Clinical trials: Abdominal Sepsis
Appendicitis Acute, Covid19
Management of Acute Appendicitis at District General Hospital
The Investigators aim to assess; 1. whether the changes in managing patients during COVID has reduced the negative appendicectomy rate? 2.
- Trial name
- NCT04707339
- Testing
- Appendicectomy
- Where
- United Kingdom
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Princess Alexandra Hospital NHS Trust
Lower Abdominal Pain, Right Iliac Fossa Pain
Non Operative Treatment for Acute Appendicitis
Case control studies that randomly assign patients to either surgical or non-surgical treatment yield a relapse rate of approximately 14% at one year.
- Conditions
- Lower Abdominal Pain, Right Iliac Fossa Pain, Acute Appendicitis
- Trial name
- NOTA (NCT01096927)
- Testing
- Amoxicillin and Clavulanic Acid
- Where
- Italy
- Volunteers
- 160 people
- Sponsor
- Maggiore Bellaria Hospital, Bologna
Pneumonia, Lung Abscess
Special Use-Result Surveillance of Unasyn-S (Kit) for Intravenous Use - A Surveillance on High-dose (>6 g Daily) Administration -
The purpose of the survey is to study the followings under practical use, regarding the safety and effectiveness in high-dose administration (exceeding 6 g per day) of UNASYN-S and UNASYN-S KIT for intravenous use (UNASYN). 1.
- Conditions
- Pneumonia, Lung Abscess, Peritonitis
- Trial name
- NCT01793688
- Testing
- Sulbactam Sodium/Ampicillin Sodium
- Volunteers
- 982 people
- Sponsor
- Pfizer
Cholecystitis, Appendicitis
Ultrasound Guided Rectus Sheath Block and Transversus Abdominis Plane Block
The current study aimed to assess the efficacy of Dexmedetomidine (DEX) and Dexamethasone as an adjuvant to ultrasound guided TAP and RS block to prolongation of postoperative analgesia and better pain control in children…
- Trial name
- NCT04838379
- Testing
- Dexmedetomidine
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Assiut University
Peritonitis
Health Economic Assessment of Tygacil® in the Treatment of Secondary Peritonitis in Intensive Care Units (ICUs)
The main goals of the study are: Assessment of Tygacil's cost-effectiveness; Process cost analysis from a hospital perspective (including length of stay, treatment costs, side effect management costs, costs of monitoring, costs…
- Trial name
- NCT00481962
- Testing
- Tygacil
- Where
- Germany
- Volunteers
- 180 people
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Perforated Appendicitis
Role of Intravenous Versus Home Oral Antibiotics in Perforated Appendicitis
To compare the effect of a single-agent home intravenous (IV) versus oral antibiotic therapy on complication rates and resource utilization following appendectomy for perforated appendicitis
- Trial name
- NCT02724410
- Testing
- home intravenous ertapenem, home oral amoxicillin-clavulanate, peripheral inserted central Catheter
- Volunteers
- 82 people
- Sponsor
- Wake Forest University Health Sciences
Peritonitis
Point-of-care Test for Diagnosis of Peritonitis in Peritoneal Dialysis Patients
Peritoneal dialysis (PD) is a home-based dialysis therapy and peritonitis is a serious complication in PD. A reliable point-of-care test to detect peritonitis is important for patients to self-detect peritonitis at home as…
- Trial name
- Periplex (NCT04070196)
- Testing
- Periplex
- Where
- Singapore
- Volunteers
- 120 people
- Sponsor
- Singapore General Hospital
Secondary Peritonitis
Treatment of Peritonitis in Automated Peritoneal Dialysis
The main infectious complication of peritoneal dialysis (PD) is bacterial peritonitis, which increases morbidity, mortality and conversion to hemodialysis. In Mexico, 485 patients per million people undergo PD.
- Trial name
- NCT04077996
- Testing
- Peritonitis treatment placed in APD, Peritonitis treatment with one exchange in CAPD
- Where
- 3 sites in Mexico
- Volunteers
- 64 people
- Sponsor
- Universidad de Colima
Intra-abdominal Infection
Hellenic Registry for cIAIs (HERCO-II)
Complicated Intra-Abdominal Infections (cIAIs) represent an emergent surgical situation which lead to important non trauma-related mortality in several Emergency Surgical Centers worldwide.
- Trial name
- HERCO-II (NCT05549076)
- Where
- Greece
- Volunteers
- 300 people
- Sponsor
- Maximos Frountzas
Bacterial Infections and Mycoses, Appendicitis
Doripenem in the Treatment of Complicated Intra-Abdominal Infections
The purpose of this study is to compare the clinical response rate of doripenem versus a comparator in the treatment of hospitalized patients with complicated intra-abdominal infections.
- Conditions
- Bacterial Infections and Mycoses, Appendicitis, Cholecystitis, Pancreatitis
- Trial name
- NCT00229060
- Testing
- doripenem
- Volunteers
- 483 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Appendicitis
Appendectomy vs. Symptomatic Treatment in Uncomplicated Acute Appendicitis Among Pediatric Patients
The APPSYPP trial is a randomized national multicenter feasibility superiority pilot study comparing appendectomy with symptomatic treatment in children with imaging-confirmed uncomplicated acute appendicitis.
- Trial name
- APPSYPP (NCT05289713)
- Testing
- appendectomy
- Where
- Finland
- Volunteers
- 64 people
- Sponsor
- Helsinki University Central Hospital
Postoperative Infections, Jaundice
Effectiveness Of Symbiotic Therapy In Jaundiced Patients
The aim of the present study was therefore to evaluate if the perioperative administration of symbiotics reduces postoperative infectious morbidity in jaundiced patients scheduled for hepato-biliary and pancreatic surgery.
- Trial name
- NCT01683708
- Testing
- Symbiotic therapy
- Volunteers
- 20 people
- Sponsor
- Azienda Ospedaliera Ordine Mauriziano di Torino
Septic Shock, Peritonitis
Pharmacokinetic Study on Echinocandins for Patients With Septic Shock Following Secondary Peritonitis (EPI Study)
The main objective of this study is to describe the pharmacokinetics of the prescribed echinocandins for septic shock with secondary peritonitis for which intra-abdominal fungal infection is suspected or proven.
- Trial name
- NCT02805049
- Testing
- Echinocandins
- Where
- 2 sites in Australia, France
- Volunteers
- 24 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Peritoneal Dialysis Associated Peritonitis, Peritoneal Dialysis (PD)
Pharmacokinetics of Meropenem and Aztreonam After Intraperitoneal Administration Via Cycler-therapy in APD Patients Without Peritonitis
Peritoneal dialysis-associated peritonitis (PDAP) remains one of the most serious complications in patients undergoing peritoneal dialysis (PD), contributing significantly to hospitalization, technique failure, and mortality.
- Conditions
- Peritoneal Dialysis Associated Peritonitis, Peritoneal Dialysis (PD), Peritoneal Dialysis, Peritoneal Dialysis, Continuous Ambulatory
- Trial name
- NCT07113574
- Testing
- Meropenem 1000 mg, Aztreonam 2000 mg, automated peritoneal dialysis with following long time dwell
- Where
- Austria
- Volunteers
- 12 people
- Sponsor
- Karl Landsteiner Insitute for Nephrology and Haemato-Oncology
Perforated Appendicitis
Use of Antibiotic Irrigation to Decrease Wound Infections in Pediatric Perforated Appendicitis
The proposed study will investigate whether antibiotic irrigation using a gentamicin/clindamycin solution during laparoscopic appendectomy is superior in preventing postoperative wound infections and IAA in perforated…
- Trial name
- PA protocol (NCT04039750)
- Testing
- antibiotic rinse with suction, suction only
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Prisma Health-Upstate
Appendicitis
TRIAD Appendicitis Decision-making Surveys
While appendectomy has been the main treatment of appendicitis for over 100 years, recent European studies found that, at least among highly selected patients, antibiotics alone can be an effective alternative.
- Trial name
- TRIAD (NCT05887414)
- Testing
- Baseline, 30 Day Follow Up
- Where
- 17 sites in United States
- Volunteers
- 2,542 people
- Sponsor
- University of Washington
Complicated Intra-abdominal Infection
Study Comparing the Safety and Efficacy of Intravenous CXA-201 and Intravenous Meropenem in Complicated Intraabdominal Infections
This is a Phase 3, multicenter, prospective, randomized, double-blind, double dummy study of CXA-201 Intravenous (IV) infusions (1500mg q8h) and metronidazole (500mg q8h) versus meropenem (1000mg q8h)for the treatment of adults…
- Trial name
- NCT01445678
- Testing
- CXA-201 and metronidazole, Meropenem
- Where
- 61 sites in United States, Argentina and 13 more
- Volunteers
- 494 people
- Sponsor
- Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)
Peritoneal Infection
Pharmacokinetics Study of Intraperitoneal Administration of Daptomycin in Peritoneal Infection
Peritoneal infection is still a frequent complication in peritoneal dialysis patients . In France, It contributes to the technique failure, responsible for about 20% of cases of transfer in hemodialysis.
- Trial name
- DAPTODP (NCT02000414)
- Testing
- intraperitoneal daptomycin
- Where
- France
- Volunteers
- 8 people
- Sponsor
- University Hospital, Caen
Appendicitis
EFFECT OF USING SAME DERMATOME LİNE FOR ALL PORT SİTES IN LAPAROSCOPIC APPENDECTOMY IN ACUTE APANDICITIS
Acute apandicitis is the one of most common cause of abdominal pain.Most of center still use open appendectomy(OA) technic for acute apandisitis.But Semm was defined Laparoskopic appendectomy(LA) with 3 ports in 1983.Today…
- Trial name
- DERMATOME (NCT03792802)
- Testing
- laparoscopic appendectomy port sites
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Fatih Sultan Mehmet Training and Research Hospital
Hospital Acquired Pneumonia, Ventilator Acquired Pneumonia
Real-World Study of Ceftazidime Avibactam in China
This observational study will enroll approximately 450 in patients. Patients treated with CAZ AVI for at least 1 dose at around 20 research centers in China will be enroll.
- Conditions
- Hospital Acquired Pneumonia, Ventilator Acquired Pneumonia, Complicated Intra Abdominal Infections
- Trial name
- REACT (NCT05487586)
- Testing
- ceftazidime avibactam group
- Where
- 17 sites in China
- Volunteers
- 220 people
- Sponsor
- Pfizer