Clinical trials: Abuse Cannabis
Alcohol, Cannabis
A Hybrid Type 1 Randomized Controlled Trial of an Online and Text-Messaging Intervention to Prevent Alcohol and Cannabis Initiation, Escalation, and Consequences Among First-Year College Students
Building on promising pilot findings, this study will employ a Hybrid Type 1 Effectiveness-Implementation RCT to evaluate the effectiveness of a novel intervention for first-year college students who abstain from or use alcohol…
- Trial name
- NCT07905846
- Testing
- Online and Text Message Intervention
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- The University of Texas at Arlington
Cannabis Use
Acute Effects of Cannabis on Cognition and Affect
This study will examine how a moderate dose of THC affects mood and cognitive functioning in regular cannabis users. The study uses a double-blind, placebo-controlled, crossover design, meaning each participant will complete two…
- Trial name
- NCT07296874
- Testing
- THC 20mg
- Where
- United States
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Washington State University
Cannabis Use, Impaired Driving
Examining the Role of Tolerance on Dose-dependent Effects of Acute THC on Oculomotor and Cognitive Performance
The purpose of this research is to determine the extent to which oculomotor function accurately detects THC-impairment, if cannabis use experience impacts this detection threshold, and to examine how the oculomotor index…
- Conditions
- Cannabis Use, Impaired Driving, Cognitive Impairment
- Trial name
- NCT06351540
- Testing
- Cannabis
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Cannabis Intoxication
Effects of Cannabidiol (CBD) on a Fixed Dose of Delta-9-tetrahydrocannabinol (THC)
This study will evaluate the subjective and behavioral effects of cannabis products containing delta-9-tetrahydrocannabinol and cannabidiol
- Trial name
- NCT07870187
- Testing
- 0mg THC + 0mg CBD Brownie, 10mg THC + 0mg CBD Brownie, 10mg THC + 10mg CBD Brownie
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Cannabis Use
Perceptions of Proposed Warnings for Cannabis Edibles Packaging
The purpose of this study is to compare a delayed-effects warning to an expanded warning developed in previous experiments on knowledge, harm perceptions, and willingness to try cannabis edibles.
- Trial name
- NCT07496489
- Testing
- No Warning Control, Delayed Effects Text Only, Delayed Effects Plus Icon
- Where
- United States
- Volunteers
- 1,250 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Substance Use, Substance-Related Disorders
Clinician Practice Companion to Address Youth Substance Use
Substance use, including the use of opioids, cannabis, and other drugs, is common among adolescents and young adults, and overdose has become a leading cause of death among youth in Canada and the United States.
- Conditions
- Substance Use, Substance-Related Disorders, Adolescent Substance Use, Cannabis Use
- Trial name
- NCT07725289
- Testing
- Practice Companion
- Where
- 5 sites in United States, Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Cannabis Use, Tobacco
Lung Health and Breath Biomarkers: Acute Effects of Inhaled Cannabis
This outpatient study examines how inhaled cannabis, combustible or vaporized, alters lung health and breath biomarkers compared to a tobacco cigarette.
- Conditions
- Cannabis Use, Tobacco, Biomarkers
- Trial name
- NCT07694466
- Testing
- Cannabis (THC), Tobacco Cigarette
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Hannah Harris
Cannabis, Marijuana Use
Developing and Strengthening Cannabis Warnings: Warning Message Testing
The purpose of this activity is to identify promising cannabis warning messages from different themes. Participants will be adults who live in the United States, including both people who use cannabis and those who do not use…
- Trial name
- NCT07699198
- Testing
- Constituents, Cognitive Functioning, Cardiovascular Health
- Where
- United States
- Volunteers
- 1,750 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Alcohol Drinking, Cannabis Use
Cannabis' Impact on Alcohol Consumption
This study employs a repeated measures experimental design to examine the effect of THC-dominant dose of cannabis and CBD-dominant dose of cannabis, relative to placebo, on subsequent drinking in an alcohol choice task in which…
- Conditions
- Alcohol Drinking, Cannabis Use, Cannabis, Alcohol Use Disorder
- Trial name
- NCT05389930
- Testing
- THC-dominant cannabis, CBD-dominant cannabis, Alcohol
- Where
- United States
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Brown University
Cannabis, Drug Effects, Driving Performance
Clinical Study to Evaluate the Effects of Oral Delta-9-tetrahydrocannabinol (Δ9-THC) With and Without Alcohol on Perception and Driving Performance in Healthy Adults
With the increasing prevalence and use of cannabis products by the public, there exists a need to better understand the safety impact of cannabis use, particularly when it comes to subjective perceptions of drug effect and…
- Trial name
- NCT07176208
- Testing
- 5 mg Dronabinol (Marinol®) + Alcohol Beverage, 10 mg Dronabinol (Marinol®) + Alcohol Beverage
- Where
- 2 sites in United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Food and Drug Administration (FDA)
Cannabis Intoxication
Pregnenolone as a Treatment for Cannabis Intoxication
The present study will characterize the ability of pregnenolone to reverse the acute intoxication and associated symptoms of cannabis.
- Trial name
- NCT07216690
- Testing
- Cannabis, Pregnenolone 250 mg, Pregnenolone 500 mg
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Cannabis Dependence
Evaluating the Delivery and Effects of THC Vaping Liquids in the Bloodstream
This clinical trial assesses differences in the delivery of THC to the bloodstream depending on whether nicotine vapes are used before or after THC.
- Trial name
- NCT06334016
- Testing
- Biospecimen Collection, Cannabis sativa Extract, Nicotine
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Roswell Park Cancer Institute
Cannabis, Pain
Impact of Repeatedly-Administered THC-cannabis on Experimental Pain and Abuse Liability in Humans
Chronic pain is a significant public health concern in the U.S., for which prescription opioids have historically been the standard treatment. This has resulted in striking rates of opioid use disorders and fatal overdoses.
- Conditions
- Cannabis, Pain, Tolerance, Hyperalgesia
- Trial name
- NCT04596644
- Testing
- Active Cannabis
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- New York State Psychiatric Institute
Cannabis Intoxication
Effects of Various Cannabis Strains on Perceptual, Subjective and Objective Use Outcomes
This study will evaluate the subjective and behavioral effects of cannabis products labeled as indica, sativa, or generic.
- Trial name
- NCT07214155
- Testing
- Cannabis
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Psychotic Disorders, Cannabis Use Disorder
Investigating the Neural Correlates of Cognitive Function in Psychosis Patients and Non-Psychiatric Controls With Cannabis Use
Cognitive impairment is well established in people with psychosis and is associated with cannabis use. The current study will investigate the neurobiological basis of cognitive change associated with 28-days of cannabis…
- Conditions
- Psychotic Disorders, Cannabis Use Disorder, Cannabis Dependence, Cannabis Use
- Trial name
- NCT05445180
- Testing
- Contingency management
- Where
- Canada
- Volunteers
- 134 people, healthy volunteers welcome
- Sponsor
- Douglas Mental Health University Institute
Methamphetamine Induced Psychosis, Cannabis Use
Psychiatric Symptom Characteristics in Methamphetamine-Induced Psychosis With and Without Lifetime Cannabis Use
This prospective cohort study aims to investigate factors associated with psychiatric symptom severity in participants diagnosed with methamphetamine-induced psychotic disorder (MP) with and without lifetime cannabis use (LCU).
- Trial name
- NCT07459270
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Elazığ Mental Health and Diseases Hospital
Abuse Cannabis, Pain
High Potency Cannabis: Acute and Protracted Effects
The purpose of this research is to assess the effects of smoked cananbis when cannabis is smoked during periods of cannabis use as usual and after a brief period of abstinence.
- Conditions
- Abuse Cannabis, Pain, Pharmacokinetics
- Trial name
- HIGH-CAP (NCT06859723)
- Testing
- Low dose THC, High dose THC
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Cannabis
The Pharmacokinetics of a Hemp-Based Topical Product
This study will evaluate the pharmacokinetic effects of acute and chronic dosing of a hemp-based cannabidiol (CBD) topical lotion with low levels of delta-9-tetrahydrocannabinol (THC) in a sanitized and controlled environment.
- Trial name
- NCT07603518
- Testing
- CBD, THC
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Cannabis
Repeated Administration of Cannabis Varying in THC and CBD
The majority of the >3 million medical cannabis patients in the U.S. use cannabis products to manage pain but many questions remain.
- Trial name
- NCT05563948
- Testing
- Cannabis
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- New York State Psychiatric Institute
Cannabis
Changes in Cognition and Psychiatric Disorder Symptoms During Cannabis Abstinence Using a Novel Discordant Twin Design
This study will test whether 42 days of cannabis abstinence, compared to continued cannabis use, is associated with improvements in cognition and psychiatric disorder symptoms.
- Trial name
- NCT05160688
- Testing
- Contingency management
- Where
- United States
- Volunteers
- 146 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver