Clinical trials: Abuse Tobacco
Nicotine Dependence
Brain Networks and Addiction Susceptibility
Background: The risk for becoming addicted to drugs varies from person to person, even among those using similar drugs in a similar way.
- Trial name
- NCT01924468
- Testing
- Oral methylphenidate and Oral haloperidol
- Where
- United States
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Smoking Cessation, Tobacco Use Disorder
Engaging Pharmacists to Advance Tobacco Treatment Service Delivery
This research will test the effects of a novel program (ENHANCE-TTS) with tools, training, and clinic facilitation support that capitalizes on pharmacists' roles by expanding their scope of practice to deliver tobacco treatment.
- Conditions
- Smoking Cessation, Tobacco Use Disorder, Smoking, HIV
- Trial name
- NCT07501624
- Testing
- ENgaging pHarmacists to AdvANCE Tobacco Treatment Service delivery (ENHANCE-TTS)
- Where
- United States
- Volunteers
- 172 people
- Sponsor
- Medical University of South Carolina
Tobacco Use Disorder, Tobacco Use Cessation
Cannabis-Tobacco Co-Use Treatment Study
The purpose of the RECLAIM study is to evaluate the effectiveness of varenicline (sometimes known as Chantix) compared to placebo (an inactive substance) for the treatment of cigarettes and cannabis (marijuana).
- Conditions
- Tobacco Use Disorder, Tobacco Use Cessation, Cannabis Use, Cannabis Use Disorder
- Trial name
- RECLAIM (NCT06883162)
- Testing
- Varenicline, Counseling, Psychosocial modules
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Tobacco Dependence
Targeted Pharmacological and Behavioral Treatments for Smoking in Schizophrenia Study 1
Schizophrenia is associated with high rates of cigarette smoking and associated morbidity and mortality. In this study, smokers with schizophrenia will complete a baseline session and then randomized to varenicline (VAR) or…
- Trial name
- NCT03507127
- Testing
- Varenicline
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Brown University
Smoking Cessation, Cigarette Smoking
Quit With Sense: Using Mindful Smoking and Wearable Device for Smoking Cessation
This pilot randomized controlled trial will test the feasibility of a smoking cessation intervention using mindful smoking practice and a smartphone-based sensor-band among adults who regularly smoke cigarettes.
- Conditions
- Smoking Cessation, Cigarette Smoking, Tobacco Use, Nicotine Dependence
- Trial name
- NCT07789496
- Testing
- Mindful Smoking and Sensor-Band Intervention, Smoking Cessation Information
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Minnesota
Addictive Behavior, Alcohol Use Disorder (AUD)
Volitional Dysfunction in Self-control Failures and Addictive Behaviors
The aim of this project is to elucidate whether impairments of cognitive control, performance-monitoring, and value-based decision-making and dysfunctional interactions between underlying brain systems are mediating mechanisms…
- Conditions
- Addictive Behavior, Alcohol Use Disorder (AUD), Tobacco Use Disorder, Self-Control
- Trial name
- NCT04498988
- Testing
- Observational study without interventions
- Where
- Germany
- Volunteers
- 338 people, healthy volunteers welcome
- Sponsor
- Technische Universität Dresden
Nicotine Dependence
Understanding How Cigarette Direct Mail Marketing Influences Smoking Behaviors Among High and Low Socioeconomic Status Young Adult Smokers
Background: Smoking is a major public health problem in the U.S. Almost a half a million Americans die from it in a year. One thing that contributes to why people smoke is the marketing of cigarettes.
- Trial name
- NCT02974582
- Testing
- Exposure to smoking advertising with coupon, Exposure to smoking advertising without coupons, Exposure to non health related images
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- National Institute on Minority Health and Health Disparities (NIMHD)
Tobacco Dependence
System Based Tracking and Treatment for Emergency Patients Who Smoke: STTEPS
Emergency Departments (EDs) are a critical component of the U.S. healthcare system, treating over 119 million patients each year.
- Trial name
- STTEPS (NCT01839903)
- Testing
- EDIS, Care as usual
- Where
- 2 sites in United States
- Volunteers
- 444 people
- Sponsor
- The Miriam Hospital
Opioid-use Disorder, Tobacco Use Disorder
Adjunctive Transcranial Stimulation to Reduce Impulsivity in Opiate Use Disorder
The goal of this study is to examine the effect of four sessions of theta burst stimulation (TBS) versus sham TMS on attentional bias for smoking and opioid cues versus neutral stimuli in a population of patients with tobacco use…
- Trial name
- NCT05049460
- Testing
- Theta Burst Stimulation
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Gopalkumar Rakesh
Nicotine Dependence
The Interaction of Flavor With Nicotine Form in Adult Smokers
This study seeks to elucidate the impact of e-cigarette flavor on subjective effects and nicotine exposure from e-cigarettes containing different forms of nicotine.
- Trial name
- NCT04262817
- Testing
- Nicotine form, E-cigarette experimental flavor
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Yale University
Schizophrenia, Substance Abuse
Screening Protocol for Research Participants
The Screening Protocol is a system devised to evaluate potential research participants for National Institute on Drug Abuse/Maryland Psychiatric Research Center (NIDA/MPRC) studies.
- Conditions
- Schizophrenia, Substance Abuse, Cocaine Abuse, Tobacco Use Disorder
- Trial name
- ScreenProt (NCT01010620)
- Testing
- Various Screening psychiatric and medical assessments
- Where
- United States
- Volunteers
- 523 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Nicotine Dependence, Other Tobacco Product, Bladder Cancer
Evaluation of Appeal and Impact of E-Cigarettes Among Chronic Smokers With Smoking-Related Cancers
This study will test feasibility, in smokers with lung, head \& neck, and bladder cancers, that examines the effect of e-cigarette substitution, on measures of smoking-related toxicity and medical outcomes.
- Conditions
- Nicotine Dependence, Other Tobacco Product, Bladder Cancer, Lung Cancer, Cancer of Head and Neck
- Trial name
- NCT02648178
- Testing
- HALO
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Nicotine Dependence, Nicotine Withdrawal
Auricular Stimulation for Nicotine Withdrawal in Psychiatric Inpatients
The goal of this clinical trial is to evaluate the feasibility and preliminary effectiveness of auricular acupressure (ear seeds) combined with nicotine replacement therapy (NRT) in psychiatric inpatients (both male and female…
- Conditions
- Nicotine Dependence, Nicotine Withdrawal, Tobacco Use Disorder, Anxiety
- Trial name
- NCT07466875
- Testing
- Auricular acupressure, Nicotine Replacement Therapy (Nicotine patch plus NRT gum or lozenge)
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- Chiao-Chiao Liao
Schizophrenia and Disorders With Psychotic Features, Tobacco Use Disorder
Nicotine and Cotinine Levels in Smokers With Schizophrenia and Schizoaffective Disorder - 2
Nicotine dependence is very common among individuals with schizophrenia and schizoaffective disorder. Cotinine is a chemical that is made by the body from nicotine.
- Trial name
- NCT00135772
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Smoking Cessation, Tobacco Use Disorder
Effectiveness of Various Smoking Cessation Therapies in Reducing Smoking in Adolescents - 1
Currently one in five high school students smokes. Smoking can harm adolescents well before they reach adulthood by causing a number of immediate, sometimes irreversible, health risks and problems.
- Trial name
- NCT00158171
- Testing
- Nicotine Replacement Therapies, Nicotine patch, Folic Acid
- Where
- United States
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Nicotine Use Disorder
Identify the Optimal TMS Pulse Protocol to Modulate Reward Activity
The primary goal will be to identify the optimal pulse protocol by systematically measuring the efficacy of various theta burst stimulation and repetitive rTMS protocols to increase and decrease the reward positivity in dependent…
- Trial name
- NCT06695884
- Testing
- Transcranial Magnetic Stimulation
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Rutgers, The State University of New Jersey
Nicotine Dependence
Coping Skills Treatment for Smoking Cessation
The primary purpose of this study is to evaluate the efficacy of a new type of exposure- and acceptance-based smoking cessation treatment vs.
- Trial name
- Project-WIN (NCT01061528)
- Testing
- Transdermal Nicotine
- Where
- United States
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- Butler Hospital
Nicotine Dependence
EEG & Behavioral Predictors of Changes in Smoking Trajectories in Young Light Smokers
The purpose of the proposal is to identify new predictors of smoking progression in young light smokers (YLS: 18-25 years \& cpd < 5) using an 18-month longitudinal design and to relate these predictors of progression to the…
- Trial name
- NCT02129387
- Where
- United States
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- Southern Illinois University Carbondale
Nicotine Dependence, Nicotine Addiction
Effectiveness of N-Acetylcysteine (NAC) in Motivational Enhancement Therapy for Nicotine Addiction
The goal of this clinical trial is to determine the effectiveness of the combination of n-acetylcysteine and motivational enhancement therapy on laboratory improvement in the form of changes in blood nicotine, radiological…
- Trial name
- NCT05903014
- Testing
- n-acetylcysteine, Motivational Enhancement Therapy
- Where
- Indonesia
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Universitas Indonesia
Precancerous Lesions of the Oral Mucosa
Autofluorescence for the Screening of Precancerous and Malignant Lesions
Diagnosis of oral squamous cell carcinoma is always too late. Due to this delay for diagnosis, prognosis is very bad. It has been demonstrate that systematic oral examination decrease mortality in tobacco and alcohol consumers…
- Trial name
- FLUOK (NCT01167790)
- Testing
- buccal cavity examination
- Where
- France
- Volunteers
- 180 people
- Sponsor
- University Hospital, Bordeaux
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