Clinical trials: ALL
Heavy Uterine Bleeding, Uterine Fibroids
Safety and Efficacy in Premenopausal Women With Heavy Menstrual Bleeding (HMB) Associated With Uterine Fibroids (UF)
This is a Phase 2b randomized, double-blind, placebo-controlled study evaluating the safety and efficacy of elagolix alone and in combination with add-back therapy versus placebo on heavy menstrual bleeding in premenopausal women…
- Trial name
- NCT01817530
- Testing
- Elagolix, 0.5 mg estradiol / 0.1 mg norethindrone acetate, 1 mg estradiol / 0.5 mg norethindrone acetate
- Volunteers
- 571 people
- Sponsor
- AbbVie
Influenza, Vaccination
Flu2Text: Text Message Reminders for 2nd Dose of Influenza Vaccine
This multi-site study assesses the impact of text message reminders on the receipt of the second dose of influenza vaccine, and takes place primarily in practices from the American Academy of Pediatrics (AAP) Pediatric Research…
- Trial name
- F2T (NCT03287830)
- Testing
- Text message influenza vaccine reminders
- Where
- 3 sites in United States
- Volunteers
- 2,105 people
- Sponsor
- Columbia University
Lennox-Gastaut Syndrome
Transcranial Direct Current Stimulation, Treatment of Childhood Drug-Resistant Lennox-Gastaut Syndrome, A Pilot Study
Background: Lennox-Gastaut syndrome (LGS) is a severe childhood epileptic syndrome with high pharmacoresistance. The treatment outcomes are still unsatisfied.
- Trial name
- NCT02731300
- Testing
- tDCS
- Volunteers
- 22 people
- Sponsor
- Khon Kaen University
Hemiplegia, Spastic, Spastic
Wearable Robotic System and Robotic Mirror Therapy in Spastic Hemiplegia Post Botulinum Toxin Injection
The purpose of this project is to examine and compare the immediate and long-term effects of combined Botulinum toxin type A(BoNT-A) injection with wearable robotic hand system (RT) and Robotic mirror therapy (RMT) in patients…
- Trial name
- NCT04826900
- Testing
- BoNT-A injections, Robotic therapy (RT), Robotic mirror therapy (RMT)
- Where
- Taiwan
- Volunteers
- 31 people
- Sponsor
- Chang Gung Memorial Hospital
Tobacco Use
Expanding the Click City Tobacco Prevention Program to Include E-cigarettes and Other Novel Tobacco Products
The goal of this study is to modify a smoking prevention program for 5th and 6th grade students to also target vaping e-cigarettes.
- Trial name
- NCT03682900
- Testing
- Click City®: Tobacco, Usual Tobacco Curriculum
- Where
- United States
- Volunteers
- 2,673 people, healthy volunteers welcome
- Sponsor
- Oregon Research Behavioral Intervention Strategies, Inc.
Overweight, Obesity
The Beneficial Effects of a Protein-rich Breakfast on Appetite Control & Cognition in Overweight and Obese Adolescents
The purpose of this study is to assess whether the daily addition of a protein-rich breakfast leads to beneficial changes in appetite control, food intake regulation,and cognitive function in overweight \& obese 'breakfast…
- Trial name
- NCT01192100
- Testing
- Breakfast Skipping, Normal Protein Breakfast Meals, Protein-rich Breakfast Meals
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Sickle Cell Disease, COVID-19
COVID-19 Vaccine Response in Sickle Cell Disease
The purpose of this study is to assess the antibody response to COVID-19 vaccination in a cohort of patients with sickle cell disease (SCD) and to assess vaccine and SCD related complications around the time of vaccination.
- Trial name
- NCT05139992
- Testing
- COVID-19 Vaccine
- Where
- 8 sites in United States
- Volunteers
- 59 people
- Sponsor
- ASH Research Collaborative
Healthy Adult Subjects
A Study to Investigate the PK, Safety, and Tolerability Between AVT05, US and EU Simponi® in Healthy Adult Participants
Rationale: Alvotech is developing AVT05 globally as a proposed biosimilar to the reference product Simponi (golimumab) for subcutaneous (SC) use. This is a first-in-human (FIH) clinical study with AVT05.
- Trial name
- NCT05632211
- Testing
- AVT05, Simponi
- Where
- 2 sites in New Zealand, United Kingdom
- Volunteers
- 336 people, healthy volunteers welcome
- Sponsor
- Alvotech Swiss AG
Rabies
Effect of Antimalarial Drugs to Rabies Vaccine for Post-exposure Prophylaxis.
This is an exploratory trial to evaluate the effect of antimalarial drugs on the immune response generated by rabies vaccine when administered for post-exposure prophylaxis.
- Trial name
- MALRAB (NCT02564471)
- Testing
- Chloroquine, Atovaquone and Proguanil, Doxycycline
- Where
- United States
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- State University of New York - Upstate Medical University
Obesity, Prostate Cancer
Weight Management Aimed to Reduce Risk and Improve Outcomes From Radical Prostatectomy
The purpose of this study is to test how a weight management program affects substances in the blood called biomarkers that can show the presence or severity of cancer, compared to a standardized diet and exercise educational…
- Trial name
- WARRIOR (NCT03261271)
- Testing
- Weight Loss Program, Standardized educational flyer, Weight Maintenance Program
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Kansas Medical Center
Asthma
Singulair(R) In Asthma And Allergic Rhinitis (0476-383)
Effectiveness of adding montelukast to inhaled corticosteroids in adult subjects with both uncontrolled asthma and allergic rhinitis.
- Trial name
- NCT00545844
- Testing
- montelukast sodium
- Volunteers
- 313 people
- Sponsor
- Organon and Co
Thromboembolic Events
Clinical Performance Evaluation of Pefakit® PiCT® UC In Vitro Diagnostic Medical Device
To demonstrate the substantial equivalence (SE) of Pefakit® PiCT® UC (test device, T) to aPTT-SP (Hemosil) (predicate device, P) in determining heparin levels in subjects undergoing heparin therapy in support of a United States…
- Trial name
- NCT02052544
- Where
- 3 sites in United States, Germany and 1 more
- Volunteers
- 123 people
- Sponsor
- dsm-firmenich Switzerland AG
Barrett's Esophagus
Detection of Barrett s Esophagus in Patients Without GERD Symptoms
The purpose of this study is to develop a method to detect Barrett's esophagus (BE) in individuals with a new office-based diagnostic test.
- Trial name
- NCT04880044
- Testing
- EsoCheck/EsoGuard (EC/EG), Esophago-gastro-duodenoscopy (EGD)
- Where
- United States
- Volunteers
- 132 people
- Sponsor
- Case Comprehensive Cancer Center
Neuroblastoma
Therapy for Children With Advanced Stage Neuroblastoma
Neuroblastoma is the most common extracranial solid tumor in childhood, with nearly 50% of patients presenting with widespread metastatic disease.
- Trial name
- NCT01857934
- Testing
- cyclophosphamide, topotecan, hu14.18K322A
- Where
- United States
- Volunteers
- 153 people
- Sponsor
- St. Jude Children's Research Hospital
Chronic Graft Versus Host Disease
Efficacy and Tolerability of Entospletinib in Combination With Systemic Corticosteroids as First-Line Therapy in Adults With Chronic Graft Versus Host Disease (cGVHD)
The primary objective of this study is to evaluate the effect of entospletinib (ENTO) on the best overall response rate in adults with chronic graft versus host disease (cGVHD) who are currently receiving systemic corticosteroids…
- Trial name
- NCT02701634
- Testing
- ENTO
- Where
- 30 sites in United States, Canada and 5 more
- Volunteers
- 66 people
- Sponsor
- Gilead Sciences
Chronic Cough
A Study of Gefapixant (MK-7264) in Adult Participants With Chronic Cough (MK-7264-027)
The main objectives of this study will be to evaluate the efficacy of gefapixant in reducing cough frequency as measured over a 24-hour period at Week 12, and to evaluate the safety and tolerability of gefapixant.
- Trial name
- NCT03449134
- Testing
- Gefapixant
- Where
- 156 sites in United States, Argentina and 15 more
- Volunteers
- 732 people
- Sponsor
- Merck Sharp & Dohme LLC
Tobacco Abstinence Syndrome
Efficacy Study of Intranasal Insulin to Treat Tobacco Abstinence Syndrome
This study will evaluate safety and efficacy of intranasal insulin in abstinent smokers. Groups' (placebo vs. insulin) cognitive function and stress response will be compared.
- Trial name
- NCT01781234
- Testing
- Intranasal Insulin
- Where
- United States
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Ajna Hamidovic
Substance Use Disorders, Posttraumatic Stress Disorder
SUPER Study (Substance Use and PTSD Treatment Effectiveness Research Study)
This study proposes a prospective program of research that will identify feasible and inexpensive methods to detect and treat comorbid PTSD among VA SUD patients, thereby improving substance abuse treatment outcomes.
- Trial name
- NCT00265564
- Testing
- Modified Seeking Safety integrated into std outpatient SUD care, Standard outpatient SUD care
- Where
- United States
- Volunteers
- 117 people
- Sponsor
- VA Office of Research and Development
Colorectal Cancer
Feasibility of Home-based Preoperative Exercise in Older People
The purpose of the study is to evaluate the feasibility of recruitment procedure, intervention including compliance and the collaboration between in- and out patient clinics of preoperative home-based exercise in older people…
- Trial name
- NCT02895464
- Testing
- Exercise
- Where
- Sweden
- Volunteers
- 23 people
- Sponsor
- Karolinska Institutet
Hemorrhagic Fever, Ebola
Long-term Safety Follow-up of Participants Exposed to the Candidate Ebola Vaccines Ad26.ZEBOV and/or MVA-BN-Filo
The purpose of the study is to assess the long-term safety profile of Ad26.ZEBOV and MVA-BN-Filo in participants previously exposed to these vaccines in Phase 1, 2, or 3 clinical studies.
- Trial name
- NCT02661464
- Testing
- Ad26.ZEBOV, MVA-BN-Filo
- Where
- 16 sites in United States, Burkina Faso and 5 more
- Volunteers
- 677 people, healthy volunteers welcome
- Sponsor
- Janssen Vaccines & Prevention B.V.