Clinical trials: Ablation Techniques
Atrial Fibrillation
Comparing Surgical Management Methods of Atrial Fibrillation
Compare the efficacy of the left atrial Cox-Maze IV lesion set versus the Tampa 2 lesion set versus the EnCompass ablation alone, in the surgical treatment of atrial fibrillation at one year post-operatively.
- Trial name
- NCT07100483
- Testing
- Atrial Fibrillation Ablation
- Where
- United States
- Volunteers
- 220 people
- Sponsor
- Corewell Health West
Atrial Fibrillation
Augmented Wide Area Circumferential Catheter Ablation for Reduction of Atrial Fibrillation Recurrence
Atrial fibrillation (AF) is an abnormal heart rhythm in which the top chambers of the heart beat very fast. AF catheter ablation is a known technique to convert heart rhythm from AF to normal rhythm.
- Trial name
- AWARE (NCT02150902)
- Testing
- Wide area circumferential catheter ablation, Augmented- wide area circumferential ablation procedure
- Where
- 11 sites in Canada
- Volunteers
- 411 people
- Sponsor
- Ottawa Heart Institute Research Corporation
Superficial Vein Thrombosis, Endovenous Laser Ablation
Endovenous Laser Ablation in Acute Thrombophlebitis of the Varicose Great Saphenous Vein
Рrospective single-centre randomized open-label study for comparison three modes of treatment for thrombosis of varicose great saphena vein - standard medical with fondaparinux sodium for 45 days, endovenous laser ablation close…
- Trial name
- NCT05001776
- Testing
- Endovenous laser ablation, Fondaparinux Sodium
- Where
- Russia
- Volunteers
- 105 people
- Sponsor
- National Medical Research Center for Therapy and Preventive Medicine
Cancer
Safety And Accuracy Study Of The Actisight™ Needle Guidance System In Patients Undergoing CT-Guided Procedures
This will be a prospective, single-arm, single-center, open-label study to evaluate the preliminary safety and accuracy of the ActiSight™ Needle Guidance System in patients undergoing CT-guided percutaneous aspiration and RF…
- Trial name
- NCT01040884
- Testing
- ActiSight Needle Guidance System
- Where
- Israel
- Volunteers
- 40 people
- Sponsor
- ActiViews Ltd.
Atrial Fibrillation, Atrial Fibrillation (Paroxysmal)
Wide-Antral Pulmonary Vein Isolation in Atrial Fibrillation Ablation with a Single-shot Technique (WIDER-PVI)
The WIDER PVI study is a multicentre randomized clinical trial to compare the efficacy of antral versus extended antral PVI in patients with paroxysmal or persistent AF undergoing this procedure using a cryoablation balloon…
- Trial name
- WIDER-PVI (NCT06698159)
- Testing
- Cryoablation with cryoballoon 28 mm, Cryoablation with cryoballoon 31 mm
- Where
- 17 sites in Italy, Spain
- Volunteers
- 440 people
- Sponsor
- Hospital Universitario 12 de Octubre
Breast Cancer
High Intensity Focused Ultrasound Guided by MRI as Thermic Destruction in Primitive Small Size Breast Cancer
This is a non-randomized, prospective phase II trial evaluating an innovative treatment, focused MRI-guided ultrasound, as thermic destruction in primitive small size breast cancer.
- Trial name
- MRHEATBREAST (NCT03126487)
- Testing
- HIGH INTENSITY FOCUSED ULTRASOUND
- Where
- France
- Sponsor
- Centre Antoine Lacassagne
Lung Diseases
Defining a Technique for the Use of Cryogenic Catheters for Biopsy and Ablation for the Diagnostic and Treatment of Pulmonary Lesions: An Ex-Vivo Human Lung Model Study.
Developing a standardized methodology for the use of novel cryogenic catheters for transbronchial cryobiopsy and cryoablation of pulmonary lesions.
- Trial name
- CT0129 (NCT05948904)
- Testing
- Cryo Ex Vivo
- Where
- Canada
- Volunteers
- 200 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Atrial Tachycardia, Atrial Fibrillation
Catheter Ablation of All Inducible AT Post AF Ablation
In the treatment of symptomatic drug resistant persistent atrial fibrillation (Ps AF), catheter ablation has a class IIA indication.
- Trial name
- INDUCATH (NCT03343860)
- Testing
- AT case 1.1, AT case 2.1, AT case 1.2
- Where
- 6 sites in Belgium, France and 2 more
- Volunteers
- 60 people
- Sponsor
- AZ Sint-Jan AV
PVC - Premature Ventricular Complex, Ablation
Virtual Reality in Electrophysiology Laboratory (EP)
The purpose of this study is to evaluate the use of virtual reality (VR) technology as adjunct to routine anesthesia care for patients undergoing electrophysiology (EP) procedures.
- Trial name
- NCT04893278
- Testing
- Virtual reality
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Mayo Clinic
Hepato Cellular Carcinoma (HCC), Sedation and Analgesia
The Impact of Anaesthesia and Sedation on Inflammation and NETosis in Hepatocellular Carcinoma Ablation
According to recent literature, liver disease causes approximately 2 million deaths annually; 1 million are attributed to the complications of cirrhosis, while the remaining deaths are caused by hepatocellular carcinoma (HCC).
- Conditions
- Hepato Cellular Carcinoma (HCC), Sedation and Analgesia, Ablation Techniques
- Trial name
- NCT07657897
- Testing
- Sedation using combination of Propofol and Fentanyl., Sedation using combination of Propofol and Fentanyl and lidocaine
- Where
- Romania
- Volunteers
- 100 people
- Sponsor
- Iuliu Hatieganu University of Medicine and Pharmacy
Knee Osteoarthritis
Parallel Versus Perpendicular Technique for Genicular Radiofrequency
Although there are different ways of performing genicular nerve radiofrequency on knee pain, to our knowledge, there is no stuies comparing the clinical outcomes of a parallel technique vs. a perpendicular technique.
- Trial name
- NCT05528965
- Testing
- Perpendicular Group, Parallel Group
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Diskapi Teaching and Research Hospital
Hepatocellular Carcinoma
Changing Trends in HCC Procedures
In France, as in most countries, the incidence of primary liver cancer has increased significantly since the 1980s. In the United States, a study estimating cancer incidence and mortality rates in the coming years predicts that…
- Trial name
- NCT04163627
- Where
- France
- Volunteers
- 1,000 people
- Sponsor
- University Hospital, Montpellier
Atrial Fibrillation
Visualization and Structured Attention Behaviour for Pain and Anxiety Reduction During Ablation of Atrial Fibrillation
The purpose of this study is to test the efficacy of visualization and relaxation exercises together with a structured behavioural attention from nurses during ablation of atrial fibrillation.
- Trial name
- NCT01162811
- Testing
- visualization together with structured behavioural attention.
- Where
- Denmark
- Volunteers
- 140 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Chronic Rhinitis, Non-allergic Rhinitis
A Randomized Controlled Trial Comparing Posterior Nasal Nerve Ablation Procedures for Chronic Rhinitis
The goal of this clinical trial is to learn which procedural intervention most effectively reduces symptoms of chronic rhinitis (non-allergic rhinitis) in adult patients (18 years and older).
- Trial name
- NCT07706595
- Testing
- RhinAer, Neuromark, Clarifix
- Where
- 2 sites in United States
- Volunteers
- 50 people
- Sponsor
- University of California, San Diego
Human Immunodeficiency Virus, HPV Infection
Thermocoagulation for Treatment of Precancerous Cervical Lesions
The purpose of this study is to evaluate the safety, acceptability, and efficacy of Thermocoagulation for treatment of precancerous lesions among HIV-positive women in a screen-and-treat program in Western Kenya.
- Conditions
- Human Immunodeficiency Virus, HPV Infection, CIN 2/3
- Trial name
- NCT04191967
- Testing
- Thermocoagulation
- Where
- Kenya
- Volunteers
- 379 people
- Sponsor
- University of California, San Francisco
Atrial Fibrillation (AF), Persistent Atrial Fibrillation
Conquer-AF Protocol for Redo Ablation Procedures in Recurrent Paroxysmal and Persistent Atrial Fibrillation Using the Sphere-9 Catheter and Affera Ablation System (Conquer-AF)
Conquer-AF is a prospective, multi-center, interventional, non-randomized clinical study that will enroll up to 400 subjects at up to 30 sites across the United States, Europe, and Australia.
- Conditions
- Atrial Fibrillation (AF), Persistent Atrial Fibrillation, Paroxysmal Atrial Fibrillation (PAF)
- Trial name
- Conquer-AF (NCT07298473)
- Testing
- Sphere-9 Catheter Ablation
- Where
- 30 sites in United States, Australia and 4 more
- Volunteers
- 400 people
- Sponsor
- Medtronic Cardiac Ablation Solutions
Cardiac Arrhythmia, Atrial Fibrillation
Spanish Registry of Redo Procedures Following Pulmonary Vein Ablation by Pulsed Field Ablation Technology: RESET-PFA
RESET-PFA is a prospective, multicenter, non-randomized post-market study. All patients will be treated according to the standard care followed by each center.
- Conditions
- Cardiac Arrhythmia, Atrial Fibrillation, Pulsed Field Ablation
- Trial name
- RESET-PFA (NCT07185412)
- Testing
- Pulsed Field ablation: Ablation to treat atrial fibrillation
- Where
- Spain
- Volunteers
- 1,100 people
- Sponsor
- Instituto de Investigación Sanitaria Aragón
Supraventricular Tachycardia, Atrioventricular Nodal Re Entrant Tachycardia
High-density Activation Mapping of the Slow Pathwayto Guide Catheter Ablation in Patients With Typical Atrioventricular Nodal Reentrant Tachycardia
Atrioventricular nodal reentrant tachycardia (AVNRT) is the most common supraventricular tachycardia inducible during an electrophysiological study.
- Trial name
- NCT05531903
- Testing
- Description of Slow pathway signals to facilitate ablation
- Where
- Spain
- Volunteers
- 119 people
- Sponsor
- Parc de Salut Mar
Barrett Esophagus, Barrett Adenocarcinoma
Neoplastic Barrett Esophagus: Endoscopic Piecemeal vs. En Bloc Resection
The study will compare EMR versus ESD technique (both combined with subsequent ablative therapy) of mucosal resection in Barrett's esophagus with regard to efficacy and risk in a long term setting.
- Conditions
- Barrett Esophagus, Barrett Adenocarcinoma, Esophagus Neoplasm
- Trial name
- BEEPER (NCT03427346)
- Testing
- Endoscopic mucosal resection, Endoscopic submucosal dissection
- Where
- 2 sites in United States, Germany
- Volunteers
- 407 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Premature Ventricular Contraction
Comparision of PVC Ablation Techniques
Several reports have shown the utility of PVC ablation with cryo catheters. The aim of this study is to compare the outcomes and safety of Cryo vs. RF for PVCs.
- Trial name
- PVC (NCT03086902)
- Testing
- Radiofrequency Ablation Catheter, Cryo Ablation catheter
- Volunteers
- 88 people
- Sponsor
- Sheba Medical Center