Clinical trials: ASA I-III
Anesthesia, General, Neuromuscular Blockade
Comparison of 2.0 mg/kg Sugammadex and Neostigmine at Reappearance of T2 in Chinese and European Subjects (Study 19.4.324)(P05768AM1)(COMPLETED)
The present trial was set up to evaluate the efficacy and safety of 2.0 mg.kg-1 sugammadex compared to neostigmine administered at reappearance of T2 in Chinese and Caucasian subjects for registration purposes in China.
- Trial name
- NCT00825812
- Testing
- Sugammadex, neostigmine
- Volunteers
- 308 people
- Sponsor
- Merck Sharp & Dohme LLC
Multiple Myeloma in Relapse, Multiple Myeloma Progression
Rivaroxaban or Aspirin As Thromboprophylaxis in Multiple Myeloma
The intended study is designed as a a phase IV pragmatic multicenter randomized controlled clinical trial, comparing the impact of two different therapies including ASA vs.
- Conditions
- Multiple Myeloma in Relapse, Multiple Myeloma Progression, Multiple Myeloma Stage II, Multiple Myeloma Stage I
- Trial name
- RithMM (NCT03428373)
- Testing
- Rivaroxaban, ASA
- Where
- Canada
- Volunteers
- 57 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Liver Dysfunction, Pain
Efficacy of Multimodal Opioid Therapy During Hepatic Resection Surgery
The patient population requiring hepatic resection can demonstrate an unpredictable risk of exhibiting peri-operative coagulopathy resulting either from the pre-operative hepatic pathophysiology or volume of parenchymal…
- Trial name
- RITM-IVM (NCT00553553)
- Testing
- Morphine sulphate, Morphine hydrochloride, remifentanil hydrochloride
- Where
- Ireland
- Volunteers
- 45 people
- Sponsor
- St Vincent's University Hospital, Ireland
Hypoxia, Pars Plana Vitrectomy
Influence of HFNO on Spontaneous Breathing Support in Patients of Different ASA Risk During Moderate Multimodal Analgo-sedation for Pars Plana Vitrectomy
Pars plana vitrectomy is minimally invasive endoscopic procedure which is usually performed in moderate analgo-sedation given by anesthesiologist combined with topical anesthesia and regional eye anesthesia (retrobulbar or…
- Conditions
- Hypoxia, Pars Plana Vitrectomy, Respiratory Complications
- Trial name
- NCT04055077
- Testing
- Low-flow nasal oxygenation (LFNO) ASA I, Low-flow nasal oxygenation (LFNO) ASA II, Low-flow nasal oxygenation (LFNO) ASA III
- Where
- Croatia
- Volunteers
- 176 people
- Sponsor
- University of Split, School of Medicine
Patients With ASA Status I-III Scheduled for Surgery
Intraoperative Air-Test
Although imaging techniques are the reference standard to diagnose alveolar collapse, in the postoperative period and using the peripheral hemoglobin oxygen saturation (SpO2), a non-invasive simple and accurate test (Air-Test)…
- Trial name
- NCT03469648
- Testing
- Air-Test
- Where
- 2 sites in Spain
- Volunteers
- 180 people
- Sponsor
- Fundación para la Investigación del Hospital Clínico de Valencia
Patients Scheduled for Elective Lower Extremity Surgery, Ages 18-80
Parasacral Ischial Plane Block in Lower Extremity Surgery
The parasacral ischial plane block is a novel fascial plane approach targeting the sacral plexus. This technique is technically less challenging and eliminates the requirement for direct visualization of the sacral plexus.
- Conditions
- Patients Scheduled for Elective Lower Extremity Surgery, Ages 18-80, ASA I-III, Patients Operated on Under Regional Anesthesia
- Trial name
- NCT07594197
- Testing
- Parasacral Ischial Plan Block, Sacral plexus block
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Bursa Yuksek Ihtisas Training and Research Hospital
Recurrent Prostate Carcinoma, Stage I Prostate Cancer
Metformin Hydrochloride and Aspirin in Treating Patients With Hormone-Dependent Prostate Cancer That Has Progressed After Surgery or Radiation Therapy
This randomized phase II trial studies how well metformin hydrochloride and aspirin work in treating patients with hormone-dependent prostate cancer that has progressed after surgery or radiation therapy.
- Conditions
- Recurrent Prostate Carcinoma, Stage I Prostate Cancer, Stage IIA Prostate Cancer, Stage IIB Prostate Cancer
- Trial name
- PRIMA (NCT02420652)
- Testing
- Aspirin, Laboratory Biomarker Analysis, Metformin Hydrochloride
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Rutgers, The State University of New Jersey
Tertiary Prevention in Colon Cancer
A Randomized, 2x2 Factorial Design Biomarker Prevention Trial of Low-dose ASA and Metformin in Stage I-III Crc Patients
It has been shown that Aspirin (ASA) as well as Metformin (Met) can inhibit the incidence and mortality of colorectal cancer (CRC).
- Trial name
- ASAMET (NCT03047837)
- Testing
- ASA, MET
- Where
- Italy
- Volunteers
- 160 people
- Sponsor
- Ente Ospedaliero Ospedali Galliera
Adenocarcinoma of the Lung, Recurrent Non-small Cell Lung Cancer
Low-Dose Acetylsalicylic Acid in Treating Patients With Stage I-III Non-Small Cell Lung Cancer
This pilot clinical trial studies low-dose acetylsalicylic acid in treating patients with stage I-III non-small cell lung cancer.
- Conditions
- Adenocarcinoma of the Lung, Recurrent Non-small Cell Lung Cancer, Stage IA Non-small Cell Lung Cancer, Stage IB Non-small Cell Lung Cancer
- Trial name
- NCT01707823
- Testing
- acetylsalicylic acid, laboratory biomarker analysis
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Vanderbilt-Ingram Cancer Center
Patients ASA I, II, III
Postoperative Cognitive Dysfunction After Propofol Anesthesia for Noncardiac Surgery
Background: Postoperative cognitive dysfunction (POCD) in elderly patients after noncardiac surgery is a common problem. Therefore,this study was designed to assess POCD after closed-loop coadministration of propofol and…
- Trial name
- POCD ELA (NCT02841423)
- Testing
- neuropsychological test battery
- Where
- France
- Volunteers
- 204 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Noninvasive Ventilation, Respiratory Insufficiency
The Effect of High-flow Nasal Oxygenation to the Saturation During Analgo-sedation in Different ASA Risk Class Patients
Analgo-sedation is standard procedure in anesthesiology practice and is often given for colonoscopy in the setting of daily hospital.
- Conditions
- Noninvasive Ventilation, Respiratory Insufficiency, Deep Sedation, Hypoxia
- Trial name
- NCT03687385
- Testing
- high-flow nasal oxygenation (HFNO), low-flow nasal oxygenation (LFNO)
- Volunteers
- 126 people
- Sponsor
- Anita Vukovic
Colorectal Cancer
Comparison of Sulindac, Aspirin, and Ursodiol in Preventing Colorectal Cancer
RATIONALE: Chemoprevention therapy is the use of certain drugs to try to prevent the development or recurrence of cancer. It is not yet known whether sulindac, aspirin, or ursodiol is more effective in preventing colorectal…
- Trial name
- NCT00062023
- Testing
- Acetylsalicylic acid (Aspirin), Sulindac, Ursodiol
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- M.D. Anderson Cancer Center
Anesthesia, General, Neuromuscular Blockade
Efficacy and Safety of 4.0 mg/kg Sugammadex at 1-2 PTC in Chinese and European Subjects (Study 19.4.335)(P05775AM1)(COMPLETED)
The present trial is set up to evaluate the efficacy and safety of 4.0 mg.kg-1 sugammadex in Chinese and Caucasian subjects for registration purposes in China.
- Trial name
- NCT00826176
- Testing
- Sugammadex
- Volunteers
- 164 people
- Sponsor
- Merck Sharp & Dohme LLC
Asa I-III Patients, Intubated Patients
Dental Injury Related To Conventional Direct Laryngoscopy
This research explores the occurrence of minor dental injuries and their associated effects by employing the transillumination technique with a cold light source.
- Conditions
- Asa I-III Patients, Intubated Patients, Laryngoscopy
- Trial name
- dentalinjury (NCT06760247)
- Testing
- intubated general anesthesia with propofol IV, rocuronium IV ,sevoflurane and N2O gas
- Where
- Turkey (Türkiye)
- Volunteers
- 300 people
- Sponsor
- Selcuk University
Hepatocellular Carcinoma, ASA I-III Patients
Phase II Trial of Immunonutrition in Hepatectomy
A randomised open labelled study to evalaute the impact of immunonutrition in Patients Undergoing Hepatectomies for Liver Tumors
- Trial name
- NCT07395635
- Testing
- Immunonutrition
- Where
- India
- Volunteers
- 100 people
- Sponsor
- Tata Memorial Centre
Patients With ASA Status I-III Scheduled for Elective Surgery
The Air Test: A New Simple, Non-invasive Method to Diagnose Anesthesia-induced Atelectasis
Anesthesia-induced atelectasis persist in the postoperative period but are not usually diagnosed because imaging techniques are required.
- Trial name
- NCT02650037
- Testing
- Air Test
- Where
- Spain
- Volunteers
- 181 people
- Sponsor
- Fundación para la Investigación del Hospital Clínico de Valencia
Prostate Adenocarcinoma, Stage I Prostate Cancer AJCC v8
Aspirin and Rintatolimod With or Without Interferon-alpha 2b in Treating Patients With Prostate Cancer Before Surgery
This phase II trial studies how well enteric-coated (EC) aspirin and rintatolimod with or without interferon-alpha 2b work in treating patients with prostate cancer before surgery.
- Conditions
- Prostate Adenocarcinoma, Stage I Prostate Cancer AJCC v8, Stage II Prostate Cancer AJCC v8, Stage IIA Prostate Cancer AJCC v8
- Trial name
- NCT03899987
- Testing
- EC Aspirin, Radical Prostatectomy, Recombinant Interferon Alfa-2b
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Roswell Park Cancer Institute
Sepsis, Systemic Inflammatory Response Syndrome
Influence of Age, Sepsis and SLCO1A2 Polymorphisms on Rocuronium Pharmacokinetics
This study aims to evaluate the influence of age and sepsis on in vivo activity of OATP1A2 using rocuronium (ROC) as a probe and evaluating the pharmacokinetics and pharmacodynamics in ASA I-III surgical patients.
- Conditions
- Sepsis, Systemic Inflammatory Response Syndrome, Septic Shock
- Trial name
- ROCSEPSIS (NCT02399397)
- Testing
- Serial blood sampling, Train of four monitoring, Blood testing for liver and renal function
- Where
- Brazil
- Volunteers
- 36 people
- Sponsor
- Universidade Estadual Paulista Júlio de Mesquita Filho