Clinical trials: Abdominal Discomfort
Gut Health, Microbiome
A Clinical Trial to Evaluate the Effects of a Fibre Supplement on Microbiome and Gut Health
This study will evaluate the effects of the Artah Essential Fibre+ supplement on the microbiome and gut health over an 8-week period.
- Conditions
- Gut Health, Microbiome, Bloating, Indigestion
- Trial name
- NCT07781488
- Testing
- Essential Fibre+
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Artah Nutrition Limited
Abdominal Pain/ Discomfort, Slightly Constipation
Effect of Perilla Extract on Improvement on Gastrointestinal Discomfort
In the current study the effects of proprietary Perilla frutescens leaf extract in comparison to Maltodextrin, a fully digestible carbohydrate (placebo control), on gastrointestinal discomfort and bowel function were…
- Trial name
- NCT01931930
- Testing
- Perilla extract, Maltodextrin
- Where
- Germany
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Amino Up Chemicals Co., Ltd.
Abdominal Pain
Impact of Carbon Dioxide Insufflation and Water Exchange on Post-Colonoscopy Outcomes
Room air insufflated during colonoscopy cannot be completely suctioned, is not easily absorbed and remains in the bowel for quite some time, resulting in prolonged bowel distension with the discomfort of bloating.
- Trial name
- NCT02409979
- Testing
- Carbon dioxide method, Water Exchange-CO2, Water Exchange-AI
- Where
- 3 sites in United States, Czechia and 1 more
- Volunteers
- 246 people
- Sponsor
- Presidio Ospedaliero Santa Barbara
Gastrointestinal Discomfort, Gastrointestinal Side Effects of GLP-1 Receptor Agonist Use
A Study to Evaluate the Effects of a Supplement on Gut Comfort in GLP-1 Receptor Agonist Users
This is a randomized, triple-blind, placebo-controlled, virtual clinical trial evaluating the effects of the Oxxynea® botanical supplement on gut comfort in adults who use GLP-1 receptor agonists (GLP-1 RAs).
- Conditions
- Gastrointestinal Discomfort, Gastrointestinal Side Effects of GLP-1 Receptor Agonist Use, Nausea, Abdominal Pain
- Trial name
- NCT07898189
- Testing
- Oxxynea® Supplement
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- AB Mauri (UK) Limited,
Chronic Pain
Lichtenstein Patch or Prolene Hernia System (PHS) for Inguinal Hernia Repair
This randomised prospective study was designed to compare the convalescence and the long-term sequelae in inguinal hernia repair with either a bilayer mesh as devised by Gilbert (Prolene Hernia System®) or an onlay mesh applied…
- Trial name
- NCT01070693
- Testing
- Open mesh inguinal hernia repair, Prolene Hernia System, Lichtenstein technique
- Where
- Finland
- Volunteers
- 300 people
- Sponsor
- Helsinki University Central Hospital
Healthy Subjects
Evaluation of the the Efficacy of a Digestive Health Supplement in Healthy Subjects
The objective of this study is to evaluate the efficacy of a digestive health supplement via waist circumference measurements, daily bowel habit and symptom logs, and self-perception questionnaires (SPQ) over 4 weeks.
- Trial name
- NCT06680219
- Testing
- Active comparator
- Where
- United Kingdom
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Pharmanex
Postoperative Thirst, Comfort
Effect of Postoperative Oral Rinsing on Dehydration-Related Discomfort, Comfort, and Bowel Sounds
The aim of this study is to evaluate the effects of oral rinsing with water in the postoperative period on thirst, comfort level, and bowel motility in patients undergoing abdominal surgery under general anesthesia.
- Conditions
- Postoperative Thirst, Comfort, Bowel Movements, Abdominal Surgeries
- Trial name
- NCT07236749
- Testing
- oral rinsing, rutine service operation
- Where
- Turkey (Türkiye)
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- Cumhuriyet University
Gut Health
Effectiveness of a Butyrate Formulation and Butyrate + Polyphenol Formulation on Gut Health, Permeability and Associated Symptoms
The purpose of this study is the assess the effectiveness and safety of a Butyrate formulation and a Butyrate + Polyphenol formulation on gut health, permeability and associated symptoms
- Trial name
- NCT06419231
- Testing
- Butyrate Formulation, Butyrate + Polyphenol Formulation
- Where
- United States
- Volunteers
- 143 people, healthy volunteers welcome
- Sponsor
- Supplement Formulators, Inc.
Appendicitis, Chronic Post-Procedural Pain
Pain and Discomfort After Appendectomy in Children
Appendectomy is the most common surgical procedure. Chronic abdominal pain is an uncommon complication following appendectomy. It is observed that pediatric patients who have undergone abdominal surgical procedure complained of…
- Trial name
- NCT03791229
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Sakarya University
Gastritis, Peptic Ulcer Disease
Frequent Ketamine Use and Gastrointestinal, Liver and Biliary Sequelae
30% of ketamine users complain of abdominal discomfort. Long-term ketamine use is associated with hepatotoxicity and pathologic changes to the biliary tract.
- Conditions
- Gastritis, Peptic Ulcer Disease, Cholangiopathy, Liver Fibrosis
- Trial name
- NCT02165488
- Where
- Hong Kong
- Volunteers
- 100 people
- Sponsor
- The University of Hong Kong
Colic
Study to Evaluate Efficacy and Safety of Oral Doses of Hyoscine Butylbromide for the Treatment of Occasional Abdominal Pain, Cramping, and Discomfort
Study to determine whether hyoscine butylbromide can provide adequate symptomatic relief of a single episode - defined as lasting not longer than 1 day - and multiple episodes of abdominal pain or discomfort associated with…
- Trial name
- NCT02242292
- Testing
- Hyoscine butylbromide
- Volunteers
- 527 people
- Sponsor
- Boehringer Ingelheim
Abdominal Pain, Abdominal Discomfort
Pilot Study Studying Physiological Effects of Probiotic Pills in Patients With Abdominal Pain/Discomfort and Bloating
We are conducting a study to learn if probiotics, which are live bacteria found in food like yogurt and cheese, will improve symptoms of abdominal pain.
- Conditions
- Abdominal Pain, Abdominal Discomfort, Bloating, Functional Bowel Disorders
- Trial name
- NCT01064661
- Testing
- Single probiotic arm of L-NCFM alone, Blend probiotic arm of L-NCFM and B-LBi07
- Volunteers
- 22 people
- Sponsor
- University of North Carolina, Chapel Hill
Catheter Related Complication
Intrathecal Morphine for Radical Robot Assisted Prostatectomy (TORNADO)
investigators aim to compare the efficacy of intrathecal morphine, intravenous tramadol and transversus abdominis plane block in the treatment of catheter related bladder discomfort syndrome in patients scheduled for robotic…
- Trial name
- TORNADO (NCT04814745)
- Testing
- intrathecal infusion, Intravenous Infusion, Ropivacaine injection
- Where
- Italy
- Volunteers
- 33 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Abdominal Pain/ Discomfort, Irritable Bowel Syndrome
The Mechanism Underlying the Analgesic Effect of the Music of IBS Pain
The proposed pilot study aims to assess the underlying mechanisms of the MBI on IBS pain and the feasibility of using novel technology in the outcome measurements.
- Trial name
- NCT06706778
- Testing
- Music intervention
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Yale University
Irritable Bowel Syndrome
A Study To Investigate The Effect Of PD-217,014 On Abdominal Pain/Discomfort In Patients With IBS.
The purpose of this study is to determine the effectiveness of PD-217,014 in the treatment of abdominal pain/discomfort associated with irritable bowel disease.
- Trial name
- NCT00139672
- Testing
- PD-217,014
- Volunteers
- 330 people
- Sponsor
- Pfizer
Endoscopy
Is End Tidal CO2 Level Elevation During Upper Endoscopy With CO2 Gas Insufflation Physiologically Significant
During the course of an endoscopic procedure, air has historically been used to inflate the lumen to provide adequate visualization and allow for the endoscope to advance as necessary.
- Trial name
- ETCO2 (NCT04541667)
- Testing
- Air, Carbon Dioxide
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- University of Nebraska
Breast Cancer, Chemotherapy-induced Diarrhea
Probiotics for Abemaciclib-Induced Abdominal Discomfort.
This study aims to evaluate whether the addition of probiotics can help reduce abdominal discomfort (such as diarrhea) in breast cancer patients receiving Abemaciclib treatment.
- Trial name
- NCT07605728
- Where
- Taiwan
- Volunteers
- 80 people
- Sponsor
- Leeuwenhoek Laboratories Co. Ltd.
Abdominal Discomfort, Bloating
Study to Evaluate a Probiotic in Healthy Subjects With a History of Abdominal Discomfort and Bloating
This is a multicenter, double-blind, randomized, placebo-controlled, 6-week study of a probiotic for abdominal discomfort and bloating in healthy subjects.
- Trial name
- NCT01099696
- Testing
- B. infantis 35624
- Where
- 10 sites in United States
- Volunteers
- 302 people, healthy volunteers welcome
- Sponsor
- Procter and Gamble
Chronic Pain, Ventral Hernia
Chronic Complaints After Small Umbilical Hernia Repair
There are only little data on the risk of chronic complaints (pain and discomfort) following open non-mesh sutured repairs of small umbilical or epigastric hernias.
- Trial name
- NCT01741740
- Volunteers
- 295 people
- Sponsor
- Hvidovre University Hospital
Bloating
A Study to Evaluate OPTI-BIOME™ Bacillus Subtilis MB40 on Abdominal Discomfort, Gas and Bloating in a Healthy Population
The purpose of this study is to investigate the effects of OPTI-BIOME™ (Bacillus subtilis MB40), a probiotic supplement, on bloating, gas and abdominal discomfort symptoms in otherwise healthy adults.
- Trial name
- NCT02950012
- Testing
- OPTI-BIOME™ Bacillus subtilis MB40
- Where
- 3 sites in United States, Canada
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- BIO-CAT Microbials, LLC