Clinical trials: Abuse Tobacco
Tobacco Use Cessation
A Smart Approach to Treating Tobacco Use Disorder in Persons Living With HIV
Many people living with HIV (PLWH) smoke. Smoking in these individuals is often undertreated. This study plans to assess the ability of various clinical pathways involving tobacco treatment medications and contingency management…
- Trial name
- SMARTTT (NCT04490057)
- Testing
- Nicotine patch, nicotine gum, nicotine nasal spray, nicotine inhaler, Varenicline or bupropion, Contingency Management
- Where
- 4 sites in United States
- Volunteers
- 323 people
- Sponsor
- Yale University
Tobacco Dependence
Study to Determine the Efficacy and Safety of a Novel Nicotine Replacement Therapy
The purpose of this study is to assess the efficacy and safety of a novel nicotine product for continuous abstinence from smoking.
- Trial name
- NCT02355665
- Testing
- Nicotine Spray
- Where
- 8 sites in United States
- Volunteers
- 1,198 people
- Sponsor
- McNeil Consumer Healthcare Division of McNEIL-PPC, Inc.
Tobacco Use Disorder
Improving Smoking Cessation Outcomes in Heavy Drinkers - 1
To test the effectiveness of an smoking cessation treatment for smokers who also drink alcohol heavily.
- Trial name
- NCT00107575
- Testing
- Standard treatment plus brief alcohol intervention, Standard treatment (ST)
- Where
- United States
- Volunteers
- 236 people
- Sponsor
- Brown University
Tobacco Use Disorder
Text Message Support to Prevent Smoking Relapse
The purpose of this research is to test a text message intervention for people who are beginning an attempt to quit smoking. The intervention seeks to teach people to think about their cravings to smoke in more helpful ways.
- Trial name
- NCT02968095
- Testing
- Text Message Craving Program, Self-Help Manual Plus Control Texts
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- Miami University
Nicotine Dependence
Transcranial Magnetic Stimulation Effects on Nicotine Craving
The proposed study will measure the change of cortical excitability during nicotine craving and examine the effects of Repetitive Transcranial Magnetic Stimulation (rTMS) on nicotine craving and cue-reactivity among adult regular…
- Trial name
- NCT01690130
- Testing
- Transcranial Magnetic Stimulation (Neuronetics)
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Nicotine Dependence
The Effects of Menthol as Delivered by an Electronic Cigarette on the Desirability of Nicotine in Tobacco Users
This study will help determine if menthol administered by inhalation via electronic cigarettes (e-cigarette) changes the reinforcing effects of pure nicotine administered intravenously in cigarette smokers who smoke mentholated…
- Trial name
- NCT02102100
- Testing
- nicotine, menthol
- Where
- 2 sites in United States
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Yale University
Nicotine Dependence
Repetitive Transcranial Magnetic Stimulation (rTMS) for Nicotine Addiction
Cigarette smoking remains a significant public health concern. A magnetic field applied to the outside of the skull can produce electrical activity in the brain without significant pain or the need for anesthesia.
- Trial name
- rTMS (NCT02401672)
- Testing
- Transcranial magnetic stimulation
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Nicotine Dependence, Drug Abuse
Effects of Nicotine on Cognitive Task Performance and Brain Activity as Measured by fMRI
Background: Many cigarette smokers claim that smoking improves their ability to think and concentrate, and have reported problems in thinking and concentration after quitting smoking.
- Trial name
- NCT01036711
- Where
- United States
- Volunteers
- 249 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Nicotine Dependence
E-cigarettes and Blood Vessel Function
Randomized controlled trial of electronic cigarettes with nicotine, without nicotine, and sham control, on endothelial function and markers of oxidative stress.
- Trial name
- NCT02740595
- Testing
- one time exposure to e-cig with nicotine, one time exposure to e-cig without nicotine, one time exposure to empty e-cig
- Where
- United States
- Volunteers
- 148 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Tobacco Use Disorder
Study of Bupropion Versus Bupropion + Naltrexone for Smoking Cessation
The purpose of this study is to compare the effects of bupropion + placebo to bupropion + naltrexone as treatments to help smokers quit.
- Trial name
- NCT00419731
- Testing
- Bupropion, Bupropion + Naltrexone
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Tobacco Use Disorder
Computer-Assisted Stop-Smoking Program in Helping Doctors Counsel Patients Who Smoke Cigarettes
RATIONALE: A computer-assisted stop-smoking program may help doctors counsel patients who smoke and may help increase the number of patients who stop smoking.
- Trial name
- NCT00865553
- Testing
- computer-assisted smoking cessation intervention, cancer prevention, educational intervention
- Where
- United States
- Volunteers
- 630 people
- Sponsor
- University of Vermont
Nicotine Dependence
Stage Ib Trial of mSMART for Smoking Cessation Medication Adherence
The primary aim of this study is to conduct a 60-patient feasibility, acceptability, and preliminary efficacy study of mSMART (Mobile App based Personalized Solutions and Tools for Medication Adherence of Rx Pill), a smartphone…
- Trial name
- mSMART-Ib (NCT02635919)
- Testing
- mSMART
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Duke University
Tobacco Use Disorder
Computer-Based Stop Smoking Program in Assisting Doctors in Helping Adults Stop Smoking
RATIONALE: Computer-based stop smoking programs may assist doctors in helping patients stop smoking. PURPOSE: This randomized clinical trial is studying how well a computer-based stop smoking program works in assisting doctors in…
- Trial name
- NCT00383461
- Testing
- smoking cessation intervention, counseling intervention
- Where
- 2 sites in United States
- Volunteers
- 4,314 people
- Sponsor
- Brigham and Women's Hospital
Tobacco Use Disorder
Project 3, Study 2: Extended Exposure to Low Nicotine Content Cigarettes in People With Current Affective Disorders
This study will examine extended exposure to cigarettes varying in nicotine content among disadvantaged women. Adults with affective disorders are at increased risk for smoking, nicotine dependence, and using high nicotine yield…
- Trial name
- NCT02232737
- Testing
- Very low nicotine content cigarettes
- Where
- 2 sites in United States
- Volunteers
- 775 people, healthy volunteers welcome
- Sponsor
- Brown University
Nicotine Dependence
Nicotine's Potential Abuse With Menthol
To examine if switching from menthol to non-menthol cigarettes will change the dose-effect curves for positive subjective effects and alleviation of smoking urges as a function of nicotine delivery rate in smokers.
- Trial name
- NCT04535362
- Testing
- Nicotine
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Yale University
Smoking
Naltrexone and Patch for Smokers
The aim of this study is to investigate the effects of naltrexone, alone and combined with nicotine patch, on responses of smokers to smoking cues after 10 hours of tobacco deprivation.
- Trial name
- NCT00018213
- Testing
- Naltrexone Hydrochloride, Transdermal Nicotine
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Tobacco Use Disorder, Nicotine Dependence
Effect of Teleconsultation Counseling on Smoking Cessation
This randomized controlled trial conducted at Dokuz Eylül University evaluated whether video teleconsultations are as effective as traditional face-to-face clinic visits for helping people quit smoking Over a 6-month period, the…
- Trial name
- NCT07737288
- Testing
- Tele-consultation Counseling, Face-to-Face Counseling
- Where
- Turkey (Türkiye)
- Volunteers
- 68 people
- Sponsor
- Dokuz Eylul University
Tobacco Dependence
CO Monitoring for Tobacco Cessation in Quitlines
The present study is a 3-arm randomized controlled pilot study. Participants who call the Maryland Tobacco Quitline and are eligible for study participation are randomized to receive quitline tobacco cessation treatment as usual…
- Trial name
- NCT05327660
- Testing
- Quitline Treatment as Usual (TAU), Remote Carbon Monoxide (CO) Monitoring, Incentivized Remote CO Monitoring
- Where
- United States
- Volunteers
- 229 people, healthy volunteers welcome
- Sponsor
- Consumer Wellness Solutions
Nicotine Dependence, Tobacco Smoking
Smoking Cessation and Menstrual Cycle Phase
Tobacco use is a risk factor for at least 20 types of cancer and remains the leading preventable cause of cancer in Canada. Smoking cessation is an important cancer prevention strategy for the close to 2 million Canadian women…
- Conditions
- Nicotine Dependence, Tobacco Smoking, Smoking Cessation, Nicotine Use Disorder
- Trial name
- MC-NRT (NCT05515354)
- Testing
- Timing of nicotine replacement therapy start date, Nicotine Replacement Therapy Agent
- Where
- Canada
- Volunteers
- 1,200 people
- Sponsor
- Centre for Addiction and Mental Health
Tobacco Use Disorder
Acute Effects of Smoking on Airway Dendritic Cells
Airway dendritic cells control pulmonary immune responses to inhaled particles. It is the aim of the present study to investigate the acute effects of smoking on the number and surface molecule expression of human airway…
- Trial name
- NCT00740896
- Testing
- Smoking
- Where
- Germany
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Rostock
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