Clinical trials: Abdominal (ABD) Infection
Acute Peritonitis, Abdominal Sepsis
Physiologic Indicators for Prognosis in Abdominal Sepsis Study
Early detection and timely therapeutic intervention can improve the prognosis of patients with sepsis. However, early diagnosis of sepsis can be difficult; because determining which patients presenting with signs of infection…
- Trial name
- PIPAS (NCT03408600)
- Testing
- Management
- Where
- Italy
- Volunteers
- 4,000 people
- Sponsor
- World Society of Emergency Surgery
Liver Abscess
Characteristics and Treatment Outcome of Liver Abscesses: An Observational Study
1. To assess the frequency, clinical presentation, microbiological and radiological characteristics of liver abscesses. 2. To evaluate the management plan and treatment outcome of liver abscess. 3.
- Trial name
- NCT06852235
- Volunteers
- 70 people
- Sponsor
- Assiut University
Complicated Intra-Abdominal Infection
Impact Of Bacterial Resistance On Healthcare Costs For Hospitalized Patients With Complicated Intra-Abdominal Infections
The objective of this study is to estimate the costs of empiric antibiotic therapy and hospitalization costs for patients with a complicated intra-abdominal infection, and to assess the impact of treatment failure of initial…
- Trial name
- NCT00929643
- Testing
- no intervention
- Where
- 13 sites in Greece
- Volunteers
- 203 people
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Sepsis, Cardiac Arrest
Validation of Molecular and Protein Biomarkers in Sepsis
Background: Sepsis (blood poisoning) is a clinical syndrome characterised by a dysregulated host response to infection causing life-threatening organ dysfunction which results in admission to an intensive care unit.
- Conditions
- Sepsis, Cardiac Arrest, Pneumonia, Abdominal Sepsis
- Trial name
- VAMp-sepsis (NCT04289506)
- Testing
- mRNA expression
- Where
- 3 sites in United Kingdom
- Volunteers
- 270 people, healthy volunteers welcome
- Sponsor
- Public Health England
Pregnancy, Abdominal, Sexual Behavior
Making Healthy Decisions: A Trial Evaluating the "Your Move" Teen Pregnancy-prevention Intervention
The purpose of Making Healthy Decisions is to design and rigorously evaluate a new sexual health education program, "Your Move" (YM) against a nutrition control program, "Eat Smart" (ES).
- Conditions
- Pregnancy, Abdominal, Sexual Behavior, Sexually Transmitted Infection, Sexually Transmitted Diseases
- Trial name
- NCT02993185
- Testing
- Your Move, Eat Smart
- Where
- United States
- Volunteers
- 808 people
- Sponsor
- Carnegie Mellon University
Community Acquired Bacterial Pneumonia, Complicated Intra-Abdominal Infection
Study Evaluating Tigecycline Versus Ceftriaxone In Complicated Intra-Abdominal Infections & Community Acquired Pneumonia
The main purpose of this study is to compare the safety of tigecycline versus a ceftriaxone regimen in pediatric subjects (aged 8 to 17 years) with complicated intra-abdominal infections (cIAI) and community acquired pneumonia…
- Trial name
- NCT01602874
- Testing
- Tigecycline, cIAI: Ceftriaxone with metronidazole, plus if applicable aminoglycoside, CAP: Ceftriaxone, plus if applicable oral clarithromycin
- Sponsor
- Pfizer
Appendicitis
EHR-based Decision Support for Pediatric Acute Abdominal Pain in Emergency Care
Although appendicitis is the most common surgical emergency in children, its diagnosis remains a challenge and thus, emergency department (ED) providers increasingly rely on computed tomography to distinguish appendicitis from…
- Trial name
- Appy-CDS (NCT02633735)
- Testing
- Appy CDS
- Where
- 2 sites in United States
- Volunteers
- 5,940 people, healthy volunteers welcome
- Sponsor
- HealthPartners Institute
Healthy
A Study to Assess the Levels of Two Antibiotics in the Blood When Given Together and Separately
This is a randomised study divided into 2 parts. Part A investigates the effect of prolonged dosing (ten days) with Avibactam and Ceftazidime when given together and how this will effect how much Avibactam and Ceftazidime enters…
- Trial name
- NCT01430910
- Testing
- CAZ104, Avibactam, Ceftazidime
- Where
- United Kingdom
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Pfizer
Incisional Hernia, Ventral Hernia
Risk Factors for Mesh Infection After Abdominal Wall Reconstruction
Abdominal wall reconstruction (AWR) with mesh is the standard repair for ventral, incisional, parastomal and complex abdominal wall defects, but mesh-related infection remains one of its most serious complications - prolonging…
- Conditions
- Incisional Hernia, Ventral Hernia, Parastomal Hernia, Abdominal Wall Defect
- Trial name
- NCT07725718
- Where
- Egypt
- Volunteers
- 420 people
- Sponsor
- Minia University
Surgical Wound Infection
Comparison of Surgical Site Infection Rate Between Primary, Delayed Primary and Vacuum Assisted Closures.
The objective of the study is to compare infection rates between primary, delayed primary and vacuum assisted closures in contaminated and dirty/infected laparotomy wounds.
- Trial name
- NCT02649543
- Testing
- Primary Closure, Vacuum Assisted Closure, Delayed Primary Closure
- Where
- Mexico
- Volunteers
- 81 people
- Sponsor
- Eduardo Flores Villalba
Surgical Site Infection, Post-Op Infection
Analysis of Risk Factors for Surgical Site Infections in Patients With Acute Abdomen at Hospital of State University of Haiti
The purpose of this study is to identify the risk factors associated with surgical site infection.
- Trial name
- NCT06480344
- Where
- Haiti
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- University of Haiti
Post-Acute COVID-19 Syndrome, Irritable Bowel Syndrome
Effect of Lecithin-based Curcuma and Boswellia on Post-acute COVID-19 IBS
This open-label study investigates the effects of lecithin-based formulations of Curcuma longa (Meriva™) and Boswellia serrata (Casperome™) extracts on post-acute COVID-19 irritable bowel syndrome (PCIBS) and irritable bowel…
- Conditions
- Post-Acute COVID-19 Syndrome, Irritable Bowel Syndrome, Abdominal Pain, Dysbiosis
- Trial name
- NCT06423586
- Testing
- Curcuma longa and Boswellia serrata extracts
- Where
- Italy
- Volunteers
- 44 people
- Sponsor
- Azienda di Servizi alla Persona di Pavia
Community Acquired Bacterial Pneumonia, Complicated Intra-Abdominal Infection
Study Evaluating Tigecycline Versus Ceftriaxone In Complicated Intra-Abdominal Infections & Community Acquired Pneumonia
The main purpose of this study is to compare the safety of tigecycline versus a ceftriaxone regimen in pediatric subjects (aged 8 to 17 years) with complicated intra-abdominal infections (cIAI) and community acquired pneumonia…
- Trial name
- NCT00914888
- Testing
- Tigecycline, cIAI: Ceftriaxone with metronidazole, plus if applicable aminoglycoside, CAP: Ceftriaxone, plus if applicable oral clarithromycin
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Acute Appendicitis, Acute Abdomen
Transversus Abdominis Plane Block in Acute Appendicitis Pain Managment
In this study, it was aimed to investigate the analgesic efficacy of the preoperatively applied Transversus Abdominis Plane (TAP) Block in the management of acute appendicitis-related abdominal pain and post-appendectomy pain.
- Conditions
- Acute Appendicitis, Acute Abdomen, Postoperative Pain
- Trial name
- NCT05004532
- Volunteers
- 22 people
- Sponsor
- Erol Olcok Corum Training and Research Hospital
Abdominal Abscess, Tissue Plasminogen Activator
Treatment of Abdominal Abscesses With or Without Fibrinolysis
The objective of this study is to evaluate the utility of fibrinolysis when draining an abdominal abscess as defined by length of stay after drainage.
- Trial name
- NCT01597336
- Testing
- Tissue plasminogen activator abscess flush, Saline flush of abscess
- Where
- United States
- Volunteers
- 92 people
- Sponsor
- Children's Mercy Hospital Kansas City
Complicated Intra-abdominal Infection
Study to Compare TP-434 and Ertapenem in Community-acquired Complicated Intra-abdominal Infections
This is a Phase 2, randomized, double-blind, double-dummy, multicenter, prospective study to assess the efficacy, safety, and pharmacokinetics of two dose regimens of TP-434 compared with ertapenem in the treatment of adult…
- Trial name
- NCT01265784
- Testing
- TP-434, Ertapenem
- Where
- 38 sites in United States, Bulgaria and 4 more
- Volunteers
- 143 people
- Sponsor
- Tetraphase Pharmaceuticals, Inc
Surgical Site Infection, Groin Hernia
Prophylactic Antibiotics in Groin Hernioplasty
The role of prophylactic antibiotics in preventing surgical site infections (SSI) for clean procedures like groin hernia repair remains controversial.
- Conditions
- Surgical Site Infection, Groin Hernia, Hernioplasty
- Trial name
- NCT07111702
- Testing
- Cefazolin
- Where
- Yemen
- Volunteers
- 100 people
- Sponsor
- Sana'a University
Intra Abdominal Infections, Candidiasis, Invasive
Peritoneal 1.3-ß-D-glucan for the Diagnosis of Intra-abdominal Candidiasis in Critically Ill Patients (pBDG2)
New rapid diagnostic strategies are warranted in intra-abdominal candidiasis (IAC). A previous retrospective study showed that one measure, the day of the surgery, of peritoneal 1.3-Beta-D-Glucan ≤ 310pg/ml could rule out an IAC.
- Conditions
- Intra Abdominal Infections, Candidiasis, Invasive, Peritoneal Candidiasis, Critically Ill
- Trial name
- pBDG2 (NCT03997929)
- Testing
- 1.3 BETA D GLUCAN
- Where
- 4 sites in France
- Volunteers
- 200 people
- Sponsor
- Central Hospital, Nancy, France
Appendicitis (Diagnosis)
Precision Antibiotic Dosing for Appendectomy
This research is studying a drug called cefoxitin already approved by the Food and Drug Administration (FDA) to reduce the risk of infection after surgery to remove an appendix.
- Trial name
- PANDA (NCT06860802)
- Testing
- Cefoxitin
- Where
- United States
- Volunteers
- 53 people
- Sponsor
- University of Michigan
Surgical Site Infection
Roles of Prophylactic Subcutaneous Drain in Preventing Surgical Site Infection in Surgical Wound After Abdominal Surgery
Surgical site infections (SSI) pose a common challenge in the field of surgery. Current evidence and literature do not provide clear consensus whether the use of subcutaneous drainage will help reduce the incidence of SSI in…
- Trial name
- NCT06063629
- Testing
- Subcutaneous drain, No drain
- Volunteers
- 180 people
- Sponsor
- Queen Savang Vadhana Memorial Hospital, Thailand