Clinical trials: ANS Function
Anxiety, Hypertension
Anxiety-mediated Impairments in Large Elastic Artery Function and the Autonomic Nervous System
The goal of this study is to evaluate the effectiveness of a short-term (4 weeks) pharmacological blockade of sympathetic nerve activity (clonidine) on anxiety symptoms, vascular function, inflammation, muscle sympathetic nerve…
- Trial name
- ATLAS (NCT03109795)
- Testing
- Clonidine Pill, Hydrochlorothiazide
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University of Iowa
Stress
Time, Touch, Attention and the Autonomic Nervous System
The purpose of this study is to describe the onset, duration and dose-response of interpersonal mindful compassion on respiratory rate and heart rate variability in healthy adults in order to prepare for research evaluating the…
- Trial name
- NCT01428674
- Testing
- Interpersonal Mindful Compassion with Touch, Reading while extending loving kindness
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Wake Forest University
Vascular Health, Autonomic Function
Vascular and Neuro-inflammatory Effects of Endurance Exercise Training in African Americans
The purpose of this study is to test the effects of endurance exercise training on arterial structure and function, and to examine potential mechanisms producing changes in arterial structure and function in young (18-35 years of…
- Trial name
- VINE (NCT01024634)
- Testing
- Endurance Exercise
- Where
- United States
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Urbana-Champaign
Functional Gastrointestinal Disorders (FGIDs), Cyclic Vomiting Syndrome
Autonomic Reactivity and Personalized Neurostimulation
Disorders of gut-brain interaction (DGBI) affect up to 25% of U.S. children. Patients often suffer from disabling, multisystem comorbidities that suggest a common root (sleep disturbances, fatigue, anxiety, etc).
- Conditions
- Functional Gastrointestinal Disorders (FGIDs), Cyclic Vomiting Syndrome, Functional Dyspepsia, Dysautonomia
- Trial name
- NCT06863207
- Testing
- Percutaneous electrical nerve field stimulation, Hypnotherapy
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Medical College of Wisconsin
Atrial Fibrillation
Effects of Exercise Training in Patients With Permanent Atrial Fibrillation
Atrial fibrillation (AF) is a common arrhythmia. The proposed patholophysiological mechanisms of AF include abnormal electrical conduction in atrium and sympathovagal imbalance with increased vagal tone.
- Trial name
- NCT01721863
- Testing
- Exercise training
- Where
- Taiwan
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Obesity, Pre-hypertension
Low-intensity Resistance Exercise and Diet on Arterial Function and Blood Pressure
Obesity is a major risk factor for premature arterial abnormalities including high blood pressure and increased stiffness. Previous studies have shown that weight loss via lifestyle modifications is associated with a decrease in…
- Conditions
- Obesity, Pre-hypertension, Hypertension
- Trial name
- NCT01371370
- Testing
- Resistance exercise training, Hypocaloric diet, Resistance exercise training & diet
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Florida State University
Immune System Processes, Inflammatory Activation and Modulation
The Sounds of Compassion: Testing How Specific Elements of Meditation Change Daily Life
Important health benefits of meditation may be conferred as much by what people actually do and say in their daily lives as by how they self-perceive the effect of training on their behavior and emotions.
- Conditions
- Immune System Processes, Inflammatory Activation and Modulation, ANS Function
- Trial name
- NCT01643369
- Testing
- Cognitive-Based Compassion Training, Adult Health Education Curriculum, Mindful Attention Training
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Arizona
Irritable Bowel Syndrome, Colonic Diseases, Functional
fMRI and Visceral Perception Upon Capsaicin Infusion
Brain imaging has shown abnormal brain activations in response to visceral stimulation in patients with the Irritable Bowel Syndrome (IBS) and Functional Dyspepsia (FD).
- Conditions
- Irritable Bowel Syndrome, Colonic Diseases, Functional, Dyspepsia, Gastrointestinal Diseases
- Trial name
- NCT02551029
- Testing
- Capsaicin
- Where
- Netherlands
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Ageing, Aerobic Exercise
Acute Exercise Effects on Arterial Stiffness and Cardiovagal Modulation in Adults
Background and Gap: The physiological importance of large artery distensibility in cardiovascular function is well-established. Stiffening of central arteries leads to elevated systolic blood pressure (SBP), increased left…
- Conditions
- Ageing, Aerobic Exercise, Resistance Exercise, Combined Exercise
- Trial name
- PUMPING ARTERY (NCT06616428)
- Testing
- Bike group fitness class, Pump Power, Global Training
- Where
- Portugal
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Egas Moniz - Cooperativa de Ensino Superior, CRL
Cardiovascular Reactivity to Stress
Effects of Yoga on Heart Rate and Heart Rate Variability Responses to Stress
Introduction: Yoga has been shown to reduce stress and have benefits for a number of stress-related disorders. However, the effects of an acute bout of yoga practice on cardiac autonomic response to and recovery from stress…
- Trial name
- NCT04897230
- Testing
- Hatha Yoga, Video Watching
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Kaohsiung Medical University Chung-Ho Memorial Hospital
Vagus Nerve Stimulations, Spirometry
Transcutaneous Auricular Vagus Nerve Stimulation and Spirometry: Sham-Controlled Randomized Trial
This study will examine the short-term effects of transcutaneous auricular vagus nerve stimulation (a non-invasive electrical stimulation delivered through the outer ear) on lung function measured by spirometry in healthy adults.
- Conditions
- Vagus Nerve Stimulations, Spirometry, Autonomic Nervous System (ANS) Functioning and Mood State, Blood Pressure Monitoring
- Trial name
- taVNS-SPIRO (NCT07482930)
- Testing
- Transcutaneous auricular vagus nerve stimulation
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- SEFA HAKTAN HATIK
Neuropathic Pain, Depression
The Effect of Diet on Chronic Inflammation and Related Disorders Following Spinal Cord Injury
Spinal cord Injury (SCI) is a condition commonly associated with a state of chronic low-grade inflammation due to a variety of factors such heightened risk for infection and development of metabolic disorders.
- Conditions
- Neuropathic Pain, Depression, Cognitive Impairment, Somatic Neuropathy
- Trial name
- NCT02099890
- Testing
- Omega-3, Vegetation Protein Powder, InflanNox
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Brock University
Laser Acupuncture, Meridian
The Effect of Laser Acupuncture in Different Meridians on the Autonomic Nervous System and Its Brain Mechanisms
Traditional Chinese acupuncture has a history of several thousand years. The World Health Organization has published guidelines describing the efficacy of acupuncture in the cure or relief of 64 different symptoms and conditions…
- Conditions
- Laser Acupuncture, Meridian, Heart Rate Variability, Brain Mechanism
- Trial name
- NCT05458713
- Testing
- Laser acupuncture
- Where
- Taiwan
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- China Medical University, Taiwan
Complex Regional Pain Syndromes
Physical and Psychological Changes in CRPS Patients Undergoing Multimodal Rehabilitation
The goal of this clinical trial is to learn about cognitive changes during rehabilitation in CRPS patients. The main questions it aims to answer are: What are the cognitive changes in CRPS? Do cognitive functions change during…
- Trial name
- NCT05696587
- Testing
- Multimodal rehabilitation
- Where
- Poland
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- National Institute of Geriatrics, Rheumatology and Rehabilitation, Poland
Healthy
Effects of Low Doses of Caffeine on Mood, Physiology and Mental Function
It is often assumed that levels of caffeine found in 'decaffeinated' beverages are below any psychopharmacological threshold. However, recent findings indicate that caffeine doses as low as 9 mg may be psychoactive.
- Trial name
- NCT00487227
- Testing
- caffeine
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Northumbria University
Type 2 Diabetes Mellitus
GLP-1 and Hypoglycemia
Low blood sugar can negatively affect how blood vessels function, and this can lead to an increase in the risk for heart attacks, strokes and other problems related to the stiffening and blockage of blood vessels.
- Trial name
- NCT01858896
- Testing
- Glucagon-Like Peptide- 1 (GLP-1) infusion
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Chronic Pain
Microneurography and Spinal Cord Stimulation in Chronic Visceral Pain
The purpose of this study is to assess the effect of the spinal cord stimulator (A small wire is surgically implanted under the skin.
- Trial name
- AFTSCSCVP (NCT00678717)
- Testing
- Autonomic Evaluation
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Hot Flashes, Menopause
Hot Flashes and Neurovascular Function in Women
Women who experience hot flashes are at greater risk for hypertension and other cardiovascular disease. Neurovascular control mechanisms are likely to play an important role in this relationship.
- Conditions
- Hot Flashes, Menopause, Vasomotor System; Labile
- Trial name
- NCT05193968
- Testing
- Sympathoexcitatory stressors, Sodium Nitroprusside, Acetylcholine
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Pain
The Effects of Pain and the Memory of Pain on Autonomic and Neuromuscular Function
The prevalence of chronic pain has been estimated at 30% in the US and these values may under report the true prevalence of people who experience long term pain as additional research has shown that 73% will have a reoccurrence…
- Trial name
- NCT02269384
- Testing
- Experimental Noxious Stimulus, Memory of Experimental Noxious Stimulus, Memory of Prior Significant Injury
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Mount St. Mary's College, Los Angeles, CA
Mood Modulation, Modulation of Cognition
Investigation of the Acute Cognitive, Mood and Autonomic Effects of Hops in Healthy Participants
Hops have been used for many years for their supposed sedative and anxiety reducing properties and can be found in many natural remedies for stress, anxiety and sleeping that are already available to buy.
- Trial name
- NCT01376869
- Testing
- Hops Extract
- Where
- United Kingdom
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Northumbria University