Clinical trials: Acetaminophen Toxicity
Acetaminophen, Drug Overdose
Evaluation of the Efficacy of Fomepizole in the Treatment of Acetaminophen Overdose
This study is a randomized, placebo-controlled double-blinded clinical trial of patients presenting with acetaminophen poisoning who are at increased risk of developing liver injury.
- Conditions
- Acetaminophen, Drug Overdose, Acetaminophen Overdose, Acetaminophen Poisoning
- Trial name
- NCT05517668
- Testing
- Intravenous infusion of N-acetylcysteine, Intravenous infusion of Fomepizole (4-MP)
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Richard Dart, MD, PhD
Fever, Sepsis
Paracetamol Toxicity in Septic Patients
The investigators will examine the toxicity of therapeutic doses of paracetamol in patients in severe sepsis. Patients with fever and severe sepsis will be randomized to receive paracetamol or dypirone.
- Trial name
- NCT01182974
- Testing
- paracetamol, dypirone
- Where
- Israel
- Volunteers
- 80 people
- Sponsor
- Barzilai Medical Center
Drug Toxicity, Healthy
Aminotransferase Trends During Prolonged Acetaminophen Dosing
The objective of this study is to monitor liver function tests (blood levels of an indicator of liver function) of healthy people taking the maximum labeled daily dose of acetaminophen compared to people taking placebo for 16 to…
- Trial name
- NCT00743093
- Testing
- acetaminophen
- Where
- 2 sites in United States
- Volunteers
- 398 people, healthy volunteers welcome
- Sponsor
- Denver Health and Hospital Authority
Drug Toxicity
Cytokines Polymorphisms and Acetaminophen Toxicity
Genotyping assays for polymorphisms in the interleukin 10(IL10)gene and the inducible nitric oxide synthase (iNOS) gene will be performed. Genotypes will be compared to the severity of toxicity following overdose.
- Trial name
- NCT00166608
- Testing
- Blood sampling
- Where
- 7 sites in United States
- Volunteers
- 111 people
- Sponsor
- Arkansas Children's Hospital Research Institute
Acetaminophen Toxicity
Adduct Dipstick for Diagnosis of Acetaminophen Toxicity
This study is a non-intervention, clinical study to test "research use only" APAP protein adducts dipsticks in human blood samples. The study will be conducted in two phases.
- Trial name
- NCT01575847
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Arkansas Children's Hospital Research Institute
Hepatitis, Pharmacology
A Partial Randomized, Single-blind or Open-label, Dose-escalation With Multiple-dose Design Study to Evaluate the Pharmacokinetics of Acetaminophen and Its Toxic Metabolites With Panadol® and SafeTynadol® in Healthy Volunteers
To investigate and compare the possible response of Panadol® and SafeTynadol® formulations in healthy volunteers and the safety in SafeTynadol® dose-limiting hepatotoxicity.
- Trial name
- NCT05563961
- Testing
- Panadol®, SafeTynadol®
- Where
- Taiwan
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Sinew Pharma Inc.
Acetaminophen Toxicity
Acetaminophen Biomarkers
This study is a non-intervention, multicenter study to address biomarkers of acetaminophen toxicity in children. Specifically, the study will examine acetaminophen (APAP) protein adducts and markers of liver injury in the blood…
- Trial name
- NCT01005173
- Where
- 8 sites in United States
- Volunteers
- 253 people, healthy volunteers welcome
- Sponsor
- Arkansas Children's Hospital Research Institute
Paracetamol Toxicity, Hepatotoxicity
APAP Hepatotoxicity After Therapeutic Doses
Paracetamol (acetaminophen, APAP) is the most commonly used antipyretic and painkiller worldwide, but also the leading cause of acute liver failure (ALF) in developed countries after supra-therapeutic doses (half overdoses being…
- Conditions
- Paracetamol Toxicity, Hepatotoxicity, Malnutrition
- Trial name
- NCT03602274
- Testing
- Hepatic function monitoring, Nutritional status assesment, Biomarker research sampling
- Where
- Switzerland
- Volunteers
- 96 people
- Sponsor
- University Hospital, Geneva
Overdose
Scottish and Newcastle Anti-emetic Pre-treatment for Paracetamol Poisoning Study (SNAP)
This study is designed to assess the impact of new approaches to therapy for paracetamol poisoning. Standard therapy is currently acetylcysteine by intravenous infusion over 20.25h.
- Trial name
- SNAP (NCT01050270)
- Testing
- Ondansetron, acetylcysteine
- Where
- 3 sites in United Kingdom
- Volunteers
- 222 people
- Sponsor
- University of Edinburgh
Acute Liver Failure, Hepatic Encephalopathy
A Multi-Center Group to Study Acute Liver Failure in Children
The PALF study group began with 20 sites and now continues with 12 sites (11 in the United States and 1 in Canada) in the new funding period.
- Trial name
- NCT00986648
- Where
- 20 sites in United States, Canada and 1 more
- Volunteers
- 158 people
- Sponsor
- University of Pittsburgh
Paracetamol Toxicity
Evaluation of Differences Between the Standered NAC Regimen Protocol and the SNAP Regimen Protocol in the Treatment of Paracetamol Toxicity for Cases Presented Early and Late to Assiut University Hospitals in Terms of Safety and Efficiecy.
Evaluation of differences between the 21 h NAC regimen protocol and the 12 h NAC regimen protocol in the treatment of paracetamol toxicity (over dose) for cases presented early and late to Assiut University Hospitals in terms of…
- Trial name
- NCT07454590
- Testing
- Evidence-based medical care for paracetamol toxicity
- Where
- Egypt
- Volunteers
- 102 people
- Sponsor
- Assiut University
Acetaminophen Metabolism, Acetaminophen Poisoning
Effect on Acetaminophen Metabolism by Liquid Formulations
The purpose of this study is to determine whether excipients in the liquid formulation of acetaminophen prevent the formation of the toxic metabolites of acetaminophen.
- Conditions
- Acetaminophen Metabolism, Acetaminophen Poisoning, Drug Metabolism by Excipients
- Trial name
- NCT01246713
- Testing
- Acetaminophen liquid formulation, Acetaminophen solid formulation
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Drug Toxicity
Protective Effect of Nicotinamide Riboside Against Acetaminophen Toxicity
Over-the-counter drugs like acetaminophen (e.g., Tylenol®) can be detrimental. In space, astronauts who have pain and constant discomfort use acetaminophen extensively.
- Trial name
- NCT06214468
- Testing
- Acetaminophen and Nicotinamide Riboside, Acetaminophen
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of South Alabama
Paracetamol Overdose
The Markers and Paracetamol Poisoning Study 2
Paracetamol overdose is one of the most common medical emergencies. Annually in the UK, 100,000 people seek medical attention and 50,000 need hospital admission.
- Trial name
- MAPP2 (NCT03497104)
- Testing
- Surplus blood tests
- Where
- United Kingdom
- Volunteers
- 464 people
- Sponsor
- NHS Lothian
Acetaminophen Toxicity
A Randomized, Single-blind, Parallel Group and Multiple - Dose Design Study
To investigate and compare the possible response of Panadol® and SafeTynadol® formulations in healthy volunteers.
- Trial name
- NCT03451487
- Testing
- Panadol®, SafeTynadol®
- Where
- Taiwan
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Sinew Pharma Inc.
Acetaminophen Toxicity, Obesity, Morbid
Pharmacokinetics and Pharmacodynamics of Intravenous Paracetamol in Morbidly Obese and Non- Obese Patients.
Obese patients may need higher doses of acetaminophen (APAP) for adequate analgesia, due to increased total clearance and distribution volume. APAP-induced hepatotoxicity is mainly caused through CYP2E1 pathway.
- Trial name
- NCT06549062
- Where
- Belgium
- Volunteers
- 70 people
- Sponsor
- University Hospital, Ghent
Acetaminophen Toxicity
Treatment of Acetaminophen Toxicity With N-acetylcysteine
Retrospective chart review of patients who received N-acetylcysteine for APAP toxicity to assess length of oral vs IV treatment and overall healthcare costs.
- Trial name
- NCT00725179
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- Akron Children's Hospital
Acetaminophen Toxicity
Treatment of APAP Toxicity With IV and Oral NAC 2008-2011
Retrospective chart review of patients who receive N-acetylcysteine for Acetaminophen(APAP) toxicity to assess length of oral vs.
- Trial name
- NCT01465542
- Where
- United States
- Volunteers
- 47 people
- Sponsor
- Akron Children's Hospital
Pain
Metabolism and Toxicity of Acetaminophen
The purpose of this study is to investigate how acetaminophen (APAP) is released into the urine and blood; to determine how the blood levels of acetaminophen and its breakdown products affect the preterm infant's health; to…
- Trial name
- NCT01328808
- Testing
- Acetaminophen/APAP
- Where
- 2 sites in United States
- Volunteers
- 31 people
- Sponsor
- John van den Anker
Acetaminophen Toxicity
Protective Effects of Propylene Glycol in Daily Acetaminophen Dosing
A purpose of this protocol is to is to compare the metabolites of the toxic bioactivating pathway after acetaminophen alone or acetaminophen followed by Propylene Glycol (PG) and to determine if it prevents the formation of the…
- Trial name
- APAPII (NCT02322879)
- Testing
- First Treatment Period, Washout, Second Treatment Period
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center