Clinical trials: AKI - Acute Kidney Injury
Acute Kidney Injury, The Changes of Plasma Creatinine
Short-Term Alpha Lipoic Acid Therapy for Prevention of Contrast-induced Acute Kidney Injury and Endothelial Dysfunction in Type 2 Diabetes
Contrast-induced acute kidney injury (CIAKI) is a major complication with adverse outcomes after contrast media injection. Although the risk of developing CIAKI is low in patients with normal renal function, it is dramatically…
- Conditions
- Acute Kidney Injury, The Changes of Plasma Creatinine, The Changes of Plasma Free Radicals, The Changes of Endothelium-dependent Arterial Dilation
- Trial name
- NCT01978405
- Testing
- Alpha lipoic acid
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Xiang Guang-da
Chronic Kidney Disease
Efficacy Trial of N-Acetylcysteine and Sodium Bicarbonate for the Prevention of Contrast-Induced Acute Kidney Injury
Contrast-Induced Acute Kidney Injury(CIAKI) was defined as an absolute increase in serum creatinine of more than or equal to 0.3mg/dl (≥ 26.4 μmol/l), a percentage increase in serum creatinine of more than or equal to 50%…
- Trial name
- PREKIT (NCT01210456)
- Testing
- Physiological Saline, N-Acetylcysteine and Sodium Bicarbonate
- Where
- Japan
- Volunteers
- 458 people
- Sponsor
- Tokushukai Medical Group
Hypotension, Acute Kidney Injury
A Clinical Decision Support Trial to Reduce Intraoperative Hypotension
The purpose of this study is to provide messages to providers if their patient is at high risk of developing intraoperative hypotension based on past medical history and co-morbidities preoperatively and minutes of hypotension…
- Trial name
- NCT04062994
- Testing
- Nudge to reduce intraoperative hypotension
- Where
- 4 sites in United States
- Volunteers
- 30,000 people
- Sponsor
- University of California, Los Angeles
Acute Kidney Injury
The Efficacy and Safety of Sodium-glucose Cotransporter 2 Inhibitors in Patients With Acute Kidney Disease
Acute kidney disease (AKD) happens between 7 and 90 days after an initial kidney injury (AKI). This period is crucial because it can determine whether the condition worsens into chronic kidney disease (CKD).
- Trial name
- ESS-AKD (NCT06528405)
- Testing
- dapagliflozin, Other anti-diabetic drug or no anti-diabetic drug, empagliflozin
- Where
- Taiwan
- Volunteers
- 264 people
- Sponsor
- National Taiwan University Hospital
Acute Kidney Injury
Effect of Cholesterol Level on Postoperative Acute Kidney Injury of Non-cardiac Surgeries
Preoperative serum cholesterol level may influence occurrence of postoperative acute kidney injury of cardiac surgeries. However, the effect of Preoperative serum cholesterol level for non cardiac surgery remains unknown.
- Trial name
- NCT03954353
- Where
- China
- Volunteers
- 78,888 people
- Sponsor
- Peking University First Hospital
Aortic Dissection
Effects of Intraoperative Hemoperfusion on Acute Kidney Injury After Aortic Dissection
Acute kidney injury (AKI) is a common and serious complication after aortic dissection (AD), and it is closely related to the inflammatory response associated with cardiopulmonary bypass.
- Trial name
- EIHPOAKIAD (NCT05331495)
- Testing
- Intraoperative Hemoperfusion
- Where
- China
- Volunteers
- 206 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Proteinuria, Kidney Injury
Inflammatory and Immune Profiling of Kidney Tissue Obtained From Patients With Newly Diagnosed Kidney Disease
This study will evaluate in patients with kidney disease, the role that certain inflammatory and immune mediators play in promoting kidney damage.
- Conditions
- Proteinuria, Kidney Injury, Chronic Kidney Disease
- Trial name
- NCT01156428
- Where
- United States
- Volunteers
- 119 people, healthy volunteers welcome
- Sponsor
- The Rogosin Institute
Acute Kidney Injury
Online Hemodiafiltration vs Conventional Hemodialysis in Acute Kidney Injury
Only limited data exist on the benefit of online hemodiafiltration in patient with Acute kidney injury. The objective of this pilot RCT is to assess the feasibility of a large multicentre RCT to determine whether, in patients…
- Trial name
- HDFAKI (NCT04525092)
- Testing
- Online Pre-dilution Hemodiafiltration, Conventional Hemodialysis, Online Post-dilution Hemodiafiltration
- Where
- 2 sites in Canada, Ireland
- Volunteers
- 45 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Cardiac Surgery, Acute Kidney Injury
Angiopoietin and Adverse Outcomes in Cardiac Surgery
Cardiac surgery and cardiopulmonary bypass can lead to systemic organ failure trough excess inflammation and endothelial injury.
- Trial name
- ANGE (NCT05817929)
- Testing
- blood sample
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Traumatic Haemorrhagic Shock, AKI (Acute Kidney Injury) Due to Trauma
Renal Perfusion and the Development of AKI Following Traumatic Injury
Acute kidney injury (AKI) is a complication of traumatic haemorrhagic shock (THS) and together these conditions increase mortality risk.
- Conditions
- Traumatic Haemorrhagic Shock, AKI (Acute Kidney Injury) Due to Trauma, AKI - Acute Kidney Injury
- Trial name
- PERTAKI (NCT06917053)
- Testing
- Ultrasound (including contrast enhanced ultrasound), Sublingual incident dark field videomicroscopy, Urinary oxygen tension.
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- King's College Hospital NHS Trust
Acute Kidney Injury
Learning Alerts for Acute Kidney Injury
The primary objective of this study is to determine whether the use of uplift (also known as Conditional Average Treatment Effect - CATE) modeling to empirically identify patients expected to benefit the most from AKI alerting…
- Trial name
- NCT02786277
- Testing
- Alert
- Where
- United States
- Volunteers
- 2,046 people
- Sponsor
- Yale University
Acute on Chronic Liver Failure
Safety and Efficacy of Continuous Infusion of Terlipressin With Norepinephrine Versus Norepinephrine Alone in Improving Outcomes of Acute Kidney Injury in Acute on Chronic Liver Failure With Septic Shock
ACLF is defined differently in APASL,EASL and AASLD.APASL talks of reversibility in ACLF as per its definition and constitution of Homogenous population with ACLF.The definition of ACLF as per APASL is an acute hepatic insult…
- Trial name
- NCT06556472
- Testing
- Terlipressin, Norephrine
- Where
- India
- Volunteers
- 126 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Acute Kidney Injury
Detection and Management of Acute Kidney Injury (AKI) in Low and Low Middle Income Countries: A Pilot Feasibility Project
This feasibility study will be conducted at 4 international sites located in Asia (Dhahran, Nepal); Africa (Blantyre, Malawi and Kilimanjaro, Tanzania) and Latin America (Cochabamba, Bolivia).
- Trial name
- NCT02912611
- Testing
- Education and Protocol based management
- Where
- 3 sites in Bolivia, Malawi and 1 more
- Volunteers
- 2,101 people
- Sponsor
- University of California, San Diego
Burns, Hemofiltration
Hemofiltration in Burns: RESCUE (Randomized Controlled Evaluation of Hemofiltration in Adult Burn Patients With Septic Shock and Acute Renal Failure)
The purpose of this study is determine if High-Volume Hemofiltration in addition to 'contemporary' care will result in an improvement of select clinical outcomes when compared to 'contemporary' care alone in the treatment of…
- Conditions
- Burns, Hemofiltration, Kidney Failure, Acute, Shock, Septic
- Trial name
- RESCUE (NCT01213914)
- Testing
- An FDA approved continuous renal replacement device, Control Group
- Where
- 9 sites in United States
- Volunteers
- 37 people
- Sponsor
- American Burn Association
Chronic Renal Insufficiency, Serum Creatinine Concentration
MESNA for Prevention of Acute Deterioration of Renal Function Following Contrast Agent Application
The purpose of this study is to determine wether Mesna could prevent contrast-induced nephropathy
- Conditions
- Chronic Renal Insufficiency, Serum Creatinine Concentration, Contrast Media Exposition
- Trial name
- NCT00223548
- Testing
- sodium 2-mercaptoethane sulfonate
- Where
- Germany
- Volunteers
- 106 people
- Sponsor
- University of Ulm
Acute Kidney Injury
Efficacy of RIPC to Reduce AKI for Patients Undergoing PCI
The purpose of the present study is to determine if remote ischemic preconditioning reduces incidence of acute kidney injury in patients with reduced kidney function undergoing Percutaneous Coronary Intervention.
- Trial name
- EUROCRIPS (NCT02195726)
- Testing
- Remote ischemic preconditioning
- Where
- 7 sites in France, Italy and 1 more
- Volunteers
- 1,110 people
- Sponsor
- A.O.U. Città della Salute e della Scienza
Acute Kidney Injury
Acute Kidney Attack in Severe Traumatized Patients
Acute Kidney Injury (AKI) is a common complication of severe traumatized patients. The diagnosis is often delayed. The Nephrocheck® test allows an earlier assessment of renal stress.
- Trial name
- NEPHROTRAUMA (NCT03877978)
- Testing
- Nephrocheck test
- Where
- France
- Volunteers
- 196 people
- Sponsor
- Hospices Civils de Lyon
Acute Kidney Injury, Fluid Overload
Prospective, Multi-center, Single-arm, Observational Study. US FDA 522 Pediatric Post Market Surveillance Study.
The post market surveillance study will employ a prospective, multi-center, single-arm, observational design to capture data on children who undergo CRRT using the Carpediem™ system.
- Trial name
- NCT04608149
- Testing
- Carpediem System
- Where
- 6 sites in United States
- Volunteers
- 36 people
- Sponsor
- Mozarc Medical US LLC
Nephrolithiasis
Outcomes and Inter-Stage Interval in Staged Bilateral PCNL
This prospective, single-center observational study evaluated patients undergoing staged bilateral standard percutaneous nephrolithotomy (PCNL) for bilateral renal stones.
- Trial name
- NCT07854743
- Where
- Turkey (Türkiye)
- Volunteers
- 34 people
- Sponsor
- Ankara Training and Research Hospital
Acute Kidney Injury, Extracorporeal Circulation; Complications
Tissue Inhibitor of Metalloproteinases 2 Level in Patients Undergoing Cardiac Surgery
Acute kidney injury (AKI) is one of the most frequent major complications in patients undergoing cardiac surgery. CSA-AKI is independently related to increased perioperative mortality, increased hospital and ICU length of stay as…
- Conditions
- Acute Kidney Injury, Extracorporeal Circulation; Complications, Surgery
- Trial name
- NCT06871826
- Testing
- TIMP2 level
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Wuhan University
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