Clinical trials: Abuse Tobacco
HIV/AIDS, Smoking Cessation
Learn to Quit-HIV Pilot Study
The study team will conduct a feasibility, acceptability, and preliminary efficacy trial comparing Learn to Quit-HIV (n=30) to an app based on U.S.
- Conditions
- HIV/AIDS, Smoking Cessation, Tobacco Use Disorder
- Trial name
- NCT04609514
- Testing
- Learn to Quit-HIV, QuitGuide, Nicotine patch
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- Duke University
Nicotine Use Disorder
Identify the Optimal TMS Pulse Protocol to Modulate Reward Activity
The primary goal will be to identify the optimal pulse protocol by systematically measuring the efficacy of various theta burst stimulation and repetitive rTMS protocols to increase and decrease the reward positivity in dependent…
- Trial name
- NCT06695884
- Testing
- Transcranial Magnetic Stimulation
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Rutgers, The State University of New Jersey
Nicotine Dependence, Tobacco Smoking
Effects of Intranasal Oxytocin on Cigarette Smoking
Socioemotional processing dysfunctions (i.e., disruptions in affective, cognitive, and neural processes that encode, interpret, and respond to socially and emotionally relevant stimuli) have been implicated in tobacco smoking and…
- Trial name
- NCT02595749
- Testing
- Oxytocin
- Where
- United States
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Tobacco Dependence
Varenicline for Long-term Nicotine Replacement Therapy (NRT) Users
Primary aim: Will varenicline be better than placebo to get long-term users of NRT to stop? Secondary aim: To assess in details some side effects of varenicline i.e. nausea and abnormal dreams.
- Trial name
- NCT00977249
- Testing
- support and visits, varenicline
- Where
- Denmark
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University Hospital, Gentofte, Copenhagen
Nicotine Dependence
IV Nicotine Induced Changes in Hormone Function, Mood States and Behavior
Clinical studies are proposed to analyze the interactions between nicotine, alterations in endocrine hormones, mood and cardiovascular measures.
- Trial name
- NCT01589055
- Testing
- Intravenous Nicotine
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Mclean Hospital
Tobacco Use Disorder/Cigarette Smoking, HIV
Smoking Cessation Medication And Rewards Using a Teamlet to Treat Tobacco Use Disorder (SMARTTT 2.0) Among Persons With HIV: A Multi-site Hybrid Type 2 Effectiveness-implementation Trial
Cigarette smoking is an important cause of illness and death among persons with HIV (PWH). This project will study the impact of adding contingency management (use of financial rewards) to receiving medications and counseling on…
- Trial name
- NCT07835555
- Testing
- nicotine patch, nicotine gum, nicotine lozenge, varenicline, bupropion, Multi-target Contingency Management, Teamlet booster
- Where
- 5 sites in United States
- Volunteers
- 794 people
- Sponsor
- Yale University
Tobacco Use Disorder, Bone Fractures
Smoking Cessation and a Teachable Moment in Patients With Acute Fractures
Patients who smoke and suffer from fractures are worse off than those who do not smoke. Orthopaedic patients represent a group that can benefit from physician contributions to smoking cessation, and a special opportunity to cue…
- Trial name
- NCT02781038
- Testing
- Teaching intervention, Control
- Volunteers
- 40 people
- Sponsor
- University of Pennsylvania
Tobacco Dependence, Alcohol Dependence
Effect of Varenicline on Reactivity to Smoking and Drinking Cues
Alcohol and nicotine dependence are often co-morbid, with 85% of alcoholics also smoking. However, very little research has been conducted into the nature of this co-occurrence.
- Trial name
- NCT00873535
- Testing
- Varenicline
- Where
- Canada
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Centre for Addiction and Mental Health
Tobacco Use Disorder, Alcohol Use Disorder
Cytisine for Smoking Cessation
The goal of this clinical trial is to evaluate the safety and effectiveness of cytisine as a smoking cessation treatment in individuals with concurrent alcohol use disorder.
- Conditions
- Tobacco Use Disorder, Alcohol Use Disorder, Smoking Cessation
- Trial name
- NCT05729243
- Testing
- Cytisine
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- Centre for Addiction and Mental Health
Asperger's Disorder, Asperger Disorder
QAIAx - SGI/SI Smart Health Cities: Microcity Enclave Program (Quantum SI/AGI Agency a/k/a AI City Hall Project - UPSTO App Nos. 64/074,526, 64/063,557, 64/105,164, 63/903,181, 63/729,428, 64/125,360; USPTO EO 9424 Assignment ID: 2101042 / ARN: REEL/FRAME: 76481/0026 - OUSD-R&E, Department of War)
BRIEF SUMMARY A. "What is the purpose of this study?" BACKGROUND. The QAIAx clinical trial (Quantum SI/SGI Public Health Agency), known operationally as the "AI City Hall Project," represents a landmark intergovernmental research…
- Conditions
- Asperger's Disorder, Asperger Disorder, Autism Disorder, Autism
- Trial name
- QAIAx (NCT07661823)
- Testing
- AI City Hall Project (AIhealth4u - Public Health Central), AI City Hall Project (QAIAx Microcity A - AI Public Health Central)
- Where
- United States
- Volunteers
- 1,000,000 people, healthy volunteers welcome
- Sponsor
- Veterans Recovery Network Inc.
Smoking, Tobacco Use
Testing Counseling Styles to Motivate Smokers to Quit
The purpose of this study is to determine, among a sample of general adult smokers, the effectiveness of three different counseling interventions for motivating quit attempts among smokers not yet ready to quit.
- Conditions
- Smoking, Tobacco Use, Nicotine Dependence
- Trial name
- NCT01188018
- Testing
- Brief Advice (BA), Motivational Interviewing (MI), Health Education (HE)
- Where
- United States
- Volunteers
- 255 people, healthy volunteers welcome
- Sponsor
- University of Missouri, Kansas City
Alcoholism, Nicotine Dependence
Varenicline and Alcohol in Inpatient Addictions Program (IAP)
The overall hypothesis of this line of research is that varenicline will decrease alcohol consumption and tobacco use and will increase alcohol and tobacco abstinence rates.
- Trial name
- NCT01169610
- Testing
- Varenicline
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Mayo Clinic
Nicotine Dependence, Cigarettes
Negotiating a Quit Date or Not in Online Interventions
The primary purpose of the current study is to test the effect of providing users of automated web-based smoking cessation interventions with the option of negotiating and re-negotiating the quit date.
- Trial name
- NCT03194919
- Testing
- Endre: a digital smoking cessation counsellor
- Where
- 2 sites in Czechia, Norway
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- University of Oslo
Nicotine Dependence, Tobacco Dependence
Adapting and Evaluating a Tobacco Use Cessation Program for People Living With HIV in Uganda and Zambia
This proposal tests the efficacy of a phone-based tobacco cessation intervention for people living with HIV (PLWH) in comparison to the standard of care (brief advice to quit) and nicotine replacement therapy (nicotine patches)…
- Trial name
- Quit4Life (NCT05487807)
- Testing
- Nicotine patch, text messaging
- Where
- 2 sites in Uganda, Zambia
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Cannabis Use Disorder, Tobacco Use Disorder
Clinical Trial Tobacco Marijuana
Approximately 50% of persons seeking treatment for cannabis-use disorders (CUDs) regularly smoke tobacco. Combining tobacco with cannabis has become a common method of smoking cannabis.
- Trial name
- RCTTM (NCT02277665)
- Testing
- CUD Treatment, Tobacco Treatment
- Where
- 3 sites in United States
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- Dartmouth-Hitchcock Medical Center
Tobacco Use Disorder, Cigarette Smoking
Pharmacokinetics of Nicotine Sublingual Tablets Versus Nicorette Lozenge in Healthy Smokers
The purpose of the study is to compare two different dosage forms from which nicotine is released and absorbed into the bloodstream.
- Trial name
- NCT02906995
- Testing
- Sublingual tablet 4 mg versus Nicorette Lozenge 4mg
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Friends Research Institute, Inc.
Cigarette Smoking, Nicotine Addiction
STOP Study: Effectiveness of Zyban in a Clinical Population
Despite the significant health, social and economic costs of cigarette smoking, 17% of Ontarians still currently smoke. Use of smoking cessation pharmacotherapy such as Zyban (bupropion HCl) has been shown to double quit rates…
- Conditions
- Cigarette Smoking, Nicotine Addiction, Smoking Cessation
- Trial name
- NCT01015170
- Testing
- bupropion HCl
- Where
- 24 sites in Canada
- Volunteers
- 454 people
- Sponsor
- Centre for Addiction and Mental Health
Tobacco Dependence, Smoking Cessation
Tailoring Varenicline to Individual Needs (TVIN Study)
Varenicline is a partial nicotinic agonist which acts on alpha4 beta2 nicotinic receptors. It is presumed to alleviate withdrawal discomfort, but also to diminish rewarding effects of cigarettes.
- Trial name
- TVIN (NCT01206010)
- Testing
- Varenicline
- Where
- United Kingdom
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Queen Mary University of London
Nicotine Dependence, Tobacco Use Disorder
A Survey on Consumer Use of Over-the-Counter (OTC) Nicotine Patches
Since 1996, the nicotine patch has been re-classified from prescription to over-the-counter (OTC) status in the United States. Little is known about how the public uses the OTC nicotine patch due to lack of monitoring.
- Trial name
- NCT00134927
- Where
- United States
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Bladder Cancer, Cervical Cancer
Acceptability of Less Harmful Alternatives to Cigarettes
RATIONALE: A study that evaluates participants' beliefs about smokeless tobacco products and nicotine replacement therapy may be useful in helping smokers stop smoking.
- Conditions
- Bladder Cancer, Cervical Cancer, Esophageal Cancer, Gastric Cancer
- Trial name
- NCT00957424
- Testing
- telephone-based intervention, nicotine replacement therapy, informational intervention
- Where
- United States
- Volunteers
- 67 people
- Sponsor
- Roswell Park Cancer Institute
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