Clinical trials: ASV
Hepatitis C Virus Genotype 4 Infection
Pilot Study to Assess Efficacy and Safety of a Triple Therapy With Asunaprevir, Daclatasvir, and BMS-791325 in HCV Genotype 4-infected Patients After Failure of Pegylated Interferon-Ribavirin Regimen
ANRS HC 33 is a pilot study to assess efficacy and safety of a DCV 3DAA therapy with Asunaprevir, Daclatasvir and BMS-791325 in HCV genotype 4-infected patients after failure of pegylated Interferon-Ribavirin regimen.
- Trial name
- QUATTROTURBO (NCT02309450)
- Testing
- .Asunaprevir, Daclatasvir and BMS - 791325
- Where
- France
- Sponsor
- ANRS, Emerging Infectious Diseases
COPD Exacerbation Acute, COPD Exacerbation
PSV Versus ASV With Intellisync Mode for Delivery of NIV in AECOPD
Acute exacerbation of chronic obstructive pulmonary disease (COPD) is defined acute worsening of respiratory symptoms requiring additional therapy.
- Trial name
- PAINT-COPD (NCT06160687)
- Testing
- PSV mode during NIV, ASV intellisync
- Where
- India
- Volunteers
- 55 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Chronic Obstructive Pulmonary Disease, Invasive Mechanical Ventilation
Trial to Study Intubation Rates of Non-invasive Ventilation Using Pressure Support Ventilation (PSV) Versus Adaptive Support Ventilation (ASV) Mode in Patients With Acute Exacerbation of Chronic Obstructive Pulmonary Disease
The clinical course of chronic obstructive pulmonary disease (COPD) is associated with recurrent episodes of exacerbation that results in respiratory failure.
- Conditions
- Chronic Obstructive Pulmonary Disease, Invasive Mechanical Ventilation, Adaptive Support Ventilation
- Trial name
- PSV vs ASV for (NCT02877524)
- Testing
- Adaptive support ventilation, Pressure support ventilation
- Where
- India
- Volunteers
- 74 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Covid19, ARDS
Closed Loop Ventilation in Patients With COVID-19
Transpulmonary pressure may be higher in ARDS patients due to decreased respiratory system compliance. The hypothesis is that tidal volumes which are generated by Intellivent- Adaptive support ventilation (ASV) are safe range by…
- Trial name
- NCT04873336
- Testing
- Intellivent ASV
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people
- Sponsor
- Izmir Dr Suat Seren Chest Diseases and Surgery Education and Research Hospital
Hepatitis C
A Phase 3 Study in Combination With BMS-790052 and BMS-650032 in Japanese Hepatitis C Virus (HCV) Patients
The purpose of this study is to assess the anti-viral activity of BMS-790052 and BMS-650032 combination therapy in Japanese subjects.
- Trial name
- NCT01497834
- Testing
- BMS-790052 (Daclatasvir), BMS-650032 (Asunaprevir)
- Where
- 24 sites in Japan
- Volunteers
- 224 people
- Sponsor
- Bristol-Myers Squibb
Hepatitis C
Food Effect of a Fixed Dose Combination of Daclatasvir, Asunaprevir and BMS-791325
The purpose of this study is to assess the effect of a high fat meal and light meal on the blood levels of Daclatasvir, Asunaprevir and BMS-791325 after administration of the 3 drugs as a fixed-dose combination in healthy…
- Trial name
- NCT02095860
- Testing
- DCV 3DAA FDC
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Bristol-Myers Squibb
Central Sleep Apnea, ASV
Interface Selection for Adaptive Servo Ventilation
The purpose of this study is to compare the effects of nasal and oronasal interfaces during ASV treatment on sleep efficiency and sleep architecture.
- Trial name
- NCT02919930
- Testing
- Switch from oronasal to nasal mask during ASV treatment, Switch from nasal to oronasal mask during ASV treatment
- Where
- Belgium
- Volunteers
- 15 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Hepatitis C, Chronic
Efficacy and Safety of Daclatasvir Plus Asunaprevir in Chronic Hepatitis C
We perform this study to identity efficacy and safety of Daclatasvir and Asunaprevir in real practice.
- Trial name
- ESDAC (NCT02639585)
- Testing
- Daclinza and Sunvepra
- Where
- 2 sites in South Korea
- Volunteers
- 32 people
- Sponsor
- Pusan National University Hospital
Hepatitis C Virus
Drug Interaction Oral Contraceptive Pill (OCP)
To assess the effects of BMS-650032 on Pharmacokinetics (PK) of ethinyl estradiol (EE) and norelgestromin (NGMN) in healthy female subjects
- Trial name
- NCT01063023
- Testing
- Ortho Tri-Cyclen®, BMS-650032
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Bristol-Myers Squibb
Hepatitis C
Study of the Pharmacokinetics and Safety of Asunaprevir in Patients With Kidney Disease
The purpose of the study is to determine how Asunaprevir is handled by the body of subjects with kidney disease compared with subjects with normal kidney function
- Trial name
- NCT01886599
- Testing
- Asunaprevir
- Where
- 3 sites in United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Bristol-Myers Squibb
Advanced Cancer
Safety and Tolerability Study of AutoSynVax™ Vaccine in Subjects With Advanced Cancer
Open-label Phase 1 study of AutoSynVax™ vaccine with QS-21 Stimulon® adjuvant in subjects with advanced cancer
- Trial name
- NCT02992977
- Testing
- AutoSynVax™ vaccine
- Where
- 2 sites in United States
- Volunteers
- 3 people
- Sponsor
- Agenus Inc.
Hepatitis C
Drug Interaction & Methadone & Buprenorphine
The purpose of this study is to assess the effects of steady state DCV/ASV/BMS-791325 fixed dose combination (FDC) + 75mg BMS-791325 on the Pharmacokinetics (PK) of Methadone in subjects with the stable dose of Methadone and on…
- Trial name
- NCT02045693
- Testing
- Methadone, DCV 3DAA FDC, BMS-791325
- Where
- 3 sites in United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Bristol-Myers Squibb
Respiratory Distress Syndrome
(S5-SAMU) Randomized Study Comparing the ASV (Adaptative Support Ventilation) to Conventional Ventilation
Compare ventilation parameters in Adaptative Support Ventilation mode to conventional mode, on intubated, ventilated and sedated patients, during their secondary transfer from an hospital to another, by a SMUR team.
- Trial name
- S5-SAMU (NCT02348047)
- Testing
- Hamilton T1
- Where
- France
- Volunteers
- 27 people
- Sponsor
- Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer
Acute Myocardial Infarction, Sleep Apnea
ASV for Sleep Apnea After Myocardial Infarction
The aim of this randomized controlled trial is to test the effect of 12 weeks Adaptive Servo-Ventilation (ASV) therapy (additionally to optimal medical management of myocardial infarction) on myocardial salvage (MSI=myocardial…
- Trial name
- TEAM-ASV-I (NCT02093377)
- Testing
- Adaptive servo-ventilation
- Where
- 5 sites in Germany
- Volunteers
- 79 people
- Sponsor
- University Hospital Regensburg
Hepatitis C Virus
Phase III Hallmark QUAD: ASV+DCV+Peg+Rib (Nulls/Partials)
The purpose of this study is to assess efficacy, as determined by the proportion of subjects with Sustained Virologic Response at Post-Treatment Week 12 (SVR12), defined as Hepatitis C virus (HCV) Ribonucleic acid (RNA) < Limit…
- Trial name
- Hallmark QUAD (NCT01573351)
- Testing
- Asunaprevir, Daclatasvir, Peg-interferon Alfa-2a
- Where
- 79 sites in United States, Argentina and 13 more
- Volunteers
- 398 people
- Sponsor
- Bristol-Myers Squibb
Heart Failure, Cheyne Stokes Respiration
Chronic Heart Failure - Cheyne Stokes Respiration - CS2 (3C-study)
An investigation where patients with chronic heart failure and cheyne stokes respiration, treated with adapitve servo ventilator, will improve their cardiac function and quality of life.
- Trial name
- 3C (NCT00563693)
- Testing
- ASV, without Autoset CS2
- Where
- Norway
- Volunteers
- 40 people
- Sponsor
- University of Oslo
Burn, Mechanical Ventilation
BURN-ASV Trial: Adaptive Support Ventilation in Severe Burn Injury
Severe burn injury frequently requires prolonged mechanical ventilation because of inhalation injury, respiratory failure, systemic inflammation, and repeated surgical procedures.
- Conditions
- Burn, Mechanical Ventilation, Mechanical Ventilation Complication, ICU
- Trial name
- BURN-ASV (NCT07674563)
- Testing
- Adaptive Support Ventilation (ASV), Conventional Lung-Protective Mechanical Ventilation
- Volunteers
- 100 people
- Sponsor
- Ukrainian Society of Regional Anesthesia and Pain Therapy
Hepatitis C Virus
Study of BMS-650032 With Peginterferon Alfa-2a Plus Ribavirin
The purpose of this study is to identify one or more doses of BMS-650032 that, when used in combination with pegylated-interferon alpha and ribavirin are safe and demonstrate sufficient activity against hepatitis C virus…
- Trial name
- NCT01030432
- Testing
- BMS-650032, Peginterferon Alfa-2a, Ribavirin
- Where
- 40 sites in United States, Argentina and 6 more
- Volunteers
- 285 people
- Sponsor
- Bristol-Myers Squibb
Hepatitis C
Safety Study of Pegylated Interferon Lambda Plus Single or 2 Direct Antiviral Agents With Ribavirin
The purpose of this study is to determine if combination therapy with Pegylated Interferon Lambda (BMS-914143) plus Ribavirin (RBV) with a single direct antiviral agent (BMS-790052 or BMS-650032) for 24 weeks is effective and…
- Trial name
- D-LITE (NCT01309932)
- Testing
- Pegylated Interferon Lambda (pegIFNλ), BMS-790052 (NS5A Inhibitor), Ribavirin (RBV)
- Where
- 40 sites in United States, Australia and 7 more
- Volunteers
- 165 people
- Sponsor
- Bristol-Myers Squibb
Chronic Hepatitis C
A Single Ascending Dose Study of BMS-650032 in HCV Infected Subjects
The primary purpose of this study is to evaluate the safety profile and tolerability of single oral doses of BMS-650032 in subjects with chronic hepatitis C infection
- Trial name
- NCT00559247
- Where
- 5 sites in United States
- Volunteers
- 24 people
- Sponsor
- Bristol-Myers Squibb