Clinical trials: ARDS, Human, open to volunteers
Nonintubated Acute Respiratory Distress Syndrome (ARDS), Pathogen-associated Lung Injury
Vadadustat for the Treatment of Nonintubated Acute Respiratory Distress Syndrome Due to Pathogen-Associated Lung Injury
The objective of this study is to assess the efficacy and safety of vadadustat for treating hospitalized patients with nonintubated Acute Respiratory Distress Syndrome (ARDS) secondary to pathogen-associated lung injury.
- Trial name
- NCT07086755
- Testing
- Vadadustat 900mg, Vadadustat 1200mg
- Where
- United States
- Volunteers
- 1,100 people
- Sponsor
- Paul Potnuru
Heart Failure, Cardiomyopathies
Multimodal Physiologic State Intelligence Study
The OMNIPHYS study will investigate whether multimodal ultrasound and other routinely collected clinical and physiologic data can be combined with artificial intelligence to characterize changes in a person's physiologic state…
- Conditions
- Heart Failure, Cardiomyopathies, Pulmonary Hypertension, Myocarditis; Acute or Subacute
- Trial name
- OMNIPHYS (NCT07814118)
- Testing
- OMNIPHYS Multimodal Ultrasound Imaging System
- Where
- United States
- Volunteers
- 25,000 people, healthy volunteers welcome
- Sponsor
- Truway Health, Inc.
ARDS, Human
Depth of Sedation and Its Impact on Cerebrovascular Reactivity in Acute Respiratory Distress Syndrome: a Pilot Analysis
Investigation of the feasibility of monitoring processed transcutaneous electroencephalography (EEG), a method of interpreting brain activity, and near-infrared spectroscopy (NIRS), a method of determining levels of tissue…
- Trial name
- NCT05847634
- Testing
- Masimo O3 NIRS cerebral oximetry and SedLine processed EEG
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- University of Manitoba
ARDS (Acute Respiratory Distress Syndrome)
Effects of Low Tidal Volume and Airway Pressure Release Ventilation on Lung Tissue Mechanics in ARDS Patients Under Mechanical Ventilation: A Prospective Randomized Crossover Study
The goal of this clinical trial is to learn how low tidal volume ventilation (LTV) and airway pressure release ventilation (APRV) affect lung tissue mechanics in adults with ARDS.
- Trial name
- NCT06790875
- Testing
- Airway Pressure Release Ventilation (APRV)
- Where
- China
- Volunteers
- 15 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Acute Respiratory Distress Syndrome
Clinical Study on the Safety and Preliminary Efficacy of hUC-MSCs Intravenous Infusion Therapy for ARDS
The object of this study is to observe the safety of umbilical cord mesenchymal stem cell therapy for acute respiratory distress syndrome, consisting with two phases.
- Trial name
- NCT06505941
- Testing
- umbilical cord mesenchymal stem cell
- Volunteers
- 60 people
- Sponsor
- Southeast University, China
ARDS (Acute Respiratory Distress Syndrome)
Effect of EIT-guided PEEP in ARDS Patients
Acute respiratory syndrome distress (ARDS) is a clinical common syndrome with high mortality. Mechanical ventilation (MV) is the cornerstone of management of ARDS but can lead to ventilator-induced lung injury.
- Trial name
- NCT06990477
- Testing
- EIT-guided PEEP
- Where
- 17 sites in China, South Korea and 1 more
- Volunteers
- 2,400 people
- Sponsor
- Southeast University, China
Acute Respiratory Distress Syndrome (ARDS)
Assessment of the Reproducibility of the Recruitment-to-inflation Ratio (R/I Ratio) Measurement in Patients With Acute Respiratory Distress Syndrome
Acute respiratory distress syndrome (ARDS) is a severe lung condition that often requires invasive mechanical ventilation in the intensive care unit.
- Trial name
- RIRR (NCT07666503)
- Where
- 4 sites in France
- Volunteers
- 80 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Acute Respiratory Distress Syndrome (ARDS)
Clinical Features, Treatments, and Outcomes in Acute Respiratory Distress Syndrome (ARDS-CTO)
The goal of this observational prospective cohort study is to explore the clinical characteristics, treatment strategies, and outcomes of adult patients with acute respiratory distress syndrome (ARDS) admitted to the medical…
- Trial name
- ARDS-CTO (NCT07186140)
- Where
- South Korea
- Volunteers
- 800 people
- Sponsor
- Jee Hwan Ahn
ARDS, Covid19
Evaluating AVM0703 for Treatment of COVID-19 or Influenza-mediated ARDS
This is a randomized, double-blinded, placebo-controlled study of AVM0703 administered as a single intravenous (IV) infusion to patients with moderate or severe immediately life-threatening Acute Respiratory Distress Syndrome…
- Conditions
- ARDS, Covid19, Influenza, Human
- Trial name
- AVM0703 (NCT04366115)
- Testing
- AVM0703
- Volunteers
- 16 people
- Sponsor
- AVM Biotechnology Inc
Respiratory Failure, ARDS (Acute Respiratory Distress Syndrome)
The Impact of Low Versus High Positive End-expiratory Pressure on Diaphragm Function, Ventilation Efficiency, and Lung Mechanics
The goal of this interventional study is to evaluate the effect of different positive end-expiratory pressures (PEEP) on lung and diaphragm function in patients mechanically ventilated with pressure support ventilation in the…
- Conditions
- Respiratory Failure, ARDS (Acute Respiratory Distress Syndrome), Pneumonia, Respiratory Insufficiency
- Trial name
- INFLATE-ICU (NCT07188038)
- Testing
- Low positive end-expiratory pressure, Medium positive end-expiratory pressure, High positive end-expiratory pressure
- Where
- 2 sites in Sweden
- Volunteers
- 25 people
- Sponsor
- Vastra Gotaland Region
Cardiogenic Shock, Malignant Arrhythmias
The Caribbean Registry of Extracorporeal Membrane Oxygenation (ECMO) From the University Hospital in Martinique
The project's main goal is to collect baseline clinical and procedural data as well as to assess clinical outcomes for all patients undergoing VV, VA or VAV ECMO implantation in the French West Indies and Guiana.
- Conditions
- Cardiogenic Shock, Malignant Arrhythmias, Ischemic or Valvular Heart Failure, Drepanocytosis and Thoracic Syndrome
- Trial name
- NCT07351435
- Volunteers
- 1,200 people
- Sponsor
- University of Genova
Sepsis, Burn Injury
TDAP in Burn Patients (Group 2)
This study is following adult patients with serious burn injuries to better understand how their bodies respond to treatment and recovery.
- Conditions
- Sepsis, Burn Injury, Wound Healing, Critical Illness
- Trial name
- NCT07223684
- Testing
- Observational Cohort (No Intervention)
- Where
- 3 sites in United States
- Volunteers
- 80 people
- Sponsor
- Henry M. Jackson Foundation for the Advancement of Military Medicine