Clinical trials: AI Chatbot, open to volunteers
AI Companionship
How Do Artificially Intelligent Companions Influence Psychological Outcomes?
This randomized longitudinal study examines how interacting with an artificially intelligent (AI) companion affects psychological well-being, social experiences, and interpersonal attitudes and behaviors over time.
- Trial name
- NCT07858279
- Testing
- AI Companion Interaction
- Where
- United States
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Diabetes, Gestational, Pre-eclampsia
Usability Evaluation of Gen AI-based Nutrition Chatbot for Pregnant Women
Background: Pregnancy imposes significant physical demands, with complications like gestational diabetes (GDM) and pre-eclampsia posing serious risks.
- Conditions
- Diabetes, Gestational, Pre-eclampsia, AI Chatbot for Prenatal Nutrition Guidance
- Trial name
- NCT07458997
- Testing
- a culturally tailored nutrition AI chatbot for pregnant women
- Where
- Hong Kong
- Volunteers
- 100 people
- Sponsor
- Hong Kong Metropolitan University
Epilepsy, Seizure
AI-Based Mobile Intervention on Medication Non-Adherence and Transition
This study aims to examine whether the AI-personalized version of the Medilepsy® app is more effective than the non-AI (standard version without AI personalization) can improve key outcomes, such as medical adherence and…
- Trial name
- NCT07445074
- Testing
- Medilepsy® Chatbot AI-Enhanced, Medilepsy® Chatbot Standard
- Where
- 2 sites in United States
- Volunteers
- 200 people
- Sponsor
- University of Central Florida
Oral Cancer, Chatbot
Enhancing Oral Cancer Awareness
To evaluate the impact of AI-powered chatbot interactions versus traditional educational handouts on increasing participants' knowledge of oral cancer and its prevention
- Conditions
- Oral Cancer, Chatbot, Patient Education, Prevention
- Trial name
- NCT06682494
- Testing
- Traditional Education, AI-powered Chatbox
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Hematopoietic and Lymphatic System Neoplasm, Malignant Solid Neoplasm
An Artificial Intelligence-Powered Supportive Care Chatbot to Address the Supportive Care Needs of Young Adult Cancer Survivors
This clinical trial studies whether an artificial intelligence (AI)-powered supportive care chatbot is helpful for addressing the supportive care needs of young adult cancer survivors.
- Trial name
- NCT07772596
- Testing
- Artificial Intelligence-based Intervention, Interview, Survey Administration
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Michigan Rogel Cancer Center
Chatbot-Based Training, Hemodialysis
DialysisBot: AI Chatbot for Hemodialysis Self-Management
End-stage kidney disease requiring hemodialysis is a chronic condition with substantial clinical, functional, and psychosocial burden.
- Conditions
- Chatbot-Based Training, Hemodialysis, Self-management
- Trial name
- NCT07830810
- Testing
- DialysisBot
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- University of Rome Tor Vergata
Cancer
Artificial Intelligence-Powered Support For Quality Of Life Improvement In Participants With Cancer
This research study is for people who are diagnosed with cancer and are receiving treatment for cancer who may benefit from psychotherapy.
- Trial name
- NCT07167056
- Testing
- Standard of Care Psychotherapy, WYSA App
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Case Comprehensive Cancer Center
Sarcoma
Information-providing Chatbot
This study aims to develop and examine the feasibility and preliminary effectiveness of an AI-based sarcoma chatbot building on ChatGPT (ASCC) to address the information needs of sarcoma patients.
- Trial name
- NCT07505732
- Testing
- ASCC (sarcoma-specific AI chatbot), Routine Clinical Care
- Volunteers
- 78 people
- Sponsor
- The Hong Kong Polytechnic University
Healthy
Chatbot Intervention Effects on Belief Updating in Anhedonia
The main aim of the present study is to investigate the effects of a Motivational Interviewing-based artificial intelligence chatbot on belief updating in college students with elevated levels of depression and anhedonia by…
- Trial name
- NCT07663019
- Testing
- MI Chatbot Interaction, Active Control Chatbot Interaction
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Electronic Science and Technology of China
Healthy
Chatbot Intervention Effects on Social and Monetary Incentive Processing in Anhedonia
The main aim of the present study is to investigate the effects of a Motivational Interviewing-based artificial intelligence chatbot on social incentive processing in college students with elevated levels of depression and…
- Trial name
- NCT07665242
- Testing
- MI Chatbot Interaction, Active Control Chatbot Interaction
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Electronic Science and Technology of China
Metabolic Dysfunction-Associated Steatotic Liver Disease, Metabolic Alcohol-Related Liver Disease
A Large Language Model-based Chatbot for Alcohol Reduction in Patients With Metabolic Alcohol-Related Liver Disease
The goal of this pilot randomized controlled trial is to evaluate the trial feasibility and acceptability of LLM-based chatbot for reducing alcohol use among patients with metabolic alcohol-related liver disease.
- Trial name
- NCT07450144
- Testing
- LLM-based chatbot, Telephone counseling, Alcohol Brief Intervention
- Where
- Hong Kong
- Volunteers
- 50 people
- Sponsor
- The University of Hong Kong
Cardiovascular-kidney-metabolic Syndrome
AI Chatbot-Enabled ePRO Monitoring and Nurse-Led Self-Management for Early-Stage Cardiovascular-Kidney-Metabolic Syndrome
This randomized controlled trial will evaluate the effectiveness of an AI chatbot-enabled electronic patient-reported outcome (ePRO) monitoring and nurse-led self-management intervention for adults with early-stage…
- Trial name
- NCT07577284
- Testing
- AI chatbot-enabled nurse-led program., Usual Care
- Where
- Taiwan
- Volunteers
- 80 people
- Sponsor
- Taipei Medical University
Physical Activity
Self-directed Use of Resources for Physical Activity
This is a pilot RCT examining physical activity outcomes at 3 months across 3 conditions: use of large language model (LLM) fully self-directed; use of LLM with guidance; and use of online tools to help with sleep.
- Trial name
- CHARGE (NCT07654868)
- Testing
- LLM alone, LLM enhanced, Sleep promotion
- Volunteers
- 39 people
- Sponsor
- University of Florida
Osteoporosis, Sarcopenia
Osteoporosis and Sarcopenia Prevention in Middle-Aged Population
This initiative is designed to yield substantial and multi-level benefits for the Hong Kong community by pioneering a transformative model of preventive healthcare.
- Trial name
- FORTIFY (NCT07611097)
- Testing
- Intervention Group, Control Group
- Where
- Hong Kong
- Volunteers
- 8,336 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Smoking Cessation
Gen AI Powered Behavioral Support Plus Chewing Gum Intervention for Construction Workers Who Smoke
The goal of this pilot trial is to learn if 1-week NRT sampling, 3-week chewing gum, and 12-week chatbot-delivered instant messaging support works to help smoking cessation in construction workers who smoke.
- Trial name
- NCT07649018
- Testing
- AWARD advice, Brief leaflet on health warning and smoking cessation, Referral card
- Where
- Hong Kong
- Volunteers
- 200 people
- Sponsor
- The University of Hong Kong
Breast Cancer Early Stage Breast Cancer (Stage 1-3)
Reflects the Intervention (AI Chatbot)
The goal of this clinical trial is to investigate the impact of an AI-powered chatbot intervention on improving knowledge, attitudes, and empowerment in breast cancer patients.
- Trial name
- BC-CHAT (NCT06943911)
- Testing
- AI Chatbot for Breast Cancer Patient Education and Empowerment
- Where
- Egypt
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- Mostafa Shaban
Pelvic Floor Disorder, Loneliness
Postpartum Education Via Artificial Intelligence for Recovery and Loneliness: A Randomized Controlled Trial
The goal of this clinical trial is to learn whether a postpartum chatbot powered by generative artificial intelligence (genAI) can help new mothers get better pelvic floor health information and feel less lonely after childbirth.
- Conditions
- Pelvic Floor Disorder, Loneliness, Postpartum, Mental Health
- Trial name
- PEARL (NCT07223736)
- Testing
- Generative artificial intelligence (genAI) postpartum chatbot, Standard of Care (SOC)
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- University of California, San Diego
Caregivers
Feasibility and Acceptability of an LLM-based Chatbot for Family Caregivers: Evaluation Study
This study evaluates the feasibility and acceptability of using the artificial intelligence (AI) chatbot mobile application (an LLM-based Chatbot) to support the well-being of informal care partners of individuals with traumatic…
- Trial name
- NCT07280650
- Testing
- LLM-based Chatbot
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Michigan
Healthy
Building Cognitive Resilience to Vaccine Misinformation Using AI in Europe
This multi-country trial evaluates an AI chatbot designed to counter cognitive biases and inoculate parents against vaccine misinformation, embedded within a large survey across five European countries (n=5,000).
- Trial name
- NCT07551986
- Testing
- AI-driven chatbot, Social media infographic
- Where
- United Kingdom
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Psychological Stress, Perceived Stress
A Persian AI-Based CBT Chatbot and Voice Analysis System for Managing Perceived Stress
This pilot randomized controlled trial aims to evaluate a Persian-language artificial intelligence (AI)-based cognitive behavioral therapy (CBT) chatbot designed to support adults in managing perceived stress.
- Trial name
- PersianAI-CBT (NCT07840469)
- Testing
- Persian AI-Based CBT Chatbot, Active Mental Health Content
- Where
- Iran
- Volunteers
- 120 people
- Sponsor
- Hamid Reza Marateb