Clinical trials: Absorption
Leishmaniasis
Safety and Drug Absorption of Orally Administered Oleylphosphocholine (OlPC) in Healthy Adults
The goal of this interventional study is to assess the safety and tolerability of OlPC and to characterize the pharmacokinetics (PK) of OlPC following single, ascending doses administered orally in healthy-fed subjects.
- Trial name
- NCT06124144
- Testing
- Oleylphosphocholine
- Where
- Germany
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- University Hospital Tuebingen
Nutrition, Absorption
Bioavailability From Chickpea Meals in Ileostomists?
The matrix of a food can significantly affect how well humans can absorb and use nutrients. Plants like fruits, vegetables, nuts, grains, and legumes have cell walls that form a network around their cells.
- Conditions
- Nutrition, Absorption, Polyphenolic Compounds and Metabolism, Polyphenols Absorption Profile
- Trial name
- NCT06921811
- Testing
- Intact chickpeas, Broken chickpeas
- Where
- United Kingdom
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- University of Ulster
Type II Diabetes Mellitus
Effects of a Spiced Meat Patty on Inflammation in Men With Type 2 Diabetes
Polyphenols belong to the largest group of secondary metabolites produced by plants, mainly, in response to biotic or abiotic stresses such as infections, wounding, UV irradiation, exposure to ozone, pollutants, and other hostile…
- Trial name
- NCT01076829
- Testing
- Spice polyphenols
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Simulation of Weightlessness by Anti-Orthostatic Long Term Bed Rest
Toulouse Male Long Term Bed Rest 2001-2002
Microgravity during space flight induces physiological changes that affect astronauts' health and performance. Space flight simulations such as prolonged bed rest can mimic some of these changes and provide study conditions that…
- Trial name
- NCT00311571
- Testing
- Ethidronate, Physical training
- Where
- France
- Volunteers
- 28 people
- Sponsor
- Centre National d'Etudes Spatiales
Intracerebral Hemorrhage
Minocycline Accelerates Intracerebral Hemorrhage Absorption
Minocycline has been found to reduce cerebral edema secondary to cerebral hemorrhage, promote hematoma absorption, and shorten hematoma absorption time; clinical studies have been conducted to confirm the safety in the treatment…
- Trial name
- MACHA (NCT05630534)
- Testing
- Minocycline, starch
- Volunteers
- 90 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Cystic Fibrosis
Development Of An Innovative Panel of Methods To Measure Intestinal Macronutrient Digestion, Absorption, and Function
Malnutrition is a significant problem in children and adults with Cystic fibrosis (CF). An impaired intestinal digestion and absorption capacity is one of the main factors responsible for the malnutrition in CF.
- Trial name
- NCT01494909
- Testing
- Ensure plus
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Texas A&M University
Healthy Subjects
Study to Evaluate the Effect of Single Doses of LX4211 and Canagliflozin on Intestinal Glucose Absorption in Healthy Adult Subjects
The purpose of this study is to assess the effect of LX4211 and the comparator drug canagliflozin on intestinal glucose absorption and metabolism after a single dose in healthy subjects in comparison to placebo.
- Trial name
- NCT01916863
- Testing
- LX4211 400 mg, canagliflozin 300 mg
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Lexicon Pharmaceuticals
Healthy
A Study of [14C]-LY3866288 in Healthy Participants
The main purpose of this study is to evaluate how much of the study drug (LY3866288), administered as a single dose that has the radioactive substance 14C incorporated into it, passes from blood into urine, feces and expired air…
- Trial name
- NCT06644378
- Testing
- [14C]-LY3866288, LY3866288
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Eli Lilly and Company
Epidermal Growth Factor Receptor (EGFR) Mutations, Solid Tumors
A Study to Investigate the Absorption, Metabolism and Excretion of [14C]ASP8273 in Subjects With Solid Tumors
This is a study to investigate the absorption, metabolism and excretion of [14C] labeled ASP8273 in subjects with solid tumors harboring EGFR mutations (per local testing). This study consists of two parts (A and B).
- Trial name
- NCT02674555
- Testing
- radio-labeled naquotinib, naquotinib
- Sponsor
- Astellas Pharma Global Development, Inc.
Vitamin B12 Deficiency
Can Recombinant Human Intrinsic Factor Be Used for Evaluation of the Vitamin B12 Absorption?
Vitamin B12 is an essential nutrient for normal DNA-synthesis and must be supplied by animal products. Vitamin B12 deficiency may cause anemia and irreverible neurological damage.
- Trial name
- NCT00279552
- Testing
- Recombinant human intrinsic factor
- Where
- Denmark
- Volunteers
- 37 people
- Sponsor
- University of Aarhus
Cystic Fibrosis
Comparison of Absorption of Vitamin D in Cystic Fibrosis
The investigators predict that a powder pill form of vitamin D will be more effectively absorbed than an oil form of vitamin D in people diagnosed with Cystic Fibrosis.
- Trial name
- NCT01880346
- Testing
- Vitamin D Powder, Vitamin D Oil
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Emory University
Healthy Volunteers
A Study to Evaluate the Drug Levels of [14C]CC-99677 in Healthy Male Participants
The purpose of the study is to characterize the absorption, distribution, metabolism and excretion (ADME) of a single oral dose of [14C] CC-99677.
- Trial name
- NCT05284890
- Testing
- CC-99677
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Bristol-Myers Squibb
Cardiovascular Disease
The Effect of Morphine on Prasugrel Absorption in STEMI Patients
Heart Attacks are a major cause of death in this country. When patients have a heart attack, they are treated with anti-clotting drugs, one of which is a drug called Prasugrel.
- Trial name
- NCT01536964
- Testing
- morphine, saline
- Where
- United Kingdom
- Volunteers
- 12 people
- Sponsor
- Sheffield Teaching Hospitals NHS Foundation Trust
Lower Urinary Tract Symptoms, Benign Prostatic Hyperplasia
Long Term Study of Solifenacin Succinate and Tamsulosin Hydrochloride Oral Controlled Absorption System (OCAS) in Males With Lower Urinary Tract Symptoms
Clinical study to examine the safety, tolerability and efficacy of long-term combination therapy of tamsulosin and solifenacin in the treatment of males with lower urinary tract symptoms (LUTS) associated with benign prostatic…
- Trial name
- Neptune II (NCT01021332)
- Testing
- tamsulosin hydrochloride/solifenacin succinate fixed dose combination (0.4 mg/6 mg), tamsulosin hydrochloride/solifenacin succinate fixed dose combination (0.4 mg/9 mg)
- Where
- 70 sites in Austria, Belarus and 9 more
- Volunteers
- 1,067 people
- Sponsor
- Astellas Pharma Europe B.V.
Healthy
Oral Bioavailability of Bilastine
The purpose of this study is to assess the absolute bioavailability of an oral bilastine formulation (test drug) compared to the endovenous administration of an IV bilastine formulation (control drug) in healthy volunteers.
- Trial name
- BIOBI (NCT01124123)
- Testing
- Bilastine
- Where
- Spain
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Faes Farma, S.A.
Healthy
A Study of Calderasib (MK-1084) Human Absorption, Distribution, Metabolism, and Excretion in Healthy Adult Participants (MK-1084-006)
The purpose of this study is to learn what happens to calderasib in a healthy person's body over time and how it is cleared from the body.
- Trial name
- NCT06687759
- Testing
- [14C]Calderasib
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Healthy
Zinc Absorption From Biofortified Rice
One of the newest strategies to combat micronutrient deficiencies is the biofortification of staple foods, where higher levels of minerals are obtained through breeding of staple crops.
- Trial name
- NCT01633450
- Testing
- Zinc biofortified rice, Rice extrinsically fortified with zinc
- Where
- Switzerland
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Swiss Federal Institute of Technology
Healthy Participant Study
RE104 Radiolabeled Mass Balance (hAME) Study
The purpose of this study is to characterize the absorption, metabolism and routes of excretion of RE104 and its metabolites in healthy volunteers.
- Trial name
- NCT07146191
- Testing
- 2-[14C]-RE104 for Injection
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Reunion Neuroscience Inc
Diabetes Mellitus
Bioavailability of Insulin Administered in Duodenum
A study of the bioavailability of insulin after infusion in the duodenum in healthy volunteers.
- Trial name
- NCT00353990
- Testing
- Insulin Aspart
- Where
- Denmark
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Onychomycosis
Pharmacokinetics and Safety Study of ME1111 in Moderate to Severe Onychomycosis Patients
This study is Randomized, Double-Blind, Vehicle-Controlled, Multiple-Dose Study. The purpose is to determine the safety, tolerability, systemic exposure and pharmacokinetics of ME1111 after repeated daily topical application of…
- Trial name
- NCT01841996
- Testing
- ME1111 solution, Vehicle Solution
- Where
- 2 sites in United States
- Volunteers
- 24 people
- Sponsor
- Meiji Seika Pharma Co., Ltd.
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