Clinical trials: ANS Function
Spinal Cord Injuries, Autonomic Imbalance
Deciphering Preserved Autonomic Function After Spinal Cord Injury
This study looks to characterize gradients of dysfunction in the autonomic nervous system after spinal cord injury. The autonomic nervous system plays key roles in regulation of blood pressure, skin blood flow, and bladder…
- Conditions
- Spinal Cord Injuries, Autonomic Imbalance, Autonomic Dysreflexia, Orthostatic Hypotension
- Trial name
- NCT04493372
- Testing
- Tests of sympathetic inhibition, Tests of sympathetic activation, Testing of autonomic dysreflexia
- Where
- United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Atrial Fibrillation
Relationship Between Autonomic Central Nervous System Activation and Atrial Fibrillation Using Functional MRI (fMRI)
The fMRI study is a prospective study with the objective of evaluating the effects of the autonomic central nervous system on the regulation of heart rate in patients with atrial fibrillation (AF).
- Trial name
- fMRI (NCT02524028)
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of Utah
Pain Perception, Autonomic Nervous System Functioning
Music-based Intervention for the Reduction of Pain
This study aims to compare the impact of listening to frequency-modulated music vs. non-modulated music (both researcher-selected), and to test whether there are differential effects on pain and stress perception.
- Trial name
- MINTREP (NCT02991014)
- Testing
- researcher-selected frequency-modulated music, researcher-selected non-modulated music, participant-selected non-modulated music
- Where
- 2 sites in Austria, Germany
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Vienna
Hypoglycemia, Healthy
Hypoglycemia and Autonomic Nervous System Function-B
This study tests the hypothesis that, compared to prior normal blood sugar, prior low blood sugar impairs cardiovascular autonomic function.
- Trial name
- HypoANS-B (NCT03429946)
- Testing
- Spironolactone, Hypoglycemic Hyperinsulinemic Clamp, Euglycemic Hyperinsulinemic Clamp
- Where
- 2 sites in United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Concussion, Mild, Autonomic Nervous System
Acute Nerve Stimulation For Enhancing Human and Cognitive Performance
The goal of this clinical trial is to test a wearable device's effect on performance in tactical populations with a history of concussion.
- Conditions
- Concussion, Mild, Autonomic Nervous System, Cognitive
- Trial name
- NCT05675956
- Testing
- Experimental group with 100% intensity setting on Apollo Neuro device, Active Comparator group with 10% intensity setting on the Apollo Neuro device
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University of South Carolina
Autonomic Dysfunction
Low-intensity Focused Ultrasound and Autonomic Response
Studying the effects of Low Intensity Focused Ultrasound (LIFU) to the dorsal posterior insula (dPI) and dorsal anterior cingulate cortex (dACC) on autonomic control using a test to probe the autonomic system.
- Trial name
- NCT05834829
- Testing
- Low-intensity focused ultrasound neuromodulation
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Virginia Polytechnic Institute and State University
Parkinson Disease, Autonomic Dysfunction
Parkinson's Autonomic Responses to Treadmill Walking
This study will compare examine autonomic and cardiovascular responses to peak exercise testing in Parkinson's disease patients in varying stages of the disease, and healthy, age-matched participants.
- Trial name
- NCT03156400
- Testing
- Exercise Stress Test
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Miami
Diseases, Metabolic, Insulin Sensitivity
Comparing Soybean Oil-Based (Intralipid) With an Olive Oil-Based (ClinOleic) Lipid Emulsion on Healthy Volunteers
Many patients in the hospital who are malnourished or not eating received intravenous feeding or total parenteral nutrition (TPN). Despite improving nutrition, TPN may increase the risk of infections and hospital complications.
- Trial name
- TPN1 (NCT02185729)
- Testing
- Intralipid, ClinOleic, Dextrose
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Emory University
Cardiovascular Autonomic Neuropathy
Clinical Validation of a Cardiovascular Autonomic Nervous Function Multi-Parameter Evaluation System
This is a open-label, randomized, paired design, multicenter study of the Cardiovascular Autonomic Nervous Function Multi-Parameter Evaluation System (R6000) for evaluating cardiovascular autonomic neuropathy.
- Trial name
- CARTS (NCT06447896)
- Testing
- Cardiovascular Autonomic Nervous Function Multi-Parameter Evaluation System (Model: R6000), Conventional method of CARTs, Ambulatory holter station Model i12 plus
- Volunteers
- 235 people, healthy volunteers welcome
- Sponsor
- REEM (Shenzhen) Healthcare Co., Ltd
Irritable Bowel Syndrome, Inflammatory Bowel Disease (IBD)
Cognition and Emotion in the SII and IBD
The study aims at showing that the susceptibility in the stress is more raised at the person affected digestive pathologies (SII or IBD) in forgiveness than healthy subjects.
- Conditions
- Irritable Bowel Syndrome, Inflammatory Bowel Disease (IBD), Crohn's Disease(CD), Ulcerative Colitis
- Trial name
- EMOTION (NCT01095042)
- Testing
- emotion
- Where
- France
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Obesity, Pre-hypertension
Whole Body Vibration Combined With L-citrulline Supplementation on Cardiovascular Function and Body Composition
Arterial dysfunction contributes to the development of cardiovascular disease (CVD), which is currently afflicting millions of individuals.
- Conditions
- Obesity, Pre-hypertension, Hypertension
- Trial name
- NCT02143817
- Testing
- L-citrulline supplementation, Whole Body Vibration Training
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Florida State University
Psychophysiological Reactivity and Recovery
Physiology of Liberation
This academic study examines how everyday experiences are related to short-term physiological reactivity and recovery and whether one or more brief standardized mindfulness/attention-instruction sessions change these patterns.
- Trial name
- NCT07780266
- Testing
- Brief Standardized Mindfulness/Attention Instruction
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Boston University Charles River Campus
Episodic Migraine, Chronic Migraine
CGRP Inhibition, Autonomic Function, and Migraine
The purpose of this clinical study is to better understand the function of the autonomic nervous system in patients with migraine. We aim to understand whether the autonomic functions change depending on the migraine status (i.e.
- Trial name
- CGRP-1 (NCT04628429)
- Testing
- Erenumab, Galcanezumab, Fremanezumab
- Where
- Austria
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Obesity, Pre-hypertension
The Effects of Stretching Training on Arterial Function and Autonomic Control
Hypertension is a major risk factor for cardiovascular disease. Hypertension and abdominal obesity are associated with dysfunction of the main mechanisms of cardiovascular regulation, the autonomic nervous system and the vascular…
- Conditions
- Obesity, Pre-hypertension, Hypertension
- Trial name
- NCT01741766
- Testing
- Stretching Training
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Florida State University
Dysmenorrhea, Dysmenorrhea Primary
A Research Study Exploring How Musculoskeletal Function and the Autonomic Nervous System Relate to Visceral Pain in Women With and Without Dysmenorrhea (Painful Periods).
The purpose of this clinical trial is to determine if women with dysmenorrhea demonstrate an increased musculoskeletal and autonomic nervous system response to a painful visceral stimulus compared to controls.
- Conditions
- Dysmenorrhea, Dysmenorrhea Primary, Visceral Pain, Menstrual Pain
- Trial name
- NCT07209566
- Testing
- Visceral Pain Stimulus
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Azusa Pacific University
Abdominal Pain
Heart Rate Variability in Children With a Functional Gastrointestinal Disorder
The current study is designed to assess relationships between anxiety/stress, autonomic nervous system balance, and electrical activity in the stomach before and after eating/drinking in children with abdominal pain.
- Trial name
- NCT00195975
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Children's Mercy Hospital Kansas City
Diet Habits, Athlete
Legume-Enriched Mediterranean Diet and Cellular Hydration in Competitive Swimmers
This study investigates whether increasing legume consumption within a Mediterranean diet framework improves cellular hydration, autonomic regulation, and functional performance in competitive swimmers.
- Trial name
- LEGUMES-SWIM (NCT07315529)
- Testing
- Legume-enriched Mediterranean diet
- Where
- Italy
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- San Raffaele Telematic University
Influence of Espresso on Heart Rate Variability
Action of Caffeinated and Decaffeinated Espresso on Autonomic Function
More than 80% of the population in the USA consume coffee each day. However there not many studies on change of heart rate variability and placebo effects after consumption of coffee.
- Trial name
- NCT00576030
- Testing
- hab cof with water, hab cof with dec espresso, hab cof with caf espresso
- Where
- Germany
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Gastrointestinal Diseases, Autonomic Nervous System Disease
Relationship of Cervical Region Tension With Vagal Function
The increase in the tension of the soft tissues around a nerve restricts the movement, affects the function of the nerve, and makes the nerve vulnerable to entrapment.
- Trial name
- NCT05325879
- Testing
- VAGUS-NDT
- Where
- Turkey (Türkiye)
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Hydration
Autonomic Adaptations to Hydration and Brain Functioning
The influence of relatively small decreases in hydration status have been little studied. On two occasions subjects will be allowed to lose about 0,5% of their body weight and one occasion 300ml of water will be consumed.
- Trial name
- NCT03525470
- Testing
- Water, No drink
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Swansea University