimulation to Activate RespIration
Multi-center, randomized, controlled, open-label Phase 2 feasibility trial. Subjects on mechanical ventilation (MV) for acute hypoxemic respiratory failure (AHRF) with lung injury (including subjects who meet criteria for acute…
- Conditions
- ARDS (Moderate or Severe), AHRF, Mechanically Ventilated ICU Patients
- Trial name
- STARI (NCT06832306)
- Testing
- Phrenic Nerve Stimulation
- Where
- 7 sites in United States, Canada
- Volunteers
- 30 people
- Sponsor
- Lungpacer Medical Inc.
Acute Hypoxemic Respiratory Failure
Impact of Current Volume Under High-rate Nasal Oxygen Therapy During Acute Hypoxemic Respiratory Failure de Novo
De novo acute hypoxemic respiratory failure (AHRF) is associated with high overall mortality, which increases significantly with the use of orotracheal intubation.
- Trial name
- IVOXY (NCT03919331)
- Testing
- Assessment of tidal volume using Electrical Impedance Tomography (EIT) during high flow nasal canula(HFNC)
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
ARDS, AHRF
HemodynamIc eFfects of Lung Collapse and overdIstension During ARDS
The management ARDS relies on ventilatory strategies aimed at limiting ventilator-induced lung injury (VILI). The setting of PEEP is still subject of debate, as randomized clinical trials comparing standardized higher versus…
- Trial name
- HI-FIVE (NCT07423520)
- Testing
- Change in PEEP
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Acute Hypoxemic Respiratory Failure
Predictors of HFNC Failure in Patients With AHRF Using Diaphragm Ultrasound
Ultrasound of the diaphragm is an easily reproducible bedside tool that provides a non-invasive measurement of inspiratory muscle function and respiratory efficiency.
- Trial name
- ULTRAFLOW (NCT06096376)
- Testing
- Diaphragm Ultrasound
- Where
- Hong Kong
- Volunteers
- 30 people
- Sponsor
- Queen Mary Hospital, Hong Kong
Pneumonia
A Clinical Trial to Evaluate agenT-797 Plus Standard of Care in Participants With Severe Pneumonia With Moderate to Severe Acute Hypoxemic Respiratory Failure
This clinical trial will evaluate the efficacy and safety of a single intravenous dose of agenT-797 administered in addition to standard of care (SOC), compared with placebo plus SOC, in reducing short-term mortality in adult…
- Trial name
- NCT07615010
- Testing
- agenT-797, Standard of Care (SOC)
- Where
- 4 sites in United States, Ukraine
- Volunteers
- 90 people
- Sponsor
- MiNK Therapeutics
AHRF
Optimization of Respiratory Effort With Titrated Sedation in AHRF
Prospective, observational, monocentric study to assess the physiological effects of dexmedetomidine and remifentanil in spontaneously breathing patients with acute hypoxemic respiratory failure receiving high-flow nasal oxygen.
- Trial name
- OPTIREST (NCT07679932)
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
COVID-19
I-SPY COVID-19 TRIAL: An Adaptive Platform Trial for Critically Ill Patients
The goal of this project is to rapidly screen promising agents, in the setting of an adaptive platform trial, for treatment of critically ill COVID-19 patients.
- Trial name
- I-SPY_COVID (NCT04488081)
- Testing
- Remdesivir, Imatinib Mesylate, Dexamethasone
- Where
- 36 sites in United States
- Volunteers
- 1,500 people
- Sponsor
- QuantumLeap Healthcare Collaborative
Respiratory Insufficiency, Anoxemia
Effects of Inhaled Nitric Oxide in the Treatment of Acute Hypoxemic Respiratory Failure (AHRF) in Pediatrics
The purpose of this study is to determine the effect of nitric oxide for inhalation on the duration of mechanical ventilation in pediatric patients with AHRF.
- Trial name
- NCT00041561
- Testing
- Nitrogen gas, inhaled nitric oxide
- Where
- 16 sites in United States
- Volunteers
- 55 people
- Sponsor
- Mallinckrodt
Pressure Ulcer, Noninvasive Positive Pressure Ventilation
The ROTAtional-USE of Interface STUDY
In this trial investigators will explore if a protocolized rotational use of interfaces i.e., masks, during noninvasive positive pressure ventilation (NPPV) compared to standard care is clinically effective and cost-effective in…
- Conditions
- Pressure Ulcer, Noninvasive Positive Pressure Ventilation, Acute Hypercapnic Respiratory Failure
- Trial name
- ROTA-USE (NCT05513508)
- Testing
- Protocolized rotational use of interfaces, Standard of care
- Where
- Italy
- Volunteers
- 478 people
- Sponsor
- Azienda Ospedaliero Universitaria Maggiore della Carita
Acute Hypoxemic Respiratory Failure
Predicting High-Flow Nasal Cannula Failure in Acute Hypoxemic Respiratory Failure Using Metabolomics and Clinical Data
The goal of this observational study is to determine whether metabolomic profiles combined with clinical data can predict high-flow nasal cannula (HFNC) failure and help optimize respiratory support in adult patients with acute…
- Trial name
- META-RESPIRE (NCT07607080)
- Where
- Spain
- Volunteers
- 300 people
- Sponsor
- Hospital del Mar Research Institute (IMIM)
Acute Hypercapnic Respiratory Failure
Integrated Care of Co-morbidities vs Standard Care After AHRF in the Intensive Care Unit
The study will assess the potential benefit of implementing a complex bundle of interventions to treat important - often unrecognized - comorbidities in patients surviving an episode of Acute Hypercapnic Respiratory Failure…
- Trial name
- TMIRA (NCT04650412)
- Testing
- Bundle of comorbidities care
- Where
- 3 sites in France, Switzerland
- Volunteers
- 188 people
- Sponsor
- CTU
Respiratory Insufficiency
Broncho-alveolar Lavage Under Noninvasive Ventilation With Propofol TCI in Patient With AHRF
Fiberoptic bronchoscopy (FOB) is an important tool for the diagnosis of pulmonary diseases, more particularly in infectious pneumonia.
- Trial name
- SEDA-FIBRO (NCT00741949)
- Testing
- Propofol
- Where
- 2 sites in France
- Volunteers
- 46 people
- Sponsor
- University Hospital, Bordeaux
High Flow Oxygen Therapy, Acute Hypercapnic Respiratory Failure
HFNC and Acute Hypercapnic Respiratory Failure
High-flow nasal cannula (HFNC) enables delivering humidified gas at high-flow rates controlling the oxygen inspired fraction (FiO2). Its efficacy has been demonstrated in hypoxemic acute respiratory failure.
- Conditions
- High Flow Oxygen Therapy, Acute Hypercapnic Respiratory Failure, COPD Exacerbation
- Trial name
- NCT04109560
- Where
- Argentina
- Volunteers
- 40 people
- Sponsor
- Argentinian Intensive Care Society
ARDS (Moderate or Severe), Acute Hypoxemic Respiratory Failure
PEEP-induced Effects on Respiratory dRivE and EFfort
Rationale: In patients with acute hypoxemic respiratory failure (AHRF), preserving spontaneous breathing during mechanical ventilation offers physiological benefits, but also carries risks.
- Trial name
- REEF (NCT07203781)
- Testing
- PEEP level changes
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- Radboud University Medical Center
Acute Hypercapnic Respiratory Failure
Under the Nose Face Mask to Prevent Facial Pressure Ulcers During NIV for Acute Hypercapnic Respiratory Failure (AHRF)
Noninvasive ventilation (NIV) is essential to treat acute hypercapnic respiratory failure. However, facial pressure ulcers appearing during facemask-delivered noninvasive ventilation are a source of NIV failure by interface…
- Trial name
- UNDER PRESSURE (NCT04102735)
- Testing
- Under-the-nose facemask, Over-the-nose facemask
- Where
- 2 sites in France
- Volunteers
- 108 people
- Sponsor
- Centre Hospitalier Arras
Acute Hypoxemic Respiratory Failure, COVID-19
Dexamethasone and Oxygen Support Strategies in ICU Patients With Covid-19 Pneumonia
The main manifestation of COVID-19 is acute hypoxemic respiratory failure (AHRF). In patients with AHRF, the need for invasive mechanical ventilation is associated with high mortality. Two hypotheses will be tested in this study.
- Trial name
- COVIDICUS (NCT04344730)
- Testing
- Dexamethasone injection, conventional oxygen, CPAP
- Where
- France
- Volunteers
- 550 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Acute Hypoxemic Respiratory Failure
Predictors of HFNC Failure in Patients With AHRF Using Echocardiography Parameters
Right ventricular dysfunction (RVD) and right ventricular-pulmonary arterial (RV-PA) uncoupling detected by transthoracic echocardiography (TTE) in acute respiratory distress syndrome (ARDS) are associated with poor survival.
- Trial name
- AHRF-ECHO (NCT06096363)
- Testing
- Transthoracic Echocardiography
- Where
- Hong Kong
- Volunteers
- 28 people
- Sponsor
- Queen Mary Hospital, Hong Kong
Patients With Acute Hypoxemic Respiratory Failure
Wean Early With HFNCO vs NPPV in Patients With AHRF
The main purpose of the present study is to verify whether, as compared with conventional weaning, early weaning with high-flow nasal cannula oxygenation or noninvasive positive pressure ventilation may more effective in…
- Trial name
- NCT03171935
- Testing
- High-Flow Nasal Cannula Oxygenation, Noninvasive Positive Pressure Ventilation, Conventional weaning
- Where
- China
- Volunteers
- 270 people
- Sponsor
- Beijing Chao Yang Hospital
Hypoxemic Respiratory Failure
A Pilot Study Comparing Oxygen Delivery Via Helmet Interface Versus High Flow Nasal Cannula
Our main objective is to collect feasibility data on helmet NIPPV and other clinical elements in to eventually prepare for a full scale randomized trial based on findings of this pilot study.
- Trial name
- NOVA-pilot (NCT04035460)
- Testing
- Helmet, High Flow Nasal Oxygen
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Baystate Medical Center