Clinical trials: Abortions, Spontaneous, Habitual
Preterm Birth, Cervical Length
Cervical Length Reference Range at 28-34 Weeks in Singleton Pregnancies
Cervical length, measured via transvaginal ultrasound, changes as pregnancy progresses. However, reference information for interpreting cervical length measurements during late pregnancy in Vietnam remains limited.
- Conditions
- Preterm Birth, Cervical Length, Cervical Incompetence
- Trial name
- CL-Trim3 (NCT07914595)
- Testing
- No Intervention: Observational Cohort
- Where
- Vietnam
- Volunteers
- 294 people
- Sponsor
- Mỹ Đức Hospital
Vitamin D Deficiency, Recurrent Miscarriage
The Cohort Study of the Correlation Between Serum 25(OH)D Level and Pregnancy Outcome
The objective of this single-center prospective observational study is to clarify the trend of maternal serum 25(OH)D levels before pregnancy and during pregnancy, and to explore the correlation between serum 25(OH)D levels and…
- Conditions
- Vitamin D Deficiency, Recurrent Miscarriage, Pregnancy Related
- Trial name
- NCT05824897
- Testing
- Serum levels of vitamin D
- Where
- China
- Volunteers
- 171 people, healthy volunteers welcome
- Sponsor
- Aimin Zhao
Abortion, Habitual
Effectiveness of Metformin in Recurrent Miscarriage in a Woman With Hyperinsulinaemia
The prevalence of insulin resistance is increased in women with recurrent miscarriage compared with matched fertile controls,Insulin resistance (IR) in this syndrome is not only implicated toward early pregnancy loss (EPL) but…
- Trial name
- MetRPL (NCT01718340)
- Testing
- Metformin
- Where
- Egypt
- Volunteers
- healthy volunteers welcome
- Sponsor
- Woman's Health University Hospital, Egypt
Mutation
C677T Methylenetetrahydrofolate Reductase Mutation
To investigate the effect of anticoagulant treatment on pregnancy outcomes in patients with previous recurrent miscarriages (RM) who carry a methylenetetrahydrofolate reductase (MTHFR) gene mutation.
- Trial name
- C677T (NCT05864937)
- Testing
- infertily evaluation
- Where
- France
- Volunteers
- 363 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Recurrent Pregnancy Loss, Recurrent Miscarriage
A Multi-center, Placebo-controlled Study to Evaluate NT100 in Pregnant Women With a History of Unexplained Recurrent Pregnancy Loss (RPL)
This is a randomised, double blind, multi-center, placebo-controlled study of subcutaneous NT100 in pregnant women with a history of unexplained recurrent pregnancy loss.
- Trial name
- RESPONSE (NCT02156063)
- Testing
- NT100
- Where
- 19 sites in United Kingdom
- Volunteers
- 150 people
- Sponsor
- Nora Therapeutics, Inc.
Miscarriage, Recurrent
Effects of Co-treatment on Endometrial abv3-integrin Expressions in Women With Recurrent Implantation Failure
To compare the abv3-integrin expression in endometrium tissue among RIF women between the GnRH analogue with Aromatase Inhibitor (Group A) , GnRH analogue with progesterone (Group B) and GnRH analogue alone as control group…
- Trial name
- NCT05437471
- Testing
- GNRH Analoge, Duphaston, Letrozole
- Where
- Malaysia
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Universiti Kebangsaan Malaysia Medical Centre
Preterm Birth, Threatened Preterm Labor
Cervical Softening and the Prediction of Preterm Birth
Currently, transvaginal cervical length measurement is used to screen in asymptomatic pregnant women with a history of PTB. In symptomatic women, presenting with threatened PTB cervical length in combination with the fibronectin…
- Conditions
- Preterm Birth, Threatened Preterm Labor, Premature Birth, Premature Labor
- Trial name
- STIPP (NCT05477381)
- Testing
- Measurement of cervical stiffness by Pregnolia Device
- Where
- Netherlands
- Volunteers
- 390 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Uterine Cervical Incompetence
Cervical Occlusion for the Prevention of Preterm Birth
The aim of this study was to evaluate the effect of cervical occlusion versus no cervical occlusion in women with cervical cerclages.
- Trial name
- NCT01737788
- Testing
- Cervical occlusion
- Where
- 23 sites in Australia, Denmark and 7 more
- Volunteers
- 309 people
- Sponsor
- Niels Jørgen Secher
Abortion, Spontaneous, Abortion, Habitual
Intralipid for Recurrent Miscarriage
Intralipid infusion can improve the outcome in NK cells positive females with history of recurrent miscarriages undergoing IVF/ICSI cycles.
- Trial name
- NCT01788540
- Testing
- Intralipid
- Where
- Egypt
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Woman's Health University Hospital, Egypt
Miscarriage, Recurrent, Premature Labor
PAR Family Polymorphisms and Placental Invasion Disorders
The present study will be undertaken to establish whether genetic variations of PAR1 could be involved in the occurrence of any of the "placental syndromes" of preterm delivery, preeclampsia, and/or small for gestational age…
- Trial name
- NCT00425867
- Testing
- PAR1 polymoprhisms and placental invasion
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Shaare Zedek Medical Center
Cervical Insufficiency, Cervical Stiffness
Cervical Stiffness Assessment in High-risk Pregnancies for Preterm Birth
Cervical length is usually measured using ultrasound, and if it is shortened, hormone therapy (progesterone) is recommended to reduce the risk of premature birth.
- Trial name
- PilotProPre (NCT07541313)
- Where
- Switzerland
- Volunteers
- 21 people
- Sponsor
- Luzerner Kantonsspital
Infertility, Female, Recurrent Miscarriage
Immune Cell Populations in the Endometrium
Specialized immunological studies in the diagnostics of idiopathic infertility and recurrent miscarriages have limited applicability, as the role of the immune system in these conditions is not thoroughly understood.
- Conditions
- Infertility, Female, Recurrent Miscarriage, Gynecologic Disease
- Trial name
- NCT06826365
- Testing
- Percentage distribution of immune system cells in peripheral blood, Percentage distribution of immune system cells in endometrium
- Where
- Poland
- Volunteers
- 50 people
- Sponsor
- Jagiellonian University
Cervical Insufficiency
Multifactorial Approach to Emergent Cerclage
Though cervical insufficiency is a common cause of second trimester pregnancy loss, the placement of an emergent cerclage in these patients is thought to improve perinatal outcomes.
- Trial name
- RECIA (NCT01114516)
- Testing
- Indomethacin and antibiotics (cefazolin or clindamycin)
- Where
- United States
- Volunteers
- 53 people
- Sponsor
- Northwestern University
Recurrent Miscarriage
Obstetrics , Prenatal Outcomes in Recurrent Miscarriage
The effect of recurrent miscarriage on the outcome of the current pregnancy and if there's a relation between it and adverse out come
- Trial name
- OBPORPL (NCT06356792)
- Where
- Egypt
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Assiut University
Inflammatory Response, Abortion, Habitual
Explore the Role of NLRP7 in the Regulation of Progestereone Induced Decidualization of Human Endometrial Stroma Cells
The investigators have found that NLRP7 was upregulated and nuclear translocated in an in vitro model of decidualization. Knock-down or overexpression of NLRP7 reduced or enhanced the expression of decidual marker IGFBP-1.
- Trial name
- NCT04148638
- Where
- Taiwan
- Volunteers
- 204 people, healthy volunteers welcome
- Sponsor
- National Cheng-Kung University Hospital
Abortion, Habitual
RECAB-ASA; Treatment of Recurrent Abortion With Aspirin
The aim of this study is to examine whether treatment with 75 mg aspirin daily compared with placebo could reduce the risk for a new miscarriage.
- Trial name
- RECAB-ASA (NCT02823743)
- Testing
- Aspirin
- Volunteers
- 400 people
- Sponsor
- Göteborg University
Recurrent Miscarriage
Nutritional Deficiency and Recurrent Miscarriage
This prospective cohort study primarily aims to examine the association between blood niacin levels and recurrent miscarriage.
- Trial name
- NCT05267678
- Testing
- No intervention
- Where
- China
- Volunteers
- 499 people
- Sponsor
- Westlake University
Abortion, Spontaneous, Abortion, Habitual
RPL: Interval to Live Birth and Adverse Perinatal Outcomes
This will be a retrospective observational cohort study utilizing the data from the British Columbia Perinatal Data Registry (BCPDR).
- Conditions
- Abortion, Spontaneous, Abortion, Habitual, Birth Intervals, Pregnancy Loss
- Trial name
- NCT04360564
- Testing
- Recurrent pregnancy loss
- Where
- Canada
- Volunteers
- 140,000 people, healthy volunteers welcome
- Sponsor
- Children's & Women's Health Centre of British Columbia
Preterm Delivery, Cervical Cerclage
Use of Nitrous Oxide for Pain and Anxiety Management During Cervical Cerclage Removal
The goal of this clinical trial is to determine whether inhaled nitrous oxide can reduce pain and anxiety during cervical cerclage removal compared with standard care.
- Conditions
- Preterm Delivery, Cervical Cerclage, Cervical Insufficiency
- Trial name
- NCT07491874
- Testing
- Inhaled nitrous oxide
- Where
- 4 sites in Israel
- Volunteers
- 60 people
- Sponsor
- Kaplan Medical Center
Recurrent Pregnancy Losses, Positive Anti Phospholipid Syndrome
Preconceptional Thromboprophylaxis in Recurrent PREGNANCY LOSSES Caused by Antiphospholipid Syndrome
Preconceptional use of low molecular weight heparin (enoxaparin) and aspirin in patient with recurrent miscarriages with positive anti phospholipid antibodies increase the implantation rate and the duration of pregnancy with low…
- Trial name
- NCT01661439
- Testing
- low molecular weight heparin (enoxeparine)
- Where
- Egypt
- Volunteers
- 316 people, healthy volunteers welcome
- Sponsor
- Woman's Health University Hospital, Egypt