Clinical trials: AMD
Eye Diseases, Ophthalmic Trauma
Mitochondrial DNA in Vitreous Fluid and Blood in Patients With Eye Disease or Ocular Trauma.
This study is to characterize mitochondrial DNA (mtDNA) populations in adults with eye injuries and eye diseases. The eye exam is often hindered by the clouding of tissues involved in injury or disease.
- Conditions
- Eye Diseases, Ophthalmic Trauma, Mitochondrial DNA, Age Related Macular Degeneration
- Trial name
- NCT04334499
- Testing
- Sample collection from tissue discard
- Volunteers
- healthy volunteers welcome
- Sponsor
- The University of Texas Medical Branch, Galveston
Diabetic Retinopathy (DR), Age-related Macular Degeneration (AMD)
Photobiomodulation & Ketogenic Diet for Treatment of Mid-periphery Retinal Disorders for Alzheimer's Disease Prevention
The study will explore the impact of photobiomodulation (PBM), pulsating at frequencies of red (660nm) and near-infrared (810nm)(NIR), concurrent with a ketogenic dietary protocol (serum ketones @ .5 - 2.0 mmol/L) to mediate…
- Conditions
- Diabetic Retinopathy (DR), Age-related Macular Degeneration (AMD), Mid-peripheral Drusen Formation, Diabetic Macular Edema (DME)
- Trial name
- NCT03859245
- Testing
- Photobiomodulation, Ketogenic diet
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Bristlecone Health, Inc.
Age-Related Macular Degeneration
The Role of Inflammation in AMD and Related Disorders
This prospective, non-therapeutic study will compare the relative utility of multiple ocular imaging modalities in the detection of the cellular immune response in patients with AMD and related disorders.
- Trial name
- NCT02588378
- Testing
- multi-modal cSLO imaging
- Where
- Canada
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Age-Related Macular Degeneration
Genetic Study of Age-Related Macular Degeneration
This study will examine skin and blood cells for genetic changes related to the development of age-related macular degeneration, an eye disease that can significantly impair the ability to read, drive, and carry out daily…
- Trial name
- NCT00357578
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- National Eye Institute (NEI)
Macular Degeneration
Study Of The Repeat Dosing Of Ketoconazole On The Pharmacokinetics Of A Single Dose Of Pazopanib (GW786034) Eye Drops
This is a two-period study to evaluate the effect of repeat oral dosing of ketoconazole on the pharmacokinetics of single dose pazopanib administered as an eye drop
- Trial name
- NCT00659555
- Testing
- pazopanib eye drops, Ketoconozole tablets
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Age-Related Macular Degeneration
Size Progression of Macular Degeneration After Cataract Surgery
The purpose of this study was to find out if in patients with non-exudative age-related macular degeneration (AMD), randomly assigned to cataract surgery, any AMD size progression or progression to exudative AMD could be detected…
- Trial name
- NCT01165801
- Testing
- Cataract Surgery
- Where
- Austria
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- The Ludwig Boltzmann Institute of Retinology and Biomicroscopic Laser Surgery
Stargardt Disease
A Study of DC6001 Tablet in Healthy Chinese Adult Subjects
This study adopts a randomized, double-blind, parallel placebo-controlled dose-escalation design, consisting of two parts: Part 1 includes a single ascending dose (SAD) study plus a food effect (FE) study, and Part 2 is a…
- Trial name
- NCT07417566
- Testing
- DC6001
- Where
- China
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Heronova Pharmaceuticals
Neovascular Age Related Macular Degeneration
NVAMD Satellite Study
Intravitreal delivery of anti-vascular endothelial growth factor (VEGF) drugs has revolutionized the management of neovascular age-related macular degeneration (NVAMD).
- Trial name
- NCT02251366
- Testing
- Physician-guided diagnostic
- Where
- 5 sites in United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Macular Degeneration
A Safety Study in Healthy Volunteers to Evaluate Safety, How Fast the Drug is Absorbed, and the Side Effects of the Drug in Humans
This study is to evaluate the safety, absorption rate and side effects associated with the study drug. Healthy volunteers will be given a single dose of the drug in Part 1.
- Trial name
- NCT01051700
- Testing
- GW786034
- Where
- 3 sites in United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Uveitis, Iritis
Retinal OCT and (mfERG) Related to Age, Sex, and the Use of Anti-inflammatory Medications
Retinal optical coherence tomography (OCT) is an established technology which enables a detailed cross-sectional visualization of the retinal micro-anatomy, and an objective measurement of its thickness in-vivo.
- Conditions
- Uveitis, Iritis, Iridocyclitis, Anterior Uveitis
- Trial name
- NCT00476593
- Testing
- Diclofenac, Dexamethasone
- Where
- 2 sites in Norway
- Volunteers
- 218 people, healthy volunteers welcome
- Sponsor
- Norwegian University of Science and Technology
Aged Macular Degeneration
Omega-3-fatty Acids on Age-related Macular
Aim: To demonstrate the short-term multi focal electroretinogram (mfERG) effect of oral omega-3-fatty acids in the triglyceride form on dry age-related macular degeneration (AMD).
- Trial name
- Omega 3 (NCT01258335)
- Testing
- Omega 3, Olive Oil
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Mid Atlantic Retina
Age-related Macular Degeneration
Visual Remapping to Aid Reading With Field Loss
Reading performance in patients with Central Vision Loss and age matched controls with artificial scotomas will be measured with and without different kinds of remapping of missing text to different parts of the visual field.
- Trial name
- NCT03848663
- Testing
- Traditional Remapping, Personalized Remapping
- Where
- United States
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Cornea, Retina
Spectral-domain Optical Coherence Tomography of the Eye
An increasing number of clinical studies on SD-OCT of ocular pathologies and potential new clinical applications has recently been published in the peer-reviewed literature.
- Conditions
- Cornea, Retina, Refractive Surgery, Macular Edema
- Trial name
- NCT02614625
- Where
- Austria
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Augenabteilung Allgemeines Krankenhaus Linz
Retinal Drusen, Age-related Macular Degeneration
Evaluation of a New Eye-specific Multivitamin Formula in Participants at Risk of Age-related Macular Degeneration (AMD)
The aim of this study is to evaluate the clinical benefits in visual function from dietary supplementation of the Lumega-Z carotenoid liquid-supplement in participants with drusen and at risk of AMD.
- Conditions
- Retinal Drusen, Age-related Macular Degeneration, Macular Degeneration
- Trial name
- AMD (NCT03946085)
- Testing
- Lumega-Z, AREDS2
- Where
- United States
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- Guardion Health Sciences, Inc.
Age-Related Macular Degeneration
LOC387715/HTRA1 Variants in Polypoidal Choroidal Vasculopathy in a Korean Population
This study is to investigate whether variants in the LOC387715 locus and the HtrA serine peptidase 1 (HTRA1) gene within the 10q26 locus are associated with polypoidal choroidal vasculopathy and whether they are associated with…
- Trial name
- PCV (NCT01108250)
- Testing
- LOC387715/HTRA1 genotyping
- Where
- South Korea
- Volunteers
- 215 people, healthy volunteers welcome
- Sponsor
- Kyungpook National University Hospital
Choroidal Neovascularization, Age Related Macular Degeneration
SD-OCT-guided Intravitreal Ranibizumab Treatment in Choroidal Neovascularization Due to Myopia
This investigator initiated pilot study is designed to investigate the efficacy and safety of SD-OCT-guided intravitreal ranibizumab treatment in choroidal neovascularization (CNV) due to myopia.
- Trial name
- NCT03409250
- Testing
- Ranibizumab, Lucentis
- Where
- Switzerland
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Vista Klinik
Macular Edema, CNV
Evaluation of Retinal Structure With High Resolution Optical Coherence Tomography (OCT)
Comparison of different OCT instruments to assess retinal thickness, correlation to fluorescein angiography, and visual outcome after therapy with anti-VEGF therapy
- Trial name
- NCT00564291
- Testing
- Examination with an OCT device
- Where
- 2 sites in Switzerland
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- Sebastian Wolf
Diabetic Retinopathy, Age-Related Macular Degeneration (AMD)
Genetics and Markers of Degenerative and Inflammatory Eye Diseases
This study will identify genes that are associated with inflammation or degeneration of the retina (membrane lining the back of the eye that relays vision signals to the brain).
- Conditions
- Diabetic Retinopathy, Age-Related Macular Degeneration (AMD), Uveitis
- Trial name
- NCT00647439
- Where
- United States
- Volunteers
- 609 people, healthy volunteers welcome
- Sponsor
- National Eye Institute (NEI)
Age Related Macular Degeneration, Geographic Atrophy
Project AMD: Comprehensive Characterisation of Age-Related Macular Degeneration and Its Progression
Age-related macular degeneration (AMD) is the leading cause of irreversible vision loss worldwide, and nearly two million Australians have some signs of AMD.
- Conditions
- Age Related Macular Degeneration, Geographic Atrophy, AMD, Age-related Macular Degeneration
- Trial name
- Project AMD (NCT04739319)
- Testing
- N/A Observational study
- Where
- Australia
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- Center for Eye Research Australia
Macular Degeneration, Age-Related, Diabetic Retinopathy
Visual Enhancement Device in Low Vision Patients
This study will be a prospective, non-randomized study of low-vision individuals diagnosed with either age-related macular degeneration (AMD) or diabetic macular edema with ETDRS visual acuity from 20/60 to 20/400 in both eyes…
- Trial name
- Evergaze (NCT03794752)
- Testing
- Head-Mounted Visual Enhancement Device
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center