Clinical trials: Absence, open to volunteers
Transfemoral Amputation, Limb Loss
A Biomechanical Evaluation of the Ossur Power Knee in Persons With Transfemoral Amputation
Microprocessor-controlled knees (MPKs) do not typically utilize motors to power joint rotation, but they automatically adjust resistance or damping in the joint to improve swing- and/or stance-phase control as appropriate for the…
- Conditions
- Transfemoral Amputation, Limb Loss, Limb Absence
- Trial name
- OPKTFA (NCT06218238)
- Testing
- Powered prosthetic knee joint, Conventional microprocessor-controlled prosthetic knee joint
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- VA Office of Research and Development
Gastric Cancer
Randomized Phase II Trial Evaluating DFS in The Absence of an Adjuvant Component of Perioperative Chemotherapy in Patients With Gastric Cancer
This single-center, open-label, randomized phase II trial (JAGC-1) will evaluate whether adjuvant chemotherapy can be safely omitted in patients with stage IB-III gastric cancer (cT2-4a and/or N+) who have achieved a pathological…
- Trial name
- JAGC1 (NCT06942663)
- Testing
- Surveillance, Adjuvant Chemotherapy
- Volunteers
- 228 people
- Sponsor
- Nizhny Novgorod Regional Clinical Oncology Center
Dehiscence, Tooth Extraction
Effect of Collagen Membrane on Ridge Preservation
This study will evaluate whether adding a resorbable collagen membrane to an anorganic bone-collagen composite (ABCC) graft improves ridge preservation after tooth extraction.
- Conditions
- Dehiscence, Tooth Extraction, Alveolar Bone Loss
- Trial name
- NCT07580495
- Testing
- Minimally Invasive tooth extraction, Alveolar ridge preservation with ABCC, Resorbable collagen membrane (InterCollagen® Guide)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Debora Dias
Occupational Health, Stress
Implementation of the ASCEND Training for Supervisors in Dutch Small and Medium-sized Enterprises (SMEs)
This cluster randomized controlled trial (cRCT) aims to evaluate the effectiveness of the Dutch adaptation of an in-person group intervention for workplace supervisors - Advancing Supervisors' Capacity for Mental Health at Work…
- Conditions
- Occupational Health, Stress, Burnout, Mental Health Conditions
- Trial name
- NCT06989398
- Testing
- Advancing Supervisors' Capacity for Mental Health at Work (ASCEND)
- Where
- Netherlands
- Volunteers
- 148 people, healthy volunteers welcome
- Sponsor
- VU University of Amsterdam
Transfemoral Amputation, Limb Loss
Effect of a Microprocessor-controlled Prosthetic Knee Joint on K2 Level Ambulators
Microprocessor-controlled knees (MPKs) automatically adjust resistance or damping in the joint to improve swing- and/or stance-phase control as appropriate for the prosthesis user during gait.
- Conditions
- Transfemoral Amputation, Limb Loss, Limb Absence
- Trial name
- MPK-K2 (NCT07103798)
- Testing
- College Park ICON, Conventional NMPK
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- VA Office of Research and Development
Oxygen Supply Absent
Monitoring Free Tissue Transfer Hemodynamics Using NIRS
Free tissue transfer (FTT) is a surgical procedure for repairing cancer resection wounds. Free tissue transfer usually involves taking skin from one area of the body (e.g.
- Trial name
- NCT06661525
- Testing
- Free Flap NIRS
- Where
- 2 sites in Canada
- Volunteers
- 60 people
- Sponsor
- University of British Columbia
SLAP Lesion
Biceps Tenodesis With 360 Suture Anchor Versus Self Locking Tenodesis In the Absence of Rotator Cuff Tears
This is a prospective randomized controlled trial. The aim of this study is to compare the clinical results and complications of self-locking biceps tenodesis and double-loop 360 lasso biceps tenodesis for the treatment of…
- Trial name
- Blast2 (NCT06772103)
- Testing
- self-locking biceps tenodesis, Biceps Tenodesis with 360 Suture anchor
- Where
- France
- Volunteers
- 98 people
- Sponsor
- Clinique Générale dAnnecy
Breast Cancer, Acquired Absence of Breast
Long-term Evaluation of Quality of Life and Aesthetic Outcomes After Autologous Breast Reconstruction Using the Profunda Artery Perforator (PAP) Flap
Breast reconstruction using autologous tissue is an important option for women undergoing mastectomy for breast cancer. The profunda artery perforator (PAP) flap is a reliable alternative when abdominal tissue is unavailable or…
- Conditions
- Breast Cancer, Acquired Absence of Breast, Autologous Breast Reconstruction
- Trial name
- QUALIPAP (NCT07728565)
- Where
- France
- Volunteers
- 264 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Rare Disorders, Undiagnosed Disorders
Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford
The Coordination of Rare Diseases at Sanford (CoRDS) is an international patient registry that serves as a centralized resource for rare disease research.
- Conditions
- Rare Disorders, Undiagnosed Disorders, Disorders of Unknown Prevalence, Cornelia De Lange Syndrome
- Trial name
- CoRDS (NCT01793168)
- Where
- United States
- Volunteers
- 20,000 people
- Sponsor
- Sanford Health
Autism Spectrum Disorder, Autism Spectrum Disorder (ASD)
Intranasal Insulin for Autism Spectrum Disorder in Children and Young Adults Aged 4 to 21 Years
This observational study evaluates the real-world use of intranasal insulin in children and young adults with autism spectrum disorder (ASD) utilizing the ViaNase™ device developed by Kurve Therapeutics.
- Conditions
- Autism Spectrum Disorder, Autism Spectrum Disorder (ASD), Autism Spectrum Disorder High-Functioning, Autism Spectrum Disorder With Absence of Functional Language
- Trial name
- IN-INS-AUT (NCT07521371)
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Healing Hope International
Amputation, Amputation; Traumatic, Leg, Lower
Clinical Outcomes With Non-Powered vs. Powered Prosthetic Knees by K2-level Amputees
The goal of this proposed project is to gather community-based data from the K2-level Transfemoral Amputee (TFA) population to aid in evidence-based prescription of powered prosthetic knees (i.e., choosing the right device to…
- Conditions
- Amputation, Amputation; Traumatic, Leg, Lower, Limb; Absence, Congenital, Lower, Prosthesis User
- Trial name
- NCT06194838
- Testing
- Ossur Power Knee, Reboocon Intuy Knee
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Liberating Technologies, Inc.
Pseudo Obstruction
ACTG2/FLNA Testing Yield in Adult Idiopathic Chronic Intestinal Pseudo-Obstruction (CIPO) With Reduced/Absent Distal Esophageal Contractility
To assess the diagnostic yield of Sanger sequencing for ACTG2 and FLNA genes evaluation on blood or saliva sample in patients with idiopathic CIPO in which high-resolution esophageal manometry (HRM) shows reduced (DCI <450…
- Trial name
- CIPO_GEN (NCT07448753)
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Marina Coletta
Pregnant Women, Cesarean Section
Evaluation of the Absence of Intraoperative Bladder Catheterization in Case of Planned Cesarean Section
The hypothesis of this trial is that the absence of systematic bladder catheterization in patients performing spontaneous urination in the hour preceding the planned cesarean section under spinal anesthesia would not lead to more…
- Trial name
- C2S (NCT06357546)
- Testing
- Spontaneous urination during the hour before caesarean section., Systematic bladder catherization during caesarean section.
- Where
- 2 sites in France
- Volunteers
- 550 people
- Sponsor
- University Hospital, Montpellier
Atrial Fibrillation (AF), Tricuspid Regurgitation (TR)
Natural History of Atrial Fibrillation-Induced Tricuspid Valve Remodeling in the Absence of Significant Tricuspid Regurgitation: A Three-Dimensional Echocardiographic Study
This is a prospective, observational, multicenter study aimed at characterizing tricuspid valve remodeling in patients with atrial fibrillation (AF) without significant tricuspid regurgitation (TR), in relation to AF burden…
- Trial name
- TRICUSPID-AF (NCT07617974)
- Where
- Italy
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Centro Cardiologico Monzino
Osteogenesis Imperfecta, Total Absence of Permanent Teeth
Site Preservation After Tooth Extraction
This study is mainly targeted affected teeth which could not be retained, and patients are willing to undergo implant repair at the later stage.
- Conditions
- Osteogenesis Imperfecta, Total Absence of Permanent Teeth, Tooth Socket
- Trial name
- NCT05258019
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Nanfang Hospital, Southern Medical University
Chest Pain, Ischemia
Evaluation of Patients With Non-obstructive Coronary Arteries
Patients with angina and non-obstructive CAD are common within clinical practice, but remain a challenge with regard to diagnosis and treatment.
- Trial name
- noCAD (NCT00823563)
- Testing
- 30 cc blood draw, Intravascular ultrasound (IVUS), Coronary pressure/flow wire testing
- Where
- United States
- Volunteers
- 2,000 people
- Sponsor
- Stanford University
Teeth Absent, Teeth Missing
Multicenter Clinical Study on the Efficacy and Esthetic Outcomes of Immediate Implant Placement Using the Socket-Shield Technique Versus Conventional Immediate Implantation in the Anterior Maxillary Esthetic Zone
This study plans to enroll no fewer than 48 adult patients who have non-restorable maxillary anterior teeth due to trauma or dental diseases and are candidates for immediate implant placement, meeting the inclusion and exclusion…
- Conditions
- Teeth Absent, Teeth Missing, Dental Implant
- Trial name
- NCT07822685
- Testing
- the Socket Shield Technique (SST) immediate implant placement, Conventional immediate implant placement
- Volunteers
- 48 people
- Sponsor
- First Affiliated Hospital of Wenzhou Medical University
Sick Leave, Musculoskeletal
SmaRTWork - a Decision Support System to Promote Return to Work Among People Sick-listed With Musculoskeletal Disorders
The objective of this study is to evaluate the effect of an intervention, SmaRTWork, on return to work compared to usual care for individuals who are sick-listed due to musculoskeletal disorders.
- Trial name
- SmaRTWork (NCT07034040)
- Testing
- SmaRTWork
- Where
- Norway
- Volunteers
- 298 people
- Sponsor
- Norwegian University of Science and Technology
Healthy, Musculoskeletal Disorders
Reducing Pain-Related Sickness Absence Through Workplace Health Literacy: A Hybrid II Study
The primary aim of this study is investigate whether a workplace intervention targeting employees' and managers' understanding of pain and communication (called occupational health literacy) can reduce pain-related sick leave and…
- Conditions
- Healthy, Musculoskeletal Disorders, Occupational Health, Occupational Health Literacy
- Trial name
- NCT07707180
- Testing
- Cognitive behavioural therapy-inspired digital education on pain and communication, Local work environment guidelines
- Volunteers
- 193 people, healthy volunteers welcome
- Sponsor
- National Research Centre for the Working Environment, Denmark
Autism Spectrum Disorder, Autism Spectrum Disorder With Absence of Functional Language
Aut-CARE Intervention to Improve Cognitive and Emotional Functioning in Young Adults on the Autism Spectrum
Currently, many autistic youths struggle to adapt to academic programs or the workforce, often turning to third-sector organizations such as specialized associations and foundations.
- Trial name
- Aut-CARE (NCT07041502)
- Testing
- Aut-CARE
- Where
- Spain
- Volunteers
- 37 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau