Clinical trials: AI Agent, open to volunteers
Esophageal Cancer
AI-Driven Digital Twin and Drug Simulation for Esophageal Cancer
This study aims to integrate multi-omics data (genomics, transcriptomics, proteomics) from esophageal cancer patients with artificial intelligence and digital twin technology to construct personalized virtual patient models that…
- Trial name
- ESCA-DT (NCT07757022)
- Testing
- Toripalimab, Paclitaxel, Cisplatin
- Volunteers
- 400 people
- Sponsor
- Henan Cancer Hospital
Pulmonary Tuberculosis
AIPH-TB: AI-Optimised Pyrazinamide-Hydroxychloroquine vs Standard RIPE for Drug-Sensitive Pulmonary Tuberculosis - A Phase II RCT
Tuberculosis (TB) kills 1.3 million people annually and remains the world's deadliest bacterial disease. The standard four-drug RIPE regimen achieves only 85% cure rates and causes drug-induced hepatotoxicity in 25-37% of…
- Trial name
- AIPH-TB-RCT-P2 (NCT07467252)
- Testing
- Pyrazinamide and Hydroxychloroquine (AI-Optimised), Standard RIPE Regimen (Rifampicin, Isoniazid, Pyrazinamide, Ethambutol)
- Where
- Saudi Arabia
- Volunteers
- 200 people
- Sponsor
- Ministry of Health, Saudi Arabia
Tinnitus
Fudan Tinnitus Doctor for Tinnitus Management
The goal of this clinical trial is to evaluate whether a conversational artificial intelligence-based digital intervention can improve symptoms in adults with chronic subjective tinnitus.
- Trial name
- NCT07558837
- Testing
- Fudan Tinnitus Doctor (FTD) System, Non-conversational Digital Education Program
- Where
- China
- Volunteers
- 256 people
- Sponsor
- Eye & ENT Hospital of Fudan University
Metastatic Prostate Cancer
AI-Assisted Patient Support in mHSPC
The purpose of this multicenter, open-label, randomized controlled trial is to evaluate whether patient-centered support delivered through a large language model (LLM)-based artificial intelligence (AI) agent reduces anxiety in…
- Trial name
- LUMINOUS (NCT07804030)
- Testing
- The Same Platform without AI Agent, AI Agent-Assisted Patient-Centered Support, Delayed AI Agent-Assisted Patient-Centered Support
- Where
- 4 sites in China
- Volunteers
- 160 people
- Sponsor
- Fudan University
Metastatic Prostate Cancer
PULSE Registry: for Patients Receiving Lutetium (177Lu) Vipivotide Tetraxetan
The primary objective of the study is to describe real-world drug utilisation of lutetium (177Lu) vipivotide tetraxetan among patients with metastatic prostate cancer
- Trial name
- PULSE (NCT07484269)
- Where
- Switzerland
- Volunteers
- 753 people
- Sponsor
- Novartis Pharmaceuticals
Urinary Stones, Prostate Cancer
Development of an AI-Agent for Urological Disease Diagnosis and Treatment
Urological diseases such as urinary stones, prostate cancer, and bladder cancer are very common and often require highly specialized diagnosis and treatment.
- Conditions
- Urinary Stones, Prostate Cancer, Bladder Cancer
- Trial name
- NCT07721935
- Where
- 3 sites in China
- Volunteers
- 2,000 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Cognitive Load and Task Performance in Rotating Residents
Effect of a Localized ICU AI Teaching Agent on Rotating ICU Residents
This trial is an ongoing single-center, pragmatic, parallel-group randomized controlled superiority trial currently in participant recruiting phase, conducted within intensive care unit teaching wards at Peking Union Medical…
- Trial name
- NCT07692035
- Testing
- ICU-Tutor AI Agent, General-Purpose Large Language Models
- Where
- China
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Peking Union Medical College Hospital
Ventricular Ejection Fraction, LVF
AI-Enabled Direct-from-ECG Ejection Fraction (EF) Severity Assessment Using COR ECG Wearable Monitor
This prospective, multicenter, cluster-randomized controlled study aims to evaluate the accuracy of an investigational artificial intelligence (AI) Software as a Medical Device (SaMD) designed to compute ejection fraction (EF)…
- Conditions
- Ventricular Ejection Fraction, LVF, LV Dysfunction, Atrial Enlargement
- Trial name
- EFACT (NCT06699056)
- Testing
- 15-minutes of sitting during COR ECG Acquistion
- Where
- 8 sites in United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Peerbridge Health, Inc
Vascular Parkinsonism, Drug-induced Parkinsonism
AI-Enhanced Optimization of Acute Levodopa Challenge Test
A quantitative evaluation method was developed for Parkinson's disease and other atypical parkinonism by integrating an innovative motor paradigm with perception technologies and artificial intelligence.
- Conditions
- Vascular Parkinsonism, Drug-induced Parkinsonism, Corticobasal Degeneration (CBD), Parkinson Disease (PD)
- Trial name
- NCT06949865
- Testing
- video recording
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- Beijing Tiantan Hospital
Ophthalmology, Large Language Models
A Multimodal AI Agent for Ophthalmic Clinical Decision Support
This study is a multicenter randomized controlled trial evaluating the effectiveness and safety of EyeAgent, a multimodal artificial intelligence (AI) agent designed to assist ophthalmologists in clinical decision-making.
- Conditions
- Ophthalmology, Large Language Models, AI Agent, Eye Disease
- Trial name
- NCT07401459
- Testing
- EyeAgent AI system
- Where
- China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
Asperger's Disorder, Asperger Disorder
QAIAx - SGI/SI Smart Health Cities: Microcity Enclave Program (Quantum SI/AGI Agency a/k/a AI City Hall Project - UPSTO App Nos. 64/074,526, 64/063,557, 64/105,164, 63/903,181, 63/729,428, 64/125,360; USPTO EO 9424 Assignment ID: 2101042 / ARN: REEL/FRAME: 76481/0026 - OUSD-R&E, Department of War)
BRIEF SUMMARY A. "What is the purpose of this study?" BACKGROUND. The QAIAx clinical trial (Quantum SI/SGI Public Health Agency), known operationally as the "AI City Hall Project," represents a landmark intergovernmental research…
- Conditions
- Asperger's Disorder, Asperger Disorder, Autism Disorder, Autism
- Trial name
- QAIAx (NCT07661823)
- Testing
- AI City Hall Project (AIhealth4u - Public Health Central), AI City Hall Project (QAIAx Microcity A - AI Public Health Central)
- Where
- United States
- Volunteers
- 1,000,000 people, healthy volunteers welcome
- Sponsor
- Veterans Recovery Network Inc.
Hyperglycaemia, Hypertension
Developing an AI Pharmacy Chatbot for the Population of Hong Kong
The primary objective of this study is to is to develop a conversational AI service (chatbot) in Hong Kong to assist patients and caregivers with inquires related to Hospital Authority (HA)-prescribed medications, and to evaluate…
- Conditions
- Hyperglycaemia, Hypertension, Hyperlipidaemia, Artificial Intelligence (AI)
- Trial name
- NCT07037563
- Testing
- An AI pharmacy chatbot offering information related to HA-prescribed medication for hyperglycaemia, hypertension, and hyperlipidaemia
- Where
- 2 sites in Hong Kong
- Volunteers
- 280 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Clinical Decision Support Systems, Diagnostic Reasoning
Effects of Agent-assisted, LLM-assisted and Traditional Workflows on Diagnosis and Management Planning at Admission
The goal of this clinical trial is to evaluate whether AI-assisted workflows improve physicians' admission diagnosis and management planning performance on standardized simulated inpatient cases, among practicing internal…
- Conditions
- Clinical Decision Support Systems, Diagnostic Reasoning, Artificial Intelligence (AI)
- Trial name
- NCT07760051
- Testing
- Agent-assisted workflow, LLM-assisted workflow, Traditional Workflow
- Where
- China
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Influenza, Human, Vaccine Hesitancy
Conversational AI for Adult Flu Vaccination Decisions
This randomized trial tests whether an online guide combining short evidence cards with an AI-guided conversation increases flu-vaccination intention among US adults who haven't decided whether to get a flu vaccine this season.
- Trial name
- NCT07896850
- Testing
- Flu vaccination guide, Accident safety guide
- Where
- United States
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Calypta Systems, Inc.
Chatbot-Based Training, Hemodialysis
DialysisBot: AI Chatbot for Hemodialysis Self-Management
End-stage kidney disease requiring hemodialysis is a chronic condition with substantial clinical, functional, and psychosocial burden.
- Conditions
- Chatbot-Based Training, Hemodialysis, Self-management
- Trial name
- NCT07830810
- Testing
- DialysisBot
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- University of Rome Tor Vergata
Major Depressive Disorder (MDD)
Evaluating Conversational Artificial Intelligence for Depression Management
The goal of this clinical trial is to evaluate how a conversational method of collecting medical history affects patients' perceptions and experiences compared to clinical care as usual.
- Trial name
- NCT07105397
- Testing
- Conversational AI system vs Usual Care
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- George Mason University
Diabetes, Obesity
AIManage Using an AI-driven CDS and Chatbot
The objective of this project is to define and test the GenAI-powered Clinical Decision Support (CDS) tool, AIManage, providing a broad range of incretin mimetic medication management services to optimize dose titrations.
- Conditions
- Diabetes, Obesity, Medication Side Effects
- Trial name
- NCT07546357
- Testing
- AIManage
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- NYU Langone Health
Unilateral Cerebral Palsy
Validation of AI for Personalized Assessment and Rehabilitation of Upper Limb in Children With Unilateral Cerebral Palsy
Unilateral Cerebral palsy (UCP) is the most common neurological chronic disease in childhood with a significant burden on children, their families and health care system.
- Trial name
- AInCP (NCT06073522)
- Testing
- Artificial Intelligence for combining multi-domain data acquisition
- Where
- 2 sites in Italy, Spain
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- IRCCS Fondazione Stella Maris
Cardiotoxicity
Artificial Intelligence for Reconstruction of Echocardiography Studies
To investigate the clinical utility of both 3D and 2D artificial intelligence reconstruction echocardiography (V-echo and L-echo) assessment against conventional echocardiography and clinical cardiovascular magnetic resonance…
- Trial name
- AIRES (NCT07093918)
- Testing
- V-echo, L-echo
- Volunteers
- 120 people
- Sponsor
- The Royal Wolverhampton Hospitals NHS Trust
Coronary Artery Disease, Atheroscleroses
Drug-Eluting Balloon Treatment vs. Guideline-Directed Medical Therapy for the Treatment of Lipid-Rich Plaques
The goal of this clinical trial is to find out whether treating vulnerable plaques in the coronary arteries with a drug-coated balloon can make them less dangerous than using standard medication alone.
- Conditions
- Coronary Artery Disease, Atheroscleroses, Cardiovascular Disease, Vulnerable Coronary Plaques
- Trial name
- DELETE-LRP (NCT07107971)
- Testing
- Paclitaxel-eluting balloon
- Where
- Netherlands
- Volunteers
- 400 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)