Clinical trials: ANTERIOR CRUCIATE LIGAMENT RECONSTRUCTION
Anterior Cruciate Ligament Reconstruction
Anterior Cruciate Ligament Reconstruction and Plyometric Exercise
This is a single-center, randomized, double-blind (subject/evaluator)study. Enrolled patients had anterior cruciate ligament (ACL) reconstruction and met criteria for advanced rehabilitation.
- Trial name
- NCT01851655
- Testing
- Plyometric Exercise
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Florida
Anterior Cruciate Ligament Injury
BPTB Versus Hamstring Autografts in ACL Reconstruction Among Professional Athletes
This prospective randomized controlled study compares outcomes of ACL reconstruction using bone-patellar tendon-bone (BPTB) versus hamstring tendon (HT) autografts in professional athletes.
- Trial name
- BPTB-HT ACL (NCT07573293)
- Testing
- BPTB ACL Reconstruction, Hamstring ACL Reconstruction
- Where
- Egypt
- Volunteers
- 65 people
- Sponsor
- Cairo University
Anterior Cruciate Ligament Injuries, Atrophy
Effect of Blood Flow Restriction Training on Patient With Anterior Cruciate Ligament Reconstruction
This study investigates the effects of plyometric training with blood flow restriction on muscular strength, quadriceps thickness and knee joint function in patients with muscle weakness and atrophy (quadriceps muscle and…
- Conditions
- Anterior Cruciate Ligament Injuries, Atrophy, Muscle Weakness
- Trial name
- NCT04284748
- Testing
- Plyometric exercise with blood flow restriction, Plyometric exercise, Routine physiotherapy program
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Hacettepe University
Analgesia
IPACK or Selective Tibial Nerve Block for ACL Reconstruction With an Adductor Canal Block
The purpose of this study is to compare the analgesic efficacy of the combination of an adductor canal and selective tibial nerve blocks versus adductor canal block and IPACK after ACL reconstruction under general anaesthesia.
- Trial name
- TIPACK (NCT05303233)
- Testing
- Selective tibial nerve block, IPACK
- Where
- Switzerland
- Volunteers
- 80 people
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Anterior Cruciate Ligament Reconstruction, Tranexamic Acid
Tranexamic Acid Injection With Different Drainage Clamping Time After Anterior Cruciate Ligament Reconstruction
Post-anterior cruciate ligament reconstruction (ACLR) hemarthrosis may result in increased pain thus delaying postoperative rehabilitation, which may eventually lead to arthrofibrosis and a functional deficit.
- Conditions
- Anterior Cruciate Ligament Reconstruction, Tranexamic Acid, Hemarthrosis, Knee
- Trial name
- NCT06280456
- Testing
- Tranexamic Acid Powder
- Where
- Taiwan
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Anterior Cruciate Ligament Injury
Psychological Readiness and Return to Sport After ACL Reconstruction
The goal of this observational study is to evaluate psychological readiness, kinesiophobia, subjective knee function, sport activity level, and return-to-sport status in athletes who have undergone primary anterior cruciate…
- Trial name
- NCT07733895
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people
- Sponsor
- Biruni University
Anterior Cruciate Ligament (ACL) Reconstruction
Feasibility of a Mindfulness and Physical Activity Promotion Intervention After Anterior Cruciate Ligament Reconstruction
The goal of this clinical trial is to learn whether a 6-week mobile-delivered intervention combining mindfulness meditation (Headspace) and personalized, wearable-derived physical activity goals (Oura Ring) can be feasibly…
- Trial name
- Mind in Motion (NCT07912502)
- Testing
- Mind in Motion
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Virginia
Rotator Cuff Repair, Anterior Cruciate Ligament Reconstruction
Ultrasound-Guided Percutaneous Peripheral Nerve Stimulation: A Department of Defense Funded Multicenter Pilot Study
Postoperative pain is usually treated with opioids that have undesirable and sometimes dangerous side effects (e.g., vomiting and respiratory depression)-and yet over 80% of patients still experience inadequate pain relief.
- Conditions
- Rotator Cuff Repair, Anterior Cruciate Ligament Reconstruction, Ankle Arthrodesis or Arthroplasty, Hallux Valgus Correction
- Trial name
- NCT03481725
- Testing
- ACTIVE peripheral nerve stimulation with a percutaneously inserted lead and wearable stimulator (SPR Therapeutics, Cleveland, Ohio)
- Where
- 6 sites in United States
- Volunteers
- 65 people
- Sponsor
- University of California, San Diego
Adductor Canal Block
Effect of Combining Peri-hamstring Injection or Anterior Obturator Nerve Block on the Analgesic Efficacy of Adductor Canal Block for Arthroscopic Anterior Cruciate Ligament Reconstruction Under General Anesthesia
Pain after anterior cruciate ligament reconstruction with autologous hamstring graft can be attributed to both arthroscopic surgery and the graft donor site.
- Trial name
- NCT06398717
- Testing
- adductor canal block
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Anterior Cruciate Ligament Tear, Meniscal Tear
Prospective Registry of Anterior Cruciate Ligament Reconstructions
The purpose of the study is to investigate factors that are associated with outcomes of injury to the anterior cruciate ligament (ACL) in the knee among patients who are undergoing surgical reconstruction.
- Conditions
- Anterior Cruciate Ligament Tear, Meniscal Tear, Cartilage Injury, Bone Bruising
- Trial name
- NCT04135950
- Where
- United States
- Volunteers
- 1,646 people
- Sponsor
- State University of New York at Buffalo
Post-operative Pain
Effectiveness of Continuous Femoral Nerve Block Versus Single Shot Femoral Nerve Block for Pain Control
Both single shot femoral nerve block and continuous femoral nerve block with catheter have been shown to be effective for pain control after anterior cruciate ligament reconstruction (ACLR).
- Trial name
- NCT01916590
- Testing
- Bupivicaine
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- University of Colorado, Denver
Anterior Cruciate Ligament Injury, Quadriceps Dysfunction
Exercise Loading Biology Post-Traumatic OsteoArthritis Study - a Pilot and Feasibility Study
FROM RISK FACTORS TO THE PREVENTION OF LONG-TERM CONSEQUENCES AFTER CRUCIATE LIGAMENT INJURY (ACL injury) - This is a research project where we seek new knowledge about why some people have a high risk and others a low risk of…
- Conditions
- Anterior Cruciate Ligament Injury, Quadriceps Dysfunction, Knee Joint Loading, Anterior Cruciate Ligament Reconstruction
- Trial name
- ExeLoadBioPTOA (NCT06892899)
- Where
- Norway
- Volunteers
- 40 people
- Sponsor
- May Arna Risberg
Anterior Cruciate Ligament Reconstruction
Reducing Hemarthrosis in ACL Reconstruction With BTB Autograft by the Administration of Intravenous TXA
The purpose of the proposed study is to evaluate the effects of administering intravenous tranexamic acid (TXA) to patients undergoing anterior cruciate ligament (ACL) reconstruction with bone-patellar tendon-bone autograft to…
- Trial name
- NCT03631355
- Testing
- Tranexamic Acid
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- NYU Langone Health
ACL Injury
Does Bone Grafting at the Time of Bone-Patellar Tendon-Bone ACL Reconstruction Reduce the Incidence of Post-operative Anterior Knee Pain: A Randomized Controlled Clinical Study
It is estimated that 48 out of 10,000 people, in the United States, will tear their anterior cruciate ligament (ACL) annually and undergo ACL reconstruction (ACLR).
- Trial name
- NCT04958733
- Testing
- Autologous bone grafting, Absence of autologous bone grafting
- Where
- 3 sites in United States
- Volunteers
- 60 people
- Sponsor
- Hartford Hospital
Anterior Cruciate Ligament Injuries, Cartilage Degeneration
Effect of Early Gait Training on Knee Cartilage Degeneration After Anterior Cruciate Ligament Reconstruction
A randomized controlled clinical study was conducted to elucidate the relationship between the lower extremity biomechanics of patients undergoing early gait training after ACLR surgery.The relationship between the biochemical…
- Trial name
- NCT06368544
- Testing
- lower-body positive-pressure
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Peking University Third Hospital
ACL Injury, ACL Reconstruction
Study to Use Oral Losartan to Decrease the Risk of Postoperative Scarring Following (ACL) Reconstruction
The purpose of this study to investigate the effect of using losartan (a blood pressure lowering drug with anti-scarring properties) on preventing primary postoperative arthrofibrosis (formation of abnormal scar tissue) in the…
- Conditions
- ACL Injury, ACL Reconstruction, Scar Formation
- Trial name
- NCT07135687
- Testing
- Losartan
- Where
- United States
- Volunteers
- 144 people
- Sponsor
- Rush University Medical Center
Anterior Cruciate Ligament Injuries, Anterior Cruciate Ligament Tear
Effects of Whole Body Vibration on Quadriceps Function, Landing Biomechanics, and Performance in Individuals With ACL Reconstruction
Individuals who undergo anterior cruciate ligament reconstruction (ACLR) are at heightened risk of secondary anterior cruciate ligament (ACL) injury (e.g. additional injury to the ACL in either knee).
- Conditions
- Anterior Cruciate Ligament Injuries, Anterior Cruciate Ligament Tear, ACL Injury, ACL Tear
- Trial name
- NCT07681193
- Testing
- Whole body vibration (WBV)
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- University of North Carolina, Chapel Hill
Intraoperative Musculoskeletal Injury
Intraoperative Laxity Assessment of ACL Reconstruction, ACL Revision and MAT
Intraoperative knee laxity evaluation of patiente undergoing ACL reconstruction, ACL revision, MAT
- Trial name
- INTRA_KIN (NCT03441165)
- Testing
- ligament reconstruction and meniscus transplantation
- Where
- Italy
- Volunteers
- 1,500 people
- Sponsor
- Istituto Ortopedico Rizzoli
ACL Injury, Knee Osteoarthritis
The Efficiency and Safety of PRP Treatment After Anterior Cruciate Ligament Reconstruction.
The anterior cruciate ligament (ACL) is the main stabilizer of the knee joint, as it controls anteroposterior and rotatory knee laxity.
- Conditions
- ACL Injury, Knee Osteoarthritis, Knee Injuries
- Trial name
- NCT06442319
- Testing
- Platelet-rich plasma
- Where
- Poland
- Volunteers
- 60 people
- Sponsor
- Nicolaus Copernicus University in Toruń, Collegium Medicum in Bydgoszcz
ACL Anterior Cruciate Ligament Injury, Outcome
Outcome and Tunnel Widening After ACL Reconstruction: Comparison of Aperture and Cortical Fixation
Background: Failure of graft incorporation and tunnel widening (TW) after anterior cruciate ligament (ACL) reconstruction has been frequently reported in the literature. The etiology of TW is still not fully understood.
- Trial name
- NCT01755819
- Testing
- Biocomposite interference screw, Extracortical ACL Tightrope fixation
- Where
- Austria
- Volunteers
- 60 people
- Sponsor
- Medical University Innsbruck