Clinical trials: Abuse Tobacco
Tobacco Use, Tobacco Smoking
Enhancing Equity in Smoke-free Housing
The goal of this clinical trial is to learn about the acceptability, feasibility, and effectiveness of smoke-free housing policy implementation in Permanent Supportive Housing communities.
- Conditions
- Tobacco Use, Tobacco Smoking, Tobacco Use Cessation, Tobacco Use Disorder
- Trial name
- NCT06042361
- Testing
- Smokefree Implementation Framework and Toolkit
- Where
- United States
- Volunteers
- 480 people, healthy volunteers welcome
- Sponsor
- Harvard School of Public Health (HSPH)
Nicotine Dependence
Cessation Screening Project
This project will use the Multiphase Optimization Strategy (MOST) to guide the development of optimized treatment strategies for the two most effective smoking cessation medications (Combination Nicotine Replacement [C-NRT] and…
- Trial name
- NCT04188873
- Testing
- Preparation Varenicline and Standard Duration Varenicline, Preparation Varenicline and Extended Duration Varenicline, Standard Duration Varenicline
- Where
- 2 sites in United States
- Volunteers
- 538 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Tobacco Use Disorder
Bupropion as an Adjunct to the Nicotine Patch Plus CBT
Existing and new pharmacotherapies along with prevention efforts are key to improving smoking cessation rates and reducing the premature morbidity and mortality associated with tobacco use.
- Trial name
- NCT00142831
- Testing
- Pharmacotherapies for Smoking Cessation
- Where
- United States
- Volunteers
- 293 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Bipolar Disorder
The Effect of N- Acetylcysteine on Inflammatory and Oxidative Stress Biomarkers
Background: . Bipolar disorders and tobacco use disorder are top of the causes of disability and mortality worldwide Objective: The aim of this study was to evaluate N-acetyl-cysteine (NAC) as an adjunctive treatment in patients…
- Trial name
- nac (NCT02420418)
- Testing
- N-acetyl-cysteine (NAC)
- Where
- Brazil
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Universidade Estadual de Londrina
Tobacco Use Disorder
Tobacco Treatment Using EMDR (ToTEM)
Rationale: It is well established that tobacco use has severe health consequences. The prevalence of Tobacco Use Disorder (TUD) is among the highest in populations with Substance Use Disorders (SUD).
- Trial name
- ToTEM (NCT05594810)
- Testing
- TAU + Addiction focussed - eye movement desensitization and reprocessing (AF-EMDR), TAU only: Community Reinforcement Approach (CRA) + SCP
- Where
- Netherlands
- Volunteers
- 3 people
- Sponsor
- IrisZorg
Alcoholism, Nicotine Dependence
Varenicline and Alcohol in Inpatient Addictions Program (IAP)
The overall hypothesis of this line of research is that varenicline will decrease alcohol consumption and tobacco use and will increase alcohol and tobacco abstinence rates.
- Trial name
- NCT01169610
- Testing
- Varenicline
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Mayo Clinic
Tobacco Use Disorder
Examining the Effectiveness of the Nicotine Patch in Male and Female Smokers - 2
Treatment studies have demonstrated that current smoking cessation techniques are less effective for women. The purpose of this study is to determine the role that gender plays on the effectiveness of nicotine replacement…
- Trial name
- NCT00135746
- Testing
- nicotine transdermal system
- Where
- United States
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Nicotine Dependence
Baclofen Effects in Cigarette Smokers
The proposed project will utilize perfusion functional magnetic resonance imaging (fMRI), a functional candidate gene association approach (of dopaminergic addictions-targeted polymorphisms), and the dopamine-modulating and…
- Trial name
- BAC (NCT01821560)
- Testing
- Baclofen
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Nicotine Dependence
Mechanistic Evaluations of Pre-Cessation Therapies for Smoking Cessation
The purpose of this study is to look at brain function in order to understand how different treatments work to help people quit smoking.
- Trial name
- ConNicBrain (NCT01406223)
- Testing
- Varenicline, Bupropion, Nicotine patches
- Where
- 2 sites in United States
- Volunteers
- 282 people
- Sponsor
- Duke University
Tobacco Dependence
A Bioequivalence Study Between Two Nicotine Replacement Therapies in Adult Healthy Smokers Motivated to Quit.
This is a research study to verify the same effectiveness and safety profile for the test product, Nicorette Strongmint lozenge, as for an already approved product, NiQuitin® Minimint lozenge (reference product), in a…
- Trial name
- NCT03130179
- Testing
- Nicorette Strongmint lozenge 4 mg, Niquitin MiniMint lozenge 4 mg
- Where
- Russia
- Volunteers
- 244 people, healthy volunteers welcome
- Sponsor
- McNeil AB
Nicotine Dependence
Smoked Nicotine Induced Changes in Hormone Function, Mood States and Behaviors
The proposed clinical studies will evaluate the acute effects of nicotine on the hypothalamic-pituitary-gonadal axis in women to test the hypothesis that nicotine alters gonadal steroid hormones, and/or disrupts feedback…
- Trial name
- NCT01636323
- Testing
- Nicotine
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Mclean Hospital
Vaping, Adolescent
Nicotine and Cannabis Vape Labeling Experiment - Spring 2025
This study assesses how the ways in which nicotine and cannabis vaping devices are labeled impact use susceptibility, anticipated effects, and health harm.
- Conditions
- Vaping, Adolescent, Electronic Cigarette Use, Nicotine
- Trial name
- EPIC/ADVANCE (NCT06919276)
- Testing
- Vaping Device Labeling
- Where
- United States
- Volunteers
- 3,048 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Nicotine Dependence
Glucocorticoid Antagonist Treatment for Tobacco Use Disorder
The purpose of this protocol is to examine whether mifepristone, a medication with glucocorticoid receptor antagonist activity, may be a potential treatment for Tobacco Use Disorder (TUD).
- Trial name
- NCT03248713
- Testing
- Mifepristone
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Yale University
Tobacco Dependence
UW Quitting Using Intensive Treatment Study (QUITS)
This research will determine whether two highly promising modifications to varenicline treatment (i.e. use of a nicotine patch adjuvant and extended 24-week duration) produce superior smoking outcomes when they are either used…
- Trial name
- QUITS (NCT03176784)
- Testing
- Varenicline, Nicotine patch
- Where
- 2 sites in United States
- Volunteers
- 1,251 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Nicotine Dependence, Nicotine Withdrawal
Auricular Stimulation for Nicotine Withdrawal in Psychiatric Inpatients
The goal of this clinical trial is to evaluate the feasibility and preliminary effectiveness of auricular acupressure (ear seeds) combined with nicotine replacement therapy (NRT) in psychiatric inpatients (both male and female…
- Conditions
- Nicotine Dependence, Nicotine Withdrawal, Tobacco Use Disorder, Anxiety
- Trial name
- NCT07466875
- Testing
- Auricular acupressure, Nicotine Replacement Therapy (Nicotine patch plus NRT gum or lozenge)
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- Chiao-Chiao Liao
Tobacco Use Disorder
LGBT Internet Based Smoking Treatment - 1
The overall goals of this line of research are to develop and evaluate innovative treatments for lesbian, gay, bisexual, and transgender (LGBT) cigarette smokers and to understand the processes related to smoking and relapse in…
- Trial name
- NCT00111501
- Testing
- Tobacco Use Disorder, Standard Web-based intervention
- Where
- United States
- Volunteers
- 792 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Lung Cancer, Perioperative/Postoperative Complications
Lung Rehabilitation in Treating Patients With Chronic Obstructive Pulmonary Disease Who Are Undergoing Surgery for Lung Cancer
RATIONALE: Exercise may help improve lung function and lessen complications of surgery in patients with chronic obstructive pulmonary disease who are undergoing surgery for lung cancer.
- Conditions
- Lung Cancer, Perioperative/Postoperative Complications, Pulmonary Complications, Tobacco Use Disorder
- Trial name
- NCT00363428
- Testing
- exercise intervention, smoking cessation intervention, counseling intervention
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Mayo Clinic
Cannabis Dependence
Targeting Tobacco Cessation During Treatment for Cannabis Use Disorders
This project aims to develop and test an intervention for the simultaneous treatment of cannabis use disorders and tobacco smoking.
- Trial name
- NCT01834794
- Testing
- MET/CBT/CM plus NRT
- Where
- 2 sites in United States
- Volunteers
- 33 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Nicotine Dependence
Extended Cessation Treatment for Teen Smokers
This study is designed to test the efficacy of an extended smoking cessation program for teen smokers. We hypothesize that teen smokers randomized to extended treatment will have a higher abstinence rate at 52 week follow-up than…
- Trial name
- Nicoteens (NCT00459953)
- Testing
- Extended treatment
- Where
- United States
- Volunteers
- 141 people, healthy volunteers welcome
- Sponsor
- Stanford University
Nicotine Dependence
Combination Nicotine Patch / Lorcaserin for Smoking Cessation
This study plans to compare the efficacy of the nicotine patch / lorcaserin combination treatment vs. the nicotine patch alone in terms of leading to a reduction in smoking behavior and withdrawal symptoms.
- Trial name
- LorNic (NCT02906644)
- Testing
- lorcaserin, nicotine patch
- Where
- United States
- Volunteers
- 97 people
- Sponsor
- Duke University
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