Clinical trials: ALLOGRAFT
Hopeless Tooth
Assessment of Dimensional Changes Following Grafting With Microfragmented Adipose Tissue Loaded on Allograft on Ridge Preservation
Evaluation of maxillary alveolar ridge changes (bone quantity and quality as revealed by radiographic and Histomorphometry ) utilizing microfragmented adipose tissue loaded on allograft versus allograft only for maxillary…
- Trial name
- NCT06636461
- Testing
- microfragmented adipose tissue loaded on allograft
- Where
- Egypt
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Cairo University
Disorder of Maxillary Sinus, Accessory; Bone
Comparative Study Between Lyophilized or Frozen Bone Allografts for Sinus-lifting
Bone resorption and atrophy in maxillary posterior region is due to severe periodontal disease and is consequent tooth extractions. Sinus pneumatisation can occur after tooth extraction and alveolar bone loss.
- Conditions
- Disorder of Maxillary Sinus, Accessory; Bone, Bone Atrophy
- Trial name
- NCT02583737
- Testing
- freeze bone allograft, lyophilized bone allograft
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Chronic Myeloproliferative Disorders, Graft Versus Host Disease
Sargramostim in Reducing Graft-Versus-Host Disease in Patients Who Are Undergoing Donor Stem Cell Transplantation for Hematologic Cancer or Aplastic Anemia
RATIONALE: Colony-stimulating factors such as sargramostim may increase the number of immune cells found in bone marrow or peripheral blood and may help a person's immune system recover from the side effects of chemotherapy or…
- Conditions
- Chronic Myeloproliferative Disorders, Graft Versus Host Disease, Leukemia, Lymphoma
- Trial name
- NCT00053157
- Testing
- sargramostim
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Roswell Park Cancer Institute
Periodontal Diseases
Regenafil Versus Demineralized Freeze Dried Bone Allograft (DFDBA) for Periodontal Defects
The purpose of this research study was to determine whether treatment with the bone grafting material Regenafil was as effective as the standard treatment using demineralized freeze dried bone allograft (DFDBA).
- Trial name
- NCT00255970
- Testing
- DFDBA, Regenafil
- Where
- 2 sites in United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- RTI Surgical
Graft vs Host Disease, Kidney Transplantation
Study Evaluating Sirolimus in Kidney Transplant Recipients
The purpose of this study is to compare the kidney function in patients who have received a transplanted kidney and were treated with the combination of sirolimus, daclizumab, mycophenolate and corticosteroids versus transplanted…
- Trial name
- NCT00195273
- Testing
- sirolimus, cyclosporine, mycophenolate mofetil
- Where
- 3 sites in Norway, Sweden
- Volunteers
- 61 people
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Renal Allograft Fibrosis
Renal Allograft Fibrosis Study
Despite the reduction in acute rejection episodes in renal transplant patients due to modern immunosuppression, proportionate improvements in long-term allograft survival have not been achieved.
- Trial name
- NCT05058170
- Where
- 2 sites in United States
- Volunteers
- 162 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Allograft, Post-allograft Relapse
RElapse After Allograft: Link Between LoCus of Control and QualiTy of Life
Allogeneic hematopoietic transplantation (AlloHCT) is a robust therapeutic that is used as a consolidation strategy in a number of haematological cancers. It provides durable responses as compared to chemotherapy alone.
- Trial name
- REACT (NCT05258929)
- Testing
- Data collection (Prior and planned treatments, allograft)
- Where
- France
- Volunteers
- 3 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Kidney Failure, Chronic, Transplantation
Fibrosis in Renal Allografts
This prospective, randomized study, comparing sirolimus to cyclosporine in renal transplant recipients, has two major objectives: 1.
- Conditions
- Kidney Failure, Chronic, Transplantation, Immunosuppression, Interstitial Fibrosis
- Trial name
- NCT00493194
- Testing
- sirolimus, cyclosporine, daclizumab
- Where
- 3 sites in Belgium
- Volunteers
- 100 people
- Sponsor
- University Hospital, Antwerp
Diabetes, Kidney Transplantation
Islet Transplantation in Type 1 Diabetic Recipients of Kidney Transplants
Study hypothesis is that we can reproduce results of islet transplantation in type one diabetics in patients with a kidney transplant.
- Trial name
- NCT00288977
- Testing
- Islet Infusion
- Volunteers
- 8 people
- Sponsor
- Beth Israel Deaconess Medical Center
Alveolar Ridge Augmentation
Ridge Augmentation Without Primary Closure
This study is designed to compare the clinical and histologic results of ridge augmentation with and without primary closure over the barrier membrane.
- Trial name
- NCT01901783
- Testing
- With primary closure, Without primary closure
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Louisville
Kidney Transplantation
Rituximab for Pediatric Renal Transplant Rejection
Rituximab will be tested for its safety and potential efficacy in treating B cell dense renal allograft rejection episodes in children receiving renal transplants at Stanford University
- Trial name
- NCT00697996
- Testing
- Rituximab for transplant rejection
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Stanford University
B-ALL
The Use of Blinatumomab in Patients With NGS-MRD Relapsed B-ALL After Autologous/Allogeneic Transplantation
To explore the efficacy and safety ofblinatumomab± TKI in B-ALL patients aged ≥ 14 years with NGS-MRD relapse (sensitivity: 10-6) after auto/allo HSCT, and to observe the disease-free survival (DFS), recurrence rate and toxicity…
- Trial name
- NCT06504186
- Testing
- Blinatumomab
- Volunteers
- 20 people
- Sponsor
- Institute of Hematology & Blood Diseases Hospital, China
AML - Acute Myeloid Leukemia, MDS (Myelodysplastic Syndrome)
Evaluation of Treosulfan Versus Melphalan Conditioning Followed by PTCy in Patients With AML and MDS Undergoing Allogeneic Transplantation
The aim of this study is to compare the effectiveness and tolerability of two conditioning chemotherapies prior to allogeneic stem cell transplantation.
- Trial name
- RELEVANT (NCT07025824)
- Testing
- Treosulfan (Treo), Melphalan (Mel), Fludarabine (Flud)
- Where
- 17 sites in Germany
- Volunteers
- 220 people
- Sponsor
- Technische Universität Dresden
Acute Myeloid Leukaemia, Myelodysplasia
Clofarabine Pre-conditioning With Allogeneic Transplant for Acute Myeloid Leukaemia (AML)
This study has been designed to investigate the safety and feasibility of using a chemotherapy drug, Clofarabine, to reduce the disease burden before a donor transplant, in patients with high risk Acute Myeloid Leukaemia or…
- Trial name
- NCT01422603
- Testing
- Clofarabine
- Where
- United Kingdom
- Volunteers
- 9 people
- Sponsor
- University Hospital Southampton NHS Foundation Trust
Liver Transplantation
Sequential Therapy (FK506 + Monoclonal Anti-IL2R Antibodies + MMF) Versus FK506 With Steroids in Liver TX
Study to evaluate the benefits and any risks of the delayed administration of tacrolimus in a combined regimen of mycophenolate mofetil and monoclonal anti-IL2R antibodies (daclizumab), in comparison with a standard steroid +…
- Trial name
- TAST (NCT00693524)
- Testing
- tacrolimus, Anti-IL2R AB, Mycophenolate mofetil
- Where
- 8 sites in Italy
- Volunteers
- 94 people
- Sponsor
- Astellas Pharma Inc
Vertebral Body Compression Fracture(s)
Biological Allograft Chain Tissue Implant
A prospective, multi-center study evaluating allograft tissue as a bone void filler when implanted with Lenoss Medical manual surgical instrumentation in patients with painful vertebral compression fractures.
- Trial name
- NCT04064710
- Testing
- Vertebral Body Augmentation, Manual Surgical Instruments
- Where
- 5 sites in United States
- Volunteers
- 26 people
- Sponsor
- Lenoss Medical
Breast Cancer
Allogeneic Transplantation Using Mini-Conditioning for Treatment of Stage IV Breast Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Peripheral stem cell transplantation may be able to replace immune cells that were destroyed by chemotherapy.
- Trial name
- NCT00006261
- Testing
- therapeutic allogeneic lymphocytes, cyclophosphamide, docetaxel
- Where
- United States
- Sponsor
- Case Comprehensive Cancer Center
Heart Transplant
Multimodal Imaging Evaluation and Prognostic Analysis of Cardiac Allograft Vasculopathy in Heart Transplantation
The aim is to (1) establish a system of multimodal imaging technology; (2) jointly apply multimodal imaging technology to diagnose of cardiac allograft vasculopathy of heart transplantation; (3) construct a multimodal imaging…
- Trial name
- NCT04966988
- Volunteers
- 1,000 people
- Sponsor
- Xie Mingxing
Liver Cirrhosis, Early Allograft Dysfunction
Intraoperative Assessment of Microcirculatory Function Using Vascular Occlusion Test During Liver Transplantation
Early allograft dysfunction (EAD) remains one of the most important complications following orthotopic liver transplantation (OLT).
- Trial name
- NCT07658794
- Where
- Greece
- Volunteers
- 50 people
- Sponsor
- Ippokrateio General Hospital of Thessaloniki
Kidney Allograft Fibrosis, Kidney Transplant Failure and Rejection
Urinary Transglutaminase 2 as a Biomarker for Kidney Allograft Fibrosis
The aim of this study is to verify the ability of transglutaminase type 2 to predict rejection or chronic allograft nephropathy of renal allograft.
- Trial name
- NCT03487861
- Testing
- observational(urinary biomarker for kidney allograft fibrosis)
- Where
- South Korea
- Volunteers
- 1,000 people
- Sponsor
- Asan Medical Center
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