Clinical trials: ALLOGRAFT
Liver Transplantation
Assessment Of the Safety and Benefit of Prospective Immunosuppressive Drug Withdrawal in Liver Transplantation and Prediction of Operational Tolerance
In liver transplantation up to 20% of recipients can completely discontinue immunosuppressive therapy maintaining normal graft function, and are conventionally considered as operationally tolerant.
- Trial name
- NCT00647283
- Testing
- Gradual immunosuppression drug withdrawal
- Where
- Spain
- Volunteers
- 80 people
- Sponsor
- Hospital Clinic of Barcelona
Partial Meniscal Loss, Lateral Meniscus Partial Loss
Partial Meniscal Replacement with Spongioflex®
The purpose of this investigator-initiated trial is to evaluate whether the novel graft can prevent/reduce the disadvantages of the previously used replacement materials and shows better results than the group of patients, which…
- Conditions
- Partial Meniscal Loss, Lateral Meniscus Partial Loss, Medial Meniscal Partial Loss, Meniscus Lesion
- Trial name
- NCT06775197
- Testing
- partial meniscal replacement with Spongioflex®
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- Maria-Josef-Hospital Greven
Pancreas Transplantation, Kidney Transplantation
A Study To Compare Sirolimus Versus Tacrolimus In De Novo Simultaneous Pancreas- Kidney Allograft Recipients Receiving An Induction Therapy With Antithymocyte Globulin Plus Mycophenolate Mofetil Plus Corticosteroids
Experience with tacrolimus in pancreas transplantation has become a standard for immunosuppression in almost all pancreas centers over the world.
- Trial name
- NCT00693446
- Testing
- Sirolimus, Tacrolimus
- Where
- France
- Volunteers
- 118 people
- Sponsor
- Nantes University Hospital
Kidney Transplant
MMF vs. AZA for Kidney Transplantation
The Mycophenolate Steroid Sparing (MYSS) study demonstrated that, in the setting of a maintenance immunosuppressive regimen without steroids, mycophenolate mofetil (MMF) and azathioprine (AZA) provided the same efficacy in…
- Trial name
- ATHENA (NCT00494741)
- Testing
- mycophenolate mofetil, azathioprine
- Where
- 6 sites in Italy
- Volunteers
- 233 people
- Sponsor
- Mario Negri Institute for Pharmacological Research
Lymphoma
Reduced-Intensity Regimen Before Allogeneic Transplant for Patients With Relapsed Non-Hodgkin's or Hodgkin's Lymphoma
RATIONALE: Photopheresis allows patient white blood cells to be treated with ultraviolet (UV) light and drugs outside the body to inactivate T cells.
- Trial name
- NCT00057954
- Testing
- Extracorporeal Photopheresis, Pentostatin, Total body irradiation (TBI)
- Where
- 19 sites in United States
- Volunteers
- 6 people
- Sponsor
- Eastern Cooperative Oncology Group
Alveolar Ridge Preservation
Ridge Preservation in Molar Sites Comparing Xenograft Versus Mineralized Freeze-dried Bone Allograft
The objectives of the present investigation are; to compare the dimensional changes and the histological composition after the use of an allograft or xenograft and a resorbable membrane in ridge preservation in molar sites, to…
- Trial name
- NCT05107141
- Testing
- Ridge preservation, bone graft plus a collagen membrane
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Universitat Internacional de Catalunya
Infective Endocarditis, Heart Failure
Infective Endocarditis Surgery Using Conventional Prosthetic Valves Versus Cryopreserved Aortic Homograft
: Evidence suggested that autologous or allogeneic tissue is more suitable to synthetic material in an infected field. Given the unwillingness of some surgeons to use artificial foreign materials, such as conventional mechanical…
- Trial name
- IESCOPHO (NCT05253469)
- Testing
- Cryopreserved Aortic Homograft, Stented/Non stented xenograft, Mechanical prostheses
- Where
- France
- Volunteers
- 760 people
- Sponsor
- Centre Cardiologique du Nord
Musculoskeletal Deformity, Musculoskeletal Diseases
Customized Bone Allografts by 3D-printing
Virtual surgical planning (VSP), the simulation of bone corrections in virtual reality ("Computer Aided Surgical Simulation": CASS) and 3D printing of customized implants and devices are achieving an increasingly central role in…
- Conditions
- Musculoskeletal Deformity, Musculoskeletal Diseases, Musculoskeletal Disorder
- Trial name
- 3D-MALF 2 (NCT05700526)
- Testing
- Planning of multiplanar and/or multifocal osteotomies in children by using VSP, PSIs and customized structural bone allograft, Routine preparation of bone graft according to standard protocols, Preparation of bone graft with virtual bone-matching and GSIs
- Where
- Italy
- Volunteers
- 42 people
- Sponsor
- Istituto Ortopedico Rizzoli
Kidney Transplantation
The Long-term Effect of Marine Omega-3 Fatty Acid Supplementation in Renal Transplantation
This is a long-term intervention study on the effects of marine n-3 PUFAs in renal transplantation. Our hypothesis is that patients treated with marine n-3 PUFA supplementation will have less decline in kidney transplant function…
- Trial name
- EMiRA (NCT03018041)
- Testing
- Omacor
- Where
- 6 sites in Norway
- Volunteers
- 174 people
- Sponsor
- Joe Chan
Lung Transplant Failure and Rejection, CLAD, Bronchiolitis Obliterans
Plasma and Radiologic Biomarkers of Response to ECP in Lung Transplant Recipients With CLAD
This study is for people who have had a lung transplant and developed a condition called chronic lung allograft dysfunction (CLAD), which is a type of chronic rejection.
- Conditions
- Lung Transplant Failure and Rejection, CLAD, Bronchiolitis Obliterans, Extracorporeal Photopheresis
- Trial name
- NCT07434869
- Where
- 3 sites in United States
- Volunteers
- 25 people
- Sponsor
- Brian Keller
Cardiac Allograft Vasculopathy
Early Post Transplant Cardiac Allograft Vasculopathy
Heart transplantation is an effective life-saving treatment for patients with end-stage heart disease. After a transplant, the new heart may develop narrowing in the arteries, causing heart failure, heart attacks and abnormal…
- Trial name
- ECAV (NCT03217786)
- Where
- Canada
- Volunteers
- 80 people
- Sponsor
- Ottawa Heart Institute Research Corporation
Acute Lung Injury
Acute Lung Injury After Allogeneic Transplantation - Diagnosis and Early Treatment
Acute lung injury (ALI) is an early complication after allogeneic transplantation causing significant mortality and morbidity. Little is known on early markers and treatment of this complication.
- Trial name
- NCT00852605
- Testing
- Intermittent Non-Invasive Ventilation
- Volunteers
- 86 people
- Sponsor
- Technische Universität Dresden
Transplant;Failure,Kidney, Kidney Transplant Rejection
Impact of Microvascular Inflammation on Kidney Allograft Outcome
Graft microvascular inflammation poses a significant challenge to successful kidney transplantation due to its heterogeneous clinical presentation.
- Trial name
- NCT06496269
- Testing
- No intervention
- Where
- 19 sites in United States, France and 3 more
- Volunteers
- 6,000 people
- Sponsor
- Paris Translational Research Center for Organ Transplantation
Acute Myeloid Leukemia, Myelodysplastic Syndromes
Adding Venetoclax to the High-dose Chemotherapy Regimen Prior to Mismatche Allogeneic Stem Cell Transplant
Patients eligible for a mismatch allogeneic stem cell transplant will receive Venetoclax daily for 7 days prior to transplant in addition to the following chemotherapy regimen: Decitabine daily for 5 days, Fludarabine daily for 5…
- Trial name
- NCT06337331
- Testing
- Venetoclax, Decitabine, Fludarabine
- Where
- United States
- Sponsor
- Northside Hospital, Inc.
Cardiac Allograft Vasculopathy
Physiologic Assessment of Microvascular Function in Heart Transplant Patients
The aim of the study is to evaluate the impact of early microvascular disease assessed by coronary physiologic indices such as fractional flow reserve (FFR), coronary flow reserve (CFR), index of microvascular resistance (IMR) on…
- Trial name
- NCT02798731
- Where
- South Korea
- Volunteers
- 200 people
- Sponsor
- Samsung Medical Center
Varicose Ulcer, Venous Insufficiency
Amniotic Membrane Allograft Application in the Management of Venous Leg Ulcerations
The purpose of this study is to evaluate and compare healing characteristics, reduction in the size of the wound and to measure complete healing of the wound following the application of a biologic product dressing instead of the…
- Trial name
- AmnioExCel (NCT02929056)
- Testing
- AmnioExCel dressing and compression therapy, SOC alginate dressing and compression therapy
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Prisma Health-Upstate
Edentulous Alveolar Ridge, Edentulous Alveolar Ridge Atrophy
Freeze-dried Bone Allograft vs Autologous Bone Blocks in the Lateral Augmentation of the Jaws
After tooth loss, the alveolar ridge undergoes various modeling and remodeling processes, resulting in overall bone resorption. In case of extensive alveolar atrophy, bone volume must be restored before or during implant…
- Trial name
- NCT07104370
- Testing
- Bone augmentation using an autologous bone block, Bone augmentation using freeze-dried allograft block, preoperative cone beam computed tomography (CBCT)
- Where
- Hungary
- Volunteers
- 30 people
- Sponsor
- Semmelweis University
Bilateral Traumatic Amputation of Upper Limbs
Medical Economic Evaluation of Bilateral Allograft of Hands and Forearms
The double amputation of the forearms is a rare handicap that seriously impacts the autonomy and the quality of life of patients, social and familial exclusion, and dependence on third parties for everyday activities.
- Trial name
- ARMEDIC (NCT02797457)
- Testing
- Bilateral allograft of the hands and forearms., Prosthetic forehands
- Where
- 11 sites in France
- Volunteers
- 40 people
- Sponsor
- Hospices Civils de Lyon
Hernia of Abdominal Wall
Multi-Center Study To Examine The Use Of Flex HD® And Strattice In The Repair Of Large Abdominal Wall Hernias
The primary objective of this study is to examine and compare the outcomes associated with the use of Flex HD®, a human acellular dermal matrix (HADM), and Strattice™, a porcine acellular dermal matrix, (PADM) when used as a…
- Trial name
- NCT01987700
- Testing
- FLEX-HD, Strattice
- Where
- 3 sites in United States
- Volunteers
- 120 people
- Sponsor
- Musculoskeletal Transplant Foundation
Allogeneic Hematopoietic Stem Cell Transplantation
MLN9708 for the Prophylaxis of Chronic Graft-versus-host Disease in Patient Undergoing Allogeneic Transplantation
This is a phase I/II study of MLN9708 for the prophylaxis of chronic graft-versus-host-disease (GVHD) in patients undergoing allogeneic hematopoietic stem cell transplantation (HSCT).
- Trial name
- NCT02250300
- Testing
- MLN9708 (2.3 mg), MLN9708 (4.0 mg), MLN9708 (3.0 mg)
- Where
- United States
- Volunteers
- 68 people
- Sponsor
- Mehdi Hamadani
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