Clinical trials: Ablation
Prostatic Neoplasm
A Phase II Trial of Leuprolide + Flutamide + Suramin in Untreated Poor Prognosis Prostate Carcinoma
One current hypothesis as to what limits duration of initial hormone response is the rapid emergence of hormone resistant prostate carcinoma cells.
- Trial name
- NCT00001266
- Testing
- Suramin
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- National Cancer Institute (NCI)
Paroxysmal Atrial Fibrillation (PAF), Persistent Atrial Fibrillation
Outcomes of an Optimized Workflow With PulseSelect Pulsed Field Ablation (PFA) System in Paroxysmal and Persistent Atrial Fibrillation
The NEXT PULSE study is a pre-market, prospective, multi-center, non-randomized, interventional clinical study. Adult subjects with symptomatic paroxysmal or persistent AF who provided consent will be enrolled and treated with…
- Trial name
- NEXT PULSE (NCT07575828)
- Testing
- PulseSelect Pulse Field Ablation (PFA) System
- Volunteers
- 320 people
- Sponsor
- Medtronic Cardiac Ablation Solutions
Non-small Cell Lung Cancer (NSCLC), Huaier Granules
Clinical Efficacy and Safety of Microwave Ablation Combined With Huaier Granules in Patients With Inoperable Stage IA Non-Small Cell Lung Cancer: A Prospective, Single-Center, Randomized Controlled Clinical Trial
This prospective, single-center, randomized controlled clinical trial aims to evaluate the efficacy and safety of microwave ablation (MWA) combined with Huaier granules in patients with inoperable stage IA non-small cell lung…
- Conditions
- Non-small Cell Lung Cancer (NSCLC), Huaier Granules, Microwave Ablation
- Trial name
- HAMSTER (NCT07197853)
- Testing
- Huaier Granule
- Volunteers
- 180 people
- Sponsor
- Xin Ye
Atrial Fibrillation, Heart Failure
Surgical Ablation of AF Efficacy Trial
SAFE is an international multicentre RCT of concomitant surgical atrial fibrillation (AF) ablation in patients with paroxysmal or persistent AF undergoing cardiac surgery.
- Trial name
- SAFE (NCT05434819)
- Testing
- Surgical Atrial Fibrillation Ablation
- Where
- Canada
- Volunteers
- 2,000 people
- Sponsor
- Population Health Research Institute
Non-small Cell Lung Cancer
Thermal Ablation Combined With External Beam Radiation Therapy for Patients With Inoperable Non-Small Cell Lung Cancer > 3.5 cm in Size
The main objective of this study is to assess the initial safety of the combination of interventional ablation and external beam radiotherapy including acute and late toxicity (90 days) for patients with early stage lung cancer.
- Trial name
- NSCLC (NCT01028612)
- Testing
- thermal ablation with external beam radiation
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Wake Forest University Health Sciences
Atrial Fibrillation, Catheter Ablation
Benefit of Complex Fractionated Atrial Electrograms Elimination in Atrial Fibrillation Ablation
The aim of this study is to evaluate whether performing complex fractionated atrial electrograms ablation improves outcomes in persistent or atrial fibrillation ablation.
- Trial name
- NCT00873067
- Testing
- Additional Complex Fractionated Electrograms ablation, Standard atrial fibrillation ablation procedure
- Where
- Spain
- Volunteers
- 142 people
- Sponsor
- Hospital Clinic of Barcelona
Atrial Fibrillation, Anticoagulants and Bleeding Disorders
Safety and Efficacy of Edoxaban in Thoracoscopic Ablation
The aim of this study is to compare the safety and efficacy of edoxaban and warfarin for prevention of stroke during a 6-month follow up after total thoracoscopic ablation.
- Trial name
- NCT04121767
- Testing
- Edoxaban, Warfarin
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Samsung Medical Center
Anus Cancer, Fecal Incontinence
Function Following Laser for Anal Intraepithelial Neoplasia (FLAN)
High-grade squamous intraepithelial lesions (HSIL) and anal cancer are rising in incidence and at highest risk are HIV positive men who have sex with men (MSM).
- Conditions
- Anus Cancer, Fecal Incontinence, Anal Intraepithelial Neoplasia, Post Operative Pain
- Trial name
- FLAN (NCT04109573)
- Testing
- high resolution anal manometry
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- Homerton University Hospital NHS Foundation Trust
Cholangiocarcinoma
RFA Combined With Chemotherapy for Unresectable Cholangiocarcinoma
Extrahepatic cholangiocarcinoma is a malignant tumor that is highly malignant and difficult to diagnose and treat early. Endobiliary radiofrequency ablation (RFA) has been reported to be a beneficial treatment option for…
- Trial name
- NCT05028439
- Testing
- radiofrequency ablation, Chemotherapy drug
- Where
- China
- Volunteers
- 70 people
- Sponsor
- First People's Hospital of Hangzhou
Back Pain
EuroPainClinicsStudy XIr-Zj
Determine the efficacy of lumbar medial branch neurotomy by radiofrequency and cryoablation in patients with chronic low back pain
- Trial name
- EPCS XIr-Zj (NCT05813639)
- Testing
- Lumbar medial branch cryo ablation neurotomy, Lumbar medial branch radiofrequency ablation neurotomy, Endoscopic denervation of fazet joint
- Where
- Slovakia
- Volunteers
- 150 people
- Sponsor
- EPC Education s.r.o.
Atrial Fibrillation, Atrial Flutter
Prevention of Atrial Fibrillation by Inhibition Conversion Enzyme (ICE) After Radiofrequency Ablation of Atrial Flutter
Atrial Flutter [AFL] is a relatively frequent arrhythmia, considered as benign, but associated with both invalidating symptoms and thromboembolic risk.
- Trial name
- PREFACE (NCT00736294)
- Testing
- Ramipril
- Where
- 8 sites in France
- Volunteers
- 198 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Atrial Fibrillation, Catheter Ablation
Prospective Physician-Initiated Observational Study of The Contact Detection System (CDS) in Patients Undergoing Radiofrequency Ablation Using the Niobe™ Remote Magnetic Navigation System
This observational study evaluates peri-procedural results of the Niobe™ Remote Magnetic Navigation (RMN) ES system using the contact detection system (CDS) in patients undergoing standard of care radiofrequency ablation of…
- Trial name
- STAR (NCT03103945)
- Testing
- CDS box connection of the Niobe™ Remote Magnetic Navigation System
- Where
- Netherlands
- Volunteers
- 30 people
- Sponsor
- Erasmus Medical Center
Paroxysmal Atrial Fibrillation
Cryoballoon Ablation of Pulmonary Veins After Failed RF Ablation in Patients With Paroxysmal AF
The aim of this prospective randomized double-blind study was to compare the efficacy and safety of cryoballoon ablation with the RF approach in the treatment of paroxysmal AF after failed first radiofrequency ablation.
- Trial name
- NCT01611701
- Testing
- cryoballoon ablation, Radiofrequency ablation
- Where
- 2 sites in United States, Russia
- Volunteers
- 80 people
- Sponsor
- Meshalkin Research Institute of Pathology of Circulation
Atrial Fibrillation
PV Cryoablation Efficacy (COR ADVANCE Study)
The COR advance study is a non-randomized prospective single center study to assess the results of an electrophysiologically guided approach for PV cryoablation using the Arctic Front Advance ST® catheter together with the…
- Trial name
- COR-ADVANCE (NCT02588183)
- Testing
- ArticFont Advance ST Cryoenergy Balloon Catheter
- Where
- Spain
- Volunteers
- 25 people
- Sponsor
- Hospital San Carlos, Madrid
Paroxysmal Atrial Fibrillation
Ultrasensitive Electroanatomic Mapping to Adjudicate Endpoints for Ablation In Paroxysmal AF Patients Using Cryoballoon
Ultrasensitive Electroanatomic Mapping to Adjudicate Endpoints for Ablation In Paroxysmal AF Patients Using Cryoballoon
- Trial name
- NCT04109053
- Sponsor
- BayCare Health System
Atrial Fibrillation
Efficacy, Safety and Efficiency Study of CARTO® 3 System Guided THERMOCOOL® Catheter Ablation Versus Fluoroscopy Guided Ablation With the Pulmonary Vein Ablation Catheter® (PVAC®)
The purpose of this study is to compare the efficacy, safety and efficiency of CARTO® 3 system guided THERMOCOOL® catheter ablation and fluoroscopy guided Pulmonary Vein Ablation Catheter® (PVAC®) guided ablation for the…
- Trial name
- CLARITY-AF (NCT01116557)
- Testing
- Radiofrequency Ablation procedure
- Volunteers
- 79 people
- Sponsor
- Biosense Webster, Inc.
Persistent Atrial Fibrillation
FIND CAN Trial: "CF-172"
The purpose of this feasibility study is to further explore characteristics of ablation targets identified by CARTOFINDER 4D LAT Algorithm in subjects with persistent atrial fibrillation and to assess the acute outcome of…
- Trial name
- FIND CAN (NCT03033641)
- Testing
- Ablation procedure
- Volunteers
- 25 people
- Sponsor
- Biosense Webster, Inc.
Atrial Fibrillation
Effects of Mindfulness on Atrial Fibrillation
This study aims to investigate the effect of MUSE (R) Headbands on patients with Atrial Fibrillation who is awaiting pulmonary vein isolation ablation procedure. Patients are randomized in 2 arms.
- Trial name
- NCT02564302
- Testing
- MUSE Headband
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Newmarket Electrophysiology Research Group Inc
Low Risk Differentiated Thyroid Cancer
Differentiated Thyroid Cancer: is There a Need for Radioiodine Ablation in Low Risk Patients?
Open-label randomized phase III trial, using a non-inferiority comparison design. After randomization,patients will receive either post-operative radioiodine ablation with an activity of 1.1 GBq (30 mCi) after stimulation by…
- Trial name
- ESTIMABL2 (NCT01837745)
- Testing
- rhTSH stimulation, I131, Follow up
- Where
- France
- Volunteers
- 776 people
- Sponsor
- Gustave Roussy, Cancer Campus, Grand Paris
Microwave Ablation, Contrast-enhanced Ultrasound
Efficacy and Prognosis of Microwave Ablation Treatment for Papillary Thyroid Microcarcinoma Assessed by Contrast-Enhanced Ultrasound Combined With Genetic and Molecular Diagnostics: A Prospective Observational Study
In 2016, there were 203,000 new cases of thyroid cancer in China, ranking 7th among all malignant tumours and 4th among women, and showing a rapid growth trend.
- Conditions
- Microwave Ablation, Contrast-enhanced Ultrasound, Genetic and Molecular Diagnostics, Papillary Thyroid Microcarcinoma
- Trial name
- NCT07054229
- Testing
- Contrast enhanced Ultrasound, 88-gene panel for thyroid cancer
- Where
- China
- Volunteers
- 480 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University