Clinical trials: ANTERIOR CRUCIATE LIGAMENT RECONSTRUCTION
ANTERIOR CRUCIATE LIGAMENT RECONSTRUCTION
Predictive Factors for a Successful Return to Run After ACL-R
After anterior cruciate ligament (LCA) rupture, the recommended treatment for athletes is the surgical reconstruction of the ligament (ACL-R), followed by a long rehabilitation period.
- Trial name
- NCT04130308
- Testing
- Retrun to run protocol
- Where
- Canada
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Laval University
Anterior Cruciate Ligament Reconstruction, Muscular Atrophy
Nutritional Intervention to Enhance Recovery After Arthroscopic Knee Surgery in Adults
Loss of skeletal muscle mass (atrophy) and strength in the lower limb are consequences of elective knee surgery as result of prolonged disuse from limb immobilization and impaired mobility, as well as pathophysiological trauma.
- Trial name
- NCT06233825
- Testing
- Omega-3 Fatty Acids and Essential Amino Acids, Safflower Oil and Non-Essential Amino Acids
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Dr. Chris McGlory, PhD
ACL Reconstruction, ACL Repair
Isokinetic Exercise Combined With Blood Flow Restriction: High-Load Vs Low-Load Training
The goal of this clinical trial is to see which type of strengthening exercise with a tight band (blood flow restriction) helps people recover better after ACL reconstruction.
- Trial name
- NCT07384780
- Testing
- High Load Isokinetic Training with Blood Flow Restriction, Low Load Isokinetic Training with Blood Flow Restriction
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Gulf Medical University
Anterior Cruciate Ligament Reconstruction
Proprioceptive Training for Gait and Knee Function After Anterior Cruciate Ligament Reconstruction
Anterior cruciate ligament reconstruction (ACLR) is commonly performed to restore knee stability after injury, but many patients continue to experience gait abnormalities and reduced knee function during rehabilitation.
- Trial name
- NCT07268651
- Testing
- Standard Rehabilitation, Proprioceptive Training
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Universiti Sains Malaysia
ANTERIOR CRUCIATE LIGAMENT RECONSTRUCTION
Comparison of Anterior Sciatic Nerve Block and Adductor Magnus Muscle Plane Block for Anterior Cruciate Ligament Surgery
Anterior cruciate ligament (ACL) reconstruction is frequently associated with moderate-to-severe postoperative pain despite its arthroscopic nature, owing to the complex sensory innervation of the knee involving the femoral…
- Trial name
- NCT07601529
- Testing
- Adductor canal block, Anterior sciatic nerve block, Adductor magnus plane block
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Ataturk University
ACL Reconstruction, ACL Surgery
Post Operative Use of Neuromuscular Electrical Stimulation (NMES) Device for ACLR Patients
This study is being conducted to learn about how neuromuscular electrical stimulation (NMES) in addition to standard of care aids in the recovery of muscle strength in patients undergoing ACLR procedure.
- Conditions
- ACL Reconstruction, ACL Surgery, ACL Injury, Electrotherapy
- Trial name
- NCT07171346
- Testing
- Zynex NexWave Electrotherapy Device
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Kansas Medical Center
ACL Reconstruction
Psychological and Physiological Parameters for Return-to-sport After ACL Reconstruction
Injuries to the anterior cruciate ligament are common and are usually treated with reconstruction and subsequent rehabilitation. Many people succeed in return to sport (RTS), but not to the original level.
- Trial name
- ACL-RTS (NCT07259083)
- Where
- Austria
- Volunteers
- 30 people
- Sponsor
- Johannes Kepler University of Linz
ACL - Anterior Cruciate Ligament Rupture
BioACL Reconstruction With Amnion Collagen Matrix Wrap and Stem Cells Case Series
The objective of this study is to evaluate the use of wrapping an ACL graft with a collagen matrix tissue wrap and injecting autologous bone marrow aspirate concentrate under the wrapping and into the graft.
- Trial name
- BioACL(CS) (NCT03294720)
- Testing
- Bio-ACL, amnion wrap and BMAC
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Andrews Research & Education Foundation
ACL Injury, Meniscus Tear
MOntelukast as a Potential CHondroprotective Treatment Following Anterior Cruciate Ligament Reconstruction (MOCHA Trial)
This is a multicenter randomized, placebo-controlled trial to assess whether a 6-month course of oral montelukast after ACL reconstruction reduces systemic markers of inflammation and biochemical and imaging biomarkers of…
- Conditions
- ACL Injury, Meniscus Tear, Post-traumatic Osteoarthritis
- Trial name
- MOCHA (NCT04572256)
- Testing
- Montelukast
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Austin V Stone
Quadriceps Atrophy, ACL Reconstruction
Does Blood Flow Restriction Training Improve Quadriceps Function After Arthroscopic Knee Surgery?
The purpose of this study is to evaluate the effectiveness of physical therapy (PT) plus BFR training compared to PT alone (without BFR training) after ACL reconstruction in patients who require extended limited weight bearing…
- Trial name
- NCT03096366
- Testing
- Blood flow restriction, Physical therapy
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- The University of Texas Health Science Center, Houston
Anterior Cruciate Ligament Reconstruction
Standard ACL Reconstruction vs ACL + Lateral Extra-Articular Tenodesis Study
The purpose of this study is to compare outcomes (failure, function, strength, range of motion and quality of life) between patients who receive the usual anterior cruciate ligament (ACL) reconstructive surgery and patients who…
- Trial name
- STAbiLiTY (NCT02018354)
- Testing
- Lateral Extra-Articular Tenodesis (LET), ACL Reconstruction
- Where
- 8 sites in Belgium, Canada and 1 more
- Volunteers
- 624 people
- Sponsor
- University of Western Ontario, Canada
ACL Reconstruction
Efficacy and Tolerability of a Nutritional Supplement, Plactive Progen, in ACL Reconstruction
This was a prospective, multicenter, randomized, open-label, phase IV trial to compare the efficacy of supplementation with plasma proteins, hydrolyzed collagen (CH), a complex of HA-CS (HC-15), and vitamin C combined with a…
- Trial name
- NCT03355651
- Testing
- PROGEN
- Volunteers
- 80 people
- Sponsor
- OPKO Health, Inc.
Anterior Cruciate Ligament Injuries, Post-Traumatic Osteoarthritis of Knee
Concentrated Bone Marrow Aspirate in Revision ACL Reconstruction
The goal of this pilot randomized clinical trial is to look into the efficacy of concentrated bone marrow aspirate (cBMA) in improving post traumatic osteoarthritis (PTOA) symptoms in patients undergoing revision anterior…
- Conditions
- Anterior Cruciate Ligament Injuries, Post-Traumatic Osteoarthritis of Knee, Bone Marrow Aspirate Concentrate, ACL Injury
- Trial name
- NCT06311513
- Testing
- Concentrated Bone Marrow Aspirate Injection, Revision Anterior Cruciate Ligament Reconstruction
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- Hospital for Special Surgery, New York
Anterior Cruciate Ligament Injuries
Effects of Continuous Passive Movements vs Intermittent Compression in Patients With Post ACL Reconstruction Surgery
ACL Reconstruction Surgery remains a prevalent and debilitating condition, despite invasive and non-invasive approaches aimed at reducing pain and improving function.
- Trial name
- NCT06997679
- Testing
- Patients receiving CPM, Patients receiving intermittent compression
- Where
- Pakistan
- Volunteers
- 50 people
- Sponsor
- Superior University
Anterior Cruciate Ligament Reconstruction
Proprioception, Muscle Strength and Kinesiophobia After Anterior Cruciate Ligament Reconstruction
Fear of re-injury after anterior cruciate ligament reconstruction surgery (ACLR) affects individuals' return to sports and physical activity negatively.
- Trial name
- NCT06538792
- Where
- Turkey (Türkiye)
- Volunteers
- 52 people
- Sponsor
- Bezmialem Vakif University
Anterior Cruciate Ligament Rupture, Pain, Postoperative
Effect of LIA on Postoperative Pain Following ACL Reconstruction
An anterior cruciate ligament (ACL) rupture is one of the most common sport injuries, which typically develops after a sudden knee torsion.
- Trial name
- NCT03873077
- Testing
- local infiltration analgesia
- Where
- Belgium
- Volunteers
- 40 people
- Sponsor
- Algemeen Ziekenhuis Maria Middelares
Anterior Cruciate Ligament Rupture, Enhanced Recovery After Surgery (ERAS) Protocol
Effectiveness of Enhanced Recovery After Surgery (ERAS) Protocols for Arthroscopic Anterior Cruciate Ligament Reconstruction in an Ambulatory Surgery Setting
The anterior cruciate ligament (ACL) is a critical component for maintaining knee stability by resisting anterior tibial translation and internal rotation.
- Conditions
- Anterior Cruciate Ligament Rupture, Enhanced Recovery After Surgery (ERAS) Protocol, Ambulatory Surgery
- Trial name
- NCT07602231
- Testing
- Enhanced Recovery After Surgery
- Volunteers
- 115 people
- Sponsor
- University Medical Center Ho Chi Minh City (UMC)
Anterior Cruciate Ligament Injury, ACL Injury
Factors Affecting the Speed of Recovery After ACL Reconstruction
The purpose of this study is to find out how postoperative pain affects recovery after anterior cruciate ligament (ACL) repair. Complete recovery after ACL repair involves healing of tissues at the surgical site, but also…
- Conditions
- Anterior Cruciate Ligament Injury, ACL Injury, ACL - Anterior Cruciate Ligament Rupture
- Trial name
- NCT03770806
- Testing
- Femoral Nerve Block, Adductor Nerve Block, No Block
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- University of Washington
Anterior Cruciate Ligament Rupture, Anterior Cruciate Ligament Injuries
Over-the-Top vs. Anteromedial ACLR With Lateral Extraarticular Tenodesis
This study aims to compare the over-the-top (OTT) anterior cruciate ligament (ACL) reconstruction (ACL-R) technique with the anteromedial ACL-R + lateral extraarticular tenodesis (LET).
- Conditions
- Anterior Cruciate Ligament Rupture, Anterior Cruciate Ligament Injuries, Anterior Cruciate Ligament Tear
- Trial name
- NCT06664047
- Testing
- OTT ACLR, ACLR LET
- Where
- Turkey (Türkiye)
- Volunteers
- 118 people
- Sponsor
- Ankara City Hospital Bilkent
Anterior Cruciate Ligament Injuries
Rehabilitation Exercise Using Digital Healthcare System in Patients With Anterior Cruciate Ligament Reconstruction
The study aims to examine the effect of short-term rehabilitation exercise support using digital healthcare system (Uincare homeplus) in the patients with anterior cruciate ligament reconstruction.
- Trial name
- NCT04513327
- Testing
- Rehabilitation using Digital Healthcare System (Uincare Homeplus), Conventional Rehabilitation
- Where
- 2 sites in South Korea
- Volunteers
- 60 people
- Sponsor
- Seoul National University Bundang Hospital